AMP-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AMP-binding enzyme/Ankyrin repeats (3 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4HGQ9_LEIBR

TriTrypDb:

LbrM.28.2240 , LBRM2903_280028800

Length:

1003

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGQ9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019748	secondary metabolic process	2	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043038	amino acid activation	4	1
GO:0043041	amino acid activation for nonribosomal peptide biosynthetic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0044550	secondary metabolite biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0019842	vitamin binding	3	1
GO:0031177	phosphopantetheine binding	3	1
GO:0033218	amide binding	2	1
GO:0036094	small molecule binding	2	1
GO:0072341	modified amino acid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	54	58	PF00656	0.505
CLV_C14_Caspase3-7	555	559	PF00656	0.399
CLV_NRD_NRD_1	159	161	PF00675	0.395
CLV_NRD_NRD_1	492	494	PF00675	0.376
CLV_NRD_NRD_1	579	581	PF00675	0.486
CLV_NRD_NRD_1	82	84	PF00675	0.504
CLV_NRD_NRD_1	960	962	PF00675	0.626
CLV_PCSK_FUR_1	490	494	PF00082	0.501
CLV_PCSK_KEX2_1	158	160	PF00082	0.394
CLV_PCSK_KEX2_1	25	27	PF00082	0.404
CLV_PCSK_KEX2_1	492	494	PF00082	0.376
CLV_PCSK_KEX2_1	579	581	PF00082	0.486
CLV_PCSK_KEX2_1	70	72	PF00082	0.519
CLV_PCSK_KEX2_1	82	84	PF00082	0.379
CLV_PCSK_KEX2_1	944	946	PF00082	0.710
CLV_PCSK_KEX2_1	986	988	PF00082	0.497
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.399
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.519
CLV_PCSK_PC1ET2_1	944	946	PF00082	0.824
CLV_PCSK_PC1ET2_1	986	988	PF00082	0.624
CLV_PCSK_PC7_1	154	160	PF00082	0.535
CLV_PCSK_SKI1_1	175	179	PF00082	0.249
CLV_PCSK_SKI1_1	242	246	PF00082	0.501
CLV_PCSK_SKI1_1	338	342	PF00082	0.376
CLV_PCSK_SKI1_1	503	507	PF00082	0.527
CLV_PCSK_SKI1_1	580	584	PF00082	0.480
CLV_PCSK_SKI1_1	82	86	PF00082	0.516
CLV_PCSK_SKI1_1	841	845	PF00082	0.511
CLV_Separin_Metazoa	551	555	PF03568	0.372
DEG_APCC_DBOX_1	502	510	PF00400	0.525
DEG_Kelch_Keap1_1	460	465	PF01344	0.249
DEG_SPOP_SBC_1	84	88	PF00917	0.374
DOC_CKS1_1	278	283	PF01111	0.430
DOC_CKS1_1	311	316	PF01111	0.376
DOC_CKS1_1	591	596	PF01111	0.691
DOC_CKS1_1	897	902	PF01111	0.430
DOC_CYCLIN_yClb5_NLxxxL_5	231	240	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.249
DOC_CYCLIN_yCln2_LP_2	690	696	PF00134	0.540
DOC_MAPK_gen_1	25	33	PF00069	0.394
DOC_MAPK_gen_1	490	499	PF00069	0.385
DOC_MAPK_gen_1	597	605	PF00069	0.560
DOC_MAPK_gen_1	786	796	PF00069	0.612
DOC_MAPK_gen_1	860	870	PF00069	0.448
DOC_MAPK_MEF2A_6	144	152	PF00069	0.500
DOC_MAPK_MEF2A_6	667	676	PF00069	0.457
DOC_MAPK_MEF2A_6	789	798	PF00069	0.501
DOC_PP1_RVXF_1	578	585	PF00149	0.494
DOC_PP2B_LxvP_1	570	573	PF13499	0.420
DOC_PP2B_LxvP_1	645	648	PF13499	0.550
