Putative cullin 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative cullin 2

Gene product:

cullin 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HGR6_LEIBR

TriTrypDb:

LbrM.28.2320 , LBRM2903_280029600

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

A4HGR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGR6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	17
GO:0006511	ubiquitin-dependent protein catabolic process	7	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009056	catabolic process	2	17
GO:0009057	macromolecule catabolic process	4	17
GO:0009987	cellular process	1	17
GO:0019538	protein metabolic process	3	17
GO:0019941	modification-dependent protein catabolic process	6	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043632	modification-dependent macromolecule catabolic process	5	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0044248	cellular catabolic process	3	17
GO:0044260	obsolete cellular macromolecule metabolic process	3	17
GO:0044265	obsolete cellular macromolecule catabolic process	4	17
GO:0051603	proteolysis involved in protein catabolic process	5	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17
GO:1901575	organic substance catabolic process	3	17
GO:0016567	protein ubiquitination	7	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043412	macromolecule modification	4	2
GO:0070647	protein modification by small protein conjugation or removal	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	17
GO:0005515	protein binding	2	17
GO:0019899	enzyme binding	3	17
GO:0031625	ubiquitin protein ligase binding	5	17
GO:0044389	ubiquitin-like protein ligase binding	4	17
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.463
CLV_C14_Caspase3-7	4	8	PF00656	0.524
CLV_C14_Caspase3-7	402	406	PF00656	0.595
CLV_NRD_NRD_1	117	119	PF00675	0.348
CLV_NRD_NRD_1	133	135	PF00675	0.280
CLV_NRD_NRD_1	216	218	PF00675	0.368
CLV_NRD_NRD_1	324	326	PF00675	0.343
CLV_NRD_NRD_1	512	514	PF00675	0.351
CLV_NRD_NRD_1	710	712	PF00675	0.603
CLV_PCSK_KEX2_1	216	218	PF00082	0.283
CLV_PCSK_KEX2_1	417	419	PF00082	0.348
CLV_PCSK_KEX2_1	512	514	PF00082	0.306
CLV_PCSK_KEX2_1	692	694	PF00082	0.527
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.348
CLV_PCSK_PC1ET2_1	692	694	PF00082	0.497
CLV_PCSK_PC7_1	688	694	PF00082	0.514
CLV_PCSK_SKI1_1	138	142	PF00082	0.322
CLV_PCSK_SKI1_1	266	270	PF00082	0.221
CLV_PCSK_SKI1_1	404	408	PF00082	0.301
CLV_PCSK_SKI1_1	417	421	PF00082	0.286
CLV_PCSK_SKI1_1	449	453	PF00082	0.285
CLV_PCSK_SKI1_1	52	56	PF00082	0.327
CLV_PCSK_SKI1_1	692	696	PF00082	0.443
CLV_PCSK_SKI1_1	701	705	PF00082	0.478
CLV_PCSK_SKI1_1	79	83	PF00082	0.301
CLV_PCSK_SKI1_1	89	93	PF00082	0.289
DEG_APCC_DBOX_1	133	141	PF00400	0.548
DEG_APCC_DBOX_1	687	695	PF00400	0.459
DEG_APCC_DBOX_1	78	86	PF00400	0.548
