Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGM0_LEIBR

TriTrypDb:

LbrM.28.1840 , LBRM2903_280024600

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	377	381	PF00656	0.424
CLV_NRD_NRD_1	298	300	PF00675	0.533
CLV_NRD_NRD_1	34	36	PF00675	0.461
CLV_PCSK_KEX2_1	244	246	PF00082	0.399
CLV_PCSK_KEX2_1	298	300	PF00082	0.533
CLV_PCSK_KEX2_1	34	36	PF00082	0.488
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.371
CLV_PCSK_PC7_1	240	246	PF00082	0.516
CLV_PCSK_SKI1_1	34	38	PF00082	0.571
CLV_PCSK_SKI1_1	535	539	PF00082	0.371
CLV_PCSK_SKI1_1	587	591	PF00082	0.460
CLV_PCSK_SKI1_1	628	632	PF00082	0.311
DEG_APCC_DBOX_1	198	206	PF00400	0.583
DEG_APCC_DBOX_1	586	594	PF00400	0.526
DEG_SPOP_SBC_1	190	194	PF00917	0.477
DOC_CKS1_1	121	126	PF01111	0.508
DOC_CKS1_1	136	141	PF01111	0.546
DOC_CKS1_1	37	42	PF01111	0.514
DOC_CKS1_1	89	94	PF01111	0.507
DOC_CYCLIN_RxL_1	389	399	PF00134	0.233
DOC_CYCLIN_yCln2_LP_2	121	127	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	492	498	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	529	532	PF00134	0.409
DOC_MAPK_MEF2A_6	486	494	PF00069	0.682
DOC_PP2B_LxvP_1	160	163	PF13499	0.607
DOC_PP2B_LxvP_1	311	314	PF13499	0.486
DOC_PP2B_LxvP_1	492	495	PF13499	0.510
DOC_PP2B_LxvP_1	529	532	PF13499	0.391
DOC_PP2B_PxIxI_1	564	570	PF00149	0.413
DOC_PP4_FxxP_1	267	270	PF00568	0.451
DOC_PP4_MxPP_1	131	134	PF00568	0.509
DOC_SPAK_OSR1_1	278	282	PF12202	0.483
DOC_USP7_MATH_1	107	111	PF00917	0.543
DOC_USP7_MATH_1	117	121	PF00917	0.525
DOC_USP7_MATH_1	170	174	PF00917	0.626
DOC_USP7_MATH_1	185	189	PF00917	0.620
DOC_USP7_MATH_1	190	194	PF00917	0.658
DOC_USP7_MATH_1	197	201	PF00917	0.681
DOC_USP7_MATH_1	255	259	PF00917	0.342
DOC_USP7_MATH_1	301	305	PF00917	0.462
DOC_USP7_MATH_1	332	336	PF00917	0.440
DOC_USP7_MATH_1	385	389	PF00917	0.413
DOC_USP7_MATH_1	415	419	PF00917	0.507
DOC_USP7_MATH_1	44	48	PF00917	0.648
DOC_USP7_MATH_1	61	65	PF00917	0.756
DOC_USP7_MATH_1	68	72	PF00917	0.754
DOC_USP7_UBL2_3	431	435	PF12436	0.359
DOC_WW_Pin1_4	100	105	PF00397	0.692
DOC_WW_Pin1_4	120	125	PF00397	0.543
DOC_WW_Pin1_4	135	140	PF00397	0.627
DOC_WW_Pin1_4	191	196	PF00397	0.596
DOC_WW_Pin1_4	318	323	PF00397	0.323
DOC_WW_Pin1_4	36	41	PF00397	0.704
DOC_WW_Pin1_4	381	386	PF00397	0.419
DOC_WW_Pin1_4	74	79	PF00397	0.792
DOC_WW_Pin1_4	88	93	PF00397	0.645
LIG_14-3-3_CanoR_1	164	168	PF00244	0.691
LIG_14-3-3_CanoR_1	199	203	PF00244	0.641
LIG_14-3-3_CanoR_1	302	309	PF00244	0.455
LIG_14-3-3_CanoR_1	421	426	PF00244	0.494
LIG_14-3-3_CanoR_1	481	486	PF00244	0.498
LIG_BIR_III_2	513	517	PF00653	0.409
LIG_BIR_III_2	536	540	PF00653	0.539
LIG_BRCT_BRCA1_1	237	241	PF00533	0.313
LIG_eIF4E_1	512	518	PF01652	0.414
LIG_FHA_1	199	205	PF00498	0.519
LIG_FHA_1	212	218	PF00498	0.318
LIG_FHA_1	345	351	PF00498	0.505
LIG_FHA_1	381	387	PF00498	0.454
LIG_FHA_1	417	423	PF00498	0.367
LIG_FHA_1	46	52	PF00498	0.775
LIG_FHA_2	124	130	PF00498	0.636