DOC_PP2B_LxvP_1	690	693	PF13499	0.627
DOC_PP4_FxxP_1	266	269	PF00568	0.430
DOC_PP4_FxxP_1	575	578	PF00568	0.482
DOC_USP7_MATH_1	415	419	PF00917	0.397
DOC_USP7_MATH_1	453	457	PF00917	0.362
DOC_USP7_MATH_1	797	801	PF00917	0.376
DOC_USP7_MATH_1	871	875	PF00917	0.430
DOC_WW_Pin1_4	100	105	PF00397	0.722
DOC_WW_Pin1_4	261	266	PF00397	0.399
DOC_WW_Pin1_4	277	282	PF00397	0.171
DOC_WW_Pin1_4	310	315	PF00397	0.376
DOC_WW_Pin1_4	331	336	PF00397	0.311
DOC_WW_Pin1_4	532	537	PF00397	0.655
DOC_WW_Pin1_4	590	595	PF00397	0.665
DOC_WW_Pin1_4	739	744	PF00397	0.563
DOC_WW_Pin1_4	789	794	PF00397	0.515
DOC_WW_Pin1_4	825	830	PF00397	0.350
DOC_WW_Pin1_4	896	901	PF00397	0.430
LIG_14-3-3_CanoR_1	175	181	PF00244	0.249
LIG_14-3-3_CanoR_1	398	403	PF00244	0.249
LIG_14-3-3_CanoR_1	635	641	PF00244	0.544
LIG_14-3-3_CanoR_1	789	793	PF00244	0.613
LIG_14-3-3_CanoR_1	823	829	PF00244	0.404
LIG_14-3-3_CanoR_1	863	868	PF00244	0.445
LIG_14-3-3_CanoR_1	919	927	PF00244	0.418
LIG_14-3-3_CanoR_1	961	966	PF00244	0.633
LIG_APCC_ABBA_1	437	442	PF00400	0.397
LIG_APCC_ABBAyCdc20_2	162	168	PF00400	0.249
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_BRCT_BRCA1_1	262	266	PF00533	0.378
LIG_BRCT_BRCA1_1	405	409	PF00533	0.413
LIG_BRCT_BRCA1_1	453	457	PF00533	0.457
LIG_deltaCOP1_diTrp_1	894	903	PF00928	0.376
LIG_FHA_1	137	143	PF00498	0.501
LIG_FHA_1	306	312	PF00498	0.376
LIG_FHA_1	468	474	PF00498	0.376
LIG_FHA_1	533	539	PF00498	0.574
LIG_FHA_1	543	549	PF00498	0.598
LIG_FHA_1	593	599	PF00498	0.613
LIG_FHA_1	651	657	PF00498	0.547
LIG_FHA_1	67	73	PF00498	0.349
LIG_FHA_1	808	814	PF00498	0.500
LIG_FHA_1	908	914	PF00498	0.457
LIG_FHA_1	927	933	PF00498	0.486
LIG_FHA_2	101	107	PF00498	0.683
LIG_FHA_2	287	293	PF00498	0.501
LIG_FHA_2	351	357	PF00498	0.501
LIG_FHA_2	380	386	PF00498	0.501
LIG_FHA_2	749	755	PF00498	0.530
LIG_FHA_2	968	974	PF00498	0.540
LIG_GBD_Chelix_1	170	178	PF00786	0.249
LIG_Integrin_isoDGR_2	295	297	PF01839	0.249
LIG_Integrin_RGD_1	26	28	PF01839	0.494
LIG_LIR_Apic_2	263	269	PF02991	0.430
LIG_LIR_Apic_2	574	578	PF02991	0.567
LIG_LIR_Gen_1	122	132	PF02991	0.430
LIG_LIR_Gen_1	139	148	PF02991	0.524
LIG_LIR_Gen_1	370	380	PF02991	0.353
LIG_LIR_Gen_1	639	649	PF02991	0.510
LIG_LIR_Gen_1	953	960	PF02991	0.657
LIG_LIR_Nem_3	122	128	PF02991	0.434
LIG_LIR_Nem_3	139	143	PF02991	0.494
LIG_LIR_Nem_3	30	36	PF02991	0.460
LIG_LIR_Nem_3	359	364	PF02991	0.364
LIG_LIR_Nem_3	370	375	PF02991	0.305
LIG_LIR_Nem_3	433	437	PF02991	0.430
LIG_LIR_Nem_3	631	637	PF02991	0.482
LIG_LIR_Nem_3	754	760	PF02991	0.509
LIG_LIR_Nem_3	953	959	PF02991	0.661
LIG_LIR_Nem_3	964	968	PF02991	0.622
LIG_MLH1_MIPbox_1	263	267	PF16413	0.430
LIG_MYND_1	734	738	PF01753	0.522
LIG_NRBOX	563	569	PF00104	0.576
LIG_NRBOX	845	851	PF00104	0.505
LIG_Pex3_1	564	575	PF04882	0.577
LIG_SH2_CRK	125	129	PF00017	0.422
LIG_SH2_CRK	634	638	PF00017	0.500
