LeishMANIAdb
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N2227 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
N2227 domain-containing protein
Gene product:
Putative methyltransferase, putative
Species:
Leishmania braziliensis
UniProt:
A4HGP0_LEIBR
TriTrypDb:
LbrM.28.2040 , LBRM2903_280026700 *
Length:
742

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGP0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGP0

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 2
GO:0032259 methylation 2 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0008168 methyltransferase activity 4 2
GO:0016740 transferase activity 2 2
GO:0016741 transferase activity, transferring one-carbon groups 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 422 426 PF00656 0.342
CLV_C14_Caspase3-7 588 592 PF00656 0.358
CLV_C14_Caspase3-7 706 710 PF00656 0.514
CLV_NRD_NRD_1 75 77 PF00675 0.461
CLV_PCSK_KEX2_1 249 251 PF00082 0.650
CLV_PCSK_KEX2_1 74 76 PF00082 0.502
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.559
CLV_PCSK_SKI1_1 32 36 PF00082 0.300
CLV_PCSK_SKI1_1 447 451 PF00082 0.252
CLV_PCSK_SKI1_1 459 463 PF00082 0.279
CLV_PCSK_SKI1_1 736 740 PF00082 0.518
CLV_PCSK_SKI1_1 79 83 PF00082 0.429
DEG_Nend_UBRbox_2 1 3 PF02207 0.630
DEG_SCF_FBW7_1 515 522 PF00400 0.510
DEG_SCF_FBW7_1 655 662 PF00400 0.555
DOC_CKS1_1 100 105 PF01111 0.430
DOC_CKS1_1 143 148 PF01111 0.570
DOC_CKS1_1 265 270 PF01111 0.508
DOC_CKS1_1 27 32 PF01111 0.291
DOC_CKS1_1 656 661 PF01111 0.521
DOC_CYCLIN_yCln2_LP_2 355 361 PF00134 0.216
DOC_MAPK_gen_1 539 546 PF00069 0.416
DOC_PP1_RVXF_1 43 50 PF00149 0.329
DOC_PP2B_LxvP_1 327 330 PF13499 0.354
DOC_PP2B_LxvP_1 346 349 PF13499 0.171
DOC_PP2B_LxvP_1 355 358 PF13499 0.193
DOC_PP4_FxxP_1 135 138 PF00568 0.478
DOC_USP7_MATH_1 101 105 PF00917 0.567
DOC_USP7_MATH_1 138 142 PF00917 0.445
DOC_USP7_MATH_1 160 164 PF00917 0.704
DOC_USP7_MATH_1 189 193 PF00917 0.810
DOC_USP7_MATH_1 236 240 PF00917 0.646
DOC_USP7_MATH_1 330 334 PF00917 0.374
DOC_USP7_MATH_1 367 371 PF00917 0.425
DOC_USP7_MATH_1 48 52 PF00917 0.462
DOC_USP7_MATH_1 508 512 PF00917 0.488
DOC_USP7_MATH_1 519 523 PF00917 0.597
DOC_USP7_MATH_1 647 651 PF00917 0.656
DOC_USP7_MATH_1 679 683 PF00917 0.539
DOC_WW_Pin1_4 142 147 PF00397 0.594
DOC_WW_Pin1_4 173 178 PF00397 0.532
DOC_WW_Pin1_4 181 186 PF00397 0.560
DOC_WW_Pin1_4 214 219 PF00397 0.643
DOC_WW_Pin1_4 239 244 PF00397 0.668
DOC_WW_Pin1_4 26 31 PF00397 0.276
DOC_WW_Pin1_4 261 266 PF00397 0.668
DOC_WW_Pin1_4 359 364 PF00397 0.434
DOC_WW_Pin1_4 394 399 PF00397 0.310
DOC_WW_Pin1_4 451 456 PF00397 0.479
DOC_WW_Pin1_4 515 520 PF00397 0.540
DOC_WW_Pin1_4 651 656 PF00397 0.547
DOC_WW_Pin1_4 701 706 PF00397 0.485
DOC_WW_Pin1_4 99 104 PF00397 0.453
LIG_14-3-3_CanoR_1 118 122 PF00244 0.427
LIG_14-3-3_CanoR_1 288 297 PF00244 0.363
LIG_14-3-3_CanoR_1 550 556 PF00244 0.350
LIG_14-3-3_CanoR_1 569 574 PF00244 0.363
LIG_14-3-3_CanoR_1 649 654 PF00244 0.595
LIG_14-3-3_CanoR_1 697 705 PF00244 0.507
LIG_Actin_WH2_2 720 738 PF00022 0.443
LIG_BRCT_BRCA1_1 290 294 PF00533 0.295
LIG_EH_1 136 140 PF12763 0.452
LIG_EH1_1 305 313 PF00400 0.354
LIG_FHA_1 143 149 PF00498 0.628
LIG_FHA_1 275 281 PF00498 0.397
LIG_FHA_1 311 317 PF00498 0.373
LIG_FHA_1 318 324 PF00498 0.359
LIG_FHA_1 452 458 PF00498 0.363
LIG_FHA_1 499 505 PF00498 0.317
LIG_FHA_1 602 608 PF00498 0.375
LIG_FHA_1 664 670 PF00498 0.517
LIG_FHA_2 100 106 PF00498 0.508
LIG_FHA_2 562 568 PF00498 0.279
LIG_FHA_2 637 643 PF00498 0.601
LIG_FHA_2 660 666 PF00498 0.574
LIG_FHA_2 85 91 PF00498 0.302
LIG_GBD_Chelix_1 498 506 PF00786 0.295
LIG_GSK3_LRP6_1 243 248 PF00069 0.633
LIG_GSK3_LRP6_1 655 660 PF00069 0.521
LIG_LIR_Apic_2 13 19 PF02991 0.357
LIG_LIR_Apic_2 134 138 PF02991 0.429
LIG_LIR_Apic_2 650 656 PF02991 0.536
LIG_LIR_Gen_1 114 122 PF02991 0.473
LIG_LIR_Gen_1 17 26 PF02991 0.267
LIG_LIR_Gen_1 282 289 PF02991 0.445
LIG_LIR_Gen_1 291 301 PF02991 0.311
LIG_LIR_Gen_1 570 578 PF02991 0.383
LIG_LIR_Nem_3 114 119 PF02991 0.579
LIG_LIR_Nem_3 129 135 PF02991 0.441
LIG_LIR_Nem_3 17 23 PF02991 0.272
LIG_LIR_Nem_3 282 287 PF02991 0.452
LIG_LIR_Nem_3 291 297 PF02991 0.357
LIG_LIR_Nem_3 564 568 PF02991 0.380
LIG_LIR_Nem_3 570 574 PF02991 0.331
LIG_PCNA_yPIPBox_3 550 559 PF02747 0.334
LIG_Pex14_1 302 306 PF04695 0.295
LIG_Pex14_2 135 139 PF04695 0.450
LIG_PTAP_UEV_1 148 153 PF05743 0.513
LIG_PTB_Apo_2 423 430 PF02174 0.354
LIG_SH2_CRK 571 575 PF00017 0.415
LIG_SH2_CRK 653 657 PF00017 0.532
LIG_SH2_CRK 97 101 PF00017 0.410
LIG_SH2_NCK_1 653 657 PF00017 0.532
LIG_SH2_SRC 400 403 PF00017 0.363
LIG_SH2_STAP1 381 385 PF00017 0.280
LIG_SH2_STAP1 490 494 PF00017 0.295
LIG_SH2_STAP1 721 725 PF00017 0.502
LIG_SH2_STAT3 381 384 PF00017 0.280
LIG_SH2_STAT5 16 19 PF00017 0.338
LIG_SH2_STAT5 400 403 PF00017 0.363
LIG_SH2_STAT5 571 574 PF00017 0.468
LIG_SH2_STAT5 721 724 PF00017 0.484
LIG_SH2_STAT5 85 88 PF00017 0.343
LIG_SH3_1 241 247 PF00018 0.629
LIG_SH3_1 653 659 PF00018 0.527
LIG_SH3_2 244 249 PF14604 0.548
LIG_SH3_3 137 143 PF00018 0.498
LIG_SH3_3 146 152 PF00018 0.635
LIG_SH3_3 159 165 PF00018 0.475
LIG_SH3_3 179 185 PF00018 0.613
LIG_SH3_3 212 218 PF00018 0.555
LIG_SH3_3 237 243 PF00018 0.703
LIG_SH3_3 262 268 PF00018 0.620
LIG_SH3_3 60 66 PF00018 0.449
LIG_SH3_3 653 659 PF00018 0.679
LIG_SUMO_SIM_par_1 257 264 PF11976 0.556
LIG_TRAF2_1 88 91 PF00917 0.419
LIG_TRFH_1 97 101 PF08558 0.410
LIG_WRC_WIRS_1 132 137 PF05994 0.426
LIG_WRC_WIRS_1 411 416 PF05994 0.354
LIG_WRC_WIRS_1 562 567 PF05994 0.426
LIG_WW_3 71 75 PF00397 0.437
MOD_CDC14_SPxK_1 246 249 PF00782 0.548
MOD_CDK_SPxK_1 243 249 PF00069 0.544
MOD_CDK_SPxK_1 26 32 PF00069 0.285
MOD_CDK_SPxxK_3 243 250 PF00069 0.693
MOD_CK1_1 10 16 PF00069 0.576
MOD_CK1_1 175 181 PF00069 0.599
MOD_CK1_1 188 194 PF00069 0.619
MOD_CK1_1 217 223 PF00069 0.603
MOD_CK1_1 228 234 PF00069 0.727
MOD_CK1_1 239 245 PF00069 0.616
MOD_CK1_1 260 266 PF00069 0.574
MOD_CK1_1 28 34 PF00069 0.325
MOD_CK1_1 334 340 PF00069 0.334
MOD_CK1_1 370 376 PF00069 0.437
MOD_CK1_1 530 536 PF00069 0.665
MOD_CK1_1 626 632 PF00069 0.477
MOD_CK1_1 637 643 PF00069 0.554
MOD_CK1_1 654 660 PF00069 0.501
MOD_CK1_1 663 669 PF00069 0.496
MOD_CK1_1 682 688 PF00069 0.467
MOD_CK1_1 691 697 PF00069 0.515
MOD_CK1_1 698 704 PF00069 0.480
MOD_CK2_1 123 129 PF00069 0.510
MOD_CK2_1 334 340 PF00069 0.216
MOD_CK2_1 561 567 PF00069 0.281
MOD_CK2_1 636 642 PF00069 0.634
MOD_CK2_1 84 90 PF00069 0.523
MOD_CK2_1 99 105 PF00069 0.465
MOD_GlcNHglycan 140 143 PF01048 0.465
MOD_GlcNHglycan 149 152 PF01048 0.567
MOD_GlcNHglycan 166 169 PF01048 0.530
MOD_GlcNHglycan 200 203 PF01048 0.548
MOD_GlcNHglycan 284 287 PF01048 0.526
MOD_GlcNHglycan 333 336 PF01048 0.371
MOD_GlcNHglycan 340 344 PF01048 0.411
MOD_GlcNHglycan 35 38 PF01048 0.565
MOD_GlcNHglycan 50 53 PF01048 0.263
MOD_GlcNHglycan 510 513 PF01048 0.451
MOD_GlcNHglycan 523 526 PF01048 0.511
MOD_GlcNHglycan 528 532 PF01048 0.689
MOD_GlcNHglycan 559 562 PF01048 0.306
MOD_GlcNHglycan 585 590 PF01048 0.486
MOD_GlcNHglycan 639 642 PF01048 0.615
MOD_GlcNHglycan 665 669 PF01048 0.561
MOD_GlcNHglycan 670 673 PF01048 0.514
MOD_GlcNHglycan 700 703 PF01048 0.590
MOD_GSK3_1 10 17 PF00069 0.490
MOD_GSK3_1 138 145 PF00069 0.514
MOD_GSK3_1 160 167 PF00069 0.629
MOD_GSK3_1 168 175 PF00069 0.679
MOD_GSK3_1 181 188 PF00069 0.670
MOD_GSK3_1 198 205 PF00069 0.650
MOD_GSK3_1 239 246 PF00069 0.663
MOD_GSK3_1 257 264 PF00069 0.524
MOD_GSK3_1 267 274 PF00069 0.467
MOD_GSK3_1 288 295 PF00069 0.387
MOD_GSK3_1 330 337 PF00069 0.480
MOD_GSK3_1 353 360 PF00069 0.334
MOD_GSK3_1 375 382 PF00069 0.299
MOD_GSK3_1 410 417 PF00069 0.332
MOD_GSK3_1 504 511 PF00069 0.418
MOD_GSK3_1 515 522 PF00069 0.556
MOD_GSK3_1 557 564 PF00069 0.436
MOD_GSK3_1 577 584 PF00069 0.280
MOD_GSK3_1 637 644 PF00069 0.521
MOD_GSK3_1 647 654 PF00069 0.604
MOD_GSK3_1 655 662 PF00069 0.517
MOD_GSK3_1 663 670 PF00069 0.518
MOD_GSK3_1 675 682 PF00069 0.496
MOD_GSK3_1 691 698 PF00069 0.501
MOD_N-GLC_1 173 178 PF02516 0.637
MOD_N-GLC_1 367 372 PF02516 0.295
MOD_N-GLC_1 373 378 PF02516 0.258
MOD_N-GLC_1 551 556 PF02516 0.341
MOD_N-GLC_1 685 690 PF02516 0.537
MOD_N-GLC_2 636 638 PF02516 0.499
MOD_NEK2_1 25 30 PF00069 0.337
MOD_NEK2_1 498 503 PF00069 0.295
MOD_NEK2_1 504 509 PF00069 0.295
MOD_NEK2_1 634 639 PF00069 0.495
MOD_NEK2_1 664 669 PF00069 0.563
MOD_NEK2_1 680 685 PF00069 0.479
MOD_NEK2_1 720 725 PF00069 0.451
MOD_NEK2_2 131 136 PF00069 0.438
MOD_NEK2_2 236 241 PF00069 0.647
MOD_PIKK_1 175 181 PF00454 0.619
MOD_PIKK_1 310 316 PF00454 0.216
MOD_PIKK_1 380 386 PF00454 0.281
MOD_PKA_2 117 123 PF00069 0.544
MOD_PKA_2 287 293 PF00069 0.354
MOD_PKA_2 330 336 PF00069 0.363
MOD_PKA_2 508 514 PF00069 0.607
MOD_PKA_2 581 587 PF00069 0.477
MOD_PKA_2 601 607 PF00069 0.382
MOD_PKA_2 648 654 PF00069 0.612
MOD_PKA_2 696 702 PF00069 0.519
MOD_Plk_1 14 20 PF00069 0.451
MOD_Plk_1 367 373 PF00069 0.395
MOD_Plk_1 551 557 PF00069 0.394
MOD_Plk_1 685 691 PF00069 0.535
MOD_Plk_4 117 123 PF00069 0.606
MOD_Plk_4 131 137 PF00069 0.400
MOD_Plk_4 297 303 PF00069 0.295
MOD_Plk_4 410 416 PF00069 0.333
MOD_Plk_4 569 575 PF00069 0.382
MOD_Plk_4 601 607 PF00069 0.382
MOD_ProDKin_1 142 148 PF00069 0.601
MOD_ProDKin_1 173 179 PF00069 0.569
MOD_ProDKin_1 181 187 PF00069 0.564
MOD_ProDKin_1 214 220 PF00069 0.641
MOD_ProDKin_1 239 245 PF00069 0.671
MOD_ProDKin_1 26 32 PF00069 0.285
MOD_ProDKin_1 261 267 PF00069 0.662
MOD_ProDKin_1 359 365 PF00069 0.434
MOD_ProDKin_1 394 400 PF00069 0.310
MOD_ProDKin_1 451 457 PF00069 0.479
MOD_ProDKin_1 515 521 PF00069 0.542
MOD_ProDKin_1 651 657 PF00069 0.549
MOD_ProDKin_1 701 707 PF00069 0.481
MOD_ProDKin_1 99 105 PF00069 0.452
TRG_DiLeu_BaEn_4 114 120 PF01217 0.313
TRG_DiLeu_BaEn_4 232 238 PF01217 0.510
TRG_DiLeu_BaLyEn_6 341 346 PF01217 0.363
TRG_ENDOCYTIC_2 136 139 PF00928 0.552
TRG_ENDOCYTIC_2 571 574 PF00928 0.406
TRG_ENDOCYTIC_2 721 724 PF00928 0.484
TRG_ENDOCYTIC_2 97 100 PF00928 0.504
TRG_ER_diArg_1 73 76 PF00400 0.444
TRG_NES_CRM1_1 111 124 PF08389 0.414
TRG_Pf-PMV_PEXEL_1 279 283 PF00026 0.424
TRG_Pf-PMV_PEXEL_1 447 452 PF00026 0.243

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I298 Leptomonas seymouri 47% 99%
A0A0S4IR04 Bodo saltans 25% 100%
A0A3S7X1M1 Leishmania donovani 69% 100%
A4I3R3 Leishmania infantum 69% 100%
E9B006 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 100%
Q4Q879 Leishmania major 63% 89%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS