J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGP3_LEIBR

TriTrypDb:

LbrM.28.2070 , LBRM2903_280027100

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGP3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.575
CLV_C14_Caspase3-7	434	438	PF00656	0.702
CLV_NRD_NRD_1	113	115	PF00675	0.426
CLV_NRD_NRD_1	336	338	PF00675	0.828
CLV_NRD_NRD_1	379	381	PF00675	0.743
CLV_NRD_NRD_1	398	400	PF00675	0.505
CLV_NRD_NRD_1	478	480	PF00675	0.632
CLV_NRD_NRD_1	532	534	PF00675	0.567
CLV_NRD_NRD_1	567	569	PF00675	0.809
CLV_PCSK_FUR_1	333	337	PF00082	0.832
CLV_PCSK_KEX2_1	112	114	PF00082	0.406
CLV_PCSK_KEX2_1	335	337	PF00082	0.833
CLV_PCSK_KEX2_1	398	400	PF00082	0.583
CLV_PCSK_KEX2_1	478	480	PF00082	0.689
CLV_PCSK_KEX2_1	567	569	PF00082	0.809
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.320
CLV_PCSK_SKI1_1	336	340	PF00082	0.576
CLV_PCSK_SKI1_1	604	608	PF00082	0.656
DEG_APCC_DBOX_1	398	406	PF00400	0.532
DEG_SCF_FBW7_1	518	525	PF00400	0.561
DEG_SCF_FBW7_1	82	89	PF00400	0.415
DEG_SPOP_SBC_1	454	458	PF00917	0.557
DEG_SPOP_SBC_1	512	516	PF00917	0.749
DEG_SPOP_SBC_1	517	521	PF00917	0.782
DEG_SPOP_SBC_1	552	556	PF00917	0.552
DOC_CDC14_PxL_1	353	361	PF14671	0.811
DOC_CKS1_1	258	263	PF01111	0.571
DOC_CYCLIN_yClb3_PxF_3	213	219	PF00134	0.778
DOC_CYCLIN_yClb3_PxF_3	248	254	PF00134	0.571
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.443
DOC_MAPK_gen_1	112	122	PF00069	0.426
DOC_MAPK_MEF2A_6	113	122	PF00069	0.426
DOC_MAPK_MEF2A_6	501	508	PF00069	0.579
DOC_PP4_FxxP_1	166	169	PF00568	0.567
DOC_USP7_MATH_1	146	150	PF00917	0.406
DOC_USP7_MATH_1	152	156	PF00917	0.511
DOC_USP7_MATH_1	169	173	PF00917	0.697
DOC_USP7_MATH_1	185	189	PF00917	0.588
DOC_USP7_MATH_1	250	254	PF00917	0.636
DOC_USP7_MATH_1	259	263	PF00917	0.647
DOC_USP7_MATH_1	264	268	PF00917	0.637
DOC_USP7_MATH_1	296	300	PF00917	0.585
DOC_USP7_MATH_1	464	468	PF00917	0.647
DOC_USP7_MATH_1	5	9	PF00917	0.660
DOC_USP7_MATH_1	512	516	PF00917	0.603
DOC_USP7_MATH_1	552	556	PF00917	0.683
DOC_USP7_UBL2_3	381	385	PF12436	0.587
DOC_WW_Pin1_4	204	209	PF00397	0.802
DOC_WW_Pin1_4	213	218	PF00397	0.610
DOC_WW_Pin1_4	228	233	PF00397	0.568
DOC_WW_Pin1_4	257	262	PF00397	0.662
DOC_WW_Pin1_4	30	35	PF00397	0.571
DOC_WW_Pin1_4	364	369	PF00397	0.791
DOC_WW_Pin1_4	449	454	PF00397	0.548
DOC_WW_Pin1_4	46	51	PF00397	0.462
DOC_WW_Pin1_4	518	523	PF00397	0.773
DOC_WW_Pin1_4	545	550	PF00397	0.645
DOC_WW_Pin1_4	586	591	PF00397	0.553
DOC_WW_Pin1_4	82	87	PF00397	0.525
LIG_14-3-3_CanoR_1	251	261	PF00244	0.594
LIG_14-3-3_CanoR_1	446	455	PF00244	0.678
LIG_14-3-3_CanoR_1	540	550	PF00244	0.546
LIG_14-3-3_CanoR_1	74	82	PF00244	0.367
LIG_Actin_WH2_2	69	85	PF00022	0.370
LIG_APCC_ABBA_1	120	125	PF00400	0.529
LIG_APCC_ABBA_1	502	507	PF00400	0.535
LIG_APCC_ABBAyCdc20_2	501	507	PF00400	0.537
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_BRCT_BRCA1_1	132	136	PF00533	0.529
LIG_BRCT_BRCA1_1	215	219	PF00533	0.752
LIG_deltaCOP1_diTrp_1	67	73	PF00928	0.331
LIG_EVH1_2	279	283	PF00568	0.803
LIG_EVH1_2	312	316	PF00568	0.809
LIG_EVH1_2	357	361	PF00568	0.809
LIG_FHA_1	325	331	PF00498	0.583
LIG_FHA_1	450	456	PF00498	0.757
LIG_FHA_1	460	466	PF00498	0.537
LIG_FHA_1	497	503	PF00498	0.589
LIG_FHA_1	512	518	PF00498	0.643
LIG_FHA_1	542	548	PF00498	0.560
LIG_FHA_1	77	83	PF00498	0.389
LIG_FHA_2	365	371	PF00498	0.700
LIG_FHA_2	402	408	PF00498	0.743
LIG_FHA_2	59	65	PF00498	0.617
LIG_LIR_Apic_2	462	466	PF02991	0.562
LIG_LIR_Gen_1	133	143	PF02991	0.529
LIG_LIR_Gen_1	155	165	PF02991	0.527
LIG_LIR_Gen_1	67	76	PF02991	0.500
LIG_LIR_Nem_3	133	139	PF02991	0.529
LIG_LIR_Nem_3	155	160	PF02991	0.588
LIG_LIR_Nem_3	528	532	PF02991	0.653
LIG_LIR_Nem_3	67	71	PF02991	0.504
LIG_LIR_Nem_3	9	15	PF02991	0.517
LIG_MYND_1	213	217	PF01753	0.766
LIG_MYND_2	311	315	PF01753	0.553
LIG_NRBOX	404	410	PF00104	0.730
LIG_Pex14_2	12	16	PF04695	0.526
LIG_SH2_CRK	115	119	PF00017	0.529
LIG_SH2_CRK	529	533	PF00017	0.747
LIG_SH2_STAT5	157	160	PF00017	0.609
LIG_SH2_STAT5	496	499	PF00017	0.549
LIG_SH3_1	229	235	PF00018	0.744
LIG_SH3_1	246	252	PF00018	0.618
LIG_SH3_3	208	214	PF00018	0.789
LIG_SH3_3	229	235	PF00018	0.659
LIG_SH3_3	246	252	PF00018	0.618
LIG_SH3_3	274	280	PF00018	0.760
LIG_SH3_3	305	311	PF00018	0.640
LIG_SH3_3	397	403	PF00018	0.802
LIG_SH3_3	458	464	PF00018	0.580
LIG_SH3_3	546	552	PF00018	0.540
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.537
LIG_WW_3	248	252	PF00397	0.807
MOD_CDC14_SPxK_1	231	234	PF00782	0.619
MOD_CDK_SPxK_1	228	234	PF00069	0.622
MOD_CK1_1	104	110	PF00069	0.529
MOD_CK1_1	130	136	PF00069	0.529
MOD_CK1_1	170	176	PF00069	0.654
MOD_CK1_1	188	194	PF00069	0.613
MOD_CK1_1	197	203	PF00069	0.774
MOD_CK1_1	206	212	PF00069	0.604
MOD_CK1_1	220	226	PF00069	0.585
MOD_CK1_1	227	233	PF00069	0.562
MOD_CK1_1	253	259	PF00069	0.592
MOD_CK1_1	262	268	PF00069	0.531
MOD_CK1_1	270	276	PF00069	0.512
MOD_CK1_1	324	330	PF00069	0.582
MOD_CK1_1	33	39	PF00069	0.678
MOD_CK1_1	366	372	PF00069	0.792
MOD_CK1_1	423	429	PF00069	0.690
MOD_CK1_1	516	522	PF00069	0.715
MOD_CK1_1	545	551	PF00069	0.753
MOD_CK1_1	563	569	PF00069	0.807
MOD_CK1_1	579	585	PF00069	0.572
MOD_CK1_1	586	592	PF00069	0.698
MOD_CK1_1	8	14	PF00069	0.514
MOD_CK2_1	138	144	PF00069	0.465
MOD_CK2_1	401	407	PF00069	0.752
MOD_CK2_1	422	428	PF00069	0.562
MOD_CK2_1	58	64	PF00069	0.635
MOD_Cter_Amidation	378	381	PF01082	0.598
MOD_GlcNHglycan	106	109	PF01048	0.525
MOD_GlcNHglycan	154	157	PF01048	0.589
MOD_GlcNHglycan	178	181	PF01048	0.571
MOD_GlcNHglycan	18	21	PF01048	0.556
MOD_GlcNHglycan	261	264	PF01048	0.693
MOD_GlcNHglycan	272	275	PF01048	0.745
MOD_GlcNHglycan	298	301	PF01048	0.680
MOD_GlcNHglycan	3	6	PF01048	0.518
