Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-terminal motor kinesin, putative

Species:

Leishmania braziliensis

UniProt:

A4HGN8_LEIBR

TriTrypDb:

LbrM.28.2020 , LBRM2903_280026500

Length:

966

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	7
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7
GO:0110165	cellular anatomical entity	1	7
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4HGN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGN8

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0009987	cellular process	1	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003774	cytoskeletal motor activity	1	7
GO:0003777	microtubule motor activity	2	7
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0005524	ATP binding	5	7
GO:0008017	microtubule binding	5	7
GO:0008092	cytoskeletal protein binding	3	7
GO:0015631	tubulin binding	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140657	ATP-dependent activity	1	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.386
CLV_C14_Caspase3-7	330	334	PF00656	0.327
CLV_C14_Caspase3-7	98	102	PF00656	0.607
CLV_NRD_NRD_1	131	133	PF00675	0.756
CLV_NRD_NRD_1	153	155	PF00675	0.585
CLV_NRD_NRD_1	373	375	PF00675	0.510
CLV_NRD_NRD_1	391	393	PF00675	0.405
CLV_NRD_NRD_1	4	6	PF00675	0.650
CLV_NRD_NRD_1	563	565	PF00675	0.804
CLV_NRD_NRD_1	86	88	PF00675	0.575
CLV_PCSK_FUR_1	212	216	PF00082	0.468
CLV_PCSK_KEX2_1	131	133	PF00082	0.756
CLV_PCSK_KEX2_1	153	155	PF00082	0.585
CLV_PCSK_KEX2_1	214	216	PF00082	0.476
CLV_PCSK_KEX2_1	255	257	PF00082	0.446
CLV_PCSK_KEX2_1	26	28	PF00082	0.779
CLV_PCSK_KEX2_1	391	393	PF00082	0.586
CLV_PCSK_KEX2_1	6	8	PF00082	0.637
CLV_PCSK_KEX2_1	86	88	PF00082	0.575
CLV_PCSK_KEX2_1	961	963	PF00082	0.424
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.459
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.446
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.779
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.640
CLV_PCSK_PC1ET2_1	961	963	PF00082	0.550
CLV_PCSK_PC7_1	127	133	PF00082	0.749
CLV_PCSK_SKI1_1	154	158	PF00082	0.585
CLV_PCSK_SKI1_1	163	167	PF00082	0.568
CLV_PCSK_SKI1_1	353	357	PF00082	0.593
CLV_PCSK_SKI1_1	61	65	PF00082	0.573
CLV_PCSK_SKI1_1	628	632	PF00082	0.442
CLV_PCSK_SKI1_1	655	659	PF00082	0.466
CLV_PCSK_SKI1_1	695	699	PF00082	0.339
CLV_PCSK_SKI1_1	749	753	PF00082	0.339
CLV_PCSK_SKI1_1	77	81	PF00082	0.549
CLV_PCSK_SKI1_1	875	879	PF00082	0.339
CLV_PCSK_SKI1_1	885	889	PF00082	0.339
CLV_PCSK_SKI1_1	961	965	PF00082	0.563
DEG_APCC_DBOX_1	390	398	PF00400	0.479
DEG_APCC_DBOX_1	705	713	PF00400	0.249
