DUF3342 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3342), putative

Species:

Leishmania braziliensis

UniProt:

A4HGL7_LEIBR

TriTrypDb:

LbrM.28.1810 , LBRM2903_280024200

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGL7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.492
CLV_C14_Caspase3-7	206	210	PF00656	0.508
CLV_C14_Caspase3-7	379	383	PF00656	0.552
CLV_NRD_NRD_1	355	357	PF00675	0.487
CLV_NRD_NRD_1	528	530	PF00675	0.590
CLV_NRD_NRD_1	586	588	PF00675	0.647
CLV_PCSK_KEX2_1	355	357	PF00082	0.487
CLV_PCSK_KEX2_1	528	530	PF00082	0.590
CLV_PCSK_SKI1_1	23	27	PF00082	0.448
CLV_PCSK_SKI1_1	499	503	PF00082	0.455
DEG_APCC_DBOX_1	22	30	PF00400	0.403
DEG_APCC_DBOX_1	354	362	PF00400	0.368
DEG_SPOP_SBC_1	560	564	PF00917	0.765
DOC_CYCLIN_RxL_1	350	362	PF00134	0.359
DOC_CYCLIN_yClb5_NLxxxL_5	131	140	PF00134	0.524
DOC_MAPK_gen_1	355	363	PF00069	0.481
DOC_MAPK_gen_1	69	77	PF00069	0.423
DOC_MAPK_MEF2A_6	303	310	PF00069	0.545
DOC_MAPK_MEF2A_6	504	511	PF00069	0.424
DOC_MAPK_MEF2A_6	93	101	PF00069	0.273
DOC_PP2B_LxvP_1	310	313	PF13499	0.668
DOC_PP4_FxxP_1	480	483	PF00568	0.494
DOC_USP7_MATH_1	212	216	PF00917	0.651
DOC_USP7_MATH_1	220	224	PF00917	0.489
DOC_USP7_MATH_1	230	234	PF00917	0.463
DOC_USP7_MATH_1	446	450	PF00917	0.780
DOC_USP7_MATH_1	469	473	PF00917	0.754
DOC_USP7_MATH_1	483	487	PF00917	0.485
DOC_USP7_MATH_1	560	564	PF00917	0.797
DOC_USP7_MATH_1	568	572	PF00917	0.660
DOC_USP7_MATH_1	57	61	PF00917	0.240
DOC_USP7_UBL2_3	585	589	PF12436	0.556
DOC_WW_Pin1_4	226	231	PF00397	0.472
DOC_WW_Pin1_4	257	262	PF00397	0.662
DOC_WW_Pin1_4	329	334	PF00397	0.562
DOC_WW_Pin1_4	377	382	PF00397	0.571
DOC_WW_Pin1_4	408	413	PF00397	0.528
DOC_WW_Pin1_4	479	484	PF00397	0.705
DOC_WW_Pin1_4	541	546	PF00397	0.688
DOC_WW_Pin1_4	55	60	PF00397	0.423
DOC_WW_Pin1_4	562	567	PF00397	0.685
DOC_WW_Pin1_4	601	606	PF00397	0.706
LIG_14-3-3_CanoR_1	238	244	PF00244	0.575
LIG_14-3-3_CanoR_1	251	261	PF00244	0.643
LIG_14-3-3_CanoR_1	370	378	PF00244	0.632
LIG_14-3-3_CanoR_1	45	54	PF00244	0.403
LIG_14-3-3_CanoR_1	596	606	PF00244	0.586
LIG_Actin_WH2_2	129	145	PF00022	0.513
LIG_APCC_ABBA_1	158	163	PF00400	0.580
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BRCT_BRCA1_1	101	105	PF00533	0.349
LIG_BRCT_BRCA1_1	127	131	PF00533	0.534
LIG_CaM_NSCaTE_8	341	348	PF13499	0.431
LIG_CSL_BTD_1	52	55	PF09270	0.240
LIG_deltaCOP1_diTrp_1	339	343	PF00928	0.392
LIG_FHA_1	136	142	PF00498	0.438
LIG_FHA_1	198	204	PF00498	0.528
LIG_FHA_1	229	235	PF00498	0.657
LIG_FHA_1	253	259	PF00498	0.736
LIG_FHA_1	284	290	PF00498	0.659
LIG_FHA_1	333	339	PF00498	0.562
LIG_FHA_1	86	92	PF00498	0.240
LIG_FHA_2	11	17	PF00498	0.343
LIG_FHA_2	196	202	PF00498	0.636
LIG_FHA_2	240	246	PF00498	0.579
LIG_FHA_2	324	330	PF00498	0.502
LIG_IRF3_LxIS_1	537	544	PF10401	0.621
LIG_LIR_Apic_2	477	483	PF02991	0.503
LIG_LIR_Gen_1	102	111	PF02991	0.357
LIG_LIR_Gen_1	233	244	PF02991	0.388
LIG_LIR_Gen_1	3	14	PF02991	0.583
LIG_LIR_Gen_1	76	84	PF02991	0.360
LIG_LIR_Nem_3	233	239	PF02991	0.481
LIG_LIR_Nem_3	604	609	PF02991	0.752
LIG_LIR_Nem_3	76	80	PF02991	0.336
LIG_MYND_1	436	440	PF01753	0.487
LIG_NRBOX	359	365	PF00104	0.571
LIG_PDZ_Class_1	609	614	PF00595	0.524
LIG_Pex14_2	476	480	PF04695	0.516
LIG_SH2_CRK	415	419	PF00017	0.691
LIG_SH2_CRK	606	610	PF00017	0.765
LIG_SH2_NCK_1	378	382	PF00017	0.393
LIG_SH2_STAP1	279	283	PF00017	0.530
LIG_SH2_STAP1	484	488	PF00017	0.491
LIG_SH2_STAP1	6	10	PF00017	0.504
LIG_SH2_STAT5	118	121	PF00017	0.407
LIG_SH2_STAT5	351	354	PF00017	0.404
LIG_SH2_STAT5	38	41	PF00017	0.363
LIG_SH2_STAT5	390	393	PF00017	0.468
LIG_SH2_STAT5	397	400	PF00017	0.495
LIG_SH2_STAT5	497	500	PF00017	0.626
LIG_SH2_STAT5	514	517	PF00017	0.463
LIG_SH3_1	528	534	PF00018	0.513
LIG_SH3_3	11	17	PF00018	0.438
LIG_SH3_3	213	219	PF00018	0.527
LIG_SH3_3	258	264	PF00018	0.638
LIG_SH3_3	266	272	PF00018	0.679
LIG_SH3_3	424	430	PF00018	0.660
LIG_SH3_3	49	55	PF00018	0.492
LIG_SH3_3	528	534	PF00018	0.596
LIG_SUMO_SIM_anti_2	508	513	PF11976	0.621
LIG_SUMO_SIM_par_1	306	311	PF11976	0.646
LIG_SUMO_SIM_par_1	359	365	PF11976	0.571
LIG_SUMO_SIM_par_1	505	510	PF11976	0.559
LIG_TYR_ITIM	116	121	PF00017	0.292
LIG_UBA3_1	157	162	PF00899	0.316
LIG_WW_3	312	316	PF00397	0.417
MOD_CDK_SPK_2	562	567	PF00069	0.711
MOD_CDK_SPxK_1	408	414	PF00069	0.607
MOD_CK1_1	256	262	PF00069	0.708
MOD_CK1_1	318	324	PF00069	0.717
MOD_CK1_1	332	338	PF00069	0.532
MOD_CK1_1	4	10	PF00069	0.522
MOD_CK1_1	48	54	PF00069	0.269
MOD_CK1_1	482	488	PF00069	0.650
MOD_CK1_1	561	567	PF00069	0.735
MOD_CK1_1	58	64	PF00069	0.454
MOD_CK1_1	601	607	PF00069	0.732
MOD_CK1_1	85	91	PF00069	0.476
MOD_CK2_1	16	22	PF00069	0.454
MOD_CK2_1	195	201	PF00069	0.632
MOD_CK2_1	256	262	PF00069	0.679
MOD_CK2_1	323	329	PF00069	0.630
MOD_CK2_1	431	437	PF00069	0.725
MOD_CK2_1	446	452	PF00069	0.695
MOD_Cter_Amidation	585	588	PF01082	0.558
MOD_GlcNHglycan	209	213	PF01048	0.751
MOD_GlcNHglycan	222	225	PF01048	0.717
MOD_GlcNHglycan	299	302	PF01048	0.475
MOD_GlcNHglycan	317	320	PF01048	0.680
MOD_GlcNHglycan	321	324	PF01048	0.721
MOD_GlcNHglycan	415	418	PF01048	0.717
MOD_GlcNHglycan	448	451	PF01048	0.738
MOD_GlcNHglycan	470	474	PF01048	0.733
MOD_GlcNHglycan	477	480	PF01048	0.683
MOD_GlcNHglycan	55	58	PF01048	0.240
MOD_GlcNHglycan	589	592	PF01048	0.741
MOD_GlcNHglycan	6	9	PF01048	0.564
MOD_GlcNHglycan	61	64	PF01048	0.240
MOD_GlcNHglycan	84	87	PF01048	0.454
MOD_GSK3_1	121	128	PF00069	0.470
MOD_GSK3_1	131	138	PF00069	0.532
MOD_GSK3_1	197	204	PF00069	0.645
MOD_GSK3_1	208	215	PF00069	0.755
MOD_GSK3_1	220	227	PF00069	0.690
MOD_GSK3_1	252	259	PF00069	0.655
MOD_GSK3_1	279	286	PF00069	0.523
MOD_GSK3_1	315	322	PF00069	0.493
MOD_GSK3_1	382	389	PF00069	0.456
MOD_GSK3_1	446	453	PF00069	0.697
MOD_GSK3_1	475	482	PF00069	0.725
MOD_GSK3_1	53	60	PF00069	0.333
MOD_GSK3_1	541	548	PF00069	0.650
MOD_GSK3_1	558	565	PF00069	0.658
MOD_GSK3_1	568	575	PF00069	0.685
MOD_GSK3_1	577	584	PF00069	0.501
MOD_GSK3_1	597	604	PF00069	0.714
MOD_GSK3_1	605	612	PF00069	0.664
MOD_GSK3_1	85	92	PF00069	0.390
MOD_GSK3_1	95	102	PF00069	0.332
MOD_N-GLC_1	382	387	PF02516	0.475
MOD_N-GLC_1	474	479	PF02516	0.556
MOD_NEK2_1	1	6	PF00069	0.575
MOD_NEK2_1	101	106	PF00069	0.406
MOD_NEK2_1	131	136	PF00069	0.490
MOD_NEK2_1	142	147	PF00069	0.542
MOD_NEK2_1	173	178	PF00069	0.477
MOD_NEK2_1	239	244	PF00069	0.562
MOD_NEK2_1	252	257	PF00069	0.578
MOD_NEK2_1	364	369	PF00069	0.473
MOD_NEK2_1	413	418	PF00069	0.708
MOD_NEK2_1	462	467	PF00069	0.770
MOD_NEK2_1	47	52	PF00069	0.240
MOD_NEK2_1	490	495	PF00069	0.646
MOD_NEK2_1	539	544	PF00069	0.698
MOD_NEK2_1	559	564	PF00069	0.459
MOD_NEK2_1	609	614	PF00069	0.738
MOD_NEK2_2	230	235	PF00069	0.419
MOD_PIKK_1	364	370	PF00454	0.376
MOD_PIKK_1	85	91	PF00454	0.240
MOD_PK_1	162	168	PF00069	0.357
MOD_PKA_1	376	382	PF00069	0.658
MOD_PKA_1	587	593	PF00069	0.560
MOD_PKA_2	142	148	PF00069	0.500
MOD_PKA_2	204	210	PF00069	0.610
MOD_PKA_2	253	259	PF00069	0.722
MOD_PKA_2	369	375	PF00069	0.540
MOD_PKA_2	413	419	PF00069	0.674
MOD_PKA_2	539	545	PF00069	0.743
MOD_PKA_2	592	598	PF00069	0.703
MOD_Plk_1	10	16	PF00069	0.329
MOD_Plk_1	21	27	PF00069	0.391
MOD_Plk_1	224	230	PF00069	0.611
MOD_Plk_1	386	392	PF00069	0.526
MOD_Plk_1	48	54	PF00069	0.435
MOD_Plk_2-3	382	388	PF00069	0.401
MOD_Plk_4	101	107	PF00069	0.408
MOD_Plk_4	173	179	PF00069	0.437
MOD_Plk_4	239	245	PF00069	0.582
MOD_Plk_4	359	365	PF00069	0.535
MOD_Plk_4	386	392	PF00069	0.526
MOD_Plk_4	48	54	PF00069	0.240
MOD_ProDKin_1	226	232	PF00069	0.467
MOD_ProDKin_1	257	263	PF00069	0.653
MOD_ProDKin_1	329	335	PF00069	0.546
MOD_ProDKin_1	377	383	PF00069	0.579
MOD_ProDKin_1	408	414	PF00069	0.544
MOD_ProDKin_1	479	485	PF00069	0.701
MOD_ProDKin_1	541	547	PF00069	0.687
MOD_ProDKin_1	55	61	PF00069	0.423
MOD_ProDKin_1	562	568	PF00069	0.678
MOD_ProDKin_1	601	607	PF00069	0.707
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.492
TRG_ENDOCYTIC_2	118	121	PF00928	0.290
TRG_ENDOCYTIC_2	6	9	PF00928	0.474
TRG_ENDOCYTIC_2	606	609	PF00928	0.767
TRG_ER_diArg_1	68	71	PF00400	0.492
TRG_ER_FFAT_2	470	482	PF00635	0.514
TRG_NLS_MonoExtN_4	585	591	PF00514	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G4	Leptomonas seymouri	43%	95%
A0A3Q8IDU2	Leishmania donovani	73%	99%
A0A3S5ISD3	Trypanosoma rangeli	26%	98%
A4I3P2	Leishmania infantum	75%	100%
D0A8C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AZY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q8A2	Leishmania major	73%	100%