Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGQ5_LEIBR

TriTrypDb:

LbrM.28.2200 , LBRM2903_280028400

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGQ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.724
CLV_C14_Caspase3-7	475	479	PF00656	0.398
CLV_C14_Caspase3-7	548	552	PF00656	0.465
CLV_C14_Caspase3-7	88	92	PF00656	0.470
CLV_NRD_NRD_1	16	18	PF00675	0.629
CLV_NRD_NRD_1	290	292	PF00675	0.506
CLV_PCSK_KEX2_1	16	18	PF00082	0.629
CLV_PCSK_KEX2_1	204	206	PF00082	0.580
CLV_PCSK_KEX2_1	290	292	PF00082	0.506
CLV_PCSK_KEX2_1	514	516	PF00082	0.502
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.377
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.502
CLV_PCSK_PC7_1	286	292	PF00082	0.501
CLV_PCSK_SKI1_1	176	180	PF00082	0.328
CLV_PCSK_SKI1_1	231	235	PF00082	0.374
CLV_PCSK_SKI1_1	338	342	PF00082	0.255
DEG_APCC_DBOX_1	3	11	PF00400	0.358
DEG_COP1_1	119	129	PF00400	0.514
DOC_CKS1_1	387	392	PF01111	0.488
DOC_CYCLIN_RxL_1	512	520	PF00134	0.550
DOC_CYCLIN_yCln2_LP_2	234	240	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	387	393	PF00134	0.567
DOC_MAPK_DCC_7	231	240	PF00069	0.471
DOC_MAPK_gen_1	514	521	PF00069	0.481
DOC_MAPK_MEF2A_6	338	347	PF00069	0.423
DOC_MAPK_MEF2A_6	4	11	PF00069	0.489
DOC_MAPK_MEF2A_6	514	521	PF00069	0.481
DOC_MAPK_NFAT4_5	338	346	PF00069	0.249
DOC_MAPK_NFAT4_5	514	522	PF00069	0.501
DOC_PP1_RVXF_1	445	452	PF00149	0.446
DOC_USP7_MATH_1	125	129	PF00917	0.581
DOC_USP7_MATH_1	164	168	PF00917	0.410
DOC_USP7_MATH_1	28	32	PF00917	0.595
DOC_USP7_MATH_1	323	327	PF00917	0.536
DOC_USP7_MATH_1	36	40	PF00917	0.681
DOC_USP7_MATH_1	395	399	PF00917	0.418
DOC_USP7_MATH_1	445	449	PF00917	0.549
DOC_USP7_MATH_1	499	503	PF00917	0.564
DOC_USP7_UBL2_3	200	204	PF12436	0.343
DOC_WW_Pin1_4	166	171	PF00397	0.393
DOC_WW_Pin1_4	238	243	PF00397	0.572
DOC_WW_Pin1_4	386	391	PF00397	0.455
LIG_14-3-3_CanoR_1	183	189	PF00244	0.369
LIG_14-3-3_CanoR_1	264	271	PF00244	0.484
LIG_14-3-3_CanoR_1	300	306	PF00244	0.432
LIG_14-3-3_CanoR_1	371	377	PF00244	0.607
LIG_Actin_WH2_2	185	202	PF00022	0.368
LIG_Actin_WH2_2	532	548	PF00022	0.369
LIG_BIR_III_4	478	482	PF00653	0.442
LIG_BIR_III_4	89	93	PF00653	0.588
LIG_BRCT_BRCA1_1	136	140	PF00533	0.251
LIG_BRCT_BRCA1_1	184	188	PF00533	0.340
LIG_BRCT_BRCA1_1	254	258	PF00533	0.509
LIG_BRCT_BRCA1_1	447	451	PF00533	0.542
LIG_BRCT_BRCA1_1	7	11	PF00533	0.487
LIG_Clathr_ClatBox_1	342	346	PF01394	0.318
LIG_CSL_BTD_1	387	390	PF09270	0.499
LIG_deltaCOP1_diTrp_1	134	140	PF00928	0.470
LIG_eIF4E_1	336	342	PF01652	0.282
