Kelch motif family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Galactose oxidase, central domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGL2_LEIBR

TriTrypDb:

LbrM.28.1760 , LBRM2903_280023800

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.541
CLV_NRD_NRD_1	379	381	PF00675	0.640
CLV_NRD_NRD_1	42	44	PF00675	0.575
CLV_PCSK_KEX2_1	158	160	PF00082	0.541
CLV_PCSK_KEX2_1	42	44	PF00082	0.575
CLV_PCSK_SKI1_1	371	375	PF00082	0.538
CLV_PCSK_SKI1_1	396	400	PF00082	0.482
DEG_APCC_DBOX_1	158	166	PF00400	0.508
DEG_MDM2_SWIB_1	276	284	PF02201	0.485
DEG_Nend_UBRbox_2	1	3	PF02207	0.524
DOC_CDC14_PxL_1	241	249	PF14671	0.419
DOC_CKS1_1	254	259	PF01111	0.278
DOC_CKS1_1	408	413	PF01111	0.612
DOC_CYCLIN_RxL_1	243	251	PF00134	0.535
DOC_MAPK_MEF2A_6	246	254	PF00069	0.449
DOC_PP1_RVXF_1	353	360	PF00149	0.443
DOC_PP2B_LxvP_1	21	24	PF13499	0.656
DOC_PP4_FxxP_1	254	257	PF00568	0.429
DOC_USP7_MATH_1	129	133	PF00917	0.677
DOC_USP7_MATH_1	24	28	PF00917	0.726
DOC_USP7_MATH_1	297	301	PF00917	0.486
DOC_USP7_MATH_1	330	334	PF00917	0.358
DOC_USP7_MATH_1	390	394	PF00917	0.364
DOC_USP7_MATH_1	53	57	PF00917	0.528
DOC_USP7_MATH_1	60	64	PF00917	0.629
DOC_WW_Pin1_4	171	176	PF00397	0.546
DOC_WW_Pin1_4	185	190	PF00397	0.554
DOC_WW_Pin1_4	233	238	PF00397	0.389
DOC_WW_Pin1_4	239	244	PF00397	0.343
DOC_WW_Pin1_4	253	258	PF00397	0.201
DOC_WW_Pin1_4	298	303	PF00397	0.750
DOC_WW_Pin1_4	371	376	PF00397	0.568
DOC_WW_Pin1_4	385	390	PF00397	0.337
DOC_WW_Pin1_4	407	412	PF00397	0.631
DOC_WW_Pin1_4	80	85	PF00397	0.551
LIG_14-3-3_CanoR_1	158	163	PF00244	0.503
LIG_14-3-3_CanoR_1	246	251	PF00244	0.530
LIG_14-3-3_CanoR_1	88	92	PF00244	0.558
LIG_APCC_ABBA_1	165	170	PF00400	0.507
LIG_BIR_III_2	172	176	PF00653	0.570
LIG_BIR_III_4	15	19	PF00653	0.392
LIG_BRCT_BRCA1_1	250	254	PF00533	0.487
LIG_deltaCOP1_diTrp_1	278	282	PF00928	0.479
LIG_DLG_GKlike_1	246	253	PF00625	0.424
LIG_FHA_1	164	170	PF00498	0.466
LIG_FHA_1	256	262	PF00498	0.488
LIG_FHA_1	286	292	PF00498	0.323
LIG_FHA_1	361	367	PF00498	0.513
LIG_FHA_1	386	392	PF00498	0.426
LIG_FHA_1	415	421	PF00498	0.579
LIG_FHA_1	81	87	PF00498	0.526
LIG_FHA_2	186	192	PF00498	0.508
LIG_FHA_2	53	59	PF00498	0.573
LIG_LIR_Apic_2	251	257	PF02991	0.488
LIG_LIR_Gen_1	275	284	PF02991	0.475
LIG_LIR_Gen_1	286	297	PF02991	0.491
LIG_LIR_Gen_1	66	75	PF02991	0.469
LIG_LIR_Nem_3	258	263	PF02991	0.474
LIG_LIR_Nem_3	275	279	PF02991	0.450
LIG_LIR_Nem_3	286	292	PF02991	0.396
LIG_LIR_Nem_3	66	71	PF02991	0.432
LIG_MYND_1	239	243	PF01753	0.227
LIG_Pex14_2	276	280	PF04695	0.483
LIG_SH2_GRB2like	75	78	PF00017	0.615
LIG_SH2_STAP1	163	167	PF00017	0.506
LIG_SH2_STAT5	147	150	PF00017	0.443
LIG_SH2_STAT5	206	209	PF00017	0.402
LIG_SH2_STAT5	222	225	PF00017	0.269
LIG_SH2_STAT5	336	339	PF00017	0.531
LIG_SH2_STAT5	387	390	PF00017	0.443
LIG_SH3_3	17	23	PF00018	0.633
LIG_SH3_3	288	294	PF00018	0.585
LIG_SH3_3	311	317	PF00018	0.573
LIG_SH3_3	405	411	PF00018	0.644
LIG_SH3_3	47	53	PF00018	0.544
LIG_SH3_3	6	12	PF00018	0.520
LIG_SH3_3	95	101	PF00018	0.567
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.472
LIG_SUMO_SIM_anti_2	34	41	PF11976	0.566
LIG_SUMO_SIM_par_1	246	251	PF11976	0.502
LIG_SUMO_SIM_par_1	374	379	PF11976	0.496
LIG_SUMO_SIM_par_1	414	419	PF11976	0.564
LIG_TRFH_1	326	330	PF08558	0.329
LIG_WRC_WIRS_1	273	278	PF05994	0.509
LIG_WRC_WIRS_1	279	284	PF05994	0.484
MOD_CDK_SPxxK_3	239	246	PF00069	0.480
MOD_CK1_1	130	136	PF00069	0.750
MOD_CK1_1	64	70	PF00069	0.528
MOD_CK1_1	76	82	PF00069	0.529
MOD_CK2_1	185	191	PF00069	0.598
MOD_CK2_1	60	66	PF00069	0.564
MOD_DYRK1A_RPxSP_1	371	375	PF00069	0.356
MOD_GlcNHglycan	117	120	PF01048	0.649
MOD_GlcNHglycan	129	132	PF01048	0.714
MOD_GlcNHglycan	135	138	PF01048	0.537
MOD_GlcNHglycan	24	27	PF01048	0.658
MOD_GlcNHglycan	330	333	PF01048	0.616
MOD_GlcNHglycan	371	374	PF01048	0.557
MOD_GlcNHglycan	411	414	PF01048	0.569
MOD_GlcNHglycan	47	50	PF01048	0.525
MOD_GlcNHglycan	80	83	PF01048	0.535
MOD_GSK3_1	111	118	PF00069	0.558
MOD_GSK3_1	125	132	PF00069	0.630
MOD_GSK3_1	133	140	PF00069	0.696
MOD_GSK3_1	211	218	PF00069	0.459
MOD_GSK3_1	235	242	PF00069	0.417
MOD_GSK3_1	283	290	PF00069	0.501
MOD_GSK3_1	297	304	PF00069	0.640
MOD_GSK3_1	328	335	PF00069	0.582
MOD_GSK3_1	60	67	PF00069	0.625
MOD_GSK3_1	76	83	PF00069	0.413
MOD_N-GLC_1	345	350	PF02516	0.578
MOD_N-GLC_1	76	81	PF02516	0.600
MOD_NEK2_1	248	253	PF00069	0.430
MOD_NEK2_1	414	419	PF00069	0.535
MOD_NEK2_2	163	168	PF00069	0.288
MOD_PIKK_1	211	217	PF00454	0.447
MOD_PKA_1	158	164	PF00069	0.502
MOD_PKA_2	158	164	PF00069	0.502
MOD_PKA_2	328	334	PF00069	0.598
MOD_PKA_2	64	70	PF00069	0.568
MOD_PKA_2	87	93	PF00069	0.400
MOD_Plk_2-3	272	278	PF00069	0.424
MOD_Plk_4	158	164	PF00069	0.502
MOD_Plk_4	248	254	PF00069	0.443
MOD_Plk_4	255	261	PF00069	0.459
MOD_Plk_4	332	338	PF00069	0.541
MOD_Plk_4	64	70	PF00069	0.567
MOD_Plk_4	87	93	PF00069	0.456
MOD_ProDKin_1	171	177	PF00069	0.547
MOD_ProDKin_1	185	191	PF00069	0.559
MOD_ProDKin_1	233	239	PF00069	0.389
MOD_ProDKin_1	253	259	PF00069	0.197
MOD_ProDKin_1	298	304	PF00069	0.750
MOD_ProDKin_1	371	377	PF00069	0.576
MOD_ProDKin_1	385	391	PF00069	0.331
MOD_ProDKin_1	407	413	PF00069	0.613
MOD_ProDKin_1	80	86	PF00069	0.548
TRG_DiLeu_BaEn_1	395	400	PF01217	0.564
TRG_DiLeu_BaEn_1	66	71	PF01217	0.466
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.364
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.347
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P824	Leptomonas seymouri	54%	100%
A0A1X0NSF3	Trypanosomatidae	35%	100%
A0A3R7MSX4	Trypanosoma rangeli	40%	100%
A0A3S7X1L8	Leishmania donovani	84%	100%
A4I3N8	Leishmania infantum	84%	100%
D0A8C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AZX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q8A6	Leishmania major	84%	100%
V5AVA5	Trypanosoma cruzi	39%	100%