Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania braziliensis

UniProt:

A4HGN0_LEIBR

TriTrypDb:

LbrM.28.1940 , LBRM2903_280025700

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGN0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.228
CLV_NRD_NRD_1	64	66	PF00675	0.433
DEG_SCF_FBW7_2	81	87	PF00400	0.415
DOC_CKS1_1	81	86	PF01111	0.576
DOC_PP2B_LxvP_1	96	99	PF13499	0.544
DOC_USP7_MATH_1	148	152	PF00917	0.538
DOC_USP7_MATH_1	189	193	PF00917	0.632
DOC_USP7_MATH_1	212	216	PF00917	0.644
DOC_USP7_MATH_2	296	302	PF00917	0.526
DOC_USP7_UBL2_3	62	66	PF12436	0.320
DOC_WW_Pin1_4	100	105	PF00397	0.719
DOC_WW_Pin1_4	128	133	PF00397	0.615
DOC_WW_Pin1_4	233	238	PF00397	0.631
DOC_WW_Pin1_4	300	305	PF00397	0.601
DOC_WW_Pin1_4	80	85	PF00397	0.548
LIG_BRCT_BRCA1_1	18	22	PF00533	0.235
LIG_deltaCOP1_diTrp_1	14	22	PF00928	0.235
LIG_deltaCOP1_diTrp_1	201	209	PF00928	0.588
LIG_FHA_1	140	146	PF00498	0.534
LIG_FHA_1	91	97	PF00498	0.737
LIG_FHA_2	257	263	PF00498	0.505
LIG_FHA_2	51	57	PF00498	0.235
LIG_FHA_2	81	87	PF00498	0.500
LIG_FHA_2	9	15	PF00498	0.228
LIG_LIR_Apic_2	122	128	PF02991	0.626
LIG_LIR_Apic_2	37	41	PF02991	0.307
LIG_LIR_Gen_1	273	283	PF02991	0.517
LIG_LIR_Gen_1	72	81	PF02991	0.319
LIG_LIR_Nem_3	72	76	PF02991	0.319
LIG_PCNA_PIPBox_1	149	158	PF02747	0.475
LIG_Pex14_2	205	209	PF04695	0.592
LIG_Pex14_2	73	77	PF04695	0.317
LIG_Rb_pABgroove_1	261	269	PF01858	0.474
LIG_SH2_NCK_1	38	42	PF00017	0.307
LIG_SH2_STAP1	36	40	PF00017	0.320
LIG_SH2_STAP1	63	67	PF00017	0.422
LIG_SH3_3	126	132	PF00018	0.634
LIG_SH3_3	158	164	PF00018	0.501
LIG_SH3_3	231	237	PF00018	0.555
LIG_SUMO_SIM_par_1	262	269	PF11976	0.476
LIG_TRAF2_1	84	87	PF00917	0.455
MOD_CDC14_SPxK_1	303	306	PF00782	0.532
MOD_CDK_SPxK_1	300	306	PF00069	0.528
MOD_CK1_1	130	136	PF00069	0.607
MOD_CK1_1	197	203	PF00069	0.569
MOD_CK1_1	238	244	PF00069	0.640
MOD_CK1_1	254	260	PF00069	0.454
MOD_CK2_1	148	154	PF00069	0.503
MOD_CK2_1	256	262	PF00069	0.468
MOD_CK2_1	50	56	PF00069	0.294
MOD_CK2_1	58	64	PF00069	0.346
MOD_CK2_1	69	75	PF00069	0.415
MOD_CK2_1	80	86	PF00069	0.445
MOD_GlcNHglycan	196	199	PF01048	0.695
MOD_GlcNHglycan	220	223	PF01048	0.649
MOD_GlcNHglycan	268	271	PF01048	0.538
MOD_GSK3_1	127	134	PF00069	0.717
MOD_GSK3_1	150	157	PF00069	0.509
MOD_GSK3_1	162	169	PF00069	0.583
MOD_GSK3_1	235	242	PF00069	0.798
MOD_GSK3_1	249	256	PF00069	0.609
MOD_GSK3_1	262	269	PF00069	0.561
MOD_GSK3_1	3	10	PF00069	0.320
MOD_GSK3_1	46	53	PF00069	0.307
MOD_N-GLC_1	238	243	PF02516	0.567
MOD_NEK2_1	251	256	PF00069	0.497
MOD_NEK2_1	266	271	PF00069	0.583
MOD_NEK2_1	279	284	PF00069	0.640
MOD_NMyristoyl	1	7	PF02799	0.410
MOD_PIKK_1	139	145	PF00454	0.679
MOD_PKA_2	178	184	PF00069	0.530
MOD_PKA_2	44	50	PF00069	0.323
MOD_Plk_2-3	262	268	PF00069	0.473
MOD_Plk_4	16	22	PF00069	0.348
MOD_Plk_4	166	172	PF00069	0.595
MOD_Plk_4	212	218	PF00069	0.712
MOD_Plk_4	262	268	PF00069	0.558
MOD_Plk_4	50	56	PF00069	0.228
MOD_ProDKin_1	100	106	PF00069	0.718
MOD_ProDKin_1	128	134	PF00069	0.618
MOD_ProDKin_1	233	239	PF00069	0.632
MOD_ProDKin_1	300	306	PF00069	0.607
MOD_ProDKin_1	80	86	PF00069	0.562
MOD_SUMO_rev_2	61	67	PF00179	0.410
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.320
TRG_ENDOCYTIC_2	276	279	PF00928	0.528
TRG_ER_diArg_1	31	34	PF00400	0.319
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT1	Leptomonas seymouri	45%	76%
A0A3S7X1K9	Leishmania donovani	61%	100%
A4I3Q4	Leishmania infantum	62%	100%
E9AZZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
Q4Q889	Leishmania major	59%	100%