Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0220), putative

Species:

Leishmania braziliensis

UniProt:

A4HGR3_LEIBR

TriTrypDb:

LbrM.28.2290 , LBRM2903_280029300

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HGR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGR3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007034	vacuolar transport	4	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.344
CLV_PCSK_KEX2_1	3	5	PF00082	0.344
CLV_PCSK_SKI1_1	81	85	PF00082	0.281
DEG_MDM2_SWIB_1	96	103	PF02201	0.227
DOC_CDC14_PxL_1	40	48	PF14671	0.408
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.480
DOC_MAPK_gen_1	3	10	PF00069	0.572
DOC_MAPK_gen_1	78	85	PF00069	0.539
DOC_MAPK_MEF2A_6	109	118	PF00069	0.205
DOC_PP1_RVXF_1	107	114	PF00149	0.386
LIG_14-3-3_CanoR_1	3	10	PF00244	0.572
LIG_APCC_ABBA_1	20	25	PF00400	0.447
LIG_BIR_II_1	1	5	PF00653	0.475
LIG_BRCT_BRCA1_1	81	85	PF00533	0.541
LIG_Clathr_ClatBox_1	21	25	PF01394	0.480
LIG_CSL_BTD_1	41	44	PF09270	0.335
LIG_EH1_1	120	128	PF00400	0.227
LIG_FHA_1	5	11	PF00498	0.580
LIG_FHA_2	64	70	PF00498	0.579
LIG_LIR_Gen_1	34	44	PF02991	0.289
LIG_LIR_Gen_1	52	61	PF02991	0.183
LIG_LIR_Gen_1	93	103	PF02991	0.411
LIG_LIR_Nem_3	34	40	PF02991	0.289
LIG_LIR_Nem_3	52	56	PF02991	0.183
LIG_LIR_Nem_3	93	99	PF02991	0.367
LIG_MLH1_MIPbox_1	81	85	PF16413	0.562
LIG_NRBOX	45	51	PF00104	0.480
LIG_Pex14_2	85	89	PF04695	0.227
LIG_Pex14_2	92	96	PF04695	0.200
LIG_SH2_CRK	37	41	PF00017	0.299
LIG_SH2_STAP1	37	41	PF00017	0.205
LIG_SH2_STAT5	62	65	PF00017	0.547
LIG_SH3_3	108	114	PF00018	0.362
LIG_SH3_3	30	36	PF00018	0.292
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.447
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.391
LIG_SUMO_SIM_par_1	6	12	PF11976	0.560
LIG_TYR_ITIM	35	40	PF00017	0.313
LIG_WRC_WIRS_1	50	55	PF05994	0.415
MOD_CK2_1	28	34	PF00069	0.205
MOD_GlcNHglycan	11	14	PF01048	0.379
MOD_GlcNHglycan	17	20	PF01048	0.357
MOD_GSK3_1	91	98	PF00069	0.428
MOD_NEK2_1	119	124	PF00069	0.426
MOD_NEK2_1	49	54	PF00069	0.347
MOD_NEK2_1	90	95	PF00069	0.389
MOD_PKA_1	3	9	PF00069	0.544
MOD_PKA_2	3	9	PF00069	0.595
MOD_Plk_1	79	85	PF00069	0.582
MOD_Plk_4	119	125	PF00069	0.366
MOD_Plk_4	35	41	PF00069	0.297
MOD_Plk_4	4	10	PF00069	0.595
MOD_Plk_4	49	55	PF00069	0.314
MOD_Plk_4	79	85	PF00069	0.535
MOD_Plk_4	91	97	PF00069	0.342
TRG_ENDOCYTIC_2	37	40	PF00928	0.313
TRG_ER_diArg_1	3	5	PF00400	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6R2	Leptomonas seymouri	59%	100%
A0A0S4IPW8	Bodo saltans	33%	77%
A0A1X0NQU1	Trypanosomatidae	36%	100%
A0A3S7X1P5	Leishmania donovani	79%	100%
A0A422NBE9	Trypanosoma rangeli	36%	100%
A4I3T8	Leishmania infantum	78%	100%
D0A870	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B030	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q856	Leishmania major	79%	100%