Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 20

Species:

Leishmania braziliensis

UniProt:

A4HGL9_LEIBR

TriTrypDb:

LbrM.28.1830 , LBRM2903_280024500

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HGL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGL9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	406	410	PF00656	0.476
CLV_C14_Caspase3-7	551	555	PF00656	0.515
CLV_NRD_NRD_1	162	164	PF00675	0.411
CLV_NRD_NRD_1	2	4	PF00675	0.405
CLV_NRD_NRD_1	228	230	PF00675	0.443
CLV_NRD_NRD_1	31	33	PF00675	0.366
CLV_NRD_NRD_1	413	415	PF00675	0.503
CLV_NRD_NRD_1	463	465	PF00675	0.694
CLV_NRD_NRD_1	470	472	PF00675	0.630
CLV_NRD_NRD_1	535	537	PF00675	0.502
CLV_PCSK_KEX2_1	162	164	PF00082	0.327
CLV_PCSK_KEX2_1	228	230	PF00082	0.452
CLV_PCSK_KEX2_1	31	33	PF00082	0.366
CLV_PCSK_KEX2_1	413	415	PF00082	0.503
CLV_PCSK_KEX2_1	470	472	PF00082	0.647
CLV_PCSK_KEX2_1	802	804	PF00082	0.515
CLV_PCSK_PC1ET2_1	802	804	PF00082	0.467
CLV_PCSK_SKI1_1	131	135	PF00082	0.360
CLV_PCSK_SKI1_1	168	172	PF00082	0.397
CLV_PCSK_SKI1_1	234	238	PF00082	0.516
CLV_PCSK_SKI1_1	378	382	PF00082	0.555
CLV_PCSK_SKI1_1	4	8	PF00082	0.392
CLV_PCSK_SKI1_1	518	522	PF00082	0.414
CLV_PCSK_SKI1_1	537	541	PF00082	0.618
CLV_PCSK_SKI1_1	764	768	PF00082	0.430
CLV_PCSK_SKI1_1	805	809	PF00082	0.385
DEG_APCC_DBOX_1	233	241	PF00400	0.509
DEG_APCC_DBOX_1	517	525	PF00400	0.567
DEG_APCC_DBOX_1	759	767	PF00400	0.400
DEG_Nend_Nbox_1	1	3	PF02207	0.401
DEG_SPOP_SBC_1	276	280	PF00917	0.621
DEG_SPOP_SBC_1	404	408	PF00917	0.492
DEG_SPOP_SBC_1	627	631	PF00917	0.597
DOC_CKS1_1	286	291	PF01111	0.547
DOC_CYCLIN_RxL_1	518	528	PF00134	0.564
DOC_CYCLIN_RxL_1	760	771	PF00134	0.335
DOC_CYCLIN_RxL_1	802	811	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.339
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.412
DOC_MAPK_gen_1	162	171	PF00069	0.422
DOC_MAPK_gen_1	3	9	PF00069	0.399
DOC_MAPK_gen_1	55	64	PF00069	0.354
DOC_MAPK_HePTP_8	159	171	PF00069	0.487
DOC_MAPK_MEF2A_6	162	171	PF00069	0.422
DOC_MAPK_RevD_3	148	163	PF00069	0.439
DOC_PP1_RVXF_1	735	741	PF00149	0.525
DOC_PP2B_LxvP_1	146	149	PF13499	0.338
DOC_PP2B_LxvP_1	150	153	PF13499	0.344
DOC_PP2B_LxvP_1	178	181	PF13499	0.376
DOC_PP2B_LxvP_1	624	627	PF13499	0.545
DOC_PP2B_LxvP_1	696	699	PF13499	0.670
DOC_USP7_MATH_1	227	231	PF00917	0.447
DOC_USP7_MATH_1	277	281	PF00917	0.676
DOC_USP7_MATH_1	295	299	PF00917	0.663
DOC_USP7_MATH_1	301	305	PF00917	0.619
DOC_USP7_MATH_1	323	327	PF00917	0.654
DOC_USP7_MATH_1	367	371	PF00917	0.775
DOC_USP7_MATH_1	404	408	PF00917	0.605
DOC_USP7_MATH_1	642	646	PF00917	0.743
DOC_USP7_MATH_1	649	653	PF00917	0.646
DOC_USP7_MATH_1	663	667	PF00917	0.712
DOC_USP7_MATH_1	707	711	PF00917	0.683
DOC_USP7_UBL2_3	335	339	PF12436	0.574
DOC_WW_Pin1_4	285	290	PF00397	0.608
DOC_WW_Pin1_4	356	361	PF00397	0.699
DOC_WW_Pin1_4	382	387	PF00397	0.570
DOC_WW_Pin1_4	391	396	PF00397	0.620
DOC_WW_Pin1_4	425	430	PF00397	0.577
DOC_WW_Pin1_4	465	470	PF00397	0.646
DOC_WW_Pin1_4	502	507	PF00397	0.782
DOC_WW_Pin1_4	615	620	PF00397	0.799
DOC_WW_Pin1_4	632	637	PF00397	0.569
DOC_WW_Pin1_4	690	695	PF00397	0.811
DOC_WW_Pin1_4	716	721	PF00397	0.815
LIG_14-3-3_CanoR_1	455	462	PF00244	0.669
LIG_14-3-3_CanoR_1	464	468	PF00244	0.681
LIG_14-3-3_CanoR_1	549	556	PF00244	0.541
LIG_14-3-3_CanoR_1	632	636	PF00244	0.560
LIG_14-3-3_CanoR_1	664	668	PF00244	0.571
LIG_14-3-3_CanoR_1	709	713	PF00244	0.676
LIG_14-3-3_CanoR_1	760	764	PF00244	0.474
LIG_Actin_WH2_2	820	837	PF00022	0.477
LIG_APCC_ABBA_1	47	52	PF00400	0.446
LIG_APCC_ABBAyCdc20_2	805	811	PF00400	0.310
LIG_EVH1_2	573	577	PF00568	0.675
LIG_FHA_1	13	19	PF00498	0.398
LIG_FHA_1	139	145	PF00498	0.489
LIG_FHA_1	189	195	PF00498	0.481
LIG_FHA_1	231	237	PF00498	0.368
LIG_FHA_1	285	291	PF00498	0.680
LIG_FHA_1	392	398	PF00498	0.697
LIG_FHA_1	456	462	PF00498	0.738
LIG_FHA_1	480	486	PF00498	0.567
LIG_FHA_1	594	600	PF00498	0.560
LIG_FHA_1	64	70	PF00498	0.363
LIG_FHA_1	85	91	PF00498	0.394
LIG_FHA_2	202	208	PF00498	0.367
LIG_FHA_2	37	43	PF00498	0.313
LIG_FHA_2	404	410	PF00498	0.482
LIG_FHA_2	549	555	PF00498	0.511
LIG_FHA_2	592	598	PF00498	0.762
LIG_FHA_2	670	676	PF00498	0.551
LIG_FHA_2	774	780	PF00498	0.467
LIG_LIR_Gen_1	417	427	PF02991	0.677
LIG_LIR_Gen_1	666	674	PF02991	0.562
LIG_LIR_Gen_1	680	691	PF02991	0.544
LIG_LIR_Gen_1	71	81	PF02991	0.355
LIG_LIR_Gen_1	97	104	PF02991	0.329
LIG_LIR_Nem_3	417	422	PF02991	0.658
LIG_LIR_Nem_3	680	686	PF02991	0.583
LIG_LIR_Nem_3	71	76	PF02991	0.359
LIG_LIR_Nem_3	811	817	PF02991	0.304
LIG_LIR_Nem_3	97	101	PF02991	0.344
LIG_MYND_1	694	698	PF01753	0.677
LIG_NRBOX	762	768	PF00104	0.416
LIG_NRBOX	803	809	PF00104	0.459
LIG_NRP_CendR_1	844	847	PF00754	0.546
LIG_PCNA_PIPBox_1	532	541	PF02747	0.496
LIG_PTB_Apo_2	118	125	PF02174	0.438
LIG_SH2_CRK	156	160	PF00017	0.459
LIG_SH2_SRC	396	399	PF00017	0.543
LIG_SH2_SRC	477	480	PF00017	0.588
LIG_SH2_STAT3	155	158	PF00017	0.401
LIG_SH2_STAT5	396	399	PF00017	0.543
LIG_SH2_STAT5	477	480	PF00017	0.588
LIG_SH2_STAT5	667	670	PF00017	0.558
LIG_SH3_1	344	350	PF00018	0.556
LIG_SH3_2	294	299	PF14604	0.615
LIG_SH3_3	145	151	PF00018	0.336
LIG_SH3_3	267	273	PF00018	0.468
LIG_SH3_3	286	292	PF00018	0.625
LIG_SH3_3	344	350	PF00018	0.591
LIG_SH3_3	357	363	PF00018	0.727
LIG_SH3_3	383	389	PF00018	0.630
LIG_SH3_3	507	513	PF00018	0.515
LIG_SH3_3	568	574	PF00018	0.714
LIG_SH3_3	688	694	PF00018	0.784
LIG_SUMO_SIM_anti_2	554	560	PF11976	0.558
LIG_SUMO_SIM_anti_2	562	568	PF11976	0.530
LIG_SUMO_SIM_anti_2	71	79	PF11976	0.352
LIG_SUMO_SIM_anti_2	99	105	PF11976	0.281
LIG_SUMO_SIM_par_1	13	22	PF11976	0.370
LIG_SUMO_SIM_par_1	215	220	PF11976	0.437
LIG_SUMO_SIM_par_1	5	10	PF11976	0.358
LIG_SUMO_SIM_par_1	65	72	PF11976	0.453
LIG_TRAF2_1	39	42	PF00917	0.476
LIG_TRAF2_1	776	779	PF00917	0.462
LIG_TRAF2_1	97	100	PF00917	0.381
LIG_TYR_ITIM	154	159	PF00017	0.438
MOD_CDC14_SPxK_1	428	431	PF00782	0.610
MOD_CDC14_SPxK_1	468	471	PF00782	0.670
MOD_CDK_SPK_2	465	470	PF00069	0.652
MOD_CDK_SPK_2	632	637	PF00069	0.725
MOD_CDK_SPxK_1	425	431	PF00069	0.584
MOD_CDK_SPxK_1	465	471	PF00069	0.673
MOD_CDK_SPxxK_3	502	509	PF00069	0.684
MOD_CDK_SPxxK_3	632	639	PF00069	0.724
MOD_CK1_1	10	16	PF00069	0.299
MOD_CK1_1	192	198	PF00069	0.573
MOD_CK1_1	230	236	PF00069	0.349
MOD_CK1_1	250	256	PF00069	0.414
MOD_CK1_1	280	286	PF00069	0.679
MOD_CK1_1	312	318	PF00069	0.574
MOD_CK1_1	342	348	PF00069	0.635
MOD_CK1_1	356	362	PF00069	0.731
MOD_CK1_1	370	376	PF00069	0.807
MOD_CK1_1	402	408	PF00069	0.528
MOD_CK1_1	441	447	PF00069	0.560
MOD_CK1_1	598	604	PF00069	0.586
MOD_CK1_1	631	637	PF00069	0.592
MOD_CK1_1	652	658	PF00069	0.651
MOD_CK1_1	666	672	PF00069	0.716
MOD_CK1_1	711	717	PF00069	0.738
MOD_CK1_1	719	725	PF00069	0.645
MOD_CK1_1	72	78	PF00069	0.336
MOD_CK1_1	79	85	PF00069	0.376
MOD_CK2_1	183	189	PF00069	0.454
MOD_CK2_1	36	42	PF00069	0.320
MOD_CK2_1	442	448	PF00069	0.716
MOD_CK2_1	591	597	PF00069	0.775
MOD_CK2_1	608	614	PF00069	0.572
MOD_CK2_1	656	662	PF00069	0.634
MOD_CK2_1	669	675	PF00069	0.726
MOD_CK2_1	747	753	PF00069	0.514
MOD_CK2_1	773	779	PF00069	0.444
MOD_CK2_1	94	100	PF00069	0.378
MOD_DYRK1A_RPxSP_1	632	636	PF00069	0.723
MOD_GlcNHglycan	186	189	PF01048	0.706
MOD_GlcNHglycan	229	232	PF01048	0.445
MOD_GlcNHglycan	283	286	PF01048	0.719
MOD_GlcNHglycan	303	306	PF01048	0.513
MOD_GlcNHglycan	311	314	PF01048	0.639
MOD_GlcNHglycan	344	347	PF01048	0.567
MOD_GlcNHglycan	373	376	PF01048	0.693
MOD_GlcNHglycan	40	46	PF01048	0.459
MOD_GlcNHglycan	436	439	PF01048	0.562
MOD_GlcNHglycan	646	649	PF01048	0.681
MOD_GlcNHglycan	651	654	PF01048	0.833
MOD_GlcNHglycan	658	661	PF01048	0.677
MOD_GlcNHglycan	683	686	PF01048	0.697
MOD_GlcNHglycan	700	703	PF01048	0.678
MOD_GlcNHglycan	712	716	PF01048	0.638
MOD_GlcNHglycan	749	752	PF01048	0.469
MOD_GlcNHglycan	837	840	PF01048	0.645
MOD_GlcNHglycan	9	12	PF01048	0.331
MOD_GSK3_1	184	191	PF00069	0.531
MOD_GSK3_1	217	224	PF00069	0.398
MOD_GSK3_1	250	257	PF00069	0.413
MOD_GSK3_1	275	282	PF00069	0.632
MOD_GSK3_1	284	291	PF00069	0.594
MOD_GSK3_1	301	308	PF00069	0.629
MOD_GSK3_1	350	357	PF00069	0.691
MOD_GSK3_1	367	374	PF00069	0.804
MOD_GSK3_1	398	405	PF00069	0.568
MOD_GSK3_1	434	441	PF00069	0.650
MOD_GSK3_1	498	505	PF00069	0.565
MOD_GSK3_1	589	596	PF00069	0.622
MOD_GSK3_1	626	633	PF00069	0.674
MOD_GSK3_1	649	656	PF00069	0.727
MOD_GSK3_1	68	75	PF00069	0.389
MOD_GSK3_1	690	697	PF00069	0.614
MOD_GSK3_1	707	714	PF00069	0.711
MOD_GSK3_1	715	722	PF00069	0.686
MOD_GSK3_1	741	748	PF00069	0.578
MOD_GSK3_1	830	837	PF00069	0.529
MOD_N-GLC_1	192	197	PF02516	0.591
MOD_N-GLC_1	323	328	PF02516	0.820
MOD_N-GLC_1	351	356	PF02516	0.653
MOD_N-GLC_1	425	430	PF02516	0.577
MOD_N-GLC_1	627	632	PF02516	0.599
MOD_N-GLC_1	740	745	PF02516	0.544
MOD_N-GLC_1	830	835	PF02516	0.357
MOD_NEK2_1	381	386	PF00069	0.558
MOD_NEK2_1	403	408	PF00069	0.545
MOD_NEK2_1	442	447	PF00069	0.653
MOD_NEK2_1	668	673	PF00069	0.588
MOD_NEK2_1	68	73	PF00069	0.462
MOD_NEK2_1	7	12	PF00069	0.324
MOD_NEK2_1	830	835	PF00069	0.438
MOD_NEK2_2	595	600	PF00069	0.560
MOD_PIKK_1	339	345	PF00454	0.605
MOD_PIKK_1	367	373	PF00454	0.778
MOD_PIKK_1	669	675	PF00454	0.713
MOD_PK_1	5	11	PF00069	0.400
MOD_PKA_1	470	476	PF00069	0.648
MOD_PKA_2	221	227	PF00069	0.441
MOD_PKA_2	247	253	PF00069	0.422
MOD_PKA_2	454	460	PF00069	0.701
MOD_PKA_2	463	469	PF00069	0.611
MOD_PKA_2	470	476	PF00069	0.519
MOD_PKA_2	548	554	PF00069	0.536
MOD_PKA_2	631	637	PF00069	0.556
MOD_PKA_2	663	669	PF00069	0.629
MOD_PKA_2	678	684	PF00069	0.578
MOD_PKA_2	708	714	PF00069	0.602
MOD_PKA_2	726	732	PF00069	0.647
MOD_PKA_2	759	765	PF00069	0.593
MOD_PKA_2	834	840	PF00069	0.586
MOD_PKB_1	453	461	PF00069	0.684
MOD_Plk_1	323	329	PF00069	0.760
MOD_Plk_1	438	444	PF00069	0.569
MOD_Plk_1	752	758	PF00069	0.463
MOD_Plk_1	830	836	PF00069	0.417
MOD_Plk_1	84	90	PF00069	0.444
MOD_Plk_1	99	105	PF00069	0.290
MOD_Plk_2-3	608	614	PF00069	0.565
MOD_Plk_2-3	94	100	PF00069	0.416
MOD_Plk_4	12	18	PF00069	0.363
MOD_Plk_4	250	256	PF00069	0.459
MOD_Plk_4	407	413	PF00069	0.534
MOD_Plk_4	63	69	PF00069	0.354
MOD_Plk_4	653	659	PF00069	0.556
MOD_Plk_4	663	669	PF00069	0.535
MOD_Plk_4	72	78	PF00069	0.336
MOD_ProDKin_1	285	291	PF00069	0.609
MOD_ProDKin_1	356	362	PF00069	0.699
MOD_ProDKin_1	382	388	PF00069	0.568
MOD_ProDKin_1	391	397	PF00069	0.622
MOD_ProDKin_1	425	431	PF00069	0.584
MOD_ProDKin_1	465	471	PF00069	0.646
MOD_ProDKin_1	502	508	PF00069	0.781
MOD_ProDKin_1	615	621	PF00069	0.797
MOD_ProDKin_1	632	638	PF00069	0.570
MOD_ProDKin_1	690	696	PF00069	0.812
MOD_ProDKin_1	716	722	PF00069	0.815
MOD_SUMO_rev_2	511	516	PF00179	0.610
TRG_DiLeu_BaEn_1	417	422	PF01217	0.544
TRG_DiLeu_BaEn_2	778	784	PF01217	0.394
TRG_DiLeu_BaEn_4	99	105	PF01217	0.342
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.286
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.545
TRG_DiLeu_BaLyEn_6	734	739	PF01217	0.537
TRG_ENDOCYTIC_2	156	159	PF00928	0.457
TRG_ENDOCYTIC_2	50	53	PF00928	0.390
TRG_ENDOCYTIC_2	667	670	PF00928	0.558
TRG_ER_diArg_1	30	32	PF00400	0.375
TRG_ER_diArg_1	412	414	PF00400	0.508
TRG_ER_diArg_1	469	471	PF00400	0.640
TRG_ER_diArg_1	767	770	PF00400	0.440
TRG_ER_diArg_1	844	847	PF00400	0.756
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.273
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	522	527	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	770	775	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	802	806	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM49	Leptomonas seymouri	47%	100%
A0A3S7X1L3	Leishmania donovani	74%	100%
A4I3P4	Leishmania infantum	74%	100%
E9AZY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q8A0	Leishmania major	73%	100%