Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGQ6_LEIBR

TriTrypDb:

LbrM.28.2210 , LBRM2903_280028500

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGQ6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007098	centrosome cycle	3	1
GO:0009987	cellular process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010824	regulation of centrosome duplication	6	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0031023	microtubule organizing center organization	3	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0044089	positive regulation of cellular component biogenesis	5	1
GO:0045787	positive regulation of cell cycle	5	1
GO:0046599	regulation of centriole replication	6	1
GO:0046601	positive regulation of centriole replication	7	1
GO:0046605	regulation of centrosome cycle	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0051495	positive regulation of cytoskeleton organization	7	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090068	positive regulation of cell cycle process	6	1
GO:1902115	regulation of organelle assembly	5	1
GO:1902117	positive regulation of organelle assembly	6	1
GO:1903722	regulation of centriole elongation	6	1
GO:1903724	positive regulation of centriole elongation	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.475
CLV_C14_Caspase3-7	383	387	PF00656	0.677
CLV_C14_Caspase3-7	441	445	PF00656	0.768
CLV_MEL_PAP_1	152	158	PF00089	0.606
CLV_NRD_NRD_1	125	127	PF00675	0.574
CLV_NRD_NRD_1	168	170	PF00675	0.541
CLV_NRD_NRD_1	238	240	PF00675	0.483
CLV_NRD_NRD_1	257	259	PF00675	0.363
CLV_NRD_NRD_1	50	52	PF00675	0.508
CLV_NRD_NRD_1	528	530	PF00675	0.563
CLV_PCSK_FUR_1	255	259	PF00082	0.385
CLV_PCSK_KEX2_1	105	107	PF00082	0.457
CLV_PCSK_KEX2_1	125	127	PF00082	0.277
CLV_PCSK_KEX2_1	167	169	PF00082	0.547
CLV_PCSK_KEX2_1	231	233	PF00082	0.524
CLV_PCSK_KEX2_1	257	259	PF00082	0.551
CLV_PCSK_KEX2_1	267	269	PF00082	0.584
CLV_PCSK_KEX2_1	50	52	PF00082	0.521
CLV_PCSK_KEX2_1	528	530	PF00082	0.563
CLV_PCSK_KEX2_1	90	92	PF00082	0.522
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.500
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.574
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.531
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.504
CLV_PCSK_SKI1_1	105	109	PF00082	0.482
CLV_PCSK_SKI1_1	172	176	PF00082	0.491
CLV_PCSK_SKI1_1	42	46	PF00082	0.544
DEG_APCC_DBOX_1	70	78	PF00400	0.498
DOC_MAPK_gen_1	335	344	PF00069	0.697
DOC_MAPK_gen_1	372	380	PF00069	0.720
DOC_MAPK_gen_1	528	535	PF00069	0.360
DOC_MAPK_MEF2A_6	372	380	PF00069	0.529
DOC_MAPK_MEF2A_6	528	535	PF00069	0.360
DOC_USP7_MATH_1	353	357	PF00917	0.664
DOC_USP7_MATH_1	384	388	PF00917	0.722
DOC_USP7_MATH_1	469	473	PF00917	0.696
DOC_USP7_MATH_1	521	525	PF00917	0.703
DOC_USP7_MATH_1	56	60	PF00917	0.624
DOC_WW_Pin1_4	2	7	PF00397	0.754
DOC_WW_Pin1_4	365	370	PF00397	0.794
DOC_WW_Pin1_4	390	395	PF00397	0.685
DOC_WW_Pin1_4	494	499	PF00397	0.618
DOC_WW_Pin1_4	500	505	PF00397	0.612
LIG_14-3-3_CanoR_1	155	163	PF00244	0.529
LIG_14-3-3_CanoR_1	374	379	PF00244	0.685
LIG_14-3-3_CanoR_1	409	417	PF00244	0.543
LIG_Actin_WH2_2	339	357	PF00022	0.638
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_BRCT_BRCA1_1	340	344	PF00533	0.672
LIG_EVH1_2	448	452	PF00568	0.504
LIG_FHA_1	430	436	PF00498	0.763
LIG_FHA_1	90	96	PF00498	0.606
LIG_FHA_2	14	20	PF00498	0.417
LIG_FHA_2	176	182	PF00498	0.366
LIG_FHA_2	343	349	PF00498	0.766
LIG_FHA_2	355	361	PF00498	0.596
LIG_FHA_2	377	383	PF00498	0.786
LIG_FHA_2	439	445	PF00498	0.714
LIG_FHA_2	501	507	PF00498	0.706
LIG_LIR_Gen_1	162	171	PF02991	0.503
LIG_LIR_Gen_1	238	248	PF02991	0.504
LIG_LIR_Gen_1	250	259	PF02991	0.578
LIG_LIR_Gen_1	313	322	PF02991	0.646
LIG_LIR_Gen_1	341	351	PF02991	0.573
LIG_LIR_Nem_3	162	166	PF02991	0.501
LIG_LIR_Nem_3	238	244	PF02991	0.429
LIG_LIR_Nem_3	250	256	PF02991	0.505
LIG_LIR_Nem_3	287	291	PF02991	0.467
LIG_LIR_Nem_3	313	319	PF02991	0.580
LIG_LIR_Nem_3	341	347	PF02991	0.633
LIG_MYND_1	479	483	PF01753	0.670
LIG_SH2_CRK	163	167	PF00017	0.524
LIG_SH2_CRK	241	245	PF00017	0.561
LIG_SH2_CRK	316	320	PF00017	0.559
LIG_SH2_NCK_1	20	24	PF00017	0.476
LIG_SH2_NCK_1	299	303	PF00017	0.491
LIG_SH2_STAP1	20	24	PF00017	0.476
LIG_SH2_STAP1	568	572	PF00017	0.467
LIG_SH2_STAT3	37	40	PF00017	0.577
LIG_SH2_STAT3	571	574	PF00017	0.595
LIG_SH2_STAT5	116	119	PF00017	0.576
LIG_SH2_STAT5	173	176	PF00017	0.548
LIG_SH2_STAT5	299	302	PF00017	0.486
LIG_SH2_STAT5	571	574	PF00017	0.595
LIG_SH3_3	344	350	PF00018	0.733
LIG_SH3_3	391	397	PF00018	0.689
LIG_SH3_3	477	483	PF00018	0.645
LIG_TRAF2_1	127	130	PF00917	0.582
LIG_TRAF2_1	159	162	PF00917	0.601
LIG_TRAF2_1	503	506	PF00917	0.736
LIG_UBA3_1	318	323	PF00899	0.530
LIG_WW_3	415	419	PF00397	0.663
MOD_CDK_SPxxK_3	2	9	PF00069	0.713
MOD_CDK_SPxxK_3	365	372	PF00069	0.781
MOD_CK1_1	134	140	PF00069	0.574
MOD_CK1_1	219	225	PF00069	0.543
MOD_CK1_1	362	368	PF00069	0.763
MOD_CK1_1	402	408	PF00069	0.664
MOD_CK1_1	442	448	PF00069	0.681
MOD_CK2_1	124	130	PF00069	0.578
MOD_CK2_1	13	19	PF00069	0.427
MOD_CK2_1	305	311	PF00069	0.746
MOD_CK2_1	342	348	PF00069	0.766
MOD_CK2_1	376	382	PF00069	0.743
MOD_CK2_1	425	431	PF00069	0.713
MOD_CK2_1	455	461	PF00069	0.548
MOD_CK2_1	500	506	PF00069	0.744
MOD_GlcNHglycan	11	14	PF01048	0.623
MOD_GlcNHglycan	157	160	PF01048	0.522
MOD_GlcNHglycan	208	212	PF01048	0.580
MOD_GlcNHglycan	295	298	PF01048	0.692
MOD_GlcNHglycan	327	330	PF01048	0.519
MOD_GlcNHglycan	338	341	PF01048	0.536
MOD_GlcNHglycan	382	385	PF01048	0.781
MOD_GlcNHglycan	404	407	PF01048	0.772