LIG_FHA_2	425	431	PF00498	0.416
LIG_FHA_2	472	478	PF00498	0.423
LIG_FHA_2	54	60	PF00498	0.502
LIG_FHA_2	75	81	PF00498	0.592
LIG_GSK3_LRP6_1	135	140	PF00069	0.545
LIG_LIR_Apic_2	266	270	PF02991	0.488
LIG_LIR_Apic_2	557	562	PF02991	0.380
LIG_LIR_Gen_1	214	224	PF02991	0.529
LIG_LIR_Gen_1	388	398	PF02991	0.479
LIG_LIR_Gen_1	443	452	PF02991	0.473
LIG_LIR_Gen_1	510	518	PF02991	0.367
LIG_LIR_Nem_3	214	219	PF02991	0.437
LIG_LIR_Nem_3	236	242	PF02991	0.424
LIG_LIR_Nem_3	319	323	PF02991	0.425
LIG_LIR_Nem_3	388	393	PF02991	0.482
LIG_LIR_Nem_3	440	444	PF02991	0.363
LIG_LIR_Nem_3	510	515	PF02991	0.368
LIG_LIR_Nem_3	550	555	PF02991	0.414
LIG_NRBOX	421	427	PF00104	0.373
LIG_PCNA_yPIPBox_3	4	16	PF02747	0.594
LIG_Rb_pABgroove_1	228	236	PF01858	0.309
LIG_Rb_pABgroove_1	506	514	PF01858	0.356
LIG_SH2_CRK	320	324	PF00017	0.412
LIG_SH2_CRK	423	427	PF00017	0.377
LIG_SH2_CRK	462	466	PF00017	0.460
LIG_SH2_CRK	512	516	PF00017	0.430
LIG_SH2_STAP1	468	472	PF00017	0.392
LIG_SH2_STAT5	211	214	PF00017	0.434
LIG_SH2_STAT5	242	245	PF00017	0.374
LIG_SH2_STAT5	249	252	PF00017	0.353
LIG_SH2_STAT5	320	323	PF00017	0.403
LIG_SH2_STAT5	356	359	PF00017	0.360
LIG_SH2_STAT5	555	558	PF00017	0.387
LIG_SH2_STAT5	614	617	PF00017	0.354
LIG_SH3_1	130	136	PF00018	0.681
LIG_SH3_3	130	136	PF00018	0.658
LIG_SH3_3	184	190	PF00018	0.743
LIG_SH3_3	207	213	PF00018	0.338
LIG_SH3_3	22	28	PF00018	0.472
LIG_SH3_3	221	227	PF00018	0.530
LIG_SH3_3	311	317	PF00018	0.393
LIG_SH3_3	37	43	PF00018	0.543
LIG_SH3_3	484	490	PF00018	0.549
LIG_SH3_3	559	565	PF00018	0.400
LIG_SH3_3	572	578	PF00018	0.413
LIG_SH3_3	588	594	PF00018	0.296
LIG_SH3_3	86	92	PF00018	0.617
LIG_SH3_3	98	104	PF00018	0.789
LIG_SUMO_SIM_anti_2	22	29	PF11976	0.592
LIG_SUMO_SIM_anti_2	524	531	PF11976	0.409
LIG_SUMO_SIM_anti_2	566	571	PF11976	0.407
LIG_SUMO_SIM_par_1	22	29	PF11976	0.618
LIG_WRC_WIRS_1	212	217	PF05994	0.347
LIG_WRC_WIRS_1	441	446	PF05994	0.392
LIG_WW_3	299	303	PF00397	0.504
MOD_CK1_1	10	16	PF00069	0.440
MOD_CK1_1	109	115	PF00069	0.707
MOD_CK1_1	120	126	PF00069	0.697
MOD_CK1_1	148	154	PF00069	0.736
MOD_CK1_1	175	181	PF00069	0.683
MOD_CK1_1	424	430	PF00069	0.469
MOD_CK1_1	440	446	PF00069	0.445
MOD_CK1_1	602	608	PF00069	0.539
MOD_CK1_1	622	628	PF00069	0.229
MOD_CK1_1	71	77	PF00069	0.780
MOD_CK1_1	82	88	PF00069	0.719
MOD_CK2_1	185	191	PF00069	0.624
MOD_CK2_1	424	430	PF00069	0.371
MOD_GlcNHglycan	112	115	PF01048	0.617
MOD_GlcNHglycan	147	150	PF01048	0.679
MOD_GlcNHglycan	170	173	PF01048	0.732
MOD_GlcNHglycan	180	183	PF01048	0.621
MOD_GlcNHglycan	28	31	PF01048	0.662
MOD_GlcNHglycan	284	287	PF01048	0.643
MOD_GlcNHglycan	454	457	PF01048	0.301
MOD_GlcNHglycan	48	51	PF01048	0.703
MOD_GlcNHglycan	624	627	PF01048	0.361
MOD_GlcNHglycan	63	66	PF01048	0.559
MOD_GlcNHglycan	633	636	PF01048	0.382
MOD_GlcNHglycan	70	73	PF01048	0.521
MOD_GlcNHglycan	9	12	PF01048	0.616
MOD_GlcNHglycan	96	99	PF01048	0.663
