Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

Dynein light chain LC6, flagellar outer arm, putative

Species:

Leishmania braziliensis

UniProt:

A4HGR7_LEIBR

TriTrypDb:

LbrM.28.2330 , LBRM2903_280029700

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0005874	microtubule	6	7
GO:0005875	microtubule associated complex	2	7
GO:0005929	cilium	4	6
GO:0030286	dynein complex	3	7
GO:0031514	motile cilium	5	6
GO:0032991	protein-containing complex	1	7
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:1902494	catalytic complex	2	7
GO:0005868	cytoplasmic dynein complex	4	1

Expansion

Sequence features

A4HGR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGR7

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	7
GO:0009987	cellular process	1	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	43	45	PF00675	0.340
CLV_NRD_NRD_1	48	50	PF00675	0.316
LIG_FHA_1	6	12	PF00498	0.355
LIG_FHA_1	80	86	PF00498	0.539
LIG_FHA_2	33	39	PF00498	0.486
LIG_FHA_2	66	72	PF00498	0.539
LIG_LIR_Gen_1	19	26	PF02991	0.493
LIG_LIR_Gen_1	54	63	PF02991	0.493
LIG_LIR_Gen_1	71	79	PF02991	0.493
LIG_LIR_Nem_3	19	24	PF02991	0.515
LIG_LIR_Nem_3	54	58	PF02991	0.495
LIG_LIR_Nem_3	71	77	PF02991	0.493
LIG_SH2_STAT3	78	81	PF00017	0.493
LIG_SH2_STAT5	74	77	PF00017	0.526
LIG_SH2_STAT5	78	81	PF00017	0.529
LIG_TRAF2_1	35	38	PF00917	0.524
LIG_TRAF2_1	68	71	PF00917	0.539
LIG_WRC_WIRS_1	39	44	PF05994	0.539
LIG_WRC_WIRS_1	63	68	PF05994	0.493
MOD_CK1_1	65	71	PF00069	0.493
MOD_CK2_1	32	38	PF00069	0.524
MOD_CK2_1	65	71	PF00069	0.539
MOD_GlcNHglycan	5	8	PF01048	0.379
MOD_GSK3_1	5	12	PF00069	0.392
MOD_NEK2_2	5	10	PF00069	0.328
MOD_Plk_4	38	44	PF00069	0.539
MOD_Plk_4	62	68	PF00069	0.493
MOD_Plk_4	70	76	PF00069	0.493
TRG_DiLeu_BaEn_2	37	43	PF01217	0.539
TRG_ENDOCYTIC_2	74	77	PF00928	0.493
TRG_NES_CRM1_1	13	27	PF08389	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0W1	Leptomonas seymouri	51%	99%
A0A0N1I1Z7	Leptomonas seymouri	39%	100%
A0A0N1PBY8	Leptomonas seymouri	43%	99%
A0A0N1PCF1	Leptomonas seymouri	30%	84%
A0A0N1PCX2	Leptomonas seymouri	30%	80%
A0A0S4IS05	Bodo saltans	69%	100%
A0A0S4IUR3	Bodo saltans	46%	99%
A0A0S4J005	Bodo saltans	36%	69%
A0A0S4J1R8	Bodo saltans	47%	99%
A0A0S4JE57	Bodo saltans	39%	100%
A0A0S4JH61	Bodo saltans	47%	71%
A0A0S4JKR9	Bodo saltans	35%	89%
A0A0S4JQ28	Bodo saltans	44%	100%
A0A1X0P6I9	Trypanosomatidae	36%	75%
A0A1X0P8I8	Trypanosomatidae	31%	80%
A0A3Q8IDB7	Leishmania donovani	44%	80%
A0A3Q8IDX2	Leishmania donovani	97%	100%
A0A3S5H7E1	Leishmania donovani	41%	100%
A0A3S5H7R1	Leishmania donovani	51%	99%
A0A3S7WNY4	Leishmania donovani	40%	99%
A0A3S7WTY9	Leishmania donovani	30%	80%
A0A422NC25	Trypanosoma rangeli	38%	83%
A0A422NHE2	Trypanosoma rangeli	35%	80%
A4H453	Leishmania braziliensis	41%	99%
A4H8L8	Leishmania braziliensis	31%	80%
A4HA47	Leishmania braziliensis	45%	80%
A4HDX3	Leishmania braziliensis	37%	100%
A4HK04	Leishmania braziliensis	49%	100%
A4HSD6	Leishmania infantum	40%	99%
A4HWY9	Leishmania infantum	30%	80%
A4HYB3	Leishmania infantum	44%	80%
A4I168	Leishmania infantum	41%	100%
A4I3U2	Leishmania infantum	97%	100%
A4I7I7	Leishmania infantum	51%	99%
C9ZPY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A0N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	69%
D0A2J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	80%
D0A5F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A5K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AKB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	99%
E9AQQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	80%
E9AS46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	80%
E9AXA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B034	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B2E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	99%
O02414	Heliocidaris crassispina	52%	100%
O94111	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	43%	96%
O96860	Drosophila melanogaster	52%	100%
P61273	Macaca fascicularis	49%	100%
P61285	Bos taurus	49%	100%
P63167	Homo sapiens	49%	100%
P63168	Mus musculus	49%	100%
P63169	Oryctolagus cuniculus	49%	100%
P63170	Rattus norvegicus	49%	100%
Q02647	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	98%
Q21557	Caenorhabditis elegans	26%	100%
Q22799	Caenorhabditis elegans	51%	100%
Q24117	Drosophila melanogaster	51%	100%
Q39579	Chlamydomonas reinhardtii	31%	75%
Q39580	Chlamydomonas reinhardtii	51%	99%
Q3MHR3	Bos taurus	48%	100%
Q4Q5R2	Leishmania major	50%	100%
Q4Q852	Leishmania major	97%	100%
Q4QA70	Leishmania major	41%	100%
Q4QDC0	Leishmania major	44%	80%
Q4QES6	Leishmania major	30%	100%
Q4QJJ6	Leishmania major	40%	100%
Q6BZF8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	40%	99%
Q6CWX4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	36%	100%
Q6FUJ0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	46%	100%
Q759T0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	37%	100%
Q78P75	Rattus norvegicus	48%	100%
Q86A88	Dictyostelium discoideum	43%	99%
Q94748	Schistosoma mansoni	43%	100%
Q94758	Schistosoma mansoni	46%	100%
Q96FJ2	Homo sapiens	48%	100%
Q9D0M5	Mus musculus	48%	100%
Q9UR05	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
V5AV01	Trypanosoma cruzi	41%	100%
V5BSX5	Trypanosoma cruzi	48%	100%
V5BXL9	Trypanosoma cruzi	39%	100%