DEG_Nend_UBRbox_4	1	3	PF02207	0.518
DOC_CKS1_1	124	129	PF01111	0.548
DOC_CYCLIN_RxL_1	413	425	PF00134	0.548
DOC_CYCLIN_RxL_1	49	56	PF00134	0.470
DOC_CYCLIN_RxL_1	697	708	PF00134	0.453
DOC_MAPK_gen_1	118	125	PF00069	0.548
DOC_MAPK_gen_1	325	334	PF00069	0.483
DOC_MAPK_gen_1	76	85	PF00069	0.488
DOC_PP1_RVXF_1	545	551	PF00149	0.548
DOC_USP7_MATH_1	399	403	PF00917	0.470
DOC_USP7_MATH_1	523	527	PF00917	0.534
DOC_USP7_MATH_1	534	538	PF00917	0.501
DOC_USP7_MATH_1	540	544	PF00917	0.469
DOC_USP7_MATH_1	634	638	PF00917	0.475
DOC_USP7_MATH_2	623	629	PF00917	0.472
DOC_USP7_UBL2_3	27	31	PF12436	0.548
DOC_USP7_UBL2_3	413	417	PF12436	0.483
DOC_WW_Pin1_4	104	109	PF00397	0.507
DOC_WW_Pin1_4	123	128	PF00397	0.494
DOC_WW_Pin1_4	147	152	PF00397	0.463
DOC_WW_Pin1_4	20	25	PF00397	0.526
DOC_WW_Pin1_4	439	444	PF00397	0.548
LIG_14-3-3_CanoR_1	118	124	PF00244	0.548
LIG_14-3-3_CanoR_1	128	137	PF00244	0.548
LIG_14-3-3_CanoR_1	240	244	PF00244	0.538
LIG_14-3-3_CanoR_1	350	359	PF00244	0.556
LIG_14-3-3_CanoR_1	491	499	PF00244	0.605
LIG_14-3-3_CanoR_1	76	82	PF00244	0.503
LIG_BRCT_BRCA1_1	197	201	PF00533	0.548
LIG_Clathr_ClatBox_1	101	105	PF01394	0.542
LIG_DLG_GKlike_1	357	364	PF00625	0.391
LIG_EH1_1	226	234	PF00400	0.548
LIG_FHA_1	110	116	PF00498	0.483
LIG_FHA_1	21	27	PF00498	0.547
LIG_FHA_1	455	461	PF00498	0.483
LIG_FHA_1	628	634	PF00498	0.687
LIG_FHA_2	2	8	PF00498	0.523
LIG_FHA_2	233	239	PF00498	0.495
LIG_FHA_2	46	52	PF00498	0.536
LIG_FHA_2	564	570	PF00498	0.556
LIG_FHA_2	667	673	PF00498	0.500
LIG_LIR_Apic_2	391	397	PF02991	0.548
LIG_LIR_Apic_2	519	523	PF02991	0.483
LIG_LIR_Gen_1	186	195	PF02991	0.556
LIG_LIR_Gen_1	310	321	PF02991	0.596
LIG_LIR_Gen_1	549	556	PF02991	0.527
LIG_LIR_Gen_1	625	634	PF02991	0.588
LIG_LIR_Gen_1	7	16	PF02991	0.474
LIG_LIR_Gen_1	90	96	PF02991	0.600
LIG_LIR_Gen_1	97	104	PF02991	0.441
LIG_LIR_Nem_3	169	175	PF02991	0.498
LIG_LIR_Nem_3	186	190	PF02991	0.433
LIG_LIR_Nem_3	267	272	PF02991	0.574
LIG_LIR_Nem_3	310	316	PF02991	0.481
LIG_LIR_Nem_3	318	323	PF02991	0.444
LIG_LIR_Nem_3	358	364	PF02991	0.527
LIG_LIR_Nem_3	391	396	PF02991	0.516
LIG_LIR_Nem_3	481	485	PF02991	0.502
LIG_LIR_Nem_3	625	629	PF02991	0.573
LIG_LIR_Nem_3	7	12	PF02991	0.427
LIG_LIR_Nem_3	77	81	PF02991	0.486
LIG_LIR_Nem_3	90	95	PF02991	0.492
LIG_LIR_Nem_3	97	102	PF02991	0.494
LIG_NRBOX	136	142	PF00104	0.548
LIG_NRBOX	569	575	PF00104	0.595
LIG_PCNA_PIPBox_1	552	561	PF02747	0.531
LIG_PCNA_yPIPBox_3	428	437	PF02747	0.550
LIG_Pex14_2	269	273	PF04695	0.548
LIG_SH2_CRK	13	17	PF00017	0.408
LIG_SH2_CRK	172	176	PF00017	0.516
LIG_SH2_CRK	187	191	PF00017	0.516
LIG_SH2_CRK	203	207	PF00017	0.537
LIG_SH2_CRK	313	317	PF00017	0.494
LIG_SH2_CRK	361	365	PF00017	0.548
LIG_SH2_CRK	520	524	PF00017	0.532
LIG_SH2_NCK_1	520	524	PF00017	0.391
LIG_SH2_STAP1	313	317	PF00017	0.589
