Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HGN4_LEIBR

TriTrypDb:

LbrM.28.1980 , LBRM2903_280026100

Length:

145

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGN4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.538
CLV_PCSK_KEX2_1	28	30	PF00082	0.538
DEG_SPOP_SBC_1	60	64	PF00917	0.492
DOC_MAPK_MEF2A_6	70	78	PF00069	0.321
DOC_USP7_MATH_1	106	110	PF00917	0.496
DOC_USP7_MATH_1	11	15	PF00917	0.618
DOC_USP7_MATH_1	18	22	PF00917	0.530
DOC_USP7_MATH_1	60	64	PF00917	0.711
DOC_USP7_MATH_1	86	90	PF00917	0.514
DOC_USP7_MATH_2	59	65	PF00917	0.689
DOC_USP7_UBL2_3	135	139	PF12436	0.417
LIG_14-3-3_CanoR_1	17	25	PF00244	0.691
LIG_LIR_Gen_1	102	110	PF02991	0.494
LIG_LIR_Nem_3	102	107	PF02991	0.428
LIG_Pex14_2	133	137	PF04695	0.356
LIG_SH2_STAT5	132	135	PF00017	0.349
LIG_SH2_STAT5	31	34	PF00017	0.585
MOD_CK2_1	106	112	PF00069	0.513
MOD_GlcNHglycan	12	16	PF01048	0.683
MOD_GlcNHglycan	55	58	PF01048	0.650
MOD_GlcNHglycan	63	66	PF01048	0.629
MOD_GlcNHglycan	7	10	PF01048	0.632
MOD_GlcNHglycan	71	74	PF01048	0.507
MOD_GlcNHglycan	88	91	PF01048	0.591
MOD_GSK3_1	1	8	PF00069	0.726
MOD_N-GLC_1	5	10	PF02516	0.607
MOD_NEK2_1	1	6	PF00069	0.636
MOD_NEK2_1	32	37	PF00069	0.462
MOD_NEK2_1	39	44	PF00069	0.472
MOD_NEK2_2	18	23	PF00069	0.482
MOD_PKA_2	16	22	PF00069	0.662
MOD_PKA_2	69	75	PF00069	0.353
MOD_Plk_4	121	127	PF00069	0.438
MOD_SUMO_rev_2	113	123	PF00179	0.404
TRG_ER_diArg_1	28	30	PF00400	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM51	Leptomonas seymouri	59%	81%
A0A0S4JEB4	Bodo saltans	50%	84%
A0A3Q8ID67	Leishmania donovani	79%	82%
A0A3R7M7X7	Trypanosoma rangeli	53%	72%
A4I3Q7	Leishmania infantum	80%	100%
E9B000	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q885	Leishmania major	79%	99%