Putative zinc transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc transporter 3, putative

Species:

Leishmania braziliensis

UniProt:

A4HGP7_LEIBR

TriTrypDb:

LbrM.28.2110 , LBRM2903_280027400

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 36
NetGPI	no	yes: 0, no: 36

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	37
GO:0110165	cellular anatomical entity	1	37
GO:0005886	plasma membrane	3	4
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HGP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGP7

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	4
GO:0006810	transport	3	4
GO:0006811	monoatomic ion transport	4	4
GO:0006812	monoatomic cation transport	5	4
GO:0006829	zinc ion transport	8	4
GO:0009987	cellular process	1	4
GO:0030001	metal ion transport	6	4
GO:0034220	monoatomic ion transmembrane transport	3	4
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055085	transmembrane transport	2	4
GO:0071577	zinc ion transmembrane transport	6	4
GO:0098655	monoatomic cation transmembrane transport	4	4
GO:0098660	inorganic ion transmembrane transport	4	4
GO:0098662	inorganic cation transmembrane transport	5	4
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055069	obsolete zinc ion homeostasis	8	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	37
GO:0008324	monoatomic cation transmembrane transporter activity	4	37
GO:0015075	monoatomic ion transmembrane transporter activity	3	37
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	37
GO:0022857	transmembrane transporter activity	2	37
GO:0022890	inorganic cation transmembrane transporter activity	4	37
GO:0046873	metal ion transmembrane transporter activity	5	37
GO:0005385	zinc ion transmembrane transporter activity	7	4
GO:0046915	transition metal ion transmembrane transporter activity	6	4
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0015093	ferrous iron transmembrane transporter activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.542
CLV_C14_Caspase3-7	275	279	PF00656	0.239
CLV_PCSK_KEX2_1	27	29	PF00082	0.311
CLV_PCSK_KEX2_1	330	332	PF00082	0.248
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.311
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.277
CLV_PCSK_SKI1_1	277	281	PF00082	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.264
DOC_CYCLIN_yCln2_LP_2	260	266	PF00134	0.347
DOC_MAPK_gen_1	27	34	PF00069	0.595
DOC_MAPK_MEF2A_6	220	228	PF00069	0.298
DOC_MAPK_MEF2A_6	247	256	PF00069	0.566
DOC_MAPK_MEF2A_6	27	34	PF00069	0.447
DOC_PP2B_LxvP_1	260	263	PF13499	0.505
DOC_USP7_MATH_1	242	246	PF00917	0.525
DOC_USP7_MATH_1	286	290	PF00917	0.298
LIG_14-3-3_CanoR_1	325	329	PF00244	0.510
LIG_BIR_III_4	149	153	PF00653	0.394
LIG_Clathr_ClatBox_1	307	311	PF01394	0.420
LIG_DCNL_PONY_1	1	4	PF03556	0.256
LIG_deltaCOP1_diTrp_1	80	86	PF00928	0.238
LIG_eIF4E_1	302	308	PF01652	0.363
LIG_FHA_1	141	147	PF00498	0.583
LIG_FHA_1	268	274	PF00498	0.297
LIG_FHA_1	282	288	PF00498	0.284
LIG_FHA_1	45	51	PF00498	0.397
LIG_FHA_2	273	279	PF00498	0.239
LIG_FXI_DFP_1	309	313	PF00024	0.197
LIG_GBD_Chelix_1	252	260	PF00786	0.337
LIG_LIR_Gen_1	283	292	PF02991	0.340
LIG_LIR_Gen_1	74	83	PF02991	0.232
LIG_LIR_Nem_3	204	209	PF02991	0.385
LIG_LIR_Nem_3	283	288	PF02991	0.359
LIG_LIR_Nem_3	74	78	PF02991	0.284
LIG_LIR_Nem_3	80	85	PF02991	0.299
LIG_PDZ_Wminus1_1	350	352	PF00595	0.381
LIG_Pex14_1	82	86	PF04695	0.491
LIG_Pex14_2	228	232	PF04695	0.408
LIG_Pex14_2	305	309	PF04695	0.377
LIG_SH2_CRK	285	289	PF00017	0.380
LIG_SH2_NCK_1	285	289	PF00017	0.380
LIG_SH2_SRC	37	40	PF00017	0.538
LIG_SH2_STAT5	302	305	PF00017	0.340
LIG_SH2_STAT5	37	40	PF00017	0.517
LIG_SH3_3	175	181	PF00018	0.537
LIG_SH3_3	307	313	PF00018	0.328
