Putative glycerophosphoryl diester phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerophosphoryl diester phosphodiesterase, putative

Species:

Leishmania braziliensis

UniProt:

A4HGR4_LEIBR

TriTrypDb:

LbrM.28.2300 , LBRM2903_280029400

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HGR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGR4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0009056	catabolic process	2	1
GO:0009395	phospholipid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046475	glycerophospholipid catabolic process	6	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046503	glycerolipid catabolic process	5	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008081	phosphoric diester hydrolase activity	5	11
GO:0008889	glycerophosphodiester phosphodiesterase activity	6	5
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0042578	phosphoric ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.435
CLV_C14_Caspase3-7	81	85	PF00656	0.472
CLV_NRD_NRD_1	176	178	PF00675	0.280
CLV_NRD_NRD_1	221	223	PF00675	0.300
CLV_NRD_NRD_1	27	29	PF00675	0.307
CLV_NRD_NRD_1	30	32	PF00675	0.307
CLV_PCSK_FUR_1	27	31	PF00082	0.279
CLV_PCSK_KEX2_1	125	127	PF00082	0.274
CLV_PCSK_KEX2_1	223	225	PF00082	0.285
CLV_PCSK_KEX2_1	27	29	PF00082	0.325
CLV_PCSK_KEX2_1	30	32	PF00082	0.304
CLV_PCSK_KEX2_1	339	341	PF00082	0.554
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.310
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.302
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.322
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.554
CLV_PCSK_SKI1_1	232	236	PF00082	0.282
CLV_PCSK_SKI1_1	31	35	PF00082	0.318
CLV_PCSK_SKI1_1	339	343	PF00082	0.517
CLV_PCSK_SKI1_1	65	69	PF00082	0.188
DEG_Nend_UBRbox_3	1	3	PF02207	0.245
DEG_SPOP_SBC_1	260	264	PF00917	0.329
DOC_MAPK_DCC_7	163	171	PF00069	0.358
DOC_MAPK_FxFP_2	39	42	PF00069	0.553
DOC_MAPK_gen_1	125	132	PF00069	0.443
DOC_MAPK_gen_1	339	348	PF00069	0.359
DOC_MAPK_gen_1	80	89	PF00069	0.504
DOC_MAPK_MEF2A_6	125	132	PF00069	0.510
DOC_MAPK_MEF2A_6	163	171	PF00069	0.464
DOC_MAPK_MEF2A_6	339	348	PF00069	0.433
DOC_MAPK_NFAT4_5	125	133	PF00069	0.510
DOC_MAPK_RevD_3	17	30	PF00069	0.401
DOC_PP4_FxxP_1	228	231	PF00568	0.470
DOC_PP4_FxxP_1	256	259	PF00568	0.248
DOC_PP4_FxxP_1	39	42	PF00568	0.553
DOC_USP7_MATH_1	104	108	PF00917	0.529
DOC_USP7_MATH_1	133	137	PF00917	0.454
DOC_USP7_UBL2_3	115	119	PF12436	0.565
DOC_USP7_UBL2_3	174	178	PF12436	0.554
DOC_WW_Pin1_4	284	289	PF00397	0.291
LIG_APCC_ABBA_1	167	172	PF00400	0.429
LIG_BRCT_BRCA1_1	210	214	PF00533	0.574
LIG_BRCT_BRCA1_1	249	253	PF00533	0.298
LIG_EVH1_1	164	168	PF00568	0.358
LIG_FHA_1	132	138	PF00498	0.439
LIG_FHA_1	149	155	PF00498	0.451
LIG_FHA_1	194	200	PF00498	0.502
LIG_FHA_1	235	241	PF00498	0.414
LIG_LIR_Apic_2	254	259	PF02991	0.244
LIG_LIR_Gen_1	158	169	PF02991	0.363
LIG_LIR_Gen_1	250	261	PF02991	0.233
LIG_LIR_Gen_1	59	67	PF02991	0.453
LIG_LIR_LC3C_4	109	113	PF02991	0.468
LIG_LIR_Nem_3	102	106	PF02991	0.490
LIG_LIR_Nem_3	158	164	PF02991	0.368
LIG_LIR_Nem_3	233	238	PF02991	0.280
