CEP76-C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CEP76 C2 domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGR2_LEIBR

TriTrypDb:

LbrM.28.2280 , LBRM2903_280029200

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HGR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGR2

Function

Biological processes
Term	Name	Level	Count
GO:0010564	regulation of cell cycle process	5	1
GO:0010824	regulation of centrosome duplication	6	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0046599	regulation of centriole replication	6	1
GO:0046605	regulation of centrosome cycle	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1
GO:1902115	regulation of organelle assembly	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	504	508	PF00656	0.330
CLV_NRD_NRD_1	199	201	PF00675	0.229
CLV_NRD_NRD_1	268	270	PF00675	0.313
CLV_NRD_NRD_1	283	285	PF00675	0.354
CLV_PCSK_KEX2_1	121	123	PF00082	0.308
CLV_PCSK_KEX2_1	236	238	PF00082	0.263
CLV_PCSK_KEX2_1	268	270	PF00082	0.313
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.308
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.308
CLV_PCSK_SKI1_1	16	20	PF00082	0.599
CLV_PCSK_SKI1_1	200	204	PF00082	0.235
CLV_PCSK_SKI1_1	261	265	PF00082	0.316
CLV_PCSK_SKI1_1	436	440	PF00082	0.325
CLV_PCSK_SKI1_1	557	561	PF00082	0.350
CLV_PCSK_SKI1_1	585	589	PF00082	0.332
CLV_PCSK_SKI1_1	66	70	PF00082	0.538
DEG_APCC_DBOX_1	584	592	PF00400	0.365
DEG_COP1_1	78	88	PF00400	0.542
DEG_Nend_UBRbox_2	1	3	PF02207	0.631
DEG_SPOP_SBC_1	290	294	PF00917	0.487
DOC_CDC14_PxL_1	475	483	PF14671	0.465
DOC_CKS1_1	171	176	PF01111	0.405
DOC_MAPK_DCC_7	474	482	PF00069	0.339
DOC_MAPK_FxFP_2	604	607	PF00069	0.335
DOC_MAPK_gen_1	200	210	PF00069	0.407
DOC_MAPK_gen_1	557	566	PF00069	0.293
DOC_MAPK_MEF2A_6	204	212	PF00069	0.405
DOC_MAPK_MEF2A_6	462	471	PF00069	0.307
DOC_MAPK_MEF2A_6	557	566	PF00069	0.293
DOC_MAPK_MEF2A_6	609	617	PF00069	0.449
DOC_MAPK_MEF2A_6	95	102	PF00069	0.508
DOC_MAPK_RevD_3	186	201	PF00069	0.508
DOC_MAPK_RevD_3	223	237	PF00069	0.508
DOC_PP1_RVXF_1	120	127	PF00149	0.526
DOC_PP4_FxxP_1	303	306	PF00568	0.441
DOC_PP4_FxxP_1	460	463	PF00568	0.202
DOC_PP4_FxxP_1	604	607	PF00568	0.335
DOC_USP7_MATH_1	21	25	PF00917	0.582
DOC_USP7_MATH_1	290	294	PF00917	0.401
DOC_USP7_MATH_1	381	385	PF00917	0.385
DOC_USP7_MATH_1	401	405	PF00917	0.547
DOC_USP7_MATH_1	444	448	PF00917	0.433