LIG_FHA_1	104	110	PF00498	0.631
LIG_FHA_1	173	179	PF00498	0.364
LIG_FHA_1	192	198	PF00498	0.280
LIG_FHA_1	22	28	PF00498	0.435
LIG_FHA_1	244	250	PF00498	0.478
LIG_FHA_1	342	348	PF00498	0.475
LIG_FHA_1	387	393	PF00498	0.490
LIG_FHA_1	444	450	PF00498	0.745
LIG_FHA_2	172	178	PF00498	0.475
LIG_FHA_2	275	281	PF00498	0.438
LIG_FHA_2	435	441	PF00498	0.790
LIG_GBD_Chelix_1	339	347	PF00786	0.381
LIG_LIR_Apic_2	160	166	PF02991	0.452
LIG_LIR_Gen_1	115	125	PF02991	0.590
LIG_LIR_Nem_3	115	120	PF02991	0.634
LIG_LIR_Nem_3	128	132	PF02991	0.428
LIG_LIR_Nem_3	255	261	PF02991	0.412
LIG_LIR_Nem_3	267	273	PF02991	0.367
LIG_LIR_Nem_3	373	379	PF02991	0.590
LIG_LIR_Nem_3	76	81	PF02991	0.489
LIG_LYPXL_yS_3	336	339	PF13949	0.317
LIG_NRBOX	338	344	PF00104	0.462
LIG_Pex14_2	140	144	PF04695	0.349
LIG_Pex14_2	451	455	PF04695	0.433
LIG_REV1ctd_RIR_1	449	457	PF16727	0.424
LIG_REV1ctd_RIR_1	49	57	PF16727	0.356
LIG_SH2_CRK	495	499	PF00017	0.546
LIG_SH2_SRC	54	57	PF00017	0.374
LIG_SH2_SRC	71	74	PF00017	0.499
LIG_SH2_STAP1	71	75	PF00017	0.509
LIG_SH2_STAP1	78	82	PF00017	0.512
LIG_SH2_STAT5	155	158	PF00017	0.409
LIG_SH2_STAT5	173	176	PF00017	0.441
LIG_SH2_STAT5	239	242	PF00017	0.292
LIG_SH2_STAT5	357	360	PF00017	0.403
LIG_SH2_STAT5	464	467	PF00017	0.445
LIG_SH2_STAT5	495	498	PF00017	0.478
LIG_SH2_STAT5	54	57	PF00017	0.316
LIG_SH2_STAT5	81	84	PF00017	0.512
LIG_SH3_3	265	271	PF00018	0.485
LIG_SH3_3	60	66	PF00018	0.408
LIG_SUMO_SIM_anti_2	344	353	PF11976	0.416
LIG_SUMO_SIM_par_1	341	346	PF11976	0.337
LIG_SUMO_SIM_par_1	389	394	PF11976	0.375
LIG_TRAF2_1	437	440	PF00917	0.780
LIG_TRAF2_1	74	77	PF00917	0.602
LIG_WRC_WIRS_1	126	131	PF05994	0.440
MOD_CDK_SPxxK_3	238	245	PF00069	0.445
MOD_CK1_1	128	134	PF00069	0.428
MOD_CK1_1	225	231	PF00069	0.523
MOD_CK1_1	241	247	PF00069	0.516
MOD_CK1_1	370	376	PF00069	0.342
MOD_CK1_1	39	45	PF00069	0.586
MOD_CK1_1	434	440	PF00069	0.652
MOD_CK1_1	57	63	PF00069	0.306
MOD_CK2_1	128	134	PF00069	0.442
MOD_CK2_1	171	177	PF00069	0.425
MOD_CK2_1	274	280	PF00069	0.425
MOD_CK2_1	434	440	PF00069	0.541
MOD_CK2_1	71	77	PF00069	0.544
MOD_CMANNOS	385	388	PF00535	0.467
MOD_Cter_Amidation	14	17	PF01082	0.620
MOD_GlcNHglycan	11	14	PF01048	0.537
MOD_GlcNHglycan	110	113	PF01048	0.567
MOD_GlcNHglycan	136	139	PF01048	0.483
MOD_GlcNHglycan	208	211	PF01048	0.531
MOD_GlcNHglycan	224	227	PF01048	0.483
MOD_GlcNHglycan	313	316	PF01048	0.499
MOD_GlcNHglycan	32	37	PF01048	0.597
MOD_GlcNHglycan	38	41	PF01048	0.537
MOD_GlcNHglycan	396	400	PF01048	0.482
