Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 4, putative

Species:

Leishmania braziliensis

UniProt:

A4HGP2_LEIBR

TriTrypDb:

LbrM.28.2060 , LBRM2903_280026900

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HGP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGP2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016409	palmitoyltransferase activity	5	10
GO:0016417	S-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	10
GO:0019707	protein-cysteine S-acyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.622
CLV_NRD_NRD_1	159	161	PF00675	0.281
CLV_NRD_NRD_1	278	280	PF00675	0.248
CLV_NRD_NRD_1	320	322	PF00675	0.252
CLV_NRD_NRD_1	424	426	PF00675	0.405
CLV_PCSK_KEX2_1	102	104	PF00082	0.490
CLV_PCSK_KEX2_1	161	163	PF00082	0.410
CLV_PCSK_KEX2_1	320	322	PF00082	0.266
CLV_PCSK_KEX2_1	405	407	PF00082	0.374
CLV_PCSK_KEX2_1	424	426	PF00082	0.432
CLV_PCSK_KEX2_1	437	439	PF00082	0.352
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.498
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.379
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.409
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.364
CLV_PCSK_PC7_1	157	163	PF00082	0.353
CLV_PCSK_SKI1_1	102	106	PF00082	0.507
CLV_PCSK_SKI1_1	115	119	PF00082	0.424
CLV_PCSK_SKI1_1	411	415	PF00082	0.332
CLV_PCSK_SKI1_1	428	432	PF00082	0.283
CLV_PCSK_SKI1_1	438	442	PF00082	0.355
CLV_PCSK_SKI1_1	7	11	PF00082	0.436
DEG_APCC_DBOX_1	410	418	PF00400	0.469
DOC_CKS1_1	354	359	PF01111	0.189
DOC_CYCLIN_RxL_1	424	434	PF00134	0.567
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.572
DOC_MAPK_gen_1	157	165	PF00069	0.592
DOC_MAPK_gen_1	320	328	PF00069	0.443
DOC_MAPK_MEF2A_6	320	328	PF00069	0.450
DOC_PP2B_LxvP_1	367	370	PF13499	0.203
DOC_WW_Pin1_4	353	358	PF00397	0.244
LIG_14-3-3_CanoR_1	103	107	PF00244	0.563
LIG_14-3-3_CanoR_1	175	181	PF00244	0.428
LIG_14-3-3_CanoR_1	226	232	PF00244	0.354
LIG_14-3-3_CanoR_1	279	287	PF00244	0.457
LIG_AP2alpha_1	431	435	PF02296	0.519
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BIR_III_2	66	70	PF00653	0.544
LIG_BRCT_BRCA1_1	126	130	PF00533	0.584
LIG_BRCT_BRCA1_1	431	435	PF00533	0.444
LIG_BRCT_BRCA1_2	431	437	PF00533	0.445
LIG_eIF4E_1	211	217	PF01652	0.331
LIG_FHA_1	11	17	PF00498	0.580
LIG_FHA_1	135	141	PF00498	0.573
LIG_FHA_1	183	189	PF00498	0.241
LIG_FHA_1	338	344	PF00498	0.342
LIG_FHA_2	254	260	PF00498	0.571
LIG_FHA_2	347	353	PF00498	0.330
LIG_FHA_2	391	397	PF00498	0.385
LIG_FHA_2	52	58	PF00498	0.663
LIG_IBAR_NPY_1	407	409	PF08397	0.554
LIG_LIR_Apic_2	177	183	PF02991	0.344
LIG_LIR_Apic_2	231	237	PF02991	0.476
LIG_LIR_Gen_1	127	138	PF02991	0.550
LIG_LIR_Gen_1	141	150	PF02991	0.564
LIG_LIR_Gen_1	218	229	PF02991	0.319
LIG_LIR_Gen_1	26	35	PF02991	0.570
LIG_LIR_Gen_1	266	277	PF02991	0.527
LIG_LIR_Gen_1	323	333	PF02991	0.504
LIG_LIR_Gen_1	355	366	PF02991	0.189
LIG_LIR_Nem_3	127	133	PF02991	0.573
LIG_LIR_Nem_3	13	17	PF02991	0.583
LIG_LIR_Nem_3	141	145	PF02991	0.550
LIG_LIR_Nem_3	148	153	PF02991	0.528
LIG_LIR_Nem_3	218	224	PF02991	0.344
LIG_LIR_Nem_3	26	30	PF02991	0.537
LIG_LIR_Nem_3	266	272	PF02991	0.537
LIG_LIR_Nem_3	323	328	PF02991	0.504
LIG_LIR_Nem_3	355	361	PF02991	0.189
LIG_LYPXL_SIV_4	208	216	PF13949	0.203
LIG_MLH1_MIPbox_1	130	134	PF16413	0.629
LIG_PDZ_Class_1	452	457	PF00595	0.701
LIG_Pex14_1	205	209	PF04695	0.327
LIG_Pex14_2	126	130	PF04695	0.606
LIG_Pex14_2	431	435	PF04695	0.519
LIG_PTB_Apo_2	413	420	PF02174	0.574
LIG_PTB_Phospho_1	413	419	PF10480	0.577
