Leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGP9_LEIBR

TriTrypDb:

LbrM.28.2140 , LBRM2903_280028000

Length:

779

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A4HGP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGP9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.422
CLV_C14_Caspase3-7	426	430	PF00656	0.775
CLV_C14_Caspase3-7	443	447	PF00656	0.541
CLV_C14_Caspase3-7	547	551	PF00656	0.422
CLV_C14_Caspase3-7	61	65	PF00656	0.349
CLV_NRD_NRD_1	373	375	PF00675	0.559
CLV_NRD_NRD_1	381	383	PF00675	0.607
CLV_NRD_NRD_1	441	443	PF00675	0.723
CLV_NRD_NRD_1	489	491	PF00675	0.792
CLV_NRD_NRD_1	600	602	PF00675	0.632
CLV_NRD_NRD_1	771	773	PF00675	0.642
CLV_PCSK_KEX2_1	17	19	PF00082	0.419
CLV_PCSK_KEX2_1	373	375	PF00082	0.559
CLV_PCSK_KEX2_1	381	383	PF00082	0.607
CLV_PCSK_KEX2_1	441	443	PF00082	0.723
CLV_PCSK_KEX2_1	489	491	PF00082	0.711
CLV_PCSK_KEX2_1	600	602	PF00082	0.632
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.419
CLV_PCSK_PC7_1	377	383	PF00082	0.584
CLV_PCSK_SKI1_1	33	37	PF00082	0.527
CLV_PCSK_SKI1_1	567	571	PF00082	0.545
CLV_PCSK_SKI1_1	637	641	PF00082	0.549
CLV_PCSK_SKI1_1	667	671	PF00082	0.534
DEG_Kelch_Keap1_1	733	738	PF01344	0.725
DEG_SCF_FBW7_1	233	239	PF00400	0.481
DEG_SPOP_SBC_1	615	619	PF00917	0.620
DOC_ANK_TNKS_1	424	431	PF00023	0.735
DOC_CDC14_PxL_1	177	185	PF14671	0.388
DOC_CKS1_1	233	238	PF01111	0.481
DOC_CKS1_1	557	562	PF01111	0.733
DOC_CYCLIN_RxL_1	66	77	PF00134	0.460
DOC_MAPK_DCC_7	350	358	PF00069	0.551
DOC_MAPK_gen_1	492	501	PF00069	0.566
DOC_MAPK_MEF2A_6	292	301	PF00069	0.274
DOC_PP4_FxxP_1	275	278	PF00568	0.378
DOC_PP4_FxxP_1	78	81	PF00568	0.457
DOC_USP7_MATH_1	206	210	PF00917	0.306
DOC_USP7_MATH_1	368	372	PF00917	0.545
DOC_USP7_MATH_1	451	455	PF00917	0.568
DOC_USP7_MATH_1	473	477	PF00917	0.692
DOC_USP7_MATH_1	615	619	PF00917	0.630
DOC_USP7_MATH_1	643	647	PF00917	0.664
DOC_USP7_MATH_1	648	652	PF00917	0.685
DOC_USP7_MATH_1	719	723	PF00917	0.701
DOC_USP7_UBL2_3	104	108	PF12436	0.445
DOC_USP7_UBL2_3	305	309	PF12436	0.489
DOC_USP7_UBL2_3	570	574	PF12436	0.594
DOC_WW_Pin1_4	232	237	PF00397	0.526
DOC_WW_Pin1_4	276	281	PF00397	0.454
DOC_WW_Pin1_4	304	309	PF00397	0.320
DOC_WW_Pin1_4	456	461	PF00397	0.711
DOC_WW_Pin1_4	474	479	PF00397	0.543
DOC_WW_Pin1_4	484	489	PF00397	0.628
DOC_WW_Pin1_4	505	510	PF00397	0.671
DOC_WW_Pin1_4	512	517	PF00397	0.636
DOC_WW_Pin1_4	526	531	PF00397	0.592
