ATPase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

ATPase-like protein

Gene product:

ATPase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HGN2_LEIBR

TriTrypDb:

LbrM.28.1960 , LBRM2903_280025900

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005694	chromosome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HGN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGN2

Function

Biological processes
Term	Name	Level	Count
GO:0007049	cell cycle	2	6
GO:0009987	cellular process	1	7
GO:0022414	reproductive process	1	7
GO:0051321	meiotic cell cycle	2	6
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007131	reciprocal meiotic recombination	3	1
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010639	negative regulation of organelle organization	6	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0022402	cell cycle process	2	1
GO:0033043	regulation of organelle organization	5	1
GO:0033313	meiotic cell cycle checkpoint signaling	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035556	intracellular signal transduction	3	1
GO:0035825	homologous recombination	6	1
GO:0040020	regulation of meiotic nuclear division	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045835	negative regulation of meiotic nuclear division	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051129	negative regulation of cellular component organization	5	1
GO:0051445	regulation of meiotic cell cycle	4	1
GO:0051447	negative regulation of meiotic cell cycle	5	1
GO:0051598	meiotic recombination checkpoint signaling	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0051783	regulation of nuclear division	6	1
GO:0051784	negative regulation of nuclear division	7	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1903046	meiotic cell cycle process	2	1
GO:2000241	regulation of reproductive process	3	1
GO:2000242	negative regulation of reproductive process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0016887	ATP hydrolysis activity	7	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.490
CLV_NRD_NRD_1	52	54	PF00675	0.463
CLV_PCSK_KEX2_1	185	187	PF00082	0.384
CLV_PCSK_KEX2_1	267	269	PF00082	0.399
CLV_PCSK_KEX2_1	355	357	PF00082	0.369
CLV_PCSK_KEX2_1	52	54	PF00082	0.463
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.384
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.399
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.369
CLV_PCSK_SKI1_1	212	216	PF00082	0.309
CLV_PCSK_SKI1_1	267	271	PF00082	0.369
CLV_PCSK_SKI1_1	513	517	PF00082	0.384
CLV_PCSK_SKI1_1	52	56	PF00082	0.439
DEG_APCC_DBOX_1	245	253	PF00400	0.369
DEG_APCC_DBOX_1	557	565	PF00400	0.462
DOC_ANK_TNKS_1	411	418	PF00023	0.564
DOC_CDC14_PxL_1	515	523	PF14671	0.365
DOC_CDC14_PxL_1	70	78	PF14671	0.468
DOC_CYCLIN_RxL_1	364	374	PF00134	0.383
DOC_MAPK_gen_1	16	26	PF00069	0.339
DOC_MAPK_MEF2A_6	19	26	PF00069	0.441
DOC_MAPK_MEF2A_6	78	86	PF00069	0.296
DOC_PP1_RVXF_1	210	217	PF00149	0.419