DOC_USP7_MATH_1	449	453	PF00917	0.465
DOC_WW_Pin1_4	112	117	PF00397	0.357
DOC_WW_Pin1_4	170	175	PF00397	0.405
DOC_WW_Pin1_4	302	307	PF00397	0.342
DOC_WW_Pin1_4	312	317	PF00397	0.268
DOC_WW_Pin1_4	345	350	PF00397	0.416
DOC_WW_Pin1_4	416	421	PF00397	0.419
LIG_14-3-3_CanoR_1	268	277	PF00244	0.430
LIG_14-3-3_CanoR_1	287	297	PF00244	0.486
LIG_14-3-3_CanoR_1	321	326	PF00244	0.281
LIG_14-3-3_CanoR_1	327	332	PF00244	0.373
LIG_14-3-3_CanoR_1	579	584	PF00244	0.455
LIG_14-3-3_CanoR_1	609	614	PF00244	0.383
LIG_Actin_WH2_2	189	206	PF00022	0.415
LIG_Actin_WH2_2	483	501	PF00022	0.299
LIG_APCC_ABBA_1	542	547	PF00400	0.396
LIG_BIR_III_4	400	404	PF00653	0.542
LIG_BRCT_BRCA1_1	122	126	PF00533	0.508
LIG_BRCT_BRCA1_1	171	175	PF00533	0.472
LIG_BRCT_BRCA1_1	434	438	PF00533	0.381
LIG_BRCT_BRCA1_1	593	597	PF00533	0.373
LIG_Clathr_ClatBox_1	153	157	PF01394	0.405
LIG_deltaCOP1_diTrp_1	342	352	PF00928	0.473
LIG_eIF4E_1	475	481	PF01652	0.344
LIG_EVH1_1	475	479	PF00568	0.371
LIG_FHA_1	209	215	PF00498	0.432
LIG_FHA_1	299	305	PF00498	0.302
LIG_FHA_1	331	337	PF00498	0.531
LIG_FHA_1	550	556	PF00498	0.403
LIG_FHA_2	255	261	PF00498	0.348
LIG_FHA_2	278	284	PF00498	0.439
LIG_FHA_2	411	417	PF00498	0.376
LIG_FHA_2	502	508	PF00498	0.406
LIG_FHA_2	511	517	PF00498	0.328
LIG_LIR_Apic_2	301	306	PF02991	0.437
LIG_LIR_Apic_2	343	349	PF02991	0.427
LIG_LIR_Apic_2	458	463	PF02991	0.225
LIG_LIR_Gen_1	29	39	PF02991	0.404
LIG_LIR_Gen_1	425	433	PF02991	0.330
LIG_LIR_Gen_1	540	549	PF02991	0.469
LIG_LIR_Gen_1	567	575	PF02991	0.202
LIG_LIR_Gen_1	612	621	PF02991	0.267
LIG_LIR_Nem_3	198	202	PF02991	0.406
LIG_LIR_Nem_3	205	210	PF02991	0.406
LIG_LIR_Nem_3	260	266	PF02991	0.309
LIG_LIR_Nem_3	272	277	PF02991	0.344
LIG_LIR_Nem_3	29	35	PF02991	0.402
LIG_LIR_Nem_3	348	353	PF02991	0.343
LIG_LIR_Nem_3	377	382	PF02991	0.279
LIG_LIR_Nem_3	425	429	PF02991	0.349
LIG_LIR_Nem_3	450	456	PF02991	0.391
LIG_LIR_Nem_3	458	464	PF02991	0.289
LIG_LIR_Nem_3	507	512	PF02991	0.388
LIG_LIR_Nem_3	540	545	PF02991	0.446
LIG_LIR_Nem_3	558	562	PF02991	0.201
LIG_LIR_Nem_3	567	571	PF02991	0.280
LIG_LIR_Nem_3	612	617	PF02991	0.264
LIG_LIR_Nem_3	93	99	PF02991	0.170
LIG_NRBOX	366	372	PF00104	0.267
LIG_PCNA_yPIPBox_3	181	192	PF02747	0.508
LIG_Pex14_1	270	274	PF04695	0.298
LIG_Pex14_1	346	350	PF04695	0.301
LIG_Pex14_2	126	130	PF04695	0.560
LIG_Pex14_2	148	152	PF04695	0.415
LIG_PTB_Apo_2	129	136	PF02174	0.481
