HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p21-C-terminal region-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGP4_LEIBR

TriTrypDb:

LbrM.28.2080 , LBRM2903_280027200

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.626
CLV_C14_Caspase3-7	194	198	PF00656	0.669
CLV_C14_Caspase3-7	271	275	PF00656	0.563
CLV_C14_Caspase3-7	341	345	PF00656	0.448
CLV_C14_Caspase3-7	443	447	PF00656	0.540
CLV_C14_Caspase3-7	482	486	PF00656	0.535
CLV_NRD_NRD_1	130	132	PF00675	0.662
CLV_NRD_NRD_1	210	212	PF00675	0.584
CLV_NRD_NRD_1	223	225	PF00675	0.665
CLV_NRD_NRD_1	306	308	PF00675	0.830
CLV_NRD_NRD_1	562	564	PF00675	0.303
CLV_NRD_NRD_1	660	662	PF00675	0.441
CLV_NRD_NRD_1	93	95	PF00675	0.671
CLV_PCSK_FUR_1	615	619	PF00082	0.389
CLV_PCSK_KEX2_1	129	131	PF00082	0.709
CLV_PCSK_KEX2_1	223	225	PF00082	0.751
CLV_PCSK_KEX2_1	3	5	PF00082	0.649
CLV_PCSK_KEX2_1	306	308	PF00082	0.816
CLV_PCSK_KEX2_1	575	577	PF00082	0.225
CLV_PCSK_KEX2_1	617	619	PF00082	0.404
CLV_PCSK_KEX2_1	659	661	PF00082	0.446
CLV_PCSK_KEX2_1	76	78	PF00082	0.586
CLV_PCSK_KEX2_1	93	95	PF00082	0.686
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.649
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.218
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.404
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.603
CLV_PCSK_PC7_1	571	577	PF00082	0.218
CLV_PCSK_SKI1_1	130	134	PF00082	0.697
CLV_PCSK_SKI1_1	456	460	PF00082	0.277
CLV_PCSK_SKI1_1	76	80	PF00082	0.667
CLV_PCSK_SKI1_1	93	97	PF00082	0.444
DOC_ANK_TNKS_1	130	137	PF00023	0.557
DOC_CYCLIN_RxL_1	453	463	PF00134	0.477
DOC_MAPK_DCC_7	3	13	PF00069	0.635
DOC_MAPK_gen_1	3	13	PF00069	0.635
DOC_MAPK_gen_1	454	461	PF00069	0.477
DOC_MAPK_MEF2A_6	363	370	PF00069	0.477
DOC_MAPK_MEF2A_6	466	474	PF00069	0.481
DOC_MAPK_NFAT4_5	363	371	PF00069	0.477
DOC_PP4_FxxP_1	109	112	PF00568	0.507
DOC_USP7_MATH_1	253	257	PF00917	0.671
DOC_USP7_MATH_1	374	378	PF00917	0.477
DOC_USP7_MATH_1	514	518	PF00917	0.427
DOC_USP7_MATH_1	82	86	PF00917	0.486
DOC_WW_Pin1_4	146	151	PF00397	0.552
DOC_WW_Pin1_4	249	254	PF00397	0.719
DOC_WW_Pin1_4	370	375	PF00397	0.477
DOC_WW_Pin1_4	591	596	PF00397	0.535
DOC_WW_Pin1_4	61	66	PF00397	0.595
LIG_14-3-3_CanoR_1	102	112	PF00244	0.588
LIG_14-3-3_CanoR_1	211	215	PF00244	0.672
LIG_14-3-3_CanoR_1	31	37	PF00244	0.707
LIG_14-3-3_CanoR_1	449	458	PF00244	0.463
LIG_14-3-3_CanoR_1	527	535	PF00244	0.477
LIG_14-3-3_CanoR_1	585	592	PF00244	0.418
LIG_14-3-3_CanoR_1	625	634	PF00244	0.470
LIG_14-3-3_CanoR_1	659	665	PF00244	0.441
LIG_Actin_RPEL_3	422	441	PF02755	0.477
LIG_BIR_III_4	387	391	PF00653	0.481
LIG_BIR_III_4	485	489	PF00653	0.477
