LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
divalent cation transporter, putative
Species:
Leishmania braziliensis
UniProt:
A4HGP8_LEIBR
TriTrypDb:
LbrM.28.2120 , LBRM2903_280027500 *
Length:
673

Annotations

LeishMANIAdb annotations

A bacterial-type Mg2+ transporter found in kinetoplastids.. Expanded extensively on multiple lineages, especially T cruzi

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4HGP8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGP8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 6
GO:0006811 monoatomic ion transport 4 6
GO:0006812 monoatomic cation transport 5 6
GO:0015693 magnesium ion transport 7 6
GO:0030001 metal ion transport 6 6
GO:0051179 localization 1 6
GO:0051234 establishment of localization 2 6
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 6
GO:0008324 monoatomic cation transmembrane transporter activity 4 6
GO:0015075 monoatomic ion transmembrane transporter activity 3 6
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 6
GO:0022857 transmembrane transporter activity 2 6
GO:0022890 inorganic cation transmembrane transporter activity 4 6
GO:0046873 metal ion transmembrane transporter activity 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 222 226 PF00656 0.518
CLV_NRD_NRD_1 190 192 PF00675 0.631
CLV_NRD_NRD_1 235 237 PF00675 0.732
CLV_NRD_NRD_1 281 283 PF00675 0.625
CLV_NRD_NRD_1 357 359 PF00675 0.644
CLV_NRD_NRD_1 540 542 PF00675 0.214
CLV_NRD_NRD_1 568 570 PF00675 0.234
CLV_PCSK_FUR_1 233 237 PF00082 0.621
CLV_PCSK_KEX2_1 189 191 PF00082 0.641
CLV_PCSK_KEX2_1 235 237 PF00082 0.732
CLV_PCSK_KEX2_1 281 283 PF00082 0.668
CLV_PCSK_KEX2_1 540 542 PF00082 0.217
CLV_PCSK_SKI1_1 168 172 PF00082 0.560
CLV_PCSK_SKI1_1 480 484 PF00082 0.275
CLV_PCSK_SKI1_1 529 533 PF00082 0.275
DEG_SCF_FBW7_1 117 124 PF00400 0.452
DEG_SPOP_SBC_1 632 636 PF00917 0.329
DOC_ANK_TNKS_1 64 71 PF00023 0.421
DOC_CKS1_1 287 292 PF01111 0.418
DOC_CKS1_1 663 668 PF01111 0.524
DOC_CYCLIN_yCln2_LP_2 413 419 PF00134 0.540
DOC_MAPK_FxFP_2 143 146 PF00069 0.481
DOC_MAPK_gen_1 189 195 PF00069 0.425
DOC_MAPK_gen_1 511 519 PF00069 0.569
DOC_MAPK_gen_1 527 536 PF00069 0.409
DOC_MAPK_MEF2A_6 55 64 PF00069 0.433
DOC_PP2B_LxvP_1 114 117 PF13499 0.543
DOC_PP2B_LxvP_1 534 537 PF13499 0.485
DOC_PP4_FxxP_1 143 146 PF00568 0.550
DOC_PP4_FxxP_1 443 446 PF00568 0.553
DOC_PP4_FxxP_1 96 99 PF00568 0.427
DOC_USP7_MATH_1 163 167 PF00917 0.423
DOC_USP7_MATH_1 295 299 PF00917 0.392
DOC_USP7_MATH_1 322 326 PF00917 0.506
DOC_USP7_MATH_1 399 403 PF00917 0.444