LIG_REV1ctd_RIR_1	116	126	PF16727	0.491
LIG_SH2_CRK	14	18	PF00017	0.521
LIG_SH2_CRK	150	154	PF00017	0.596
LIG_SH2_CRK	166	170	PF00017	0.601
LIG_SH2_CRK	180	184	PF00017	0.308
LIG_SH2_CRK	221	225	PF00017	0.454
LIG_SH2_CRK	419	423	PF00017	0.559
LIG_SH2_GRB2like	168	171	PF00017	0.583
LIG_SH2_GRB2like	63	66	PF00017	0.541
LIG_SH2_NCK_1	150	154	PF00017	0.596
LIG_SH2_NCK_1	180	184	PF00017	0.279
LIG_SH2_NCK_1	229	233	PF00017	0.468
LIG_SH2_PTP2	168	171	PF00017	0.588
LIG_SH2_PTP2	211	214	PF00017	0.302
LIG_SH2_PTP2	234	237	PF00017	0.555
LIG_SH2_SRC	168	171	PF00017	0.588
LIG_SH2_STAP1	221	225	PF00017	0.336
LIG_SH2_STAP1	63	67	PF00017	0.543
LIG_SH2_STAP1	75	79	PF00017	0.647
LIG_SH2_STAT5	138	141	PF00017	0.538
LIG_SH2_STAT5	142	145	PF00017	0.543
LIG_SH2_STAT5	168	171	PF00017	0.526
LIG_SH2_STAT5	211	214	PF00017	0.401
LIG_SH2_STAT5	221	224	PF00017	0.311
LIG_SH2_STAT5	234	237	PF00017	0.461
LIG_SH2_STAT5	297	300	PF00017	0.462
LIG_SH3_3	13	19	PF00018	0.526
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.388
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.203
LIG_SUMO_SIM_par_1	339	344	PF11976	0.331
LIG_TYR_ITIM	12	17	PF00017	0.565
LIG_TYR_ITIM	219	224	PF00017	0.360
LIG_TYR_ITIM	417	422	PF00017	0.554
MOD_CK1_1	2	8	PF00069	0.683
MOD_CK1_1	429	435	PF00069	0.439
MOD_CK2_1	264	270	PF00069	0.547
MOD_CK2_1	346	352	PF00069	0.400
MOD_CK2_1	390	396	PF00069	0.447
MOD_GlcNHglycan	246	249	PF01048	0.504
MOD_GlcNHglycan	75	78	PF01048	0.419
MOD_GlcNHglycan	85	88	PF01048	0.426
MOD_GSK3_1	124	131	PF00069	0.545
MOD_GSK3_1	215	222	PF00069	0.363
MOD_GSK3_1	337	344	PF00069	0.287
MOD_GSK3_1	348	355	PF00069	0.237
MOD_GSK3_1	371	378	PF00069	0.390
MOD_GSK3_1	380	387	PF00069	0.341
MOD_GSK3_1	79	86	PF00069	0.589
MOD_N-GLC_2	170	172	PF02516	0.341
MOD_NEK2_1	1	6	PF00069	0.692
MOD_NEK2_1	176	181	PF00069	0.476
MOD_NEK2_1	219	224	PF00069	0.371
MOD_NEK2_1	324	329	PF00069	0.454
MOD_NEK2_1	377	382	PF00069	0.356
MOD_NEK2_1	384	389	PF00069	0.491
MOD_NEK2_1	85	90	PF00069	0.653
MOD_PIKK_1	105	111	PF00454	0.631
MOD_PIKK_1	440	446	PF00454	0.564
MOD_PKA_1	102	108	PF00069	0.560
MOD_PKA_2	102	108	PF00069	0.560
MOD_PKA_2	174	180	PF00069	0.428
MOD_PKA_2	264	270	PF00069	0.570
MOD_Plk_1	212	218	PF00069	0.203
MOD_Plk_1	426	432	PF00069	0.450
MOD_Plk_2-3	253	259	PF00069	0.616
MOD_Plk_4	134	140	PF00069	0.547
MOD_Plk_4	212	218	PF00069	0.414
MOD_Plk_4	219	225	PF00069	0.373
MOD_Plk_4	264	270	PF00069	0.625
MOD_Plk_4	324	330	PF00069	0.520
MOD_Plk_4	337	343	PF00069	0.284
MOD_Plk_4	371	377	PF00069	0.368
MOD_Plk_4	426	432	PF00069	0.508
MOD_ProDKin_1	353	359	PF00069	0.244
TRG_ENDOCYTIC_2	14	17	PF00928	0.525
TRG_ENDOCYTIC_2	142	145	PF00928	0.565
TRG_ENDOCYTIC_2	150	153	PF00928	0.548
TRG_ENDOCYTIC_2	166	169	PF00928	0.579
TRG_ENDOCYTIC_2	209	212	PF00928	0.430
TRG_ENDOCYTIC_2	221	224	PF00928	0.362
TRG_ENDOCYTIC_2	418	421	PF00928	0.583
TRG_ER_diArg_1	159	162	PF00400	0.587
TRG_ER_diArg_1	320	322	PF00400	0.532
TRG_ER_diArg_1	424	426	PF00400	0.571
TRG_NES_CRM1_1	266	278	PF08389	0.600
TRG_NLS_MonoExtC_3	159	164	PF00514	0.596
TRG_NLS_MonoExtN_4	157	164	PF00514	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P832	Leptomonas seymouri	64%	99%
A0A1X0NSC8	Trypanosomatidae	39%	92%
A0A3S5ISD2	Trypanosoma rangeli	41%	100%
A0A3S7X1Q3	Leishmania donovani	77%	100%
A4I3R5	Leishmania infantum	77%	100%
D0A893	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	97%
E9B008	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q877	Leishmania major	76%	100%