SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania braziliensis

UniProt:

A4HGM7_LEIBR

TriTrypDb:

LbrM.28.1910 , LBRM2903_280025400

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGM7

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0070475	rRNA base methylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.568
CLV_C14_Caspase3-7	86	90	PF00656	0.518
CLV_NRD_NRD_1	136	138	PF00675	0.681
CLV_NRD_NRD_1	174	176	PF00675	0.441
CLV_NRD_NRD_1	179	181	PF00675	0.506
CLV_NRD_NRD_1	210	212	PF00675	0.584
CLV_NRD_NRD_1	26	28	PF00675	0.432
CLV_NRD_NRD_1	312	314	PF00675	0.562
CLV_NRD_NRD_1	351	353	PF00675	0.299
CLV_NRD_NRD_1	487	489	PF00675	0.227
CLV_PCSK_FUR_1	172	176	PF00082	0.412
CLV_PCSK_KEX2_1	136	138	PF00082	0.684
CLV_PCSK_KEX2_1	174	176	PF00082	0.427
CLV_PCSK_KEX2_1	181	183	PF00082	0.478
CLV_PCSK_KEX2_1	206	208	PF00082	0.646
CLV_PCSK_KEX2_1	210	212	PF00082	0.635
CLV_PCSK_KEX2_1	292	294	PF00082	0.484
CLV_PCSK_KEX2_1	33	35	PF00082	0.481
CLV_PCSK_KEX2_1	351	353	PF00082	0.234
CLV_PCSK_KEX2_1	358	360	PF00082	0.246
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.488
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.711
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.484
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.416
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.234
CLV_PCSK_SKI1_1	307	311	PF00082	0.420
CLV_PCSK_SKI1_1	358	362	PF00082	0.154
CLV_PCSK_SKI1_1	384	388	PF00082	0.238
CLV_PCSK_SKI1_1	488	492	PF00082	0.227
CLV_PCSK_SKI1_1	521	525	PF00082	0.213
CLV_PCSK_SKI1_1	93	97	PF00082	0.508
CLV_Separin_Metazoa	518	522	PF03568	0.515
CLV_TASPASE1	450	456	PF01112	0.493
DEG_APCC_DBOX_1	312	320	PF00400	0.393
DEG_COP1_1	224	232	PF00400	0.279
DEG_Nend_UBRbox_2	1	3	PF02207	0.355
DEG_SPOP_SBC_1	280	284	PF00917	0.468
DOC_ANK_TNKS_1	136	143	PF00023	0.674
DOC_ANK_TNKS_1	183	190	PF00023	0.409
DOC_CYCLIN_RxL_1	482	494	PF00134	0.459
DOC_MAPK_gen_1	155	164	PF00069	0.313
DOC_MAPK_gen_1	206	216	PF00069	0.587
DOC_MAPK_MEF2A_6	158	166	PF00069	0.350
DOC_MAPK_MEF2A_6	210	218	PF00069	0.434
DOC_MAPK_NFAT4_5	211	219	PF00069	0.419
DOC_PP2B_LxvP_1	151	154	PF13499	0.451
DOC_PP2B_LxvP_1	216	219	PF13499	0.390
DOC_PP2B_LxvP_1	336	339	PF13499	0.413
DOC_USP7_MATH_1	129	133	PF00917	0.648
DOC_USP7_MATH_1	145	149	PF00917	0.613
DOC_USP7_MATH_1	194	198	PF00917	0.722
DOC_USP7_MATH_1	246	250	PF00917	0.406
DOC_USP7_MATH_1	280	284	PF00917	0.641
DOC_USP7_MATH_1	394	398	PF00917	0.413
DOC_USP7_MATH_1	428	432	PF00917	0.583
DOC_USP7_MATH_1	458	462	PF00917	0.619
DOC_USP7_UBL2_3	28	32	PF12436	0.403
DOC_USP7_UBL2_3	292	296	PF12436	0.743
LIG_14-3-3_CanoR_1	158	163	PF00244	0.315
LIG_14-3-3_CanoR_1	210	215	PF00244	0.639
LIG_14-3-3_CanoR_1	257	265	PF00244	0.305
LIG_14-3-3_CanoR_1	34	38	PF00244	0.466
LIG_14-3-3_CanoR_1	359	364	PF00244	0.428
LIG_14-3-3_CanoR_1	384	392	PF00244	0.528
LIG_14-3-3_CanoR_1	93	102	PF00244	0.501
LIG_Actin_WH2_2	159	176	PF00022	0.379
LIG_BIR_III_2	268	272	PF00653	0.477
LIG_BIR_III_4	467	471	PF00653	0.511
LIG_Clathr_ClatBox_1	495	499	PF01394	0.424
LIG_FHA_1	159	165	PF00498	0.374
LIG_FHA_1	328	334	PF00498	0.437
LIG_FHA_1	34	40	PF00498	0.357
LIG_FHA_1	385	391	PF00498	0.432
LIG_FHA_1	506	512	PF00498	0.436
LIG_FHA_1	544	550	PF00498	0.390
LIG_FHA_2	344	350	PF00498	0.515
LIG_FHA_2	401	407	PF00498	0.429
LIG_FHA_2	84	90	PF00498	0.427
LIG_IRF3_LxIS_1	159	165	PF10401	0.455
LIG_LIR_Gen_1	36	44	PF02991	0.350
LIG_LIR_Gen_1	367	376	PF02991	0.425
LIG_LIR_Nem_3	104	109	PF02991	0.381