MOD_GlcNHglycan	323	326	PF01048	0.576
MOD_GlcNHglycan	345	348	PF01048	0.624
MOD_GlcNHglycan	354	357	PF01048	0.549
MOD_GlcNHglycan	44	47	PF01048	0.766
MOD_GlcNHglycan	441	444	PF01048	0.797
MOD_GlcNHglycan	578	581	PF01048	0.813
MOD_GlcNHglycan	76	79	PF01048	0.585
MOD_GSK3_1	1	8	PF00069	0.525
MOD_GSK3_1	126	133	PF00069	0.373
MOD_GSK3_1	194	201	PF00069	0.658
MOD_GSK3_1	209	216	PF00069	0.737
MOD_GSK3_1	217	224	PF00069	0.593
MOD_GSK3_1	230	237	PF00069	0.602
MOD_GSK3_1	253	260	PF00069	0.621
MOD_GSK3_1	291	298	PF00069	0.694
MOD_GSK3_1	32	39	PF00069	0.818
MOD_GSK3_1	337	344	PF00069	0.827
MOD_GSK3_1	362	369	PF00069	0.696
MOD_GSK3_1	42	49	PF00069	0.661
MOD_GSK3_1	423	430	PF00069	0.713
MOD_GSK3_1	449	456	PF00069	0.599
MOD_GSK3_1	465	472	PF00069	0.716
MOD_GSK3_1	512	519	PF00069	0.753
MOD_GSK3_1	521	528	PF00069	0.614
MOD_GSK3_1	541	548	PF00069	0.724
MOD_GSK3_1	559	566	PF00069	0.812
MOD_GSK3_1	579	586	PF00069	0.504
MOD_GSK3_1	82	89	PF00069	0.415
MOD_N-GLC_1	227	232	PF02516	0.580
MOD_N-GLC_1	36	41	PF02516	0.678
MOD_N-GLC_1	586	591	PF02516	0.553
MOD_NEK2_1	1	6	PF00069	0.545
MOD_NEK2_1	16	21	PF00069	0.539
MOD_NEK2_1	196	201	PF00069	0.700
MOD_NEK2_1	439	444	PF00069	0.652
MOD_NEK2_1	559	564	PF00069	0.816
MOD_PIKK_1	127	133	PF00454	0.323
MOD_PIKK_1	24	30	PF00454	0.576
MOD_PIKK_1	386	392	PF00454	0.589
MOD_PIKK_1	427	433	PF00454	0.573
MOD_PKA_2	101	107	PF00069	0.282
MOD_PKA_2	167	173	PF00069	0.566
MOD_PKA_2	250	256	PF00069	0.586
MOD_PKA_2	267	273	PF00069	0.501
MOD_PKA_2	341	347	PF00069	0.758
MOD_PKB_1	335	343	PF00069	0.826
MOD_Plk_1	170	176	PF00069	0.552
MOD_Plk_2-3	370	376	PF00069	0.593
MOD_Plk_2-3	401	407	PF00069	0.752
MOD_Plk_4	170	176	PF00069	0.565
MOD_Plk_4	206	212	PF00069	0.586
MOD_Plk_4	267	273	PF00069	0.575
MOD_Plk_4	455	461	PF00069	0.562
MOD_ProDKin_1	204	210	PF00069	0.799
MOD_ProDKin_1	213	219	PF00069	0.615
MOD_ProDKin_1	228	234	PF00069	0.568
MOD_ProDKin_1	257	263	PF00069	0.661
MOD_ProDKin_1	30	36	PF00069	0.570
MOD_ProDKin_1	364	370	PF00069	0.793
MOD_ProDKin_1	449	455	PF00069	0.548
MOD_ProDKin_1	46	52	PF00069	0.457
MOD_ProDKin_1	518	524	PF00069	0.775
MOD_ProDKin_1	545	551	PF00069	0.643
MOD_ProDKin_1	586	592	PF00069	0.545
MOD_ProDKin_1	82	88	PF00069	0.523
TRG_DiLeu_BaEn_1	67	72	PF01217	0.538
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.553
TRG_ENDOCYTIC_2	115	118	PF00928	0.413
TRG_ENDOCYTIC_2	157	160	PF00928	0.510
TRG_ENDOCYTIC_2	529	532	PF00928	0.749
TRG_ER_diArg_1	113	115	PF00400	0.411
TRG_ER_diArg_1	333	336	PF00400	0.820
TRG_ER_diArg_1	398	400	PF00400	0.576
TRG_NLS_MonoExtC_3	111	116	PF00514	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IB27	Leishmania donovani	60%	100%
A4I3R6	Leishmania infantum	60%	100%
E9B009	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
Q4Q876	Leishmania major	56%	100%