MOD_GlcNHglycan	427	430	PF01048	0.756
MOD_GlcNHglycan	455	458	PF01048	0.713
MOD_GlcNHglycan	519	522	PF01048	0.627
MOD_GlcNHglycan	523	526	PF01048	0.668
MOD_GSK3_1	190	197	PF00069	0.557
MOD_GSK3_1	280	287	PF00069	0.585
MOD_GSK3_1	293	300	PF00069	0.432
MOD_GSK3_1	334	341	PF00069	0.538
MOD_GSK3_1	354	361	PF00069	0.724
MOD_GSK3_1	376	383	PF00069	0.675
MOD_GSK3_1	386	393	PF00069	0.622
MOD_GSK3_1	395	402	PF00069	0.649
MOD_GSK3_1	425	432	PF00069	0.748
MOD_GSK3_1	438	445	PF00069	0.665
MOD_GSK3_1	494	501	PF00069	0.630
MOD_GSK3_1	517	524	PF00069	0.609
MOD_GSK3_1	545	552	PF00069	0.503
MOD_GSK3_1	9	16	PF00069	0.620
MOD_N-GLC_1	333	338	PF02516	0.681
MOD_NEK2_1	1	6	PF00069	0.722
MOD_NEK2_1	194	199	PF00069	0.571
MOD_NEK2_1	216	221	PF00069	0.503
MOD_NEK2_1	284	289	PF00069	0.604
MOD_NEK2_1	293	298	PF00069	0.592
MOD_NEK2_1	354	359	PF00069	0.787
MOD_NEK2_1	399	404	PF00069	0.754
MOD_NEK2_1	438	443	PF00069	0.721
MOD_NEK2_1	515	520	PF00069	0.694
MOD_NEK2_1	545	550	PF00069	0.487
MOD_PIKK_1	131	137	PF00454	0.425
MOD_PIKK_1	194	200	PF00454	0.567
MOD_PIKK_1	362	368	PF00454	0.708
MOD_PIKK_1	408	414	PF00454	0.655
MOD_PIKK_1	416	422	PF00454	0.763
MOD_PIKK_1	570	576	PF00454	0.468
MOD_PK_1	374	380	PF00069	0.531
MOD_PKA_2	124	130	PF00069	0.578
MOD_PKA_2	14	20	PF00069	0.525
MOD_PKA_2	154	160	PF00069	0.529
MOD_PKA_2	334	340	PF00069	0.722
MOD_PKA_2	354	360	PF00069	0.715
MOD_PKA_2	408	414	PF00069	0.626
MOD_PKA_2	56	62	PF00069	0.608
MOD_PKB_1	372	380	PF00069	0.529
MOD_Plk_1	145	151	PF00069	0.415
MOD_Plk_1	399	405	PF00069	0.695
MOD_Plk_1	439	445	PF00069	0.711
MOD_Plk_4	284	290	PF00069	0.595
MOD_Plk_4	455	461	PF00069	0.680
MOD_ProDKin_1	2	8	PF00069	0.752
MOD_ProDKin_1	365	371	PF00069	0.794
MOD_ProDKin_1	390	396	PF00069	0.686
MOD_ProDKin_1	494	500	PF00069	0.615
MOD_SUMO_for_1	322	325	PF00179	0.581
MOD_SUMO_rev_2	212	222	PF00179	0.476
MOD_SUMO_rev_2	55	64	PF00179	0.576
TRG_ENDOCYTIC_2	163	166	PF00928	0.492
TRG_ENDOCYTIC_2	241	244	PF00928	0.456
TRG_ENDOCYTIC_2	316	319	PF00928	0.563
TRG_ER_diArg_1	124	126	PF00400	0.564
TRG_ER_diArg_1	166	169	PF00400	0.553
TRG_ER_diArg_1	255	258	PF00400	0.477
TRG_ER_diArg_1	50	53	PF00400	0.561
TRG_NES_CRM1_1	530	543	PF08389	0.528
TRG_NES_CRM1_1	72	86	PF08389	0.484
TRG_NLS_Bipartite_1	90	109	PF00514	0.569
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.766
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF9	Leptomonas seymouri	55%	93%
A0A1X0NR42	Trypanosomatidae	32%	98%
A0A3S5IQW4	Trypanosoma rangeli	32%	94%
A0A3S7X1P3	Leishmania donovani	81%	100%
A4I3T0	Leishmania infantum	81%	100%
D0A877	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B022	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q864	Leishmania major	81%	100%
V5AWM8	Trypanosoma cruzi	31%	100%