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.581
LIG_SUMO_SIM_par_1	64	69	PF11976	0.311
LIG_SxIP_EBH_1	15	28	PF03271	0.381
LIG_TYR_ITSM	281	288	PF00017	0.238
LIG_UBA3_1	21	27	PF00899	0.276
MOD_CK1_1	116	122	PF00069	0.465
MOD_CK1_1	159	165	PF00069	0.407
MOD_CK1_1	281	287	PF00069	0.333
MOD_CK1_1	324	330	PF00069	0.405
MOD_Cter_Amidation	25	28	PF01082	0.363
MOD_GlcNHglycan	15	18	PF01048	0.210
MOD_GlcNHglycan	158	161	PF01048	0.330
MOD_GlcNHglycan	260	263	PF01048	0.391
MOD_GlcNHglycan	280	283	PF01048	0.383
MOD_GlcNHglycan	288	291	PF01048	0.355
MOD_GSK3_1	13	20	PF00069	0.365
MOD_GSK3_1	159	166	PF00069	0.495
MOD_GSK3_1	242	249	PF00069	0.512
MOD_NEK2_1	13	18	PF00069	0.365
MOD_NEK2_1	198	203	PF00069	0.374
MOD_NEK2_1	211	216	PF00069	0.323
MOD_NEK2_1	256	261	PF00069	0.367
MOD_NEK2_1	280	285	PF00069	0.323
MOD_NEK2_2	242	247	PF00069	0.471
MOD_PKA_2	106	112	PF00069	0.543
MOD_PKA_2	122	128	PF00069	0.447
MOD_PKA_2	324	330	PF00069	0.539
MOD_Plk_1	242	248	PF00069	0.437
MOD_Plk_4	17	23	PF00069	0.372
MOD_Plk_4	201	207	PF00069	0.362
MOD_Plk_4	61	67	PF00069	0.264
MOD_Plk_4	97	103	PF00069	0.428
TRG_DiLeu_BaEn_2	79	85	PF01217	0.290
TRG_ENDOCYTIC_2	285	288	PF00928	0.315
TRG_ENDOCYTIC_2	302	305	PF00928	0.353
TRG_ENDOCYTIC_2	335	338	PF00928	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E9	Leptomonas seymouri	65%	100%
A0A0N0P5K7	Leptomonas seymouri	33%	100%
A0A0N1PCU5	Leptomonas seymouri	42%	82%
A0A1X0NR51	Trypanosomatidae	48%	95%
A0A1X0NSB9	Trypanosomatidae	39%	87%
A0A1X0NSI7	Trypanosomatidae	38%	93%
A0A3R7LZX6	Trypanosoma rangeli	41%	100%
A0A3S7X1N7	Leishmania donovani	80%	76%
A0A3S7X501	Leishmania donovani	42%	81%
A0A3S7X7B0	Leishmania donovani	36%	100%
A0A422MUI2	Trypanosoma rangeli	39%	94%
A4HJU6	Leishmania braziliensis	55%	100%
A4HJU9	Leishmania braziliensis	44%	83%
A4HJV0	Leishmania braziliensis	44%	83%
A4HJV1	Leishmania braziliensis	40%	86%
A4HM27	Leishmania braziliensis	34%	100%
A4I3R9	Leishmania infantum	80%	76%
A4I7B1	Leishmania infantum	42%	81%
A4I9G1	Leishmania infantum	36%	100%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	90%
D0A886	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	89%
D0A887	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	89%
D0A888	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	89%
D0A889	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	91%
E9B012	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	78%
E9B2A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	81%
E9B2A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	81%
E9B4F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
O04089	Arabidopsis thaliana	29%	94%
O23039	Arabidopsis thaliana	30%	98%
O64738	Arabidopsis thaliana	26%	100%
O81123	Arabidopsis thaliana	25%	99%
O81850	Arabidopsis thaliana	24%	100%
O82643	Arabidopsis thaliana	27%	100%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	86%
P32804	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	94%
Q0DHE3	Oryza sativa subsp. japonica	28%	97%
Q12436	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	83%
Q4Q3L6	Leishmania major	35%	99%
Q4Q5V0	Leishmania major	42%	100%
Q4Q5V1	Leishmania major	42%	100%
Q4Q873	Leishmania major	78%	100%
Q6L8F9	Oryza sativa subsp. japonica	27%	89%
Q6L8G0	Oryza sativa subsp. japonica	30%	100%
Q6L8G1	Oryza sativa subsp. japonica	29%	95%
Q75HB1	Oryza sativa subsp. japonica	29%	94%
Q7XLD4	Oryza sativa subsp. japonica	27%	97%
Q8LE59	Arabidopsis thaliana	30%	83%
Q8S3W4	Arabidopsis thaliana	23%	100%
Q8W245	Arabidopsis thaliana	22%	97%
Q8W246	Arabidopsis thaliana	28%	96%
Q9FIS2	Arabidopsis thaliana	28%	99%
Q9SLG3	Arabidopsis thaliana	30%	100%
V5AWN3	Trypanosoma cruzi	39%	95%
V5BC34	Trypanosoma cruzi	39%	95%
V5DCU2	Trypanosoma cruzi	47%	95%