MOD_GSK3_1	106	113	PF00069	0.751
MOD_GSK3_1	116	123	PF00069	0.576
MOD_GSK3_1	168	175	PF00069	0.684
MOD_GSK3_1	185	192	PF00069	0.491
MOD_GSK3_1	211	218	PF00069	0.441
MOD_GSK3_1	381	388	PF00069	0.456
MOD_GSK3_1	595	602	PF00069	0.536
MOD_GSK3_1	68	75	PF00069	0.771
MOD_GSK3_1	84	91	PF00069	0.701
MOD_NEK2_1	198	203	PF00069	0.669
MOD_NEK2_1	287	292	PF00069	0.442
MOD_NEK2_1	344	349	PF00069	0.398
MOD_NEK2_1	379	384	PF00069	0.317
MOD_NEK2_1	79	84	PF00069	0.612
MOD_NEK2_2	416	421	PF00069	0.249
MOD_PIKK_1	10	16	PF00454	0.456
MOD_PIKK_1	287	293	PF00454	0.479
MOD_PIKK_1	424	430	PF00454	0.543
MOD_PKA_2	163	169	PF00069	0.637
MOD_PKA_2	198	204	PF00069	0.599
MOD_PKA_2	301	307	PF00069	0.468
MOD_PKA_2	406	412	PF00069	0.316
MOD_PKB_1	479	487	PF00069	0.625
MOD_Plk_1	234	240	PF00069	0.412
MOD_Plk_2-3	576	582	PF00069	0.557
MOD_Plk_4	211	217	PF00069	0.378
MOD_Plk_4	385	391	PF00069	0.456
MOD_Plk_4	421	427	PF00069	0.376
MOD_Plk_4	440	446	PF00069	0.477
MOD_Plk_4	471	477	PF00069	0.404
MOD_Plk_4	525	531	PF00069	0.406
MOD_Plk_4	563	569	PF00069	0.423
MOD_ProDKin_1	100	106	PF00069	0.686
MOD_ProDKin_1	120	126	PF00069	0.545
MOD_ProDKin_1	135	141	PF00069	0.627
MOD_ProDKin_1	191	197	PF00069	0.589
MOD_ProDKin_1	318	324	PF00069	0.327
MOD_ProDKin_1	36	42	PF00069	0.705
MOD_ProDKin_1	381	387	PF00069	0.419
MOD_ProDKin_1	74	80	PF00069	0.797
MOD_ProDKin_1	88	94	PF00069	0.646
MOD_SUMO_for_1	573	576	PF00179	0.456
MOD_SUMO_rev_2	405	414	PF00179	0.383
MOD_SUMO_rev_2	430	436	PF00179	0.287
TRG_DiLeu_BaEn_1	22	27	PF01217	0.416
TRG_DiLeu_BaEn_1	525	530	PF01217	0.353
TRG_DiLeu_BaEn_4	22	28	PF01217	0.429
TRG_DiLeu_BaLyEn_6	588	593	PF01217	0.467
TRG_ENDOCYTIC_2	320	323	PF00928	0.404
TRG_ENDOCYTIC_2	356	359	PF00928	0.361
TRG_ENDOCYTIC_2	423	426	PF00928	0.377
TRG_ENDOCYTIC_2	462	465	PF00928	0.476
TRG_ENDOCYTIC_2	512	515	PF00928	0.430
TRG_ER_diArg_1	261	264	PF00400	0.374
TRG_ER_diArg_1	297	299	PF00400	0.590
TRG_ER_diArg_1	34	36	PF00400	0.411
TRG_ER_diArg_1	364	367	PF00400	0.350
TRG_ER_diArg_1	479	482	PF00400	0.611
TRG_NES_CRM1_1	513	525	PF08389	0.286
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	509	513	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE00	Leptomonas seymouri	58%	90%
A0A0S4IL03	Bodo saltans	26%	100%
A0A1X0NR90	Trypanosomatidae	61%	90%
A0A1X0P2A9	Trypanosomatidae	26%	100%
A0A3S7X1J9	Leishmania donovani	81%	86%
A0A422N566	Trypanosoma rangeli	27%	100%
A0A422NYX8	Trypanosoma rangeli	60%	95%
A4HHZ8	Leishmania braziliensis	25%	100%
A4I3P5	Leishmania infantum	81%	86%
A4I575	Leishmania infantum	26%	100%
C9ZQK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A8B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	96%
E9AZY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	80%
E9B0H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	96%
Q4Q899	Leishmania major	80%	100%
V5B7S2	Trypanosoma cruzi	27%	100%
V5BJS6	Trypanosoma cruzi	52%	95%