LIG_LIR_Nem_3	250	256	PF02991	0.192
LIG_LIR_Nem_3	272	276	PF02991	0.369
LIG_MLH1_MIPbox_1	210	214	PF16413	0.404
LIG_PCNA_yPIPBox_3	317	330	PF02747	0.296
LIG_Pex14_2	235	239	PF04695	0.172
LIG_Pex14_2	249	253	PF04695	0.230
LIG_REV1ctd_RIR_1	232	240	PF16727	0.418
LIG_SH2_CRK	103	107	PF00017	0.499
LIG_SH2_CRK	242	246	PF00017	0.376
LIG_SH2_STAT5	14	17	PF00017	0.249
LIG_SH2_STAT5	213	216	PF00017	0.494
LIG_SH2_STAT5	238	241	PF00017	0.266
LIG_SH2_STAT5	242	245	PF00017	0.257
LIG_SH2_STAT5	248	251	PF00017	0.365
LIG_SH2_STAT5	293	296	PF00017	0.328
LIG_SH2_STAT5	61	64	PF00017	0.464
LIG_SH3_3	162	168	PF00018	0.416
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.381
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.160
LIG_SUMO_SIM_par_1	126	131	PF11976	0.470
LIG_SUMO_SIM_par_1	73	78	PF11976	0.429
LIG_TYR_ITIM	240	245	PF00017	0.352
LIG_TYR_ITIM	246	251	PF00017	0.434
LIG_WRC_WIRS_1	60	65	PF05994	0.464
MOD_CK1_1	264	270	PF00069	0.293
MOD_Cter_Amidation	175	178	PF01082	0.395
MOD_GSK3_1	117	124	PF00069	0.410
MOD_GSK3_1	194	201	PF00069	0.488
MOD_GSK3_1	260	267	PF00069	0.315
MOD_GSK3_1	87	94	PF00069	0.462
MOD_NEK2_1	187	192	PF00069	0.500
MOD_NEK2_1	234	239	PF00069	0.414
MOD_NEK2_1	240	245	PF00069	0.388
MOD_NEK2_1	261	266	PF00069	0.365
MOD_NEK2_1	283	288	PF00069	0.358
MOD_NEK2_1	334	339	PF00069	0.246
MOD_NEK2_1	95	100	PF00069	0.450
MOD_NEK2_2	56	61	PF00069	0.409
MOD_PIKK_1	140	146	PF00454	0.358
MOD_PIKK_1	199	205	PF00454	0.460
MOD_PKA_1	339	345	PF00069	0.279
MOD_PKA_2	339	345	PF00069	0.279
MOD_PKA_2	79	85	PF00069	0.464
MOD_Plk_1	149	155	PF00069	0.445
MOD_Plk_1	56	62	PF00069	0.409
MOD_Plk_1	91	97	PF00069	0.445
MOD_Plk_4	194	200	PF00069	0.454
MOD_Plk_4	2	8	PF00069	0.290
MOD_Plk_4	264	270	PF00069	0.294
MOD_Plk_4	49	55	PF00069	0.390
MOD_Plk_4	56	62	PF00069	0.399
MOD_ProDKin_1	284	290	PF00069	0.286
TRG_DiLeu_BaEn_1	183	188	PF01217	0.405
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.310
TRG_ENDOCYTIC_2	103	106	PF00928	0.505
TRG_ENDOCYTIC_2	14	17	PF00928	0.353
TRG_ENDOCYTIC_2	225	228	PF00928	0.484
TRG_ENDOCYTIC_2	238	241	PF00928	0.266
TRG_ENDOCYTIC_2	242	245	PF00928	0.255
TRG_ENDOCYTIC_2	248	251	PF00928	0.382
TRG_ENDOCYTIC_2	61	64	PF00928	0.470
TRG_ER_diArg_1	221	224	PF00400	0.506
TRG_ER_diArg_1	26	28	PF00400	0.484
TRG_NES_CRM1_1	69	81	PF08389	0.507
TRG_NLS_MonoCore_2	27	32	PF00514	0.500
TRG_NLS_MonoExtC_3	221	226	PF00514	0.519
TRG_NLS_MonoExtN_4	219	226	PF00514	0.560
TRG_NLS_MonoExtN_4	27	33	PF00514	0.615
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.227

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8E4	Leptomonas seymouri	55%	99%
A0A0S4IJ80	Bodo saltans	37%	85%
A0A1X0NRF0	Trypanosomatidae	45%	98%
A0A3R7NHN9	Trypanosoma rangeli	46%	99%
A0A3S7X1Q6	Leishmania donovani	79%	100%
A4I3T9	Leishmania infantum	79%	100%
D0A869	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B031	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q0VGK4	Rattus norvegicus	30%	100%
Q4Q855	Leishmania major	77%	100%
Q7L5L3	Homo sapiens	26%	100%
Q8N9F7	Homo sapiens	30%	100%
Q99LY2	Mus musculus	26%	100%
Q9CRY7	Mus musculus	30%	100%