Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGL4_LEIBR

TriTrypDb:

LbrM.28.1780 , LBRM2903_280024000

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.658
CLV_NRD_NRD_1	35	37	PF00675	0.525
CLV_PCSK_KEX2_1	183	185	PF00082	0.619
CLV_PCSK_PC7_1	179	185	PF00082	0.617
CLV_PCSK_SKI1_1	185	189	PF00082	0.685
CLV_PCSK_SKI1_1	82	86	PF00082	0.697
DEG_APCC_DBOX_1	275	283	PF00400	0.737
DEG_Nend_UBRbox_3	1	3	PF02207	0.775
DOC_MAPK_gen_1	183	192	PF00069	0.688
DOC_MAPK_MEF2A_6	183	190	PF00069	0.642
DOC_MAPK_NFAT4_5	183	191	PF00069	0.647
DOC_PP1_RVXF_1	126	133	PF00149	0.673
DOC_PP4_FxxP_1	132	135	PF00568	0.516
DOC_USP7_MATH_1	202	206	PF00917	0.578
DOC_USP7_MATH_1	219	223	PF00917	0.679
DOC_USP7_MATH_1	226	230	PF00917	0.794
DOC_USP7_MATH_1	316	320	PF00917	0.644
DOC_USP7_MATH_1	71	75	PF00917	0.820
DOC_USP7_MATH_1	84	88	PF00917	0.609
DOC_USP7_MATH_1	90	94	PF00917	0.456
DOC_USP7_UBL2_3	8	12	PF12436	0.708
DOC_WW_Pin1_4	10	15	PF00397	0.794
DOC_WW_Pin1_4	190	195	PF00397	0.653
DOC_WW_Pin1_4	206	211	PF00397	0.665
DOC_WW_Pin1_4	21	26	PF00397	0.637
DOC_WW_Pin1_4	215	220	PF00397	0.685
DOC_WW_Pin1_4	250	255	PF00397	0.744
DOC_WW_Pin1_4	289	294	PF00397	0.642
DOC_WW_Pin1_4	69	74	PF00397	0.556
DOC_WW_Pin1_4	99	104	PF00397	0.817
LIG_14-3-3_CanoR_1	120	126	PF00244	0.586
LIG_14-3-3_CanoR_1	151	159	PF00244	0.567
LIG_14-3-3_CanoR_1	276	284	PF00244	0.776
LIG_BRCT_BRCA1_1	293	297	PF00533	0.556
LIG_FHA_1	153	159	PF00498	0.609
LIG_FHA_1	53	59	PF00498	0.592
LIG_FHA_2	100	106	PF00498	0.819
LIG_FHA_2	264	270	PF00498	0.581
LIG_FHA_2	310	316	PF00498	0.575
LIG_IBAR_NPY_1	214	216	PF08397	0.584
LIG_LIR_Nem_3	44	48	PF02991	0.616
LIG_PCNA_TLS_4	88	95	PF02747	0.522
LIG_RPA_C_Fungi	174	186	PF08784	0.653
LIG_SH2_CRK	216	220	PF00017	0.623
LIG_SH2_CRK	35	39	PF00017	0.774
LIG_SH2_CRK	45	49	PF00017	0.567
LIG_SH2_CRK	68	72	PF00017	0.798
LIG_SH2_NCK_1	216	220	PF00017	0.623
LIG_SH2_SRC	314	317	PF00017	0.561
LIG_SH2_SRC	68	71	PF00017	0.757
LIG_SH2_STAT5	57	60	PF00017	0.735
LIG_SH3_1	67	73	PF00018	0.546
LIG_SH3_2	108	113	PF14604	0.567
LIG_SH3_3	1	7	PF00018	0.539
LIG_SH3_3	105	111	PF00018	0.571
LIG_SH3_3	142	148	PF00018	0.468
LIG_SH3_3	207	213	PF00018	0.833
LIG_SH3_3	290	296	PF00018	0.711
LIG_SH3_3	67	73	PF00018	0.546
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.603
LIG_TRAF2_1	102	105	PF00917	0.823
LIG_WRC_WIRS_1	91	96	PF05994	0.519
LIG_WW_3	13	17	PF00397	0.549
MOD_CDC14_SPxK_1	13	16	PF00782	0.546
MOD_CDC14_SPxK_1	218	221	PF00782	0.625
MOD_CDK_SPxK_1	10	16	PF00069	0.546
MOD_CDK_SPxK_1	215	221	PF00069	0.624
MOD_CK1_1	10	16	PF00069	0.660
MOD_CK1_1	217	223	PF00069	0.674
MOD_CK1_1	235	241	PF00069	0.649
MOD_CK1_1	253	259	PF00069	0.564
MOD_CK1_1	264	270	PF00069	0.544
MOD_CK1_1	318	324	PF00069	0.586
MOD_CK1_1	93	99	PF00069	0.556
MOD_CK2_1	151	157	PF00069	0.613
MOD_CK2_1	164	170	PF00069	0.493
MOD_CK2_1	309	315	PF00069	0.718
MOD_CK2_1	99	105	PF00069	0.817
MOD_GlcNHglycan	145	148	PF01048	0.719
MOD_GlcNHglycan	166	169	PF01048	0.655
MOD_GlcNHglycan	172	176	PF01048	0.557
MOD_GlcNHglycan	228	231	PF01048	0.823
MOD_GlcNHglycan	234	237	PF01048	0.715
MOD_GlcNHglycan	246	249	PF01048	0.530
MOD_GlcNHglycan	255	258	PF01048	0.699
MOD_GlcNHglycan	318	321	PF01048	0.803
MOD_GlcNHglycan	324	327	PF01048	0.589
MOD_GlcNHglycan	9	12	PF01048	0.664
MOD_GSK3_1	202	209	PF00069	0.636
MOD_GSK3_1	215	222	PF00069	0.592
MOD_GSK3_1	235	242	PF00069	0.660
MOD_GSK3_1	263	270	PF00069	0.673
MOD_GSK3_1	274	281	PF00069	0.749
MOD_GSK3_1	283	290	PF00069	0.646
MOD_GSK3_1	316	323	PF00069	0.800
MOD_GSK3_1	48	55	PF00069	0.646
MOD_GSK3_1	90	97	PF00069	0.719
MOD_N-GLC_1	143	148	PF02516	0.725
MOD_N-GLC_1	232	237	PF02516	0.560
MOD_N-GLC_1	274	279	PF02516	0.772
MOD_N-GLC_1	282	287	PF02516	0.726
MOD_N-GLC_1	99	104	PF02516	0.564
MOD_NEK2_1	164	169	PF00069	0.648
MOD_NEK2_1	282	287	PF00069	0.715
MOD_NEK2_1	48	53	PF00069	0.739
MOD_NEK2_1	94	99	PF00069	0.785
MOD_NEK2_2	202	207	PF00069	0.580
MOD_PIKK_1	291	297	PF00454	0.556
MOD_PIKK_1	71	77	PF00454	0.670
MOD_PK_1	113	119	PF00069	0.801
MOD_PKB_1	80	88	PF00069	0.586
MOD_Plk_1	171	177	PF00069	0.654
MOD_Plk_1	282	288	PF00069	0.601
MOD_Plk_1	53	59	PF00069	0.733
MOD_Plk_4	113	119	PF00069	0.684
MOD_Plk_4	283	289	PF00069	0.697
MOD_Plk_4	309	315	PF00069	0.581
MOD_Plk_4	53	59	PF00069	0.733
MOD_Plk_4	90	96	PF00069	0.519
MOD_ProDKin_1	10	16	PF00069	0.799
MOD_ProDKin_1	190	196	PF00069	0.658
MOD_ProDKin_1	206	212	PF00069	0.661
MOD_ProDKin_1	21	27	PF00069	0.637
MOD_ProDKin_1	215	221	PF00069	0.689
MOD_ProDKin_1	250	256	PF00069	0.747
MOD_ProDKin_1	289	295	PF00069	0.644
MOD_ProDKin_1	69	75	PF00069	0.560
MOD_ProDKin_1	99	105	PF00069	0.817
TRG_DiLeu_BaEn_1	157	162	PF01217	0.637
TRG_DiLeu_BaLyEn_6	125	130	PF01217	0.587
TRG_DiLeu_LyEn_5	44	49	PF01217	0.735
TRG_ENDOCYTIC_2	45	48	PF00928	0.613
TRG_ER_diArg_1	79	82	PF00400	0.642
TRG_NES_CRM1_1	157	170	PF08389	0.527
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID56	Leishmania donovani	74%	99%
A4I3P0	Leishmania infantum	74%	99%
E9AZY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
Q4Q8A4	Leishmania major	73%	100%