LIG_SH2_CRK	274	278	PF00017	0.473
LIG_SH2_CRK	32	36	PF00017	0.411
LIG_SH2_CRK	379	383	PF00017	0.266
LIG_SH2_GRB2like	515	518	PF00017	0.470
LIG_SH2_NCK_1	621	625	PF00017	0.427
LIG_SH2_SRC	515	518	PF00017	0.393
LIG_SH2_SRC	568	571	PF00017	0.343
LIG_SH2_STAP1	266	270	PF00017	0.298
LIG_SH2_STAP1	515	519	PF00017	0.361
LIG_SH2_STAT3	530	533	PF00017	0.450
LIG_SH2_STAT5	14	17	PF00017	0.370
LIG_SH2_STAT5	207	210	PF00017	0.445
LIG_SH2_STAT5	379	382	PF00017	0.279
LIG_SH2_STAT5	42	45	PF00017	0.442
LIG_SH2_STAT5	521	524	PF00017	0.297
LIG_SH2_STAT5	568	571	PF00017	0.423
LIG_SH2_STAT5	97	100	PF00017	0.405
LIG_SH3_1	470	476	PF00018	0.340
LIG_SH3_3	168	174	PF00018	0.447
LIG_SH3_3	406	412	PF00018	0.393
LIG_SH3_3	470	476	PF00018	0.392
LIG_SUMO_SIM_par_1	167	173	PF11976	0.426
LIG_TYR_ITIM	566	571	PF00017	0.200
LIG_UBA3_1	59	66	PF00899	0.489
LIG_WRC_WIRS_1	22	27	PF05994	0.532
MOD_CK1_1	17	23	PF00069	0.525
MOD_CK1_1	291	297	PF00069	0.493
MOD_CK1_1	345	351	PF00069	0.332
MOD_CK1_1	396	402	PF00069	0.423
MOD_CK1_1	418	424	PF00069	0.446
MOD_CK1_1	447	453	PF00069	0.303
MOD_CK1_1	50	56	PF00069	0.424
MOD_CK1_1	535	541	PF00069	0.273
MOD_CK1_1	78	84	PF00069	0.614
MOD_CK2_1	244	250	PF00069	0.479
MOD_CK2_1	277	283	PF00069	0.326
MOD_CK2_1	410	416	PF00069	0.474
MOD_CK2_1	485	491	PF00069	0.384
MOD_GlcNHglycan	136	139	PF01048	0.364
MOD_GlcNHglycan	142	145	PF01048	0.308
MOD_GlcNHglycan	19	22	PF01048	0.496
MOD_GlcNHglycan	204	207	PF01048	0.272
MOD_GlcNHglycan	403	406	PF01048	0.453
MOD_GlcNHglycan	413	416	PF01048	0.416
MOD_GlcNHglycan	536	540	PF01048	0.439
MOD_GlcNHglycan	56	59	PF01048	0.495
MOD_GlcNHglycan	593	596	PF01048	0.432
MOD_GlcNHglycan	6	9	PF01048	0.610
MOD_GlcNHglycan	621	624	PF01048	0.439
MOD_GSK3_1	17	24	PF00069	0.541
MOD_GSK3_1	298	305	PF00069	0.320
MOD_GSK3_1	326	333	PF00069	0.562
MOD_GSK3_1	341	348	PF00069	0.389
MOD_GSK3_1	362	369	PF00069	0.227
MOD_GSK3_1	401	408	PF00069	0.483
MOD_GSK3_1	411	418	PF00069	0.419
MOD_GSK3_1	481	488	PF00069	0.455
MOD_GSK3_1	50	57	PF00069	0.501
MOD_GSK3_1	501	508	PF00069	0.241
MOD_GSK3_1	517	524	PF00069	0.245
MOD_GSK3_1	545	552	PF00069	0.392
MOD_N-GLC_1	564	569	PF02516	0.294
MOD_N-GLC_1	619	624	PF02516	0.376
MOD_NEK2_1	26	31	PF00069	0.428
MOD_NEK2_1	264	269	PF00069	0.411
MOD_NEK2_1	288	293	PF00069	0.373
MOD_NEK2_1	326	331	PF00069	0.393
MOD_NEK2_1	366	371	PF00069	0.260
MOD_NEK2_1	393	398	PF00069	0.308
MOD_NEK2_1	4	9	PF00069	0.565
MOD_NEK2_1	432	437	PF00069	0.358
MOD_NEK2_1	481	486	PF00069	0.421
MOD_NEK2_1	545	550	PF00069	0.413
MOD_NEK2_2	14	19	PF00069	0.368
MOD_OFUCOSY	380	385	PF10250	0.406
MOD_PIKK_1	351	357	PF00454	0.284
MOD_PIKK_1	521	527	PF00454	0.310
MOD_PK_1	579	585	PF00069	0.458
MOD_PK_1	609	615	PF00069	0.402
MOD_PKA_2	277	283	PF00069	0.385
MOD_PKA_2	326	332	PF00069	0.504
MOD_PKA_2	396	402	PF00069	0.429
MOD_PKA_2	505	511	PF00069	0.396
MOD_PKA_2	78	84	PF00069	0.683
MOD_Plk_1	156	162	PF00069	0.400
MOD_Plk_1	341	347	PF00069	0.506
MOD_Plk_1	47	53	PF00069	0.398
MOD_Plk_1	490	496	PF00069	0.371
MOD_Plk_1	564	570	PF00069	0.294
MOD_Plk_2-3	570	576	PF00069	0.428
MOD_Plk_4	21	27	PF00069	0.467
MOD_Plk_4	321	327	PF00069	0.344
MOD_Plk_4	342	348	PF00069	0.395
MOD_Plk_4	362	368	PF00069	0.299
MOD_Plk_4	38	44	PF00069	0.313
MOD_Plk_4	405	411	PF00069	0.431
MOD_Plk_4	434	440	PF00069	0.316
MOD_Plk_4	481	487	PF00069	0.298
MOD_Plk_4	517	523	PF00069	0.360
MOD_Plk_4	564	570	PF00069	0.424
MOD_ProDKin_1	112	118	PF00069	0.357
MOD_ProDKin_1	170	176	PF00069	0.405
MOD_ProDKin_1	302	308	PF00069	0.352
MOD_ProDKin_1	312	318	PF00069	0.266
MOD_ProDKin_1	345	351	PF00069	0.412
MOD_ProDKin_1	416	422	PF00069	0.424
TRG_DiLeu_BaEn_4	342	348	PF01217	0.451
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.365
TRG_ENDOCYTIC_2	207	210	PF00928	0.429
TRG_ENDOCYTIC_2	274	277	PF00928	0.469
TRG_ENDOCYTIC_2	32	35	PF00928	0.407
TRG_ENDOCYTIC_2	379	382	PF00928	0.250
TRG_ENDOCYTIC_2	568	571	PF00928	0.201
TRG_ENDOCYTIC_2	96	99	PF00928	0.405
TRG_ER_diArg_1	237	240	PF00400	0.417
TRG_ER_diArg_1	268	270	PF00400	0.313
TRG_NLS_MonoExtC_3	234	239	PF00514	0.508
TRG_NLS_MonoExtN_4	235	240	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	492	497	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I031	Leptomonas seymouri	75%	100%
A0A0S4JE49	Bodo saltans	42%	96%
A0A1X0NQS1	Trypanosomatidae	49%	98%
A0A3R7KWK7	Trypanosoma rangeli	47%	99%
A0A3S7X1S9	Leishmania donovani	90%	100%
A4I3T7	Leishmania infantum	90%	100%
A7E2V1	Danio rerio	28%	95%
D0A871	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
E9B029	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q0VEJ0	Mus musculus	28%	95%
Q28DH9	Xenopus tropicalis	28%	95%
Q4Q857	Leishmania major	90%	100%
Q5RCP7	Pongo abelii	29%	95%
Q6DDX8	Xenopus laevis	27%	95%
Q8TAP6	Homo sapiens	28%	95%
V5BGP3	Trypanosoma cruzi	48%	99%