LIG_BRCT_BRCA1_1	105	109	PF00533	0.516
LIG_BRCT_BRCA1_1	640	644	PF00533	0.362
LIG_Clathr_ClatBox_1	328	332	PF01394	0.315
LIG_CtBP_PxDLS_1	469	473	PF00389	0.477
LIG_CtBP_PxDLS_1	595	599	PF00389	0.535
LIG_FHA_1	296	302	PF00498	0.556
LIG_FHA_1	374	380	PF00498	0.477
LIG_FHA_1	436	442	PF00498	0.477
LIG_FHA_1	471	477	PF00498	0.488
LIG_FHA_1	51	57	PF00498	0.551
LIG_FHA_1	82	88	PF00498	0.483
LIG_FHA_2	387	393	PF00498	0.479
LIG_FHA_2	497	503	PF00498	0.535
LIG_Integrin_isoDGR_2	567	569	PF01839	0.218
LIG_LIR_Apic_2	106	112	PF02991	0.502
LIG_LIR_Gen_1	372	381	PF02991	0.477
LIG_LIR_Gen_1	517	525	PF02991	0.453
LIG_LIR_Nem_3	137	143	PF02991	0.713
LIG_LIR_Nem_3	330	336	PF02991	0.477
LIG_LIR_Nem_3	372	378	PF02991	0.477
LIG_LIR_Nem_3	393	399	PF02991	0.487
LIG_LIR_Nem_3	517	522	PF02991	0.453
LIG_LIR_Nem_3	60	66	PF02991	0.495
LIG_LYPXL_SIV_4	62	70	PF13949	0.481
LIG_SH2_NCK_1	63	67	PF00017	0.479
LIG_SH2_STAT3	630	633	PF00017	0.453
LIG_SH2_STAT5	103	106	PF00017	0.503
LIG_SH2_STAT5	175	178	PF00017	0.661
LIG_SH2_STAT5	464	467	PF00017	0.477
LIG_SH2_STAT5	601	604	PF00017	0.477
LIG_SH3_2	141	146	PF14604	0.722
LIG_SH3_3	117	123	PF00018	0.625
LIG_SH3_3	135	141	PF00018	0.628
LIG_SH3_3	144	150	PF00018	0.578
LIG_SH3_3	530	536	PF00018	0.477
LIG_SH3_3	538	544	PF00018	0.477
LIG_SH3_3	589	595	PF00018	0.535
LIG_SUMO_SIM_par_1	322	332	PF11976	0.554
LIG_SUMO_SIM_par_1	457	463	PF11976	0.477
LIG_SUMO_SIM_par_1	468	473	PF11976	0.477
LIG_SUMO_SIM_par_1	9	16	PF11976	0.622
LIG_TRAF2_1	21	24	PF00917	0.569
LIG_TRAF2_1	286	289	PF00917	0.700
LIG_TRAF2_1	290	293	PF00917	0.714
LIG_TRAF2_1	389	392	PF00917	0.477
LIG_TRAF2_1	499	502	PF00917	0.451
LIG_UBA3_1	349	357	PF00899	0.414
LIG_UBA3_1	518	524	PF00899	0.477
MOD_CK1_1	139	145	PF00069	0.672
MOD_CK1_1	149	155	PF00069	0.613
MOD_CK1_1	181	187	PF00069	0.743
MOD_CK1_1	235	241	PF00069	0.643
MOD_CK1_1	275	281	PF00069	0.556
MOD_CK1_1	30	36	PF00069	0.664
MOD_CK1_1	373	379	PF00069	0.478
MOD_CK1_1	45	51	PF00069	0.584
MOD_CK1_1	496	502	PF00069	0.428
MOD_CK1_1	570	576	PF00069	0.547
MOD_CK2_1	115	121	PF00069	0.567
MOD_CK2_1	18	24	PF00069	0.730
MOD_CK2_1	231	237	PF00069	0.695
MOD_CK2_1	238	244	PF00069	0.618
MOD_CK2_1	283	289	PF00069	0.696
MOD_CK2_1	386	392	PF00069	0.479
MOD_CK2_1	496	502	PF00069	0.535
MOD_CK2_1	61	67	PF00069	0.569
MOD_Cter_Amidation	491	494	PF01082	0.210
MOD_DYRK1A_RPxSP_1	146	150	PF00069	0.549
MOD_GlcNHglycan	116	120	PF01048	0.652
MOD_GlcNHglycan	184	187	PF01048	0.763
MOD_GlcNHglycan	197	200	PF01048	0.602
MOD_GlcNHglycan	239	243	PF01048	0.631
MOD_GlcNHglycan	256	259	PF01048	0.786
MOD_GlcNHglycan	288	292	PF01048	0.688
MOD_GlcNHglycan	432	435	PF01048	0.262