DOC_WW_Pin1_4	556	561	PF00397	0.728
DOC_WW_Pin1_4	621	626	PF00397	0.710
DOC_WW_Pin1_4	715	720	PF00397	0.698
DOC_WW_Pin1_4	759	764	PF00397	0.819
LIG_14-3-3_CanoR_1	292	297	PF00244	0.284
LIG_14-3-3_CanoR_1	453	459	PF00244	0.575
LIG_14-3-3_CanoR_1	463	471	PF00244	0.617
LIG_14-3-3_CanoR_1	528	538	PF00244	0.561
LIG_14-3-3_CanoR_1	644	653	PF00244	0.547
LIG_14-3-3_CanoR_1	703	710	PF00244	0.615
LIG_14-3-3_CanoR_1	715	719	PF00244	0.623
LIG_14-3-3_CanoR_1	772	776	PF00244	0.745
LIG_APCC_ABBA_1	255	260	PF00400	0.362
LIG_BIR_II_1	1	5	PF00653	0.490
LIG_BIR_III_2	724	728	PF00653	0.548
LIG_BRCT_BRCA1_1	775	779	PF00533	0.688
LIG_Clathr_ClatBox_1	296	300	PF01394	0.423
LIG_FHA_1	211	217	PF00498	0.336
LIG_FHA_1	235	241	PF00498	0.402
LIG_FHA_1	252	258	PF00498	0.364
LIG_FHA_1	264	270	PF00498	0.296
LIG_FHA_1	293	299	PF00498	0.304
LIG_FHA_1	309	315	PF00498	0.527
LIG_FHA_1	367	373	PF00498	0.526
LIG_FHA_1	564	570	PF00498	0.675
LIG_FHA_1	589	595	PF00498	0.448
LIG_FHA_1	716	722	PF00498	0.625
LIG_FHA_2	424	430	PF00498	0.774
LIG_FHA_2	463	469	PF00498	0.555
LIG_FHA_2	557	563	PF00498	0.629
LIG_FHA_2	59	65	PF00498	0.490
LIG_FHA_2	669	675	PF00498	0.550
LIG_FHA_2	709	715	PF00498	0.609
LIG_LIR_Apic_2	75	81	PF02991	0.463
LIG_LIR_Gen_1	678	686	PF02991	0.548
LIG_LIR_Nem_3	678	682	PF02991	0.604
LIG_LRP6_Inhibitor_1	575	581	PF00058	0.432
LIG_PCNA_yPIPBox_3	316	329	PF02747	0.405
LIG_SH2_CRK	190	194	PF00017	0.312
LIG_SH2_NCK_1	375	379	PF00017	0.634
LIG_SH2_PTP2	357	360	PF00017	0.452
LIG_SH2_STAT3	172	175	PF00017	0.357
LIG_SH2_STAT3	686	689	PF00017	0.665
LIG_SH2_STAT3	720	723	PF00017	0.545
LIG_SH2_STAT5	12	15	PF00017	0.365
LIG_SH2_STAT5	172	175	PF00017	0.357
LIG_SH2_STAT5	357	360	PF00017	0.452
LIG_SH2_STAT5	366	369	PF00017	0.520
LIG_SH2_STAT5	720	723	PF00017	0.545
LIG_SH3_2	767	772	PF14604	0.538
LIG_SH3_3	455	461	PF00018	0.550
LIG_SH3_3	557	563	PF00018	0.726
LIG_SH3_3	622	628	PF00018	0.604
LIG_SH3_3	764	770	PF00018	0.541
LIG_SUMO_SIM_anti_2	295	300	PF11976	0.319
LIG_SUMO_SIM_anti_2	535	542	PF11976	0.517
LIG_SUMO_SIM_anti_2	708	714	PF11976	0.581
LIG_SUMO_SIM_par_1	127	133	PF11976	0.312
LIG_SUMO_SIM_par_1	153	159	PF11976	0.361
LIG_SUMO_SIM_par_1	212	217	PF11976	0.349
LIG_SUMO_SIM_par_1	294	300	PF11976	0.359
LIG_SUMO_SIM_par_1	535	542	PF11976	0.474
LIG_SUMO_SIM_par_1	69	75	PF11976	0.453
LIG_SxIP_EBH_1	283	292	PF03271	0.299
LIG_TRAF2_1	317	320	PF00917	0.495
LIG_TRAF2_1	465	468	PF00917	0.683
LIG_TYR_ITIM	188	193	PF00017	0.312
LIG_UBA3_1	297	305	PF00899	0.368
MOD_CDC14_SPxK_1	487	490	PF00782	0.566
MOD_CDK_SPK_2	304	309	PF00069	0.320
MOD_CDK_SPK_2	474	479	PF00069	0.727
MOD_CDK_SPK_2	484	489	PF00069	0.628
MOD_CDK_SPK_2	526	531	PF00069	0.596
MOD_CDK_SPK_2	621	626	PF00069	0.604
MOD_CDK_SPxK_1	484	490	PF00069	0.573
MOD_CDK_SPxxK_3	456	463	PF00069	0.553
MOD_CDK_SPxxK_3	474	481	PF00069	0.542
MOD_CK1_1	209	215	PF00069	0.227
MOD_CK1_1	452	458	PF00069	0.723
MOD_CK1_1	522	528	PF00069	0.705
MOD_CK1_1	529	535	PF00069	0.656
MOD_CK1_1	613	619	PF00069	0.688
MOD_CK1_1	702	708	PF00069	0.699
MOD_CK2_1	456	462	PF00069	0.710
MOD_CK2_1	529	535	PF00069	0.571
MOD_CK2_1	549	555	PF00069	0.420
MOD_CK2_1	668	674	PF00069	0.536
MOD_CK2_1	708	714	PF00069	0.626
MOD_CK2_1	729	735	PF00069	0.633
MOD_Cter_Amidation	598	601	PF01082	0.441
MOD_DYRK1A_RPxSP_1	621	625	PF00069	0.563
MOD_GlcNHglycan	13	16	PF01048	0.441
MOD_GlcNHglycan	287	290	PF01048	0.412
MOD_GlcNHglycan	484	487	PF01048	0.864
MOD_GlcNHglycan	531	534	PF01048	0.606
MOD_GlcNHglycan	621	624	PF01048	0.729
MOD_GlcNHglycan	640	643	PF01048	0.520
MOD_GlcNHglycan	646	649	PF01048	0.705
MOD_GlcNHglycan	650	653	PF01048	0.686
MOD_GlcNHglycan	734	738	PF01048	0.751
MOD_GlcNHglycan	748	751	PF01048	0.535
MOD_GSK3_1	206	213	PF00069	0.303
MOD_GSK3_1	232	239	PF00069	0.520
MOD_GSK3_1	304	311	PF00069	0.330
MOD_GSK3_1	373	380	PF00069	0.563
MOD_GSK3_1	381	388	PF00069	0.616
MOD_GSK3_1	389	396	PF00069	0.643
MOD_GSK3_1	397	404	PF00069	0.683
MOD_GSK3_1	405	412	PF00069	0.707
MOD_GSK3_1	413	420	PF00069	0.613
MOD_GSK3_1	431	438	PF00069	0.723
MOD_GSK3_1	445	452	PF00069	0.756
MOD_GSK3_1	522	529	PF00069	0.718
MOD_GSK3_1	610	617	PF00069	0.629
MOD_GSK3_1	629	636	PF00069	0.646
MOD_GSK3_1	644	651	PF00069	0.651
MOD_GSK3_1	689	696	PF00069	0.730
MOD_GSK3_1	702	709	PF00069	0.674
MOD_GSK3_1	715	722	PF00069	0.564
MOD_GSK3_1	729	736	PF00069	0.650
MOD_N-GLC_1	134	139	PF02516	0.388
MOD_N-GLC_1	264	269	PF02516	0.383
MOD_N-GLC_1	292	297	PF02516	0.303
MOD_N-GLC_1	320	325	PF02516	0.482
MOD_N-GLC_1	436	441	PF02516	0.624
MOD_N-GLC_1	648	653	PF02516	0.551
MOD_N-GLC_1	675	680	PF02516	0.581
MOD_N-GLC_1	706	711	PF02516	0.600
MOD_N-GLC_2	122	124	PF02516	0.394
MOD_NEK2_1	11	16	PF00069	0.442
MOD_NEK2_1	171	176	PF00069	0.294
MOD_NEK2_1	214	219	PF00069	0.312
MOD_NEK2_1	335	340	PF00069	0.347
MOD_NEK2_1	539	544	PF00069	0.568
MOD_NEK2_1	58	63	PF00069	0.299
MOD_NEK2_1	688	693	PF00069	0.529
MOD_NEK2_1	697	702	PF00069	0.697
MOD_NEK2_1	746	751	PF00069	0.622
MOD_NEK2_1	771	776	PF00069	0.706
MOD_NEK2_2	368	373	PF00069	0.559
MOD_NEK2_2	660	665	PF00069	0.539
MOD_PIKK_1	171	177	PF00454	0.274
MOD_PIKK_1	335	341	PF00454	0.353
MOD_PIKK_1	616	622	PF00454	0.564
MOD_PIKK_1	702	708	PF00454	0.672
MOD_PIKK_1	719	725	PF00454	0.530
MOD_PIKK_1	761	767	PF00454	0.759
MOD_PKA_1	373	379	PF00069	0.560
MOD_PKA_1	381	387	PF00069	0.611
MOD_PKA_2	219	225	PF00069	0.388
MOD_PKA_2	373	379	PF00069	0.560
MOD_PKA_2	381	387	PF00069	0.611
MOD_PKA_2	440	446	PF00069	0.773
MOD_PKA_2	452	458	PF00069	0.605
MOD_PKA_2	462	468	PF00069	0.559
MOD_PKA_2	613	619	PF00069	0.570
MOD_PKA_2	643	649	PF00069	0.544
MOD_PKA_2	702	708	PF00069	0.628
MOD_PKA_2	714	720	PF00069	0.671
MOD_PKA_2	771	777	PF00069	0.705
MOD_Plk_1	156	162	PF00069	0.363
MOD_Plk_1	264	270	PF00069	0.359
MOD_Plk_1	292	298	PF00069	0.297
MOD_Plk_1	320	326	PF00069	0.477
MOD_Plk_1	549	555	PF00069	0.425
MOD_Plk_1	706	712	PF00069	0.576
MOD_Plk_1	74	80	PF00069	0.374
MOD_Plk_4	251	257	PF00069	0.461
MOD_Plk_4	264	270	PF00069	0.290
MOD_Plk_4	292	298	PF00069	0.309
MOD_Plk_4	660	666	PF00069	0.540
MOD_ProDKin_1	232	238	PF00069	0.519
MOD_ProDKin_1	276	282	PF00069	0.450
MOD_ProDKin_1	304	310	PF00069	0.325
MOD_ProDKin_1	456	462	PF00069	0.710
MOD_ProDKin_1	474	480	PF00069	0.543
MOD_ProDKin_1	484	490	PF00069	0.628
MOD_ProDKin_1	505	511	PF00069	0.674
MOD_ProDKin_1	512	518	PF00069	0.635
MOD_ProDKin_1	526	532	PF00069	0.586
MOD_ProDKin_1	556	562	PF00069	0.725
MOD_ProDKin_1	621	627	PF00069	0.710
MOD_ProDKin_1	715	721	PF00069	0.698
MOD_ProDKin_1	759	765	PF00069	0.821
MOD_SUMO_rev_2	32	38	PF00179	0.586
MOD_SUMO_rev_2	342	351	PF00179	0.387
TRG_DiLeu_BaEn_1	535	540	PF01217	0.486
TRG_DiLeu_BaEn_4	348	354	PF01217	0.575
TRG_ENDOCYTIC_2	190	193	PF00928	0.312
TRG_ENDOCYTIC_2	679	682	PF00928	0.592
TRG_ER_diArg_1	372	374	PF00400	0.539
TRG_ER_diArg_1	478	481	PF00400	0.636
TRG_ER_diArg_1	488	490	PF00400	0.682
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	69	74	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II72	Leishmania donovani	75%	100%
A4I3S6	Leishmania infantum	75%	100%
D0A881	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B018	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q867	Leishmania major	73%	95%