DNA topoisomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA topoisomerase

Gene product:

DNA topoisomerase III, putative

Species:

Leishmania braziliensis

UniProt:

A4HGN1_LEIBR

TriTrypDb:

LbrM.28.1950 , LBRM2903_280025800

Length:

866

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Previous1Next

Expansion

Sequence features

A4HGN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGN1

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006265	DNA topological change	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12

Previous1 2 3Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003916	DNA topoisomerase activity	3	12
GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	4	12
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12

Previous1 2Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.177
CLV_C14_Caspase3-7	737	741	PF00656	0.429
CLV_MEL_PAP_1	827	833	PF00089	0.458
CLV_NRD_NRD_1	129	131	PF00675	0.248
CLV_NRD_NRD_1	29	31	PF00675	0.289
CLV_NRD_NRD_1	805	807	PF00675	0.413
CLV_NRD_NRD_1	835	837	PF00675	0.548
CLV_PCSK_KEX2_1	129	131	PF00082	0.234
CLV_PCSK_KEX2_1	29	31	PF00082	0.234
CLV_PCSK_KEX2_1	835	837	PF00082	0.522

Previous1 2 3 4 5…26Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0L0P6P7	Candida auris	34%	100%
A0A0N1I0P1	Leptomonas seymouri	86%	100%
A0A0N1PAL1	Leptomonas seymouri	35%	90%
A0A0S4J933	Bodo saltans	67%	99%
A0A0S4JI21	Bodo saltans	32%	89%
A0A1X0NSK9	Trypanosomatidae	73%	100%
A0A1X0P3I0	Trypanosomatidae	35%	93%
A0A3R7KDV1	Trypanosoma rangeli	32%	94%
A0A3S7WW83	Leishmania donovani	23%	100%
A0A3S7X1K1	Leishmania donovani	92%	100%

Previous1 2 3 4 5…10Next