UPF0573 protein C2orf70 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4586), putative

Species:

Leishmania braziliensis

UniProt:

A4HGN9_LEIBR

TriTrypDb:

LbrM.28.2030 , LBRM2903_280026600

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	24
GO:0005815	microtubule organizing center	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

A4HGN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGN9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.396
CLV_C14_Caspase3-7	37	41	PF00656	0.440
CLV_NRD_NRD_1	120	122	PF00675	0.234
CLV_NRD_NRD_1	166	168	PF00675	0.313
CLV_NRD_NRD_1	252	254	PF00675	0.298
CLV_NRD_NRD_1	64	66	PF00675	0.235
CLV_PCSK_FUR_1	210	214	PF00082	0.266
CLV_PCSK_KEX2_1	120	122	PF00082	0.332
CLV_PCSK_KEX2_1	166	168	PF00082	0.284
CLV_PCSK_KEX2_1	212	214	PF00082	0.303
CLV_PCSK_KEX2_1	286	288	PF00082	0.526
CLV_PCSK_KEX2_1	63	65	PF00082	0.227
CLV_PCSK_KEX2_1	72	74	PF00082	0.194
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.303
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.531
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.207
CLV_PCSK_PC7_1	162	168	PF00082	0.246
CLV_PCSK_SKI1_1	216	220	PF00082	0.196
CLV_PCSK_SKI1_1	73	77	PF00082	0.215
CLV_Separin_Metazoa	60	64	PF03568	0.348
DEG_SCF_FBW7_2	204	211	PF00400	0.348
DOC_CKS1_1	100	105	PF01111	0.512
DOC_CKS1_1	205	210	PF01111	0.348
DOC_PP4_FxxP_1	3	6	PF00568	0.454
DOC_USP7_UBL2_3	212	216	PF12436	0.473
DOC_USP7_UBL2_3	257	261	PF12436	0.453
DOC_WW_Pin1_4	128	133	PF00397	0.437
DOC_WW_Pin1_4	191	196	PF00397	0.479
DOC_WW_Pin1_4	204	209	PF00397	0.466
DOC_WW_Pin1_4	73	78	PF00397	0.437
DOC_WW_Pin1_4	81	86	PF00397	0.421
DOC_WW_Pin1_4	99	104	PF00397	0.448
LIG_14-3-3_CanoR_1	126	132	PF00244	0.433
LIG_BRCT_BRCA1_1	281	285	PF00533	0.417
LIG_deltaCOP1_diTrp_1	275	285	PF00928	0.472
LIG_FHA_1	25	31	PF00498	0.463
LIG_FHA_1	278	284	PF00498	0.457
LIG_FHA_2	143	149	PF00498	0.402
LIG_FHA_2	154	160	PF00498	0.389
LIG_FHA_2	188	194	PF00498	0.420
LIG_FHA_2	236	242	PF00498	0.433
LIG_FHA_2	35	41	PF00498	0.501
LIG_LIR_Apic_2	13	18	PF02991	0.512
LIG_LIR_Apic_2	241	246	PF02991	0.418
LIG_LIR_Gen_1	101	111	PF02991	0.468
LIG_LIR_Gen_1	215	226	PF02991	0.443
LIG_LIR_Nem_3	215	221	PF02991	0.425
LIG_LIR_Nem_3	244	250	PF02991	0.411
LIG_LIR_Nem_3	282	288	PF02991	0.588
LIG_LIR_Nem_3	7	11	PF02991	0.436
LIG_LIR_Nem_3	94	99	PF02991	0.442
LIG_Pex14_1	243	247	PF04695	0.430
LIG_SH2_CRK	129	133	PF00017	0.443
LIG_SH2_CRK	15	19	PF00017	0.512
LIG_SH2_CRK	82	86	PF00017	0.450
LIG_SH2_NCK_1	129	133	PF00017	0.430
LIG_SH2_NCK_1	141	145	PF00017	0.441
LIG_SH2_NCK_1	82	86	PF00017	0.470
LIG_SH2_PTP2	8	11	PF00017	0.374
LIG_SH2_SRC	141	144	PF00017	0.405
LIG_SH2_STAP1	279	283	PF00017	0.417
LIG_SH2_STAT3	158	161	PF00017	0.494
LIG_SH2_STAT5	129	132	PF00017	0.450
LIG_SH2_STAT5	153	156	PF00017	0.416
LIG_SH2_STAT5	203	206	PF00017	0.480
LIG_SH2_STAT5	232	235	PF00017	0.430
LIG_SH2_STAT5	259	262	PF00017	0.487
LIG_SH2_STAT5	279	282	PF00017	0.444
LIG_SH2_STAT5	8	11	PF00017	0.483
LIG_SH2_STAT5	95	98	PF00017	0.433
LIG_SH3_1	174	180	PF00018	0.512
LIG_SH3_3	105	111	PF00018	0.417
LIG_SH3_3	174	180	PF00018	0.443
LIG_SH3_3	223	229	PF00018	0.455
LIG_SH3_3	257	263	PF00018	0.445
LIG_SH3_3	27	33	PF00018	0.470
LIG_WW_3	123	127	PF00397	0.405
MOD_CDC14_SPxK_1	131	134	PF00782	0.390
MOD_CDK_SPxK_1	128	134	PF00069	0.390
MOD_CDK_SPxK_1	204	210	PF00069	0.348
MOD_CDK_SPxxK_3	128	135	PF00069	0.518
MOD_CK1_1	194	200	PF00069	0.431
MOD_CK1_1	264	270	PF00069	0.520
MOD_CK1_1	4	10	PF00069	0.442
MOD_CK1_1	83	89	PF00069	0.496
MOD_CK2_1	153	159	PF00069	0.542
MOD_CK2_1	187	193	PF00069	0.419
MOD_CK2_1	235	241	PF00069	0.515
MOD_GSK3_1	144	151	PF00069	0.488
MOD_GSK3_1	187	194	PF00069	0.455
MOD_GSK3_1	24	31	PF00069	0.467
MOD_GSK3_1	264	271	PF00069	0.511
MOD_GSK3_1	98	105	PF00069	0.452
MOD_N-GLC_1	73	78	PF02516	0.239
MOD_NEK2_1	1	6	PF00069	0.285
MOD_NEK2_1	277	282	PF00069	0.451
MOD_NEK2_1	28	33	PF00069	0.537
MOD_NEK2_1	68	73	PF00069	0.478
MOD_NEK2_1	80	85	PF00069	0.499
MOD_NEK2_2	153	158	PF00069	0.425
MOD_PIKK_1	277	283	PF00454	0.438
MOD_PKA_1	134	140	PF00069	0.478
MOD_PKA_1	261	267	PF00069	0.448
MOD_PKA_2	235	241	PF00069	0.430
MOD_Plk_1	264	270	PF00069	0.466
MOD_Plk_2-3	187	193	PF00069	0.512
MOD_Plk_4	153	159	PF00069	0.402
MOD_Plk_4	24	30	PF00069	0.473
MOD_Plk_4	264	270	PF00069	0.480
MOD_Plk_4	279	285	PF00069	0.461
MOD_Plk_4	4	10	PF00069	0.470
MOD_Plk_4	91	97	PF00069	0.459
MOD_ProDKin_1	128	134	PF00069	0.437
MOD_ProDKin_1	191	197	PF00069	0.479
MOD_ProDKin_1	204	210	PF00069	0.466
MOD_ProDKin_1	73	79	PF00069	0.437
MOD_ProDKin_1	81	87	PF00069	0.421
MOD_ProDKin_1	99	105	PF00069	0.448
TRG_ENDOCYTIC_2	104	107	PF00928	0.480
TRG_ENDOCYTIC_2	141	144	PF00928	0.504
TRG_ENDOCYTIC_2	8	11	PF00928	0.467
TRG_ER_diArg_1	62	65	PF00400	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6K0	Leptomonas seymouri	29%	83%
A0A0N1I4L7	Leptomonas seymouri	30%	96%
A0A0N1I8Z0	Leptomonas seymouri	75%	100%
A0A0S4IPI4	Bodo saltans	29%	86%
A0A0S4IYY4	Bodo saltans	32%	99%
A0A0S4KM52	Bodo saltans	46%	99%
A0A1X0NMW4	Trypanosomatidae	32%	97%
A0A1X0NRI3	Trypanosomatidae	56%	100%
A0A1X0P929	Trypanosomatidae	30%	82%
A0A3Q8IGT8	Leishmania donovani	88%	100%
A0A3R7NAQ1	Trypanosoma rangeli	31%	84%
A0A3S5H6B7	Leishmania donovani	32%	94%
A0A3S7X2W5	Leishmania donovani	30%	85%
A0A422NDP9	Trypanosoma rangeli	30%	97%
A0A422NZ19	Trypanosoma rangeli	57%	100%
A4H5J6	Leishmania braziliensis	31%	100%
A4HHQ4	Leishmania braziliensis	31%	85%
A4HTT9	Leishmania infantum	32%	94%
A4I3R2	Leishmania infantum	89%	100%
A4I4W9	Leishmania infantum	30%	71%
C9ZKZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	72%
D0A896	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D0A995	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
E9AEB8	Leishmania major	31%	70%
E9ALG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	68%
E9AMM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	94%
E9B005	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q2T9M0	Bos taurus	30%	93%
Q3U1D9	Mus musculus	30%	91%
Q4Q880	Leishmania major	88%	100%
Q4QI05	Leishmania major	31%	100%
V5BSF6	Trypanosoma cruzi	30%	96%
V5DTV3	Trypanosoma cruzi	28%	84%