DOC_WW_Pin1_4 117 122 PF00397 0.444
DOC_WW_Pin1_4 124 129 PF00397 0.509
DOC_WW_Pin1_4 148 153 PF00397 0.562
DOC_WW_Pin1_4 28 33 PF00397 0.524
DOC_WW_Pin1_4 286 291 PF00397 0.435
DOC_WW_Pin1_4 362 367 PF00397 0.452
DOC_WW_Pin1_4 392 397 PF00397 0.545
DOC_WW_Pin1_4 442 447 PF00397 0.500
DOC_WW_Pin1_4 448 453 PF00397 0.455
DOC_WW_Pin1_4 539 544 PF00397 0.475
DOC_WW_Pin1_4 545 550 PF00397 0.475
DOC_WW_Pin1_4 633 638 PF00397 0.299
DOC_WW_Pin1_4 651 656 PF00397 0.312
DOC_WW_Pin1_4 662 667 PF00397 0.495
DOC_WW_Pin1_4 98 103 PF00397 0.473
LIG_14-3-3_CanoR_1 119 128 PF00244 0.485
LIG_14-3-3_CanoR_1 190 196 PF00244 0.422
LIG_14-3-3_CanoR_1 21 27 PF00244 0.449
LIG_14-3-3_CanoR_1 235 244 PF00244 0.471
LIG_14-3-3_CanoR_1 358 366 PF00244 0.444
LIG_14-3-3_CanoR_1 410 416 PF00244 0.501
LIG_14-3-3_CanoR_1 455 463 PF00244 0.217
LIG_14-3-3_CanoR_1 509 514 PF00244 0.422
LIG_14-3-3_CanoR_1 556 565 PF00244 0.457
LIG_14-3-3_CanoR_1 577 583 PF00244 0.545
LIG_14-3-3_CanoR_1 589 597 PF00244 0.397
LIG_Actin_WH2_2 554 571 PF00022 0.413
LIG_BIR_II_1 1 5 PF00653 0.506
LIG_BIR_III_2 159 163 PF00653 0.522
LIG_BIR_III_4 201 205 PF00653 0.422
LIG_BRCT_BRCA1_1 297 301 PF00533 0.399
LIG_Clathr_ClatBox_1 519 523 PF01394 0.417
LIG_DLG_GKlike_1 509 516 PF00625 0.417
LIG_FHA_1 287 293 PF00498 0.417
LIG_FHA_1 363 369 PF00498 0.459
LIG_FHA_1 455 461 PF00498 0.217
LIG_FHA_1 546 552 PF00498 0.426
LIG_FHA_1 55 61 PF00498 0.431
LIG_FHA_1 606 612 PF00498 0.388
LIG_FHA_1 643 649 PF00498 0.321
LIG_FHA_2 169 175 PF00498 0.393
LIG_FHA_2 196 202 PF00498 0.452
LIG_FHA_2 628 634 PF00498 0.329
LIG_GBD_Chelix_1 467 475 PF00786 0.231
LIG_HP1_1 290 294 PF01393 0.392
LIG_LIR_Apic_2 93 99 PF02991 0.424
LIG_LIR_Gen_1 107 117 PF02991 0.481
LIG_LIR_Gen_1 242 253 PF02991 0.456
LIG_LIR_Gen_1 552 561 PF02991 0.417
LIG_LIR_Gen_1 636 647 PF02991 0.282
LIG_LIR_Nem_3 107 112 PF02991 0.473
LIG_LIR_Nem_3 242 248 PF02991 0.470
LIG_LIR_Nem_3 414 418 PF02991 0.420
LIG_LIR_Nem_3 552 557 PF02991 0.417
LIG_LIR_Nem_3 635 641 PF02991 0.278
LIG_LIR_Nem_3 73 79 PF02991 0.450
LIG_LIR_Nem_3 93 98 PF02991 0.498
LIG_LYPXL_yS_3 415 418 PF13949 0.421
LIG_MAD2 529 537 PF02301 0.475
LIG_NRBOX 530 536 PF00104 0.475
LIG_NRBOX 645 651 PF00104 0.231
LIG_Pex14_2 244 248 PF04695 0.439
LIG_SH2_CRK 237 241 PF00017 0.484
LIG_SH2_CRK 253 257 PF00017 0.353
LIG_SH2_CRK 554 558 PF00017 0.417
LIG_SH2_CRK 658 662 PF00017 0.565
LIG_SH2_CRK 663 667 PF00017 0.560
LIG_SH2_GRB2like 599 602 PF00017 0.413
LIG_SH2_SRC 599 602 PF00017 0.413
LIG_SH2_STAT5 237 240 PF00017 0.473
LIG_SH2_STAT5 247 250 PF00017 0.418
LIG_SH2_STAT5 474 477 PF00017 0.413
LIG_SH2_STAT5 599 602 PF00017 0.491
LIG_SH2_STAT5 66 69 PF00017 0.477
LIG_SH2_STAT5 95 98 PF00017 0.581
LIG_SH3_3 110 116 PF00018 0.589
LIG_SH3_3 125 131 PF00018 0.530
LIG_SH3_3 284 290 PF00018 0.452
LIG_SH3_3 393 399 PF00018 0.597
LIG_SH3_3 443 449 PF00018 0.573
LIG_SH3_3 622 628 PF00018 0.373
LIG_SH3_3 96 102 PF00018 0.491
LIG_SUMO_SIM_anti_2 313 318 PF11976 0.408
LIG_SUMO_SIM_anti_2 457 466 PF11976 0.258
LIG_SUMO_SIM_anti_2 605 611 PF11976 0.475
LIG_SUMO_SIM_anti_2 645 650 PF11976 0.244
LIG_SUMO_SIM_par_1 480 485 PF11976 0.417
LIG_SUMO_SIM_par_1 640 645 PF11976 0.296
LIG_TRAF2_1 170 173 PF00917 0.477
LIG_TRAF2_1 215 218 PF00917 0.468
LIG_TRFH_1 96 100 PF08558 0.426
LIG_TYR_ITIM 413 418 PF00017 0.421
LIG_TYR_ITIM 656 661 PF00017 0.475
LIG_UBA3_1 471 477 PF00899 0.231
LIG_UBA3_1 506 511 PF00899 0.413
LIG_UBA3_1 519 527 PF00899 0.413
LIG_UBA3_1 565 570 PF00899 0.417
LIG_WRC_WIRS_1 300 305 PF05994 0.404
MOD_CDK_SPxxK_3 28 35 PF00069 0.553
MOD_CDK_SPxxK_3 448 455 PF00069 0.404
MOD_CDK_SPxxK_3 539 546 PF00069 0.529
MOD_CK1_1 132 138 PF00069 0.570
MOD_CK1_1 151 157 PF00069 0.538
MOD_CK1_1 211 217 PF00069 0.570
MOD_CK1_1 28 34 PF00069 0.551
MOD_CK1_1 325 331 PF00069 0.488
MOD_CK1_1 341 347 PF00069 0.541
MOD_CK1_1 357 363 PF00069 0.417
MOD_CK1_1 39 45 PF00069 0.479
MOD_CK1_1 447 453 PF00069 0.420
MOD_CK1_1 466 472 PF00069 0.395
MOD_CK1_1 545 551 PF00069 0.531
MOD_CK1_1 560 566 PF00069 0.420
MOD_CK1_1 584 590 PF00069 0.468
MOD_CK2_1 168 174 PF00069 0.411
MOD_CK2_1 211 217 PF00069 0.579
MOD_CK2_1 627 633 PF00069 0.329
MOD_CK2_1 9 15 PF00069 0.518
MOD_GlcNHglycan 1 4 PF01048 0.686
MOD_GlcNHglycan 22 25 PF01048 0.646
MOD_GlcNHglycan 297 300 PF01048 0.603
MOD_GlcNHglycan 303 306 PF01048 0.644
MOD_GlcNHglycan 340 343 PF01048 0.775
MOD_GlcNHglycan 401 404 PF01048 0.811
MOD_GlcNHglycan 428 431 PF01048 0.755
MOD_GlcNHglycan 45 48 PF01048 0.717
MOD_GlcNHglycan 468 471 PF01048 0.327
MOD_GlcNHglycan 51 54 PF01048 0.658
MOD_GlcNHglycan 583 586 PF01048 0.274
MOD_GSK3_1 117 124 PF00069 0.491
MOD_GSK3_1 132 139 PF00069 0.547
MOD_GSK3_1 148 155 PF00069 0.541
MOD_GSK3_1 16 23 PF00069 0.466
MOD_GSK3_1 191 198 PF00069 0.455
MOD_GSK3_1 208 215 PF00069 0.417
MOD_GSK3_1 217 224 PF00069 0.528
MOD_GSK3_1 295 302 PF00069 0.396
MOD_GSK3_1 324 331 PF00069 0.483
MOD_GSK3_1 341 348 PF00069 0.469
MOD_GSK3_1 36 43 PF00069 0.509
MOD_GSK3_1 444 451 PF00069 0.504
MOD_GSK3_1 454 461 PF00069 0.433
MOD_GSK3_1 462 469 PF00069 0.274
MOD_GSK3_1 556 563 PF00069 0.461
MOD_GSK3_1 627 634 PF00069 0.278
MOD_N-GLC_1 124 129 PF02516 0.666
MOD_NEK2_1 1 6 PF00069 0.505
MOD_NEK2_1 266 271 PF00069 0.454
MOD_NEK2_1 301 306 PF00069 0.395
MOD_NEK2_1 433 438 PF00069 0.520
MOD_NEK2_1 475 480 PF00069 0.503
MOD_NEK2_1 544 549 PF00069 0.496
MOD_NEK2_1 557 562 PF00069 0.480
MOD_NEK2_2 163 168 PF00069 0.542
MOD_PIKK_1 16 22 PF00454 0.541
MOD_PIKK_1 25 31 PF00454 0.450
MOD_PIKK_1 433 439 PF00454 0.501
MOD_PIKK_1 602 608 PF00454 0.475
MOD_PK_1 191 197 PF00069 0.420
MOD_PKA_1 235 241 PF00069 0.405
MOD_PKA_2 20 26 PF00069 0.449
MOD_PKA_2 235 241 PF00069 0.405
MOD_PKA_2 328 334 PF00069 0.429
MOD_PKA_2 357 363 PF00069 0.443
MOD_PKA_2 399 405 PF00069 0.444
MOD_PKA_2 433 439 PF00069 0.440
MOD_PKA_2 454 460 PF00069 0.319
MOD_PKA_2 561 567 PF00069 0.429
MOD_PKA_2 568 574 PF00069 0.475
MOD_PKA_2 576 582 PF00069 0.475
MOD_PKB_1 189 197 PF00069 0.479
MOD_PKB_1 233 241 PF00069 0.409
MOD_Plk_1 374 380 PF00069 0.461
MOD_Plk_2-3 212 218 PF00069 0.557
MOD_Plk_2-3 364 370 PF00069 0.451
MOD_Plk_4 382 388 PF00069 0.422
MOD_Plk_4 463 469 PF00069 0.324
MOD_Plk_4 561 567 PF00069 0.467
MOD_Plk_4 578 584 PF00069 0.580
MOD_Plk_4 612 618 PF00069 0.231
MOD_ProDKin_1 117 123 PF00069 0.446
MOD_ProDKin_1 124 130 PF00069 0.508
MOD_ProDKin_1 148 154 PF00069 0.560
MOD_ProDKin_1 28 34 PF00069 0.523
MOD_ProDKin_1 286 292 PF00069 0.427
MOD_ProDKin_1 362 368 PF00069 0.451
MOD_ProDKin_1 392 398 PF00069 0.545
MOD_ProDKin_1 442 448 PF00069 0.498
MOD_ProDKin_1 539 545 PF00069 0.475
MOD_ProDKin_1 633 639 PF00069 0.299
MOD_ProDKin_1 651 657 PF00069 0.312
MOD_ProDKin_1 662 668 PF00069 0.501
MOD_ProDKin_1 98 104 PF00069 0.474
TRG_DiLeu_BaLyEn_6 29 34 PF01217 0.449
TRG_DiLeu_BaLyEn_6 553 558 PF01217 0.417
TRG_DiLeu_BaLyEn_6 586 591 PF01217 0.475
TRG_ENDOCYTIC_2 237 240 PF00928 0.518
TRG_ENDOCYTIC_2 253 256 PF00928 0.389
TRG_ENDOCYTIC_2 415 418 PF00928 0.421
TRG_ENDOCYTIC_2 554 557 PF00928 0.417
TRG_ENDOCYTIC_2 658 661 PF00928 0.685
TRG_ENDOCYTIC_2 95 98 PF00928 0.616
TRG_ER_diArg_1 189 191 PF00400 0.441
TRG_ER_diArg_1 233 236 PF00400 0.423
TRG_ER_diArg_1 539 541 PF00400 0.417
TRG_ER_diArg_1 60 63 PF00400 0.477
TRG_Pf-PMV_PEXEL_1 480 485 PF00026 0.268
TRG_Pf-PMV_PEXEL_1 529 533 PF00026 0.275
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.625

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5F0 Leptomonas seymouri 46% 92%
A0A3Q8IEP9 Leishmania donovani 68% 99%
A4I3S1 Leishmania infantum 67% 99%
E9B013 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 99%
Q4Q872 Leishmania major 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS