DUF115 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGM8_LEIBR

TriTrypDb:

LbrM.28.1920 , LBRM2903_280025500

Length:

935

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.730
CLV_C14_Caspase3-7	508	512	PF00656	0.539
CLV_C14_Caspase3-7	62	66	PF00656	0.544
CLV_NRD_NRD_1	111	113	PF00675	0.772
CLV_NRD_NRD_1	149	151	PF00675	0.595
CLV_NRD_NRD_1	206	208	PF00675	0.801
CLV_NRD_NRD_1	30	32	PF00675	0.576
CLV_NRD_NRD_1	404	406	PF00675	0.564
CLV_NRD_NRD_1	416	418	PF00675	0.513
CLV_NRD_NRD_1	577	579	PF00675	0.661
CLV_NRD_NRD_1	617	619	PF00675	0.661
CLV_NRD_NRD_1	634	636	PF00675	0.409
CLV_NRD_NRD_1	736	738	PF00675	0.493
CLV_NRD_NRD_1	85	87	PF00675	0.684
CLV_NRD_NRD_1	896	898	PF00675	0.667
CLV_PCSK_FUR_1	615	619	PF00082	0.562
CLV_PCSK_FUR_1	632	636	PF00082	0.424
CLV_PCSK_KEX2_1	111	113	PF00082	0.566
CLV_PCSK_KEX2_1	149	151	PF00082	0.595
CLV_PCSK_KEX2_1	30	32	PF00082	0.544
CLV_PCSK_KEX2_1	404	406	PF00082	0.564
CLV_PCSK_KEX2_1	418	420	PF00082	0.503
CLV_PCSK_KEX2_1	534	536	PF00082	0.604
CLV_PCSK_KEX2_1	576	578	PF00082	0.558
CLV_PCSK_KEX2_1	617	619	PF00082	0.650
CLV_PCSK_KEX2_1	634	636	PF00082	0.409
CLV_PCSK_KEX2_1	691	693	PF00082	0.595
CLV_PCSK_KEX2_1	736	738	PF00082	0.459
CLV_PCSK_KEX2_1	814	816	PF00082	0.698
CLV_PCSK_KEX2_1	83	85	PF00082	0.699
CLV_PCSK_KEX2_1	896	898	PF00082	0.667
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.561
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.608
CLV_PCSK_PC1ET2_1	691	693	PF00082	0.595
CLV_PCSK_PC1ET2_1	814	816	PF00082	0.698
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.699
CLV_PCSK_SKI1_1	150	154	PF00082	0.471
CLV_PCSK_SKI1_1	208	212	PF00082	0.647
CLV_PCSK_SKI1_1	431	435	PF00082	0.599
CLV_PCSK_SKI1_1	578	582	PF00082	0.742
CLV_PCSK_SKI1_1	692	696	PF00082	0.631
CLV_PCSK_SKI1_1	736	740	PF00082	0.352
CLV_PCSK_SKI1_1	897	901	PF00082	0.524
DEG_APCC_DBOX_1	231	239	PF00400	0.590
DEG_APCC_DBOX_1	513	521	PF00400	0.513
DEG_APCC_DBOX_1	816	824	PF00400	0.427
DEG_SPOP_SBC_1	132	136	PF00917	0.563
DEG_SPOP_SBC_1	294	298	PF00917	0.525
DEG_SPOP_SBC_1	655	659	PF00917	0.707
DEG_SPOP_SBC_1	866	870	PF00917	0.625
DEG_SPOP_SBC_1	914	918	PF00917	0.735
DOC_ANK_TNKS_1	45	52	PF00023	0.531
DOC_CKS1_1	61	66	PF01111	0.546
DOC_CKS1_1	675	680	PF01111	0.594
DOC_CKS1_1	685	690	PF01111	0.524
DOC_CKS1_1	898	903	PF01111	0.543
DOC_CYCLIN_RxL_1	829	840	PF00134	0.474
DOC_CYCLIN_yClb3_PxF_3	233	239	PF00134	0.551
DOC_MAPK_gen_1	632	640	PF00069	0.488
DOC_MAPK_gen_1	736	746	PF00069	0.433
DOC_MAPK_RevD_3	562	578	PF00069	0.482
DOC_PP2B_LxvP_1	599	602	PF13499	0.763
DOC_USP7_MATH_1	110	114	PF00917	0.686
DOC_USP7_MATH_1	131	135	PF00917	0.559
DOC_USP7_MATH_1	188	192	PF00917	0.510
DOC_USP7_MATH_1	270	274	PF00917	0.641
DOC_USP7_MATH_1	285	289	PF00917	0.695
DOC_USP7_MATH_1	294	298	PF00917	0.603
DOC_USP7_MATH_1	519	523	PF00917	0.774
DOC_USP7_MATH_1	529	533	PF00917	0.650
DOC_USP7_MATH_1	551	555	PF00917	0.801
DOC_USP7_MATH_1	558	562	PF00917	0.647
DOC_USP7_MATH_1	655	659	PF00917	0.685
DOC_USP7_MATH_1	678	682	PF00917	0.709
DOC_USP7_MATH_1	71	75	PF00917	0.692
DOC_USP7_MATH_1	801	805	PF00917	0.587
DOC_USP7_MATH_1	837	841	PF00917	0.704
DOC_USP7_MATH_1	854	858	PF00917	0.739
DOC_USP7_MATH_1	866	870	PF00917	0.602
DOC_USP7_MATH_1	9	13	PF00917	0.544
DOC_USP7_MATH_1	905	909	PF00917	0.544
DOC_USP7_UBL2_3	83	87	PF12436	0.547
DOC_WW_Pin1_4	233	238	PF00397	0.551
DOC_WW_Pin1_4	272	277	PF00397	0.696
DOC_WW_Pin1_4	419	424	PF00397	0.662
DOC_WW_Pin1_4	432	437	PF00397	0.683
DOC_WW_Pin1_4	578	583	PF00397	0.769
DOC_WW_Pin1_4	60	65	PF00397	0.731
DOC_WW_Pin1_4	651	656	PF00397	0.667
DOC_WW_Pin1_4	669	674	PF00397	0.838
DOC_WW_Pin1_4	684	689	PF00397	0.590
DOC_WW_Pin1_4	702	707	PF00397	0.612
DOC_WW_Pin1_4	862	867	PF00397	0.639
DOC_WW_Pin1_4	879	884	PF00397	0.593
DOC_WW_Pin1_4	897	902	PF00397	0.480
LIG_14-3-3_CanoR_1	149	159	PF00244	0.666
LIG_14-3-3_CanoR_1	317	322	PF00244	0.542
LIG_14-3-3_CanoR_1	535	541	PF00244	0.744
LIG_14-3-3_CanoR_1	557	563	PF00244	0.732
LIG_14-3-3_CanoR_1	576	585	PF00244	0.673
LIG_14-3-3_CanoR_1	615	623	PF00244	0.733
LIG_14-3-3_CanoR_1	800	809	PF00244	0.746
LIG_14-3-3_CanoR_1	815	821	PF00244	0.475
LIG_14-3-3_CanoR_1	907	913	PF00244	0.685
LIG_Actin_WH2_2	726	741	PF00022	0.482
LIG_Actin_WH2_2	819	837	PF00022	0.440
LIG_BRCT_BRCA1_1	235	239	PF00533	0.582
LIG_BRCT_BRCA1_1	709	713	PF00533	0.492
LIG_BRCT_BRCA1_1	867	871	PF00533	0.520
LIG_FHA_1	102	108	PF00498	0.759
LIG_FHA_1	258	264	PF00498	0.686
LIG_FHA_1	311	317	PF00498	0.566
LIG_FHA_1	396	402	PF00498	0.836
LIG_FHA_1	408	414	PF00498	0.593
LIG_FHA_1	422	428	PF00498	0.549
LIG_FHA_1	448	454	PF00498	0.544
LIG_FHA_1	480	486	PF00498	0.398
LIG_FHA_1	535	541	PF00498	0.573
LIG_FHA_1	557	563	PF00498	0.526
LIG_FHA_1	579	585	PF00498	0.525
LIG_FHA_1	622	628	PF00498	0.750
LIG_FHA_1	776	782	PF00498	0.531
LIG_FHA_1	862	868	PF00498	0.550
LIG_FHA_1	872	878	PF00498	0.555
LIG_FHA_1	898	904	PF00498	0.532
LIG_FHA_2	11	17	PF00498	0.564
LIG_FHA_2	133	139	PF00498	0.593
LIG_FHA_2	347	353	PF00498	0.553