LIG_SH2_STAP1	524	528	PF00017	0.486
LIG_SH2_STAT3	43	46	PF00017	0.548
LIG_SH2_STAT5	180	183	PF00017	0.492
LIG_SH2_STAT5	187	190	PF00017	0.498
LIG_SH2_STAT5	394	397	PF00017	0.548
LIG_SH2_STAT5	461	464	PF00017	0.518
LIG_SH2_STAT5	74	77	PF00017	0.495
LIG_SH2_STAT5	9	12	PF00017	0.378
LIG_SH3_3	121	127	PF00018	0.522
LIG_SH3_3	480	486	PF00018	0.499
LIG_SH3_3	711	717	PF00018	0.473
LIG_SUMO_SIM_par_1	100	107	PF11976	0.391
LIG_SUMO_SIM_par_1	603	610	PF11976	0.350
LIG_SUMO_SIM_par_1	682	687	PF11976	0.533
LIG_TRAF2_1	669	672	PF00917	0.566
LIG_TRFH_1	583	587	PF08558	0.340
LIG_TYR_ITIM	11	16	PF00017	0.428
LIG_UBA3_1	282	288	PF00899	0.479
LIG_UBA3_1	673	681	PF00899	0.348
LIG_WRC_WIRS_1	356	361	PF05994	0.332
LIG_WRC_WIRS_1	626	631	PF05994	0.604
LIG_WRC_WIRS_1	673	678	PF05994	0.356
MOD_CDK_SPK_2	123	128	PF00069	0.332
MOD_CDK_SPxxK_3	104	111	PF00069	0.364
MOD_CDK_SPxxK_3	20	27	PF00069	0.422
MOD_CK1_1	100	106	PF00069	0.282
MOD_CK1_1	456	462	PF00069	0.202
MOD_CK1_1	478	484	PF00069	0.386
MOD_CK1_1	492	498	PF00069	0.330
MOD_CK1_1	563	569	PF00069	0.455
MOD_CK1_1	604	610	PF00069	0.502
MOD_CK1_1	63	69	PF00069	0.413
MOD_CK1_1	77	83	PF00069	0.347
MOD_CK2_1	171	177	PF00069	0.367
MOD_CK2_1	239	245	PF00069	0.413
MOD_CK2_1	45	51	PF00069	0.467
MOD_CK2_1	563	569	PF00069	0.447
MOD_CK2_1	574	580	PF00069	0.409
MOD_CK2_1	666	672	PF00069	0.471
MOD_CK2_1	684	690	PF00069	0.324
MOD_GlcNHglycan	299	302	PF01048	0.244
MOD_GlcNHglycan	400	404	PF01048	0.202
MOD_GlcNHglycan	491	494	PF01048	0.416
MOD_GlcNHglycan	519	523	PF01048	0.418
MOD_GlcNHglycan	525	528	PF01048	0.360
MOD_GlcNHglycan	589	592	PF01048	0.372
MOD_GlcNHglycan	596	599	PF01048	0.544
MOD_GlcNHglycan	66	69	PF01048	0.272
MOD_GlcNHglycan	664	667	PF01048	0.459
MOD_GlcNHglycan	678	681	PF01048	0.570
MOD_GSK3_1	100	107	PF00069	0.397
MOD_GSK3_1	119	126	PF00069	0.403
MOD_GSK3_1	14	21	PF00069	0.492
MOD_GSK3_1	147	154	PF00069	0.355
MOD_GSK3_1	247	254	PF00069	0.403
MOD_GSK3_1	293	300	PF00069	0.462
MOD_GSK3_1	351	358	PF00069	0.383
MOD_GSK3_1	41	48	PF00069	0.445
MOD_GSK3_1	452	459	PF00069	0.416
MOD_GSK3_1	481	488	PF00069	0.339
MOD_GSK3_1	518	525	PF00069	0.408
MOD_GSK3_1	60	67	PF00069	0.419
MOD_GSK3_1	600	607	PF00069	0.539
MOD_GSK3_1	658	665	PF00069	0.518
MOD_GSK3_1	672	679	PF00069	0.466
MOD_GSK3_1	70	77	PF00069	0.328
MOD_GSK3_1	87	94	PF00069	0.472
MOD_N-GLC_2	338	340	PF02516	0.422
MOD_NEK2_1	1	6	PF00069	0.575
MOD_NEK2_1	232	237	PF00069	0.365
MOD_NEK2_1	272	277	PF00069	0.346
MOD_NEK2_1	287	292	PF00069	0.394
MOD_NEK2_1	407	412	PF00069	0.358
MOD_NEK2_1	45	50	PF00069	0.253
MOD_NEK2_1	452	457	PF00069	0.400
MOD_NEK2_1	489	494	PF00069	0.491
MOD_NEK2_1	546	551	PF00069	0.358
MOD_NEK2_1	594	599	PF00069	0.576
MOD_NEK2_1	662	667	PF00069	0.514
MOD_NEK2_1	676	681	PF00069	0.445
MOD_NEK2_1	684	689	PF00069	0.513