DOC_PP4_FxxP_1	216	219	PF00568	0.369
DOC_PP4_FxxP_1	457	460	PF00568	0.611
DOC_SPAK_OSR1_1	367	371	PF12202	0.346
DOC_USP7_MATH_1	123	127	PF00917	0.606
DOC_USP7_MATH_1	129	133	PF00917	0.711
DOC_USP7_MATH_1	161	165	PF00917	0.416
DOC_USP7_MATH_1	300	304	PF00917	0.399
DOC_USP7_MATH_1	310	314	PF00917	0.369
DOC_USP7_MATH_1	389	393	PF00917	0.675
DOC_USP7_MATH_1	579	583	PF00917	0.411
DOC_WW_Pin1_4	116	121	PF00397	0.432
DOC_WW_Pin1_4	124	129	PF00397	0.443
DOC_WW_Pin1_4	155	160	PF00397	0.465
DOC_WW_Pin1_4	201	206	PF00397	0.393
DOC_WW_Pin1_4	464	469	PF00397	0.621
DOC_WW_Pin1_4	6	11	PF00397	0.662
LIG_14-3-3_CanoR_1	238	244	PF00244	0.399
LIG_14-3-3_CanoR_1	260	269	PF00244	0.309
LIG_14-3-3_CanoR_1	27	35	PF00244	0.475
LIG_14-3-3_CanoR_1	4	13	PF00244	0.659
LIG_14-3-3_CanoR_1	52	61	PF00244	0.345
LIG_BIR_III_2	72	76	PF00653	0.500
LIG_BRCT_BRCA1_1	180	184	PF00533	0.437
LIG_BRCT_BRCA1_1	258	262	PF00533	0.309
LIG_BRCT_BRCA1_1	453	457	PF00533	0.665
LIG_BRCT_BRCA1_2	453	459	PF00533	0.612
LIG_Clathr_ClatBox_1	21	25	PF01394	0.415
LIG_EH1_1	493	501	PF00400	0.479
LIG_eIF4E_1	244	250	PF01652	0.369
LIG_eIF4E_1	494	500	PF01652	0.468
LIG_FHA_1	336	342	PF00498	0.331
LIG_FHA_1	345	351	PF00498	0.343
LIG_FHA_1	389	395	PF00498	0.740
LIG_FHA_1	65	71	PF00498	0.476
LIG_FHA_2	26	32	PF00498	0.458
LIG_FHA_2	320	326	PF00498	0.309
LIG_FHA_2	96	102	PF00498	0.460
LIG_GBD_Chelix_1	231	239	PF00786	0.369
LIG_Integrin_isoDGR_2	511	513	PF01839	0.447
LIG_LIR_Apic_2	454	460	PF02991	0.608
LIG_LIR_Gen_1	166	174	PF02991	0.382
LIG_LIR_Gen_1	17	26	PF02991	0.435
LIG_LIR_Gen_1	271	280	PF02991	0.224
LIG_LIR_Gen_1	44	50	PF02991	0.494
LIG_LIR_Gen_1	96	105	PF02991	0.412
LIG_LIR_Nem_3	166	172	PF02991	0.387
LIG_LIR_Nem_3	17	23	PF02991	0.475
LIG_LIR_Nem_3	271	276	PF02991	0.224
LIG_LIR_Nem_3	32	38	PF02991	0.470
LIG_LIR_Nem_3	421	425	PF02991	0.591
LIG_LIR_Nem_3	44	48	PF02991	0.427
LIG_LIR_Nem_3	96	100	PF02991	0.332
LIG_Pex14_2	258	262	PF04695	0.309
LIG_SH2_CRK	372	376	PF00017	0.460
LIG_SH2_NCK_1	372	376	PF00017	0.406
LIG_SH2_PTP2	45	48	PF00017	0.430
LIG_SH2_SRC	560	563	PF00017	0.455
LIG_SH2_STAT5	191	194	PF00017	0.419
LIG_SH2_STAT5	20	23	PF00017	0.439
LIG_SH2_STAT5	45	48	PF00017	0.430
LIG_SH2_STAT5	494	497	PF00017	0.481
LIG_SH2_STAT5	560	563	PF00017	0.455
LIG_SH3_3	356	362	PF00018	0.399
LIG_SH3_3	381	387	PF00018	0.499
LIG_SH3_3	392	398	PF00018	0.620
LIG_SH3_3	471	477	PF00018	0.737
LIG_SH3_3	548	554	PF00018	0.525
LIG_SH3_3	58	64	PF00018	0.473
LIG_SH3_3	7	13	PF00018	0.649
LIG_SH3_3	86	92	PF00018	0.396
LIG_SH3_5	556	560	PF00018	0.487
LIG_SUMO_SIM_par_1	20	25	PF11976	0.431
LIG_SUMO_SIM_par_1	268	274	PF11976	0.224
LIG_SUMO_SIM_par_1	332	339	PF11976	0.368
LIG_SUMO_SIM_par_1	66	72	PF11976	0.469
LIG_TRAF2_1	374	377	PF00917	0.349
LIG_TRAF2_1	567	570	PF00917	0.346
LIG_TRFH_1	155	159	PF08558	0.328
LIG_TYR_ITIM	370	375	PF00017	0.354
LIG_WRC_WIRS_1	527	532	PF05994	0.378
MOD_CDK_SPxxK_3	9	16	PF00069	0.472
MOD_CK1_1	153	159	PF00069	0.450
