Bms1-type G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 136, putative

Species:

Leishmania braziliensis

UniProt:

A4HGP1_LEIBR

TriTrypDb:

LbrM.28.2050 , LBRM2903_280026800

Length:

1256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0030684	preribosome	3	1
GO:0030686	90S preribosome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	1

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Expansion

Sequence features

A4HGP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGP1

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0003924	GTPase activity	7	1
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1200	1204	PF00656	0.517
CLV_C14_Caspase3-7	521	525	PF00656	0.617
CLV_C14_Caspase3-7	600	604	PF00656	0.691
CLV_C14_Caspase3-7	672	676	PF00656	0.740
CLV_C14_Caspase3-7	809	813	PF00656	0.383
CLV_NRD_NRD_1	1129	1131	PF00675	0.531
CLV_NRD_NRD_1	1190	1192	PF00675	0.518
CLV_NRD_NRD_1	1254	1256	PF00675	0.636
CLV_NRD_NRD_1	130	132	PF00675	0.396
CLV_NRD_NRD_1	201	203	PF00675	0.452

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PET3	Leptomonas seymouri	73%	99%
A0A0S4KP78	Bodo saltans	52%	100%
A0A3Q8IE00	Leishmania donovani	85%	100%
A0A3R7LAY5	Trypanosoma rangeli	58%	100%
A4I3R4	Leishmania infantum	85%	100%
D0A894	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9B007	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4Q878	Leishmania major	85%	100%
V5DBA6	Trypanosoma cruzi	57%	100%

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