MOD_NEK2_2	352	357	PF00069	0.414
MOD_PIKK_1	128	134	PF00454	0.410
MOD_PIKK_1	454	460	PF00454	0.429
MOD_PIKK_1	560	566	PF00454	0.388
MOD_PIKK_1	60	66	PF00454	0.332
MOD_PIKK_1	634	640	PF00454	0.683
MOD_PIKK_1	653	659	PF00454	0.516
MOD_PIKK_1	706	712	PF00454	0.469
MOD_PK_1	119	125	PF00069	0.332
MOD_PKA_1	118	124	PF00069	0.422
MOD_PKA_1	362	368	PF00069	0.202
MOD_PKA_2	239	245	PF00069	0.429
MOD_PKA_2	478	484	PF00069	0.410
MOD_Plk_1	151	157	PF00069	0.419
MOD_Plk_1	161	167	PF00069	0.279
MOD_Plk_2-3	239	245	PF00069	0.286
MOD_Plk_2-3	429	435	PF00069	0.385
MOD_Plk_4	1	7	PF00069	0.481
MOD_Plk_4	119	125	PF00069	0.378
MOD_Plk_4	161	167	PF00069	0.386
MOD_Plk_4	232	238	PF00069	0.371
MOD_Plk_4	264	270	PF00069	0.401
MOD_Plk_4	330	336	PF00069	0.331
MOD_Plk_4	388	394	PF00069	0.393
MOD_Plk_4	45	51	PF00069	0.276
MOD_Plk_4	456	462	PF00069	0.352
MOD_Plk_4	494	500	PF00069	0.419
MOD_Plk_4	546	552	PF00069	0.424
MOD_Plk_4	589	595	PF00069	0.367
MOD_Plk_4	601	607	PF00069	0.431
MOD_Plk_4	610	616	PF00069	0.321
MOD_Plk_4	672	678	PF00069	0.464
MOD_Plk_4	70	76	PF00069	0.449
MOD_Plk_4	87	93	PF00069	0.413
MOD_ProDKin_1	104	110	PF00069	0.364
MOD_ProDKin_1	123	129	PF00069	0.346
MOD_ProDKin_1	147	153	PF00069	0.304
MOD_ProDKin_1	20	26	PF00069	0.391
MOD_ProDKin_1	439	445	PF00069	0.422
MOD_SUMO_for_1	159	162	PF00179	0.422
MOD_SUMO_rev_2	260	265	PF00179	0.461
MOD_SUMO_rev_2	687	694	PF00179	0.596
TRG_DiLeu_BaEn_1	569	574	PF01217	0.318
TRG_DiLeu_BaEn_1	700	705	PF01217	0.455
TRG_DiLeu_BaEn_3	671	677	PF01217	0.421
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.335
TRG_DiLeu_BaLyEn_6	584	589	PF01217	0.202
TRG_ENDOCYTIC_2	13	16	PF00928	0.403
TRG_ENDOCYTIC_2	172	175	PF00928	0.355
TRG_ENDOCYTIC_2	187	190	PF00928	0.323
TRG_ENDOCYTIC_2	203	206	PF00928	0.370
TRG_ENDOCYTIC_2	313	316	PF00928	0.325
TRG_ENDOCYTIC_2	327	330	PF00928	0.227
TRG_ENDOCYTIC_2	361	364	PF00928	0.422
TRG_ENDOCYTIC_2	393	396	PF00928	0.416
TRG_ENDOCYTIC_2	9	12	PF00928	0.400
TRG_ER_diArg_1	215	217	PF00400	0.202
TRG_NES_CRM1_1	545	557	PF08389	0.350
TRG_NES_CRM1_1	612	625	PF08389	0.438
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.202

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILK0	Leptomonas seymouri	67%	93%
A0A0N1PDU6	Leptomonas seymouri	23%	93%
A0A0S4J5R6	Bodo saltans	22%	87%
A0A1X0NS98	Trypanosomatidae	24%	89%
A0A3Q8II83	Leishmania donovani	90%	100%
A0A3R7K7T8	Trypanosoma rangeli	24%	89%
A0A3S7X1Q2	Leishmania donovani	22%	94%
A4HGR5	Leishmania braziliensis	23%	100%
A4I3U0	Leishmania infantum	22%	94%
A4I3U1	Leishmania infantum	90%	100%
D0A911	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	89%
E9B032	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	94%
E9B033	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q853	Leishmania major	90%	100%
Q4Q854	Leishmania major	22%	100%