LIG_FHA_2	454	460	PF00498	0.638
LIG_FHA_2	787	793	PF00498	0.463
LIG_FHA_2	808	814	PF00498	0.481
LIG_GBD_Chelix_1	826	834	PF00786	0.637
LIG_GBD_Chelix_1	89	97	PF00786	0.647
LIG_LIR_Gen_1	375	381	PF02991	0.667
LIG_LIR_Gen_1	4	15	PF02991	0.730
LIG_LIR_Gen_1	636	645	PF02991	0.600
LIG_LIR_Gen_1	707	717	PF02991	0.481
LIG_LIR_Nem_3	21	25	PF02991	0.622
LIG_LIR_Nem_3	271	277	PF02991	0.549
LIG_LIR_Nem_3	375	379	PF02991	0.582
LIG_LIR_Nem_3	4	10	PF02991	0.639
LIG_LIR_Nem_3	42	48	PF02991	0.711
LIG_LIR_Nem_3	636	640	PF02991	0.624
LIG_LIR_Nem_3	643	648	PF02991	0.562
LIG_LIR_Nem_3	707	712	PF02991	0.417
LIG_LIR_Nem_3	760	764	PF02991	0.404
LIG_LRP6_Inhibitor_1	14	20	PF00058	0.453
LIG_MYND_1	233	237	PF01753	0.550
LIG_MYND_3	751	755	PF01753	0.401
LIG_Pex14_1	931	935	PF04695	0.658
LIG_Pex14_2	887	891	PF04695	0.642
LIG_SH2_CRK	25	29	PF00017	0.613
LIG_SH2_CRK	645	649	PF00017	0.576
LIG_SH2_CRK	709	713	PF00017	0.492
LIG_SH2_NCK_1	709	713	PF00017	0.492
LIG_SH2_PTP2	167	170	PF00017	0.535
LIG_SH2_SRC	499	502	PF00017	0.480
LIG_SH2_STAP1	709	713	PF00017	0.447
LIG_SH2_STAT5	144	147	PF00017	0.702
LIG_SH2_STAT5	167	170	PF00017	0.507
LIG_SH2_STAT5	22	25	PF00017	0.618
LIG_SH2_STAT5	43	46	PF00017	0.668
LIG_SH2_STAT5	637	640	PF00017	0.612
LIG_SH2_STAT5	647	650	PF00017	0.588
LIG_SH3_3	225	231	PF00018	0.564
LIG_SH3_3	430	436	PF00018	0.560
LIG_SH3_3	58	64	PF00018	0.554
LIG_SH3_3	601	607	PF00018	0.588
LIG_SH3_3	664	670	PF00018	0.845
LIG_SH3_3	682	688	PF00018	0.592
LIG_SH3_3	895	901	PF00018	0.746
LIG_Sin3_3	361	368	PF02671	0.654
LIG_Sin3_3	430	437	PF02671	0.559
LIG_SUMO_SIM_anti_2	459	465	PF11976	0.500
LIG_SUMO_SIM_par_1	173	179	PF11976	0.529
LIG_SUMO_SIM_par_1	486	491	PF11976	0.538
LIG_TRAF2_1	440	443	PF00917	0.552
LIG_TRAF2_1	541	544	PF00917	0.636
LIG_TRAF2_1	909	912	PF00917	0.545
LIG_TYR_ITSM	705	712	PF00017	0.388
MOD_CDK_SPxK_1	674	680	PF00069	0.594
MOD_CDK_SPxxK_3	684	691	PF00069	0.590
MOD_CDK_SPxxK_3	897	904	PF00069	0.542
MOD_CK1_1	191	197	PF00069	0.586
MOD_CK1_1	257	263	PF00069	0.529
MOD_CK1_1	278	284	PF00069	0.755
MOD_CK1_1	297	303	PF00069	0.772
MOD_CK1_1	372	378	PF00069	0.695
MOD_CK1_1	522	528	PF00069	0.550
MOD_CK1_1	538	544	PF00069	0.614
MOD_CK1_1	654	660	PF00069	0.729
MOD_CK1_1	661	667	PF00069	0.700
MOD_CK1_1	840	846	PF00069	0.725
MOD_CK1_1	869	875	PF00069	0.697
MOD_CK1_1	915	921	PF00069	0.519
MOD_CK2_1	10	16	PF00069	0.572
MOD_CK2_1	132	138	PF00069	0.599
MOD_CK2_1	171	177	PF00069	0.602
MOD_CK2_1	209	215	PF00069	0.597
MOD_CK2_1	346	352	PF00069	0.602
MOD_CK2_1	538	544	PF00069	0.640
MOD_CK2_1	807	813	PF00069	0.494
MOD_CK2_1	905	911	PF00069	0.545
MOD_Cter_Amidation	632	635	PF01082	0.500
MOD_DYRK1A_RPxSP_1	419	423	PF00069	0.546
MOD_DYRK1A_RPxSP_1	578	582	PF00069	0.523
MOD_DYRK1A_RPxSP_1	897	901	PF00069	0.524
MOD_GlcNHglycan	112	115	PF01048	0.719
MOD_GlcNHglycan	117	120	PF01048	0.766
MOD_GlcNHglycan	126	129	PF01048	0.797
MOD_GlcNHglycan	215	219	PF01048	0.656
MOD_GlcNHglycan	256	259	PF01048	0.571
MOD_GlcNHglycan	264	268	PF01048	0.616
MOD_GlcNHglycan	277	280	PF01048	0.586
MOD_GlcNHglycan	297	300	PF01048	0.554
MOD_GlcNHglycan	371	374	PF01048	0.421
MOD_GlcNHglycan	381	384	PF01048	0.566
MOD_GlcNHglycan	407	410	PF01048	0.575
MOD_GlcNHglycan	529	532	PF01048	0.720
MOD_GlcNHglycan	553	556	PF01048	0.625
MOD_GlcNHglycan	578	581	PF01048	0.677
MOD_GlcNHglycan	608	611	PF01048	0.720
MOD_GlcNHglycan	619	622	PF01048	0.579
MOD_GlcNHglycan	680	683	PF01048	0.727
MOD_GlcNHglycan	688	691	PF01048	0.565
MOD_GlcNHglycan	73	76	PF01048	0.691
MOD_GlcNHglycan	846	849	PF01048	0.647
MOD_GlcNHglycan	855	859	PF01048	0.724
MOD_GSK3_1	115	122	PF00069	0.806
MOD_GSK3_1	138	145	PF00069	0.640
MOD_GSK3_1	150	157	PF00069	0.529
MOD_GSK3_1	187	194	PF00069	0.713
MOD_GSK3_1	253	260	PF00069	0.460
MOD_GSK3_1	268	275	PF00069	0.560
MOD_GSK3_1	281	288	PF00069	0.520
MOD_GSK3_1	293	300	PF00069	0.744
MOD_GSK3_1	323	330	PF00069	0.609
MOD_GSK3_1	375	382	PF00069	0.557
MOD_GSK3_1	519	526	PF00069	0.536
MOD_GSK3_1	534	541	PF00069	0.809
MOD_GSK3_1	585	592	PF00069	0.732
MOD_GSK3_1	59	66	PF00069	0.650
MOD_GSK3_1	617	624	PF00069	0.667
MOD_GSK3_1	651	658	PF00069	0.699
MOD_GSK3_1	674	681	PF00069	0.675
MOD_GSK3_1	692	699	PF00069	0.732
MOD_GSK3_1	71	78	PF00069	0.695
MOD_GSK3_1	838	845	PF00069	0.617
MOD_GSK3_1	861	868	PF00069	0.711
MOD_GSK3_1	912	919	PF00069	0.616
MOD_LATS_1	533	539	PF00433	0.573
MOD_LATS_1	684	690	PF00433	0.588
MOD_N-GLC_1	405	410	PF02516	0.684
MOD_N-GLC_1	535	540	PF02516	0.607
MOD_NEK2_1	10	15	PF00069	0.582
MOD_NEK2_1	192	197	PF00069	0.714
MOD_NEK2_1	238	243	PF00069	0.780
MOD_NEK2_1	305	310	PF00069	0.497
MOD_NEK2_1	413	418	PF00069	0.759
MOD_NEK2_1	585	590	PF00069	0.621
MOD_NEK2_1	616	621	PF00069	0.598
MOD_NEK2_1	871	876	PF00069	0.716
MOD_NEK2_1	913	918	PF00069	0.524
MOD_NEK2_2	144	149	PF00069	0.701
MOD_NEK2_2	519	524	PF00069	0.531
MOD_NEK2_2	816	821	PF00069	0.581
MOD_NEK2_2	891	896	PF00069	0.708
MOD_PIKK_1	209	215	PF00454	0.666
MOD_PIKK_1	222	228	PF00454	0.661
MOD_PIKK_1	310	316	PF00454	0.545
MOD_PIKK_1	627	633	PF00454	0.529