MOD_GlcNHglycan	47	50	PF01048	0.668
MOD_GlcNHglycan	552	555	PF01048	0.304
MOD_GlcNHglycan	586	589	PF01048	0.270
MOD_GSK3_1	145	152	PF00069	0.644
MOD_GSK3_1	178	185	PF00069	0.747
MOD_GSK3_1	191	198	PF00069	0.649
MOD_GSK3_1	231	238	PF00069	0.643
MOD_GSK3_1	249	256	PF00069	0.792
MOD_GSK3_1	268	275	PF00069	0.604
MOD_GSK3_1	283	290	PF00069	0.624
MOD_GSK3_1	370	377	PF00069	0.477
MOD_GSK3_1	41	48	PF00069	0.716
MOD_GSK3_1	435	442	PF00069	0.500
MOD_GSK3_1	492	499	PF00069	0.427
MOD_GSK3_1	570	577	PF00069	0.585
MOD_N-GLC_1	262	267	PF02516	0.545
MOD_N-GLC_1	295	300	PF02516	0.555
MOD_NEK2_1	210	215	PF00069	0.659
MOD_NEK2_1	248	253	PF00069	0.599
MOD_NEK2_1	42	47	PF00069	0.702
MOD_NEK2_1	470	475	PF00069	0.480
MOD_NEK2_2	71	76	PF00069	0.483
MOD_PIKK_1	178	184	PF00454	0.554
MOD_PIKK_1	625	631	PF00454	0.371
MOD_PK_1	493	499	PF00069	0.410
MOD_PKA_1	493	499	PF00069	0.410
MOD_PKA_1	574	580	PF00069	0.535
MOD_PKA_1	660	666	PF00069	0.442
MOD_PKA_1	76	82	PF00069	0.504
MOD_PKA_2	145	151	PF00069	0.717
MOD_PKA_2	210	216	PF00069	0.655
MOD_PKA_2	30	36	PF00069	0.674
MOD_PKA_2	42	48	PF00069	0.624
MOD_PKA_2	526	532	PF00069	0.477
MOD_PKA_2	570	576	PF00069	0.470
MOD_PKA_2	584	590	PF00069	0.470
MOD_PKA_2	660	666	PF00069	0.442
MOD_PKA_2	76	82	PF00069	0.516
MOD_Plk_1	115	121	PF00069	0.567
MOD_Plk_1	470	476	PF00069	0.477
MOD_Plk_1	606	612	PF00069	0.490
MOD_Plk_2-3	232	238	PF00069	0.703
MOD_Plk_2-3	268	274	PF00069	0.769
MOD_Plk_2-3	321	327	PF00069	0.499
MOD_Plk_4	374	380	PF00069	0.477
MOD_Plk_4	398	404	PF00069	0.477
MOD_Plk_4	407	413	PF00069	0.477
MOD_Plk_4	440	446	PF00069	0.477
MOD_Plk_4	514	520	PF00069	0.477
MOD_Plk_4	606	612	PF00069	0.450
MOD_Plk_4	638	644	PF00069	0.278
MOD_ProDKin_1	146	152	PF00069	0.552
MOD_ProDKin_1	249	255	PF00069	0.721
MOD_ProDKin_1	370	376	PF00069	0.477
MOD_ProDKin_1	591	597	PF00069	0.535
MOD_ProDKin_1	61	67	PF00069	0.593
MOD_SUMO_rev_2	332	341	PF00179	0.418
MOD_SUMO_rev_2	485	495	PF00179	0.560
TRG_DiLeu_BaEn_1	153	158	PF01217	0.569
TRG_DiLeu_BaEn_4	606	612	PF01217	0.477
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.418
TRG_ENDOCYTIC_2	63	66	PF00928	0.476
TRG_ER_diArg_1	128	131	PF00400	0.691
TRG_ER_diArg_1	624	627	PF00400	0.420
TRG_ER_diArg_1	658	661	PF00400	0.511
TRG_ER_diArg_1	93	95	PF00400	0.557
TRG_NLS_MonoExtN_4	2	7	PF00514	0.649
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.218

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7I5	Leptomonas seymouri	53%	100%
A0A3Q8IEX8	Leishmania donovani	74%	99%
A4I3R7	Leishmania infantum	74%	99%
E9B010	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q875	Leishmania major	71%	100%