LIG_SH2_SRC	459	462	PF00017	0.249
LIG_SH2_SRC	655	658	PF00017	0.555
LIG_SH2_STAP1	125	129	PF00017	0.422
LIG_SH2_STAT3	440	443	PF00017	0.385
LIG_SH2_STAT5	218	221	PF00017	0.438
LIG_SH2_STAT5	239	242	PF00017	0.376
LIG_SH2_STAT5	286	289	PF00017	0.402
LIG_SH2_STAT5	448	451	PF00017	0.311
LIG_SH2_STAT5	655	658	PF00017	0.548
LIG_SH2_STAT5	673	676	PF00017	0.333
LIG_SH2_STAT5	708	711	PF00017	0.448
LIG_SH2_STAT5	965	968	PF00017	0.650
LIG_SH3_3	142	148	PF00018	0.515
LIG_SH3_3	249	255	PF00018	0.249
LIG_SH3_3	308	314	PF00018	0.376
LIG_SH3_3	588	594	PF00018	0.643
LIG_SH3_3	690	696	PF00018	0.502
LIG_SH3_3	732	738	PF00018	0.666
LIG_SH3_3	930	936	PF00018	0.531
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.249
LIG_TRAF2_1	505	508	PF00917	0.516
LIG_TRAF2_1	563	566	PF00917	0.507
LIG_TYR_ITIM	966	971	PF00017	0.518
LIG_TYR_ITSM	368	375	PF00017	0.430
LIG_UBA3_1	19	25	PF00899	0.331
LIG_UBA3_1	240	247	PF00899	0.249
LIG_WRC_WIRS_1	326	331	PF05994	0.249
LIG_WRC_WIRS_1	572	577	PF05994	0.567
MOD_CDK_SPxxK_3	331	338	PF00069	0.311
MOD_CDK_SPxxK_3	590	597	PF00069	0.679
MOD_CK1_1	120	126	PF00069	0.501
MOD_CK1_1	220	226	PF00069	0.376
MOD_CK1_1	318	324	PF00069	0.482
MOD_CK1_1	328	334	PF00069	0.390
MOD_CK1_1	800	806	PF00069	0.430
MOD_CK1_1	839	845	PF00069	0.319
MOD_CK1_1	923	929	PF00069	0.675
MOD_CK1_1	938	944	PF00069	0.521
MOD_CK2_1	176	182	PF00069	0.492
MOD_CK2_1	183	189	PF00069	0.385
MOD_CK2_1	379	385	PF00069	0.440
MOD_CK2_1	413	419	PF00069	0.303
MOD_CK2_1	459	465	PF00069	0.299
MOD_CK2_1	744	750	PF00069	0.633
MOD_CK2_1	967	973	PF00069	0.643
MOD_CK2_1	992	998	PF00069	0.610
MOD_Cter_Amidation	490	493	PF01082	0.376
MOD_GlcNHglycan	15	18	PF01048	0.496
MOD_GlcNHglycan	219	222	PF01048	0.376
MOD_GlcNHglycan	532	535	PF01048	0.664
MOD_GlcNHglycan	548	551	PF01048	0.502
MOD_GlcNHglycan	560	563	PF01048	0.245
MOD_GlcNHglycan	728	731	PF01048	0.529
MOD_GlcNHglycan	841	844	PF01048	0.508
MOD_GlcNHglycan	873	876	PF01048	0.380
MOD_GlcNHglycan	922	925	PF01048	0.662
MOD_GlcNHglycan	941	944	PF01048	0.751
MOD_GSK3_1	194	201	PF00069	0.450
MOD_GSK3_1	216	223	PF00069	0.378
MOD_GSK3_1	305	312	PF00069	0.408
MOD_GSK3_1	325	332	PF00069	0.171
MOD_GSK3_1	367	374	PF00069	0.423
MOD_GSK3_1	449	456	PF00069	0.341
MOD_GSK3_1	528	535	PF00069	0.622
MOD_GSK3_1	542	549	PF00069	0.426
MOD_GSK3_1	586	593	PF00069	0.555
MOD_GSK3_1	636	643	PF00069	0.377
MOD_GSK3_1	744	751	PF00069	0.513
MOD_GSK3_1	784	791	PF00069	0.510
MOD_GSK3_1	837	844	PF00069	0.320
MOD_GSK3_1	919	926	PF00069	0.613
MOD_GSK3_1	935	942	PF00069	0.706
MOD_GSK3_1	950	957	PF00069	0.661
MOD_N-GLC_1	183	188	PF02516	0.411
MOD_N-GLC_1	938	943	PF02516	0.657
MOD_N-GLC_1	950	955	PF02516	0.707
MOD_NEK2_1	128	133	PF00069	0.385
MOD_NEK2_1	136	141	PF00069	0.430
MOD_NEK2_1	217	222	PF00069	0.410
MOD_NEK2_1	260	265	PF00069	0.376
MOD_NEK2_1	329	334	PF00069	0.315
MOD_NEK2_1	350	355	PF00069	0.430
MOD_NEK2_1	476	481	PF00069	0.249
MOD_NEK2_1	666	671	PF00069	0.460
MOD_NEK2_1	837	842	PF00069	0.570
MOD_NEK2_2	797	802	PF00069	0.249
MOD_NEK2_2	967	972	PF00069	0.492
MOD_PIKK_1	286	292	PF00454	0.430
MOD_PIKK_1	344	350	PF00454	0.423
MOD_PIKK_1	519	525	PF00454	0.503
MOD_PIKK_1	598	604	PF00454	0.632
MOD_PKA_1	961	967	PF00069	0.635
MOD_PKA_2	120	126	PF00069	0.283
MOD_PKA_2	66	72	PF00069	0.469
MOD_PKA_2	788	794	PF00069	0.611
MOD_PKA_2	822	828	PF00069	0.404
MOD_PKA_2	954	960	PF00069	0.677
MOD_PKB_1	396	404	PF00069	0.249
MOD_Plk_1	208	214	PF00069	0.444
MOD_Plk_1	367	373	PF00069	0.376
MOD_Plk_4	120	126	PF00069	0.445
MOD_Plk_4	169	175	PF00069	0.501
MOD_Plk_4	325	331	PF00069	0.444
MOD_Plk_4	367	373	PF00069	0.376
MOD_Plk_4	571	577	PF00069	0.529
MOD_Plk_4	636	642	PF00069	0.548
MOD_Plk_4	841	847	PF00069	0.475
MOD_Plk_4	863	869	PF00069	0.402
MOD_Plk_4	90	96	PF00069	0.516
MOD_Plk_4	961	967	PF00069	0.714
MOD_ProDKin_1	100	106	PF00069	0.724
MOD_ProDKin_1	261	267	PF00069	0.399
MOD_ProDKin_1	277	283	PF00069	0.171
MOD_ProDKin_1	310	316	PF00069	0.376
MOD_ProDKin_1	331	337	PF00069	0.311
MOD_ProDKin_1	532	538	PF00069	0.642
MOD_ProDKin_1	590	596	PF00069	0.673
MOD_ProDKin_1	739	745	PF00069	0.562
MOD_ProDKin_1	789	795	PF00069	0.413
MOD_ProDKin_1	825	831	PF00069	0.350
MOD_ProDKin_1	896	902	PF00069	0.430
MOD_SUMO_rev_2	220	229	PF00179	0.376
MOD_SUMO_rev_2	494	499	PF00179	0.501
MOD_SUMO_rev_2	723	728	PF00179	0.674
TRG_DiLeu_BaEn_1	878	883	PF01217	0.430
TRG_DiLeu_BaEn_4	565	571	PF01217	0.326
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.498
TRG_DiLeu_BaLyEn_6	735	740	PF01217	0.666
TRG_DiLeu_BaLyEn_6	768	773	PF01217	0.565
TRG_DiLeu_BaLyEn_6	845	850	PF01217	0.519
TRG_DiLeu_LyEn_5	878	883	PF01217	0.501
TRG_ENDOCYTIC_2	125	128	PF00928	0.424
TRG_ENDOCYTIC_2	372	375	PF00928	0.353
TRG_ENDOCYTIC_2	434	437	PF00928	0.480
TRG_ENDOCYTIC_2	634	637	PF00928	0.499
TRG_ENDOCYTIC_2	673	676	PF00928	0.466
TRG_ENDOCYTIC_2	968	971	PF00928	0.531
TRG_ER_diArg_1	158	160	PF00400	0.397
TRG_ER_diArg_1	255	258	PF00400	0.341
TRG_ER_diArg_1	36	39	PF00400	0.517
TRG_ER_diArg_1	396	399	PF00400	0.501
TRG_ER_diArg_1	489	492	PF00400	0.451
TRG_ER_diArg_1	578	580	PF00400	0.495
TRG_ER_diArg_1	82	84	PF00400	0.504
TRG_ER_diArg_1	945	948	PF00400	0.749
TRG_NES_CRM1_1	168	182	PF08389	0.249
TRG_NES_CRM1_1	807	819	PF08389	0.430
TRG_NLS_Bipartite_1	944	965	PF00514	0.696
TRG_NLS_MonoExtN_4	958	965	PF00514	0.654
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	848	853	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	860	864	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5E5	Leptomonas seymouri	52%	98%
A0A0S4JM65	Bodo saltans	31%	84%
A0A3Q8IEY8	Leishmania donovani	80%	100%
A4I3T3	Leishmania infantum	80%	100%
E9B025	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q861	Leishmania major	79%	100%