DEG_SCF_FBW7_1	25	32	PF00400	0.586
DEG_SPOP_SBC_1	19	23	PF00917	0.574
DEG_SPOP_SBC_1	774	778	PF00917	0.316
DOC_ANK_TNKS_1	674	681	PF00023	0.339
DOC_CKS1_1	149	154	PF01111	0.672
DOC_CYCLIN_RxL_1	882	889	PF00134	0.339
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.567
DOC_MAPK_FxFP_2	548	551	PF00069	0.639
DOC_MAPK_gen_1	372	382	PF00069	0.621
DOC_MAPK_gen_1	410	418	PF00069	0.576
DOC_MAPK_gen_1	849	858	PF00069	0.501
DOC_MAPK_gen_1	875	883	PF00069	0.339
DOC_MAPK_gen_1	921	931	PF00069	0.339
DOC_MAPK_MEF2A_6	924	931	PF00069	0.339
DOC_PP2B_LxvP_1	139	142	PF13499	0.749
DOC_PP2B_LxvP_1	66	69	PF13499	0.559
DOC_PP4_FxxP_1	548	551	PF00568	0.639
DOC_USP7_MATH_1	100	104	PF00917	0.728
DOC_USP7_MATH_1	119	123	PF00917	0.613
DOC_USP7_MATH_1	147	151	PF00917	0.566
DOC_USP7_MATH_1	18	22	PF00917	0.606
DOC_USP7_MATH_1	193	197	PF00917	0.731
DOC_USP7_MATH_1	200	204	PF00917	0.645
DOC_USP7_MATH_1	29	33	PF00917	0.697
DOC_USP7_MATH_1	38	42	PF00917	0.682
DOC_USP7_MATH_1	458	462	PF00917	0.544
DOC_USP7_MATH_1	487	491	PF00917	0.585
DOC_USP7_MATH_1	526	530	PF00917	0.782
DOC_USP7_MATH_1	938	942	PF00917	0.466
DOC_WW_Pin1_4	108	113	PF00397	0.574
DOC_WW_Pin1_4	148	153	PF00397	0.720
DOC_WW_Pin1_4	191	196	PF00397	0.655
DOC_WW_Pin1_4	25	30	PF00397	0.669
DOC_WW_Pin1_4	36	41	PF00397	0.731
DOC_WW_Pin1_4	506	511	PF00397	0.635
DOC_WW_Pin1_4	592	597	PF00397	0.546
DOC_WW_Pin1_4	710	715	PF00397	0.391
LIG_14-3-3_CanoR_1	292	300	PF00244	0.615
LIG_14-3-3_CanoR_1	338	343	PF00244	0.621
LIG_14-3-3_CanoR_1	515	525	PF00244	0.709
LIG_14-3-3_CanoR_1	57	64	PF00244	0.603
LIG_14-3-3_CanoR_1	636	644	PF00244	0.384
LIG_14-3-3_CanoR_1	715	721	PF00244	0.268
LIG_14-3-3_CanoR_1	800	806	PF00244	0.513
LIG_14-3-3_CanoR_1	819	826	PF00244	0.201
LIG_14-3-3_CanoR_1	849	858	PF00244	0.501
LIG_14-3-3_CterR_2	962	966	PF00244	0.571
LIG_Actin_WH2_2	883	900	PF00022	0.339
LIG_APCC_ABBA_1	741	746	PF00400	0.339
LIG_BRCT_BRCA1_1	736	740	PF00533	0.339
LIG_BRCT_BRCA1_1	943	947	PF00533	0.339
LIG_DLG_GKlike_1	338	345	PF00625	0.486
LIG_DLG_GKlike_1	473	481	PF00625	0.529
LIG_FHA_1	234	240	PF00498	0.653
LIG_FHA_1	337	343	PF00498	0.559
LIG_FHA_1	354	360	PF00498	0.468
LIG_FHA_1	525	531	PF00498	0.782
LIG_FHA_1	585	591	PF00498	0.685
LIG_FHA_1	593	599	PF00498	0.503
LIG_FHA_1	793	799	PF00498	0.383
LIG_FHA_1	836	842	PF00498	0.339
LIG_FHA_1	909	915	PF00498	0.339
LIG_FHA_1	94	100	PF00498	0.592
LIG_FHA_2	199	205	PF00498	0.604
LIG_FHA_2	208	214	PF00498	0.614
LIG_FHA_2	246	252	PF00498	0.473
LIG_FHA_2	293	299	PF00498	0.468
LIG_FHA_2	425	431	PF00498	0.648
LIG_FHA_2	492	498	PF00498	0.539
LIG_FHA_2	737	743	PF00498	0.339
LIG_FHA_2	755	761	PF00498	0.339
LIG_IRF3_LxIS_1	836	842	PF10401	0.466
LIG_LIR_Gen_1	650	661	PF02991	0.339
LIG_LIR_Gen_1	665	674	PF02991	0.339
LIG_LIR_Gen_1	737	748	PF02991	0.339
LIG_LIR_Gen_1	807	816	PF02991	0.455
LIG_LIR_Nem_3	650	656	PF02991	0.339
LIG_LIR_Nem_3	665	670	PF02991	0.339
LIG_LIR_Nem_3	737	743	PF02991	0.339
LIG_LIR_Nem_3	779	785	PF02991	0.293
LIG_LIR_Nem_3	807	811	PF02991	0.336
LIG_NRBOX	909	915	PF00104	0.339
LIG_PCNA_yPIPBox_3	240	254	PF02747	0.622
LIG_PCNA_yPIPBox_3	745	758	PF02747	0.339
LIG_PDZ_Class_1	961	966	PF00595	0.538
LIG_Pex14_2	647	651	PF04695	0.466
LIG_RPA_C_Fungi	292	304	PF08784	0.567
LIG_SH2_CRK	408	412	PF00017	0.545
LIG_SH2_CRK	653	657	PF00017	0.339
LIG_SH2_CRK	782	786	PF00017	0.339
LIG_SH2_NCK_1	653	657	PF00017	0.339
LIG_SH2_STAP1	228	232	PF00017	0.623
LIG_SH2_STAP1	653	657	PF00017	0.339
LIG_SH2_STAP1	759	763	PF00017	0.339
LIG_SH2_STAT3	912	915	PF00017	0.466
LIG_SH2_STAT5	408	411	PF00017	0.537
LIG_SH2_STAT5	667	670	PF00017	0.249
LIG_SH2_STAT5	793	796	PF00017	0.249
LIG_SH2_STAT5	912	915	PF00017	0.466
LIG_SH2_STAT5	917	920	PF00017	0.395
LIG_SH2_STAT5	955	958	PF00017	0.596
LIG_SH3_1	132	138	PF00018	0.658
LIG_SH3_2	135	140	PF14604	0.765
LIG_SH3_2	149	154	PF14604	0.581
LIG_SH3_3	132	138	PF00018	0.667
LIG_SH3_3	146	152	PF00018	0.668
LIG_SH3_3	192	198	PF00018	0.558
LIG_SH3_3	414	420	PF00018	0.500
LIG_SH3_3	42	48	PF00018	0.584
LIG_SH3_3	459	465	PF00018	0.760
LIG_SH3_3	617	623	PF00018	0.740
LIG_SH3_3	82	88	PF00018	0.744
LIG_SUMO_SIM_par_1	484	490	PF11976	0.755
LIG_SUMO_SIM_par_1	924	930	PF11976	0.339
LIG_UBA3_1	887	892	PF00899	0.339
LIG_WRC_WIRS_1	644	649	PF05994	0.466
MOD_CDK_SPK_2	108	113	PF00069	0.574
MOD_CDK_SPK_2	148	153	PF00069	0.704
MOD_CDK_SPK_2	710	715	PF00069	0.339
MOD_CDK_SPxK_1	148	154	PF00069	0.573
MOD_CDK_SPxxK_3	108	115	PF00069	0.559
MOD_CK1_1	111	117	PF00069	0.698
MOD_CK1_1	120	126	PF00069	0.676
MOD_CK1_1	181	187	PF00069	0.771
MOD_CK1_1	296	302	PF00069	0.605
MOD_CK1_1	32	38	PF00069	0.678
MOD_CK1_1	384	390	PF00069	0.500
MOD_CK1_1	476	482	PF00069	0.612
MOD_CK1_1	490	496	PF00069	0.614
MOD_CK1_1	516	522	PF00069	0.660
MOD_CK1_1	524	530	PF00069	0.653
MOD_CK1_1	55	61	PF00069	0.766
MOD_CK1_1	585	591	PF00069	0.557
MOD_CK1_1	637	643	PF00069	0.324
MOD_CK1_1	645	651	PF00069	0.313
MOD_CK1_1	693	699	PF00069	0.352
MOD_CK1_1	754	760	PF00069	0.290
MOD_CK1_1	775	781	PF00069	0.324
MOD_CK1_1	830	836	PF00069	0.339
MOD_CK1_1	93	99	PF00069	0.605
MOD_CK1_1	941	947	PF00069	0.466
MOD_CK2_1	198	204	PF00069	0.709
MOD_CK2_1	207	213	PF00069	0.523
MOD_CK2_1	245	251	PF00069	0.488
MOD_CK2_1	292	298	PF00069	0.470
MOD_CK2_1	393	399	PF00069	0.560
MOD_CK2_1	438	444	PF00069	0.547
MOD_CK2_1	491	497	PF00069	0.544
MOD_CK2_1	56	62	PF00069	0.568
MOD_CK2_1	643	649	PF00069	0.450
MOD_CK2_1	736	742	PF00069	0.339
MOD_CK2_1	754	760	PF00069	0.339
MOD_CK2_1	801	807	PF00069	0.508
MOD_CMANNOS	208	211	PF00535	0.650
MOD_GlcNHglycan	116	119	PF01048	0.760
MOD_GlcNHglycan	145	148	PF01048	0.709
MOD_GlcNHglycan	158	161	PF01048	0.653
MOD_GlcNHglycan	16	19	PF01048	0.587
MOD_GlcNHglycan	188	191	PF01048	0.623
MOD_GlcNHglycan	272	275	PF01048	0.384
MOD_GlcNHglycan	283	286	PF01048	0.356
MOD_GlcNHglycan	315	318	PF01048	0.460
MOD_GlcNHglycan	329	332	PF01048	0.630
MOD_GlcNHglycan	359	362	PF01048	0.486
MOD_GlcNHglycan	452	455	PF01048	0.562
MOD_GlcNHglycan	473	476	PF01048	0.671
MOD_GlcNHglycan	481	484	PF01048	0.584
MOD_GlcNHglycan	515	518	PF01048	0.830
MOD_GlcNHglycan	692	695	PF01048	0.339
MOD_GlcNHglycan	753	756	PF01048	0.339
MOD_GlcNHglycan	778	781	PF01048	0.399
MOD_GlcNHglycan	787	790	PF01048	0.303
MOD_GlcNHglycan	841	844	PF01048	0.494
MOD_GlcNHglycan	869	872	PF01048	0.348
MOD_GSK3_1	117	124	PF00069	0.666
MOD_GSK3_1	14	21	PF00069	0.576
MOD_GSK3_1	143	150	PF00069	0.584
MOD_GSK3_1	163	170	PF00069	0.666
MOD_GSK3_1	174	181	PF00069	0.617
MOD_GSK3_1	226	233	PF00069	0.445
MOD_GSK3_1	25	32	PF00069	0.681
MOD_GSK3_1	292	299	PF00069	0.570
MOD_GSK3_1	353	360	PF00069	0.487
MOD_GSK3_1	450	457	PF00069	0.554
MOD_GSK3_1	469	476	PF00069	0.649
MOD_GSK3_1	486	493	PF00069	0.617
MOD_GSK3_1	513	520	PF00069	0.747
MOD_GSK3_1	52	59	PF00069	0.651
MOD_GSK3_1	579	586	PF00069	0.664
MOD_GSK3_1	628	635	PF00069	0.427
MOD_GSK3_1	638	645	PF00069	0.271
MOD_GSK3_1	730	737	PF00069	0.353
MOD_GSK3_1	770	777	PF00069	0.401
MOD_GSK3_1	781	788	PF00069	0.287
MOD_GSK3_1	817	824	PF00069	0.466
MOD_GSK3_1	835	842	PF00069	0.339
MOD_GSK3_1	88	95	PF00069	0.592
MOD_GSK3_1	951	958	PF00069	0.444
MOD_N-GLC_1	108	113	PF02516	0.545
MOD_N-GLC_1	261	266	PF02516	0.384
MOD_N-GLC_1	517	522	PF02516	0.567
MOD_N-GLC_1	637	642	PF02516	0.339
MOD_N-GLC_1	827	832	PF02516	0.280
MOD_N-GLC_1	844	849	PF02516	0.339
MOD_N-GLC_1	867	872	PF02516	0.339
MOD_N-GLC_1	883	888	PF02516	0.339
MOD_N-GLC_1	91	96	PF02516	0.764
MOD_NEK2_1	143	148	PF00069	0.783
MOD_NEK2_1	207	212	PF00069	0.534
MOD_NEK2_1	401	406	PF00069	0.487
MOD_NEK2_1	471	476	PF00069	0.643
MOD_NEK2_1	477	482	PF00069	0.663
MOD_NEK2_1	486	491	PF00069	0.674
MOD_NEK2_1	597	602	PF00069	0.564
MOD_NEK2_1	647	652	PF00069	0.466
MOD_NEK2_1	736	741	PF00069	0.352
MOD_NEK2_1	751	756	PF00069	0.348
MOD_NEK2_1	772	777	PF00069	0.249
MOD_NEK2_1	817	822	PF00069	0.499
MOD_NEK2_1	839	844	PF00069	0.352
MOD_NEK2_1	927	932	PF00069	0.339
MOD_NEK2_2	835	840	PF00069	0.339
MOD_PIKK_1	100	106	PF00454	0.582
MOD_PIKK_1	233	239	PF00454	0.492
MOD_PIKK_1	298	304	PF00454	0.523
MOD_PIKK_1	307	313	PF00454	0.437
MOD_PIKK_1	69	75	PF00454	0.604
MOD_PKA_2	114	120	PF00069	0.633
MOD_PKA_2	296	302	PF00069	0.573
MOD_PKA_2	521	527	PF00069	0.662
MOD_PKA_2	56	62	PF00069	0.603
MOD_PKA_2	818	824	PF00069	0.341
MOD_PKB_1	161	169	PF00069	0.578
MOD_PKB_1	351	359	PF00069	0.410
MOD_Plk_1	261	267	PF00069	0.386
MOD_Plk_1	336	342	PF00069	0.555
MOD_Plk_1	353	359	PF00069	0.469
MOD_Plk_1	424	430	PF00069	0.630
MOD_Plk_1	454	460	PF00069	0.584
MOD_Plk_1	477	483	PF00069	0.516
MOD_Plk_1	77	83	PF00069	0.618
MOD_Plk_1	789	795	PF00069	0.339
MOD_Plk_1	883	889	PF00069	0.339
MOD_Plk_2-3	381	387	PF00069	0.580
MOD_Plk_2-3	393	399	PF00069	0.402
MOD_Plk_2-3	56	62	PF00069	0.568
MOD_Plk_2-3	649	655	PF00069	0.339
MOD_Plk_2-3	730	736	PF00069	0.323
MOD_Plk_4	526	532	PF00069	0.748
MOD_Plk_4	716	722	PF00069	0.339
MOD_Plk_4	736	742	PF00069	0.183
MOD_Plk_4	908	914	PF00069	0.339
MOD_Plk_4	951	957	PF00069	0.438
MOD_ProDKin_1	108	114	PF00069	0.575
MOD_ProDKin_1	148	154	PF00069	0.722
MOD_ProDKin_1	191	197	PF00069	0.652
MOD_ProDKin_1	25	31	PF00069	0.668
MOD_ProDKin_1	36	42	PF00069	0.730
MOD_ProDKin_1	506	512	PF00069	0.639
MOD_ProDKin_1	592	598	PF00069	0.542
MOD_ProDKin_1	710	716	PF00069	0.391
MOD_SUMO_rev_2	249	257	PF00179	0.451
MOD_SUMO_rev_2	360	366	PF00179	0.531
MOD_SUMO_rev_2	396	404	PF00179	0.462
TRG_DiLeu_BaEn_1	362	367	PF01217	0.459
TRG_DiLeu_BaEn_3	608	614	PF01217	0.530
TRG_DiLeu_BaLyEn_6	593	598	PF01217	0.751
TRG_ENDOCYTIC_2	268	271	PF00928	0.475
TRG_ENDOCYTIC_2	408	411	PF00928	0.537
TRG_ENDOCYTIC_2	653	656	PF00928	0.339
TRG_ENDOCYTIC_2	667	670	PF00928	0.339
TRG_ENDOCYTIC_2	744	747	PF00928	0.339
TRG_ENDOCYTIC_2	782	785	PF00928	0.339
TRG_ER_diArg_1	112	115	PF00400	0.555
TRG_ER_diArg_1	130	132	PF00400	0.770
TRG_ER_diArg_1	152	154	PF00400	0.587
TRG_ER_diArg_1	275	278	PF00400	0.469
TRG_ER_diArg_1	46	49	PF00400	0.607
TRG_ER_diArg_1	703	706	PF00400	0.383
TRG_ER_diArg_1	848	851	PF00400	0.466
TRG_ER_diArg_1	85	87	PF00400	0.595
TRG_Pf-PMV_PEXEL_1	749	753	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	885	889	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAP4	Leptomonas seymouri	52%	100%
A0A3Q8IDV2	Leishmania donovani	78%	100%
A4I3R1	Leishmania infantum	77%	100%
E9B004	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q881	Leishmania major	80%	99%