LIG_LIR_Nem_3	36	40	PF02991	0.357
LIG_LIR_Nem_3	367	371	PF02991	0.453
LIG_LIR_Nem_3	375	379	PF02991	0.427
LIG_LIR_Nem_3	58	63	PF02991	0.344
LIG_PTB_Apo_2	370	377	PF02174	0.370
LIG_REV1ctd_RIR_1	57	63	PF16727	0.379
LIG_SH2_CRK	156	160	PF00017	0.296
LIG_SH2_CRK	37	41	PF00017	0.347
LIG_SH2_CRK	76	80	PF00017	0.323
LIG_SH2_GRB2like	368	371	PF00017	0.424
LIG_SH2_NCK_1	156	160	PF00017	0.296
LIG_SH2_PTP2	368	371	PF00017	0.438
LIG_SH2_SRC	368	371	PF00017	0.438
LIG_SH2_STAP1	76	80	PF00017	0.338
LIG_SH2_STAT3	62	65	PF00017	0.501
LIG_SH2_STAT5	101	104	PF00017	0.364
LIG_SH2_STAT5	318	321	PF00017	0.429
LIG_SH2_STAT5	368	371	PF00017	0.446
LIG_SH2_STAT5	575	578	PF00017	0.431
LIG_SH3_3	224	230	PF00018	0.352
LIG_SH3_3	231	237	PF00018	0.380
LIG_SUMO_SIM_par_1	51	58	PF11976	0.404
LIG_TRAF2_1	165	168	PF00917	0.489
LIG_WRC_WIRS_1	495	500	PF05994	0.424
LIG_WW_3	115	119	PF00397	0.504
MOD_CK1_1	147	153	PF00069	0.617
MOD_CK1_1	281	287	PF00069	0.516
MOD_CK1_1	494	500	PF00069	0.448
MOD_CK1_1	507	513	PF00069	0.372
MOD_CK2_1	162	168	PF00069	0.349
MOD_CK2_1	471	477	PF00069	0.565
MOD_CK2_1	507	513	PF00069	0.438
MOD_GlcNHglycan	130	134	PF01048	0.665
MOD_GlcNHglycan	248	251	PF01048	0.401
MOD_GlcNHglycan	284	287	PF01048	0.624
MOD_GlcNHglycan	396	399	PF01048	0.213
MOD_GlcNHglycan	460	463	PF01048	0.715
MOD_GlcNHglycan	97	100	PF01048	0.400
MOD_GSK3_1	158	165	PF00069	0.460
MOD_GSK3_1	190	197	PF00069	0.686
MOD_GSK3_1	201	208	PF00069	0.691
MOD_GSK3_1	278	285	PF00069	0.712
MOD_GSK3_1	354	361	PF00069	0.441
MOD_GSK3_1	392	399	PF00069	0.413
MOD_GSK3_1	500	507	PF00069	0.424
MOD_GSK3_1	83	90	PF00069	0.425
MOD_GSK3_1	93	100	PF00069	0.391
MOD_N-GLC_1	17	22	PF02516	0.453
MOD_N-GLC_1	305	310	PF02516	0.544
MOD_N-GLC_1	327	332	PF02516	0.213
MOD_N-GLC_1	87	92	PF02516	0.551
MOD_NEK2_1	491	496	PF00069	0.493
MOD_NEK2_1	558	563	PF00069	0.413
MOD_PIKK_1	196	202	PF00454	0.697
MOD_PIKK_1	221	227	PF00454	0.507
MOD_PIKK_1	328	334	PF00454	0.438
MOD_PIKK_1	93	99	PF00454	0.473
MOD_PKA_1	174	180	PF00069	0.424
MOD_PKA_1	206	212	PF00069	0.686
MOD_PKA_1	33	39	PF00069	0.364
MOD_PKA_1	358	364	PF00069	0.354
MOD_PKA_2	173	179	PF00069	0.544
MOD_PKA_2	206	212	PF00069	0.664
MOD_PKA_2	256	262	PF00069	0.304
MOD_PKA_2	33	39	PF00069	0.377
MOD_PKA_2	358	364	PF00069	0.494
MOD_PKA_2	534	540	PF00069	0.550
MOD_PKB_1	172	180	PF00069	0.431
MOD_Plk_1	471	477	PF00069	0.633
MOD_Plk_2-3	452	458	PF00069	0.492
MOD_Plk_4	491	497	PF00069	0.496
MOD_Plk_4	97	103	PF00069	0.439
MOD_SUMO_for_1	299	302	PF00179	0.437
MOD_SUMO_for_1	475	478	PF00179	0.453
MOD_SUMO_rev_2	273	281	PF00179	0.571
MOD_SUMO_rev_2	302	309	PF00179	0.667
TRG_ENDOCYTIC_2	106	109	PF00928	0.384
TRG_ENDOCYTIC_2	156	159	PF00928	0.297
TRG_ENDOCYTIC_2	368	371	PF00928	0.431
TRG_ENDOCYTIC_2	37	40	PF00928	0.363
TRG_ENDOCYTIC_2	47	50	PF00928	0.384
TRG_ENDOCYTIC_2	76	79	PF00928	0.315
TRG_ER_diArg_1	172	175	PF00400	0.413
TRG_NLS_MonoExtC_3	179	184	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I291	Leptomonas seymouri	70%	100%
A0A0S4JC42	Bodo saltans	52%	100%
A0A1X0NQY2	Trypanosomatidae	58%	100%
A0A3S7X1L9	Leishmania donovani	83%	99%
A0A422NZ09	Trypanosoma rangeli	59%	100%
A4I3Q1	Leishmania infantum	83%	99%
D0A8B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AZZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
O14039	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q4Q892	Leishmania major	82%	99%
Q8GYE8	Arabidopsis thaliana	27%	100%
Q8K4F6	Mus musculus	27%	100%
Q96P11	Homo sapiens	28%	100%
V5BAN7	Trypanosoma cruzi	58%	100%