DNA-directed RNA polymerase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-directed RNA polymerase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HGR0_LEIBR

TriTrypDb:

LbrM.28.2250 , LBRM2903_280028900

Length:

137

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	12
GO:0030880	RNA polymerase complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12
GO:0005666	RNA polymerase III complex	4	1
GO:0005736	RNA polymerase I complex	4	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HGR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGR0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006351	DNA-templated transcription	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0032774	RNA biosynthetic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0097659	nucleic acid-templated transcription	6	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0034062	5'-3' RNA polymerase activity	5	12
GO:0046983	protein dimerization activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097747	RNA polymerase activity	4	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	64	68	PF00082	0.211
CLV_PCSK_SKI1_1	7	11	PF00082	0.438
CLV_PCSK_SKI1_1	87	91	PF00082	0.242
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.424
DOC_USP7_MATH_1	72	76	PF00917	0.467
LIG_APCC_ABBA_1	10	15	PF00400	0.442
LIG_BIR_II_1	1	5	PF00653	0.461
LIG_FHA_1	45	51	PF00498	0.425
LIG_FHA_2	26	32	PF00498	0.505
LIG_FHA_2	40	46	PF00498	0.493
LIG_LIR_Apic_2	75	81	PF02991	0.400
LIG_SH2_CRK	78	82	PF00017	0.400
LIG_SH2_SRC	78	81	PF00017	0.424
LIG_SH2_STAP1	97	101	PF00017	0.411
LIG_SH3_3	80	86	PF00018	0.498
LIG_TRAF2_1	28	31	PF00917	0.645
LIG_WRC_WIRS_1	1	6	PF05994	0.586
LIG_WRC_WIRS_1	117	122	PF05994	0.369
LIG_WRC_WIRS_1	49	54	PF05994	0.486
MOD_CK1_1	44	50	PF00069	0.345
MOD_CK2_1	131	137	PF00069	0.609
MOD_CK2_1	25	31	PF00069	0.519
MOD_CK2_1	39	45	PF00069	0.518
MOD_GlcNHglycan	74	77	PF01048	0.202
MOD_GSK3_1	39	46	PF00069	0.476
MOD_NEK2_1	130	135	PF00069	0.540
MOD_PKA_2	39	45	PF00069	0.502
MOD_Plk_1	113	119	PF00069	0.442
MOD_Plk_1	44	50	PF00069	0.450
MOD_Plk_1	55	61	PF00069	0.335
MOD_SUMO_rev_2	25	34	PF00179	0.509
TRG_DiLeu_BaEn_1	85	90	PF01217	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P737	Leptomonas seymouri	86%	100%
A0A0S4J5W9	Bodo saltans	73%	75%
A0A1X0NR94	Trypanosomatidae	84%	100%
A0A3Q8IEQ8	Leishmania donovani	93%	100%
A0A422NBI4	Trypanosoma rangeli	76%	100%
A4I3T4	Leishmania infantum	93%	100%
D0A874	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9B026	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P0DPB6	Homo sapiens	34%	100%
P28000	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	96%
P97304	Mus musculus	32%	100%
Q1RMG8	Bos taurus	32%	100%
Q4Q860	Leishmania major	92%	100%
Q54ES6	Dictyostelium discoideum	36%	100%
Q5XK67	Xenopus laevis	35%	100%
Q6DRI4	Danio rerio	37%	100%
V5BGT6	Trypanosoma cruzi	80%	100%