MOD_GlcNHglycan	405	409	PF01048	0.491
MOD_GlcNHglycan	501	504	PF01048	0.692
MOD_GlcNHglycan	529	532	PF01048	0.383
MOD_GlcNHglycan	547	550	PF01048	0.581
MOD_GlcNHglycan	73	76	PF01048	0.395
MOD_GlcNHglycan	95	98	PF01048	0.736
MOD_GSK3_1	108	115	PF00069	0.715
MOD_GSK3_1	164	171	PF00069	0.412
MOD_GSK3_1	206	213	PF00069	0.604
MOD_GSK3_1	214	221	PF00069	0.334
MOD_GSK3_1	252	259	PF00069	0.477
MOD_GSK3_1	28	35	PF00069	0.631
MOD_GSK3_1	307	314	PF00069	0.369
MOD_GSK3_1	482	489	PF00069	0.659
MOD_GSK3_1	5	12	PF00069	0.404
MOD_GSK3_1	57	64	PF00069	0.495
MOD_N-GLC_1	183	188	PF02516	0.381
MOD_N-GLC_1	57	62	PF02516	0.460
MOD_NEK2_1	182	187	PF00069	0.359
MOD_NEK2_1	214	219	PF00069	0.442
MOD_NEK2_1	222	227	PF00069	0.521
MOD_NEK2_1	256	261	PF00069	0.476
MOD_NEK2_1	298	303	PF00069	0.579
MOD_NEK2_1	348	353	PF00069	0.365
MOD_NEK2_1	358	363	PF00069	0.348
MOD_NEK2_1	404	409	PF00069	0.500
MOD_NEK2_1	472	477	PF00069	0.500
MOD_NEK2_1	482	487	PF00069	0.501
MOD_NEK2_1	545	550	PF00069	0.628
MOD_NEK2_2	112	117	PF00069	0.468
MOD_PIKK_1	191	197	PF00454	0.266
MOD_PIKK_1	380	386	PF00454	0.503
MOD_PKA_2	103	109	PF00069	0.522
MOD_PKA_2	182	188	PF00069	0.363
MOD_PKA_2	249	255	PF00069	0.430
MOD_PKA_2	263	269	PF00069	0.461
MOD_PKA_2	370	376	PF00069	0.598
MOD_Plk_1	214	220	PF00069	0.333
MOD_Plk_1	349	355	PF00069	0.420
MOD_Plk_1	380	386	PF00069	0.481
MOD_Plk_1	57	63	PF00069	0.393
MOD_Plk_2-3	431	437	PF00069	0.718
MOD_Plk_4	168	174	PF00069	0.389
MOD_Plk_4	269	275	PF00069	0.484
MOD_Plk_4	464	470	PF00069	0.294
MOD_Plk_4	5	11	PF00069	0.396
MOD_Plk_4	77	83	PF00069	0.538
MOD_ProDKin_1	166	172	PF00069	0.382
MOD_ProDKin_1	238	244	PF00069	0.576
MOD_ProDKin_1	386	392	PF00069	0.449
TRG_DiLeu_BaEn_1	177	182	PF01217	0.444
TRG_DiLeu_BaEn_1	293	298	PF01217	0.400
TRG_DiLeu_BaEn_1	501	506	PF01217	0.542
TRG_DiLeu_BaEn_2	531	537	PF01217	0.370
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.488
TRG_ENDOCYTIC_2	117	120	PF00928	0.455
TRG_ENDOCYTIC_2	336	339	PF00928	0.317
TRG_ENDOCYTIC_2	495	498	PF00928	0.521
TRG_ER_diArg_1	290	292	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	515	520	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL93	Leptomonas seymouri	57%	100%
A0A1X0NQS9	Trypanosomatidae	34%	100%
A0A3S7X1P6	Leishmania donovani	76%	100%
A0A422NBH7	Trypanosoma rangeli	37%	100%
A4I3S9	Leishmania infantum	77%	100%
D0A878	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B021	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q865	Leishmania major	79%	99%
V5DCT5	Trypanosoma cruzi	36%	100%