MOD_CK1_1	256	262	PF00069	0.309
MOD_CK1_1	424	430	PF00069	0.595
MOD_CK1_1	467	473	PF00069	0.719
MOD_CK1_1	529	535	PF00069	0.690
MOD_CK1_1	9	15	PF00069	0.576
MOD_CK2_1	371	377	PF00069	0.433
MOD_CK2_1	95	101	PF00069	0.461
MOD_Cter_Amidation	265	268	PF01082	0.399
MOD_GlcNHglycan	121	124	PF01048	0.608
MOD_GlcNHglycan	16	19	PF01048	0.411
MOD_GlcNHglycan	264	267	PF01048	0.309
MOD_GlcNHglycan	302	305	PF01048	0.323
MOD_GlcNHglycan	401	404	PF01048	0.707
MOD_GlcNHglycan	474	477	PF01048	0.752
MOD_GlcNHglycan	489	492	PF01048	0.636
MOD_GlcNHglycan	533	536	PF01048	0.617
MOD_GlcNHglycan	540	543	PF01048	0.679
MOD_GlcNHglycan	547	550	PF01048	0.751
MOD_GlcNHglycan	6	9	PF01048	0.618
MOD_GSK3_1	119	126	PF00069	0.618
MOD_GSK3_1	149	156	PF00069	0.579
MOD_GSK3_1	174	181	PF00069	0.431
MOD_GSK3_1	187	194	PF00069	0.314
MOD_GSK3_1	219	226	PF00069	0.269
MOD_GSK3_1	25	32	PF00069	0.402
MOD_GSK3_1	256	263	PF00069	0.324
MOD_GSK3_1	335	342	PF00069	0.353
MOD_GSK3_1	37	44	PF00069	0.344
MOD_GSK3_1	447	454	PF00069	0.577
MOD_GSK3_1	466	473	PF00069	0.737
MOD_GSK3_1	48	55	PF00069	0.332
MOD_GSK3_1	526	533	PF00069	0.462
MOD_N-GLC_1	150	155	PF02516	0.430
MOD_N-GLC_1	339	344	PF02516	0.309
MOD_N-GLC_1	447	452	PF02516	0.561
MOD_N-GLC_1	545	550	PF02516	0.490
MOD_NEK2_1	239	244	PF00069	0.369
MOD_NEK2_1	262	267	PF00069	0.309
MOD_NEK2_1	3	8	PF00069	0.559
MOD_NEK2_1	336	341	PF00069	0.313
MOD_NEK2_1	371	376	PF00069	0.405
MOD_NEK2_1	41	46	PF00069	0.429
MOD_NEK2_1	530	535	PF00069	0.594
MOD_NEK2_2	310	315	PF00069	0.369
MOD_PIKK_1	319	325	PF00454	0.309
MOD_PKA_1	52	58	PF00069	0.347
MOD_PKA_2	26	32	PF00069	0.458
MOD_PKA_2	3	9	PF00069	0.797
MOD_PKA_2	300	306	PF00069	0.318
MOD_PKA_2	452	458	PF00069	0.541
MOD_PKA_2	52	58	PF00069	0.347
MOD_Plk_1	150	156	PF00069	0.420
MOD_Plk_1	36	42	PF00069	0.450
MOD_Plk_1	87	93	PF00069	0.480
MOD_Plk_2-3	187	193	PF00069	0.420
MOD_Plk_4	187	193	PF00069	0.495
MOD_Plk_4	239	245	PF00069	0.411
MOD_Plk_4	253	259	PF00069	0.228
MOD_Plk_4	37	43	PF00069	0.331
MOD_Plk_4	389	395	PF00069	0.618
MOD_Plk_4	495	501	PF00069	0.402
MOD_ProDKin_1	116	122	PF00069	0.433
MOD_ProDKin_1	124	130	PF00069	0.435
MOD_ProDKin_1	155	161	PF00069	0.460
MOD_ProDKin_1	201	207	PF00069	0.396
MOD_ProDKin_1	464	470	PF00069	0.620
MOD_ProDKin_1	6	12	PF00069	0.654
MOD_SUMO_rev_2	9	18	PF00179	0.464
TRG_DiLeu_BaEn_1	37	42	PF01217	0.465
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.489
TRG_ENDOCYTIC_2	20	23	PF00928	0.466
TRG_ENDOCYTIC_2	372	375	PF00928	0.456
TRG_ENDOCYTIC_2	422	425	PF00928	0.526
TRG_ENDOCYTIC_2	45	48	PF00928	0.430
TRG_ER_diArg_1	52	54	PF00400	0.417
TRG_NES_CRM1_1	37	49	PF08389	0.461
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.224

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P830	Leptomonas seymouri	55%	100%
A0A3Q8IEP0	Leishmania donovani	80%	100%
E9AHG7	Leishmania infantum	80%	100%
E9AZZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q887	Leishmania major	82%	100%
V5BAN2	Trypanosoma cruzi	45%	96%