MOD_PIKK_1	704	710	PF00454	0.535
MOD_PIKK_1	77	83	PF00454	0.763
MOD_PIKK_1	775	781	PF00454	0.547
MOD_PIKK_1	916	922	PF00454	0.706
MOD_PKA_1	534	540	PF00069	0.574
MOD_PKA_1	576	582	PF00069	0.555
MOD_PKA_1	617	623	PF00069	0.643
MOD_PKA_2	110	116	PF00069	0.569
MOD_PKA_2	534	540	PF00069	0.651
MOD_PKA_2	556	562	PF00069	0.536
MOD_PKA_2	576	582	PF00069	0.641
MOD_PKA_2	585	591	PF00069	0.627
MOD_PKA_2	616	622	PF00069	0.702
MOD_PKA_2	661	667	PF00069	0.771
MOD_PKA_2	799	805	PF00069	0.707
MOD_PKA_2	816	822	PF00069	0.499
MOD_PKA_2	906	912	PF00069	0.545
MOD_PKB_1	615	623	PF00069	0.555
MOD_Plk_1	535	541	PF00069	0.644
MOD_Plk_4	171	177	PF00069	0.477
MOD_Plk_4	333	339	PF00069	0.587
MOD_Plk_4	375	381	PF00069	0.692
MOD_Plk_4	707	713	PF00069	0.476
MOD_Plk_4	777	783	PF00069	0.509
MOD_Plk_4	872	878	PF00069	0.672
MOD_ProDKin_1	233	239	PF00069	0.551
MOD_ProDKin_1	272	278	PF00069	0.696
MOD_ProDKin_1	419	425	PF00069	0.659
MOD_ProDKin_1	432	438	PF00069	0.682
MOD_ProDKin_1	578	584	PF00069	0.772
MOD_ProDKin_1	60	66	PF00069	0.729
MOD_ProDKin_1	651	657	PF00069	0.672
MOD_ProDKin_1	669	675	PF00069	0.839
MOD_ProDKin_1	684	690	PF00069	0.588
MOD_ProDKin_1	702	708	PF00069	0.598
MOD_ProDKin_1	862	868	PF00069	0.639
MOD_ProDKin_1	879	885	PF00069	0.590
MOD_ProDKin_1	897	903	PF00069	0.482
MOD_SUMO_for_1	690	693	PF00179	0.591
TRG_DiLeu_BaEn_2	635	641	PF01217	0.621
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.599
TRG_ENDOCYTIC_2	167	170	PF00928	0.507
TRG_ENDOCYTIC_2	25	28	PF00928	0.622
TRG_ENDOCYTIC_2	29	32	PF00928	0.562
TRG_ENDOCYTIC_2	45	48	PF00928	0.674
TRG_ENDOCYTIC_2	637	640	PF00928	0.612
TRG_ENDOCYTIC_2	645	648	PF00928	0.568
TRG_ENDOCYTIC_2	709	712	PF00928	0.446
TRG_ER_diArg_1	110	112	PF00400	0.652
TRG_ER_diArg_1	29	31	PF00400	0.574
TRG_ER_diArg_1	575	578	PF00400	0.514
TRG_ER_diArg_1	616	618	PF00400	0.665
TRG_ER_diArg_1	632	635	PF00400	0.427
TRG_ER_diArg_1	736	738	PF00400	0.493
TRG_ER_diArg_1	815	818	PF00400	0.679
TRG_ER_diArg_1	84	86	PF00400	0.699
TRG_ER_diArg_1	896	898	PF00400	0.667
TRG_NLS_Bipartite_1	404	421	PF00514	0.562
TRG_NLS_MonoCore_2	82	87	PF00514	0.692
TRG_NLS_MonoExtC_3	82	87	PF00514	0.644
TRG_NLS_MonoExtN_4	415	421	PF00514	0.561
TRG_NLS_MonoExtN_4	82	87	PF00514	0.669
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEZ4	Leptomonas seymouri	37%	100%
A0A3S7X1L5	Leishmania donovani	63%	99%
A4I3Q2	Leishmania infantum	63%	99%
E9AZZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4Q891	Leishmania major	61%	99%