Phosphonopyruvate decarboxylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphonopyruvate decarboxylase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HGL1_LEIBR

TriTrypDb:

LbrM.28.1750 , LBRM2903_280023700

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGL1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0008152	metabolic process	1	5
GO:0009058	biosynthetic process	2	5
GO:0009987	cellular process	1	5
GO:0016053	organic acid biosynthetic process	4	1
GO:0019295	coenzyme M biosynthetic process	5	1
GO:0019296	coenzyme M metabolic process	4	1
GO:0044237	cellular metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044272	sulfur compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	5
GO:1901576	organic substance biosynthetic process	3	5
GO:0006793	phosphorus metabolic process	3	4
GO:0019634	organic phosphonate metabolic process	4	4
GO:0019637	organophosphate metabolic process	3	4
GO:0032923	organic phosphonate biosynthetic process	4	4
GO:0090407	organophosphate biosynthetic process	4	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016829	lyase activity	2	10
GO:0019842	vitamin binding	3	11
GO:0030976	thiamine pyrophosphate binding	3	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0050997	quaternary ammonium group binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:1901681	sulfur compound binding	2	11
GO:0016830	carbon-carbon lyase activity	3	5
GO:0016831	carboxy-lyase activity	4	5
GO:0050545	sulfopyruvate decarboxylase activity	5	1
GO:0033980	phosphonopyruvate decarboxylase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.634
CLV_NRD_NRD_1	396	398	PF00675	0.532
CLV_NRD_NRD_1	404	406	PF00675	0.342
CLV_NRD_NRD_1	6	8	PF00675	0.565
CLV_PCSK_KEX2_1	194	196	PF00082	0.634
CLV_PCSK_KEX2_1	396	398	PF00082	0.585
CLV_PCSK_KEX2_1	403	405	PF00082	0.583
CLV_PCSK_KEX2_1	6	8	PF00082	0.565
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.290
CLV_PCSK_SKI1_1	303	307	PF00082	0.383
CLV_PCSK_SKI1_1	6	10	PF00082	0.620
DEG_APCC_DBOX_1	271	279	PF00400	0.326
DOC_CKS1_1	77	82	PF01111	0.254
DOC_MAPK_MEF2A_6	353	360	PF00069	0.390
DOC_PP4_FxxP_1	33	36	PF00568	0.251
DOC_USP7_MATH_1	232	236	PF00917	0.457
DOC_USP7_MATH_1	241	245	PF00917	0.546
DOC_USP7_MATH_1	42	46	PF00917	0.465
DOC_USP7_MATH_1	8	12	PF00917	0.357
DOC_WW_Pin1_4	13	18	PF00397	0.397
DOC_WW_Pin1_4	174	179	PF00397	0.316
DOC_WW_Pin1_4	76	81	PF00397	0.254
LIG_14-3-3_CanoR_1	135	141	PF00244	0.332
LIG_14-3-3_CanoR_1	27	36	PF00244	0.291
LIG_BRCT_BRCA1_1	29	33	PF00533	0.386
LIG_eIF4E_1	105	111	PF01652	0.274
LIG_FHA_1	201	207	PF00498	0.601
LIG_FHA_1	307	313	PF00498	0.333
LIG_FHA_1	42	48	PF00498	0.382
LIG_FHA_1	77	83	PF00498	0.349
LIG_FHA_2	119	125	PF00498	0.404
LIG_LIR_Apic_2	103	108	PF02991	0.312
LIG_LIR_Apic_2	30	36	PF02991	0.294
LIG_LIR_Apic_2	37	42	PF02991	0.294
LIG_LIR_Gen_1	145	155	PF02991	0.291
LIG_LIR_Gen_1	166	173	PF02991	0.377
LIG_LIR_Gen_1	177	185	PF02991	0.199
LIG_LIR_Nem_3	145	151	PF02991	0.261
LIG_LIR_Nem_3	166	172	PF02991	0.456
LIG_LIR_Nem_3	177	182	PF02991	0.178
LIG_MLH1_MIPbox_1	29	33	PF16413	0.326
LIG_PCNA_PIPBox_1	93	102	PF02747	0.382
LIG_PTAP_UEV_1	201	206	PF05743	0.472
LIG_PTB_Apo_2	319	326	PF02174	0.169
LIG_PTB_Phospho_1	319	325	PF10480	0.169
LIG_SH2_CRK	105	109	PF00017	0.269
LIG_SH2_CRK	148	152	PF00017	0.314
LIG_SH2_NCK_1	148	152	PF00017	0.219
LIG_SH2_STAP1	169	173	PF00017	0.379
LIG_SH2_STAT5	19	22	PF00017	0.449
LIG_SH2_STAT5	349	352	PF00017	0.386
LIG_SH2_STAT5	39	42	PF00017	0.358
LIG_SH2_STAT5	46	49	PF00017	0.291
LIG_SH2_STAT5	56	59	PF00017	0.182
LIG_SH2_STAT5	73	76	PF00017	0.424
LIG_SH3_3	141	147	PF00018	0.419
LIG_SH3_3	199	205	PF00018	0.566
LIG_SUMO_SIM_par_1	354	362	PF11976	0.386
LIG_TRAF2_1	231	234	PF00917	0.388
LIG_TRAF2_1	366	369	PF00917	0.264
LIG_TRFH_1	38	42	PF08558	0.326
LIG_TYR_ITIM	146	151	PF00017	0.231
LIG_UBA3_1	110	118	PF00899	0.266
LIG_UBA3_1	311	316	PF00899	0.264
MOD_CK1_1	11	17	PF00069	0.258
MOD_CK1_1	174	180	PF00069	0.409
MOD_CK1_1	228	234	PF00069	0.527
MOD_CK1_1	244	250	PF00069	0.313
MOD_CK1_1	271	277	PF00069	0.326
MOD_CK1_1	384	390	PF00069	0.349
MOD_CK2_1	118	124	PF00069	0.382
MOD_CK2_1	20	26	PF00069	0.266
MOD_CK2_1	228	234	PF00069	0.388
MOD_CK2_1	386	392	PF00069	0.460
MOD_GlcNHglycan	230	233	PF01048	0.380
MOD_GlcNHglycan	243	246	PF01048	0.549
MOD_GlcNHglycan	29	32	PF01048	0.326
MOD_GlcNHglycan	389	392	PF01048	0.703
MOD_GlcNHglycan	86	89	PF01048	0.306
MOD_GSK3_1	146	153	PF00069	0.324
MOD_GSK3_1	228	235	PF00069	0.358
MOD_GSK3_1	381	388	PF00069	0.556
MOD_N-GLC_1	11	16	PF02516	0.265
MOD_N-GLC_1	219	224	PF02516	0.445
MOD_N-GLC_1	321	326	PF02516	0.264
MOD_NEK2_1	111	116	PF00069	0.336
MOD_NEK2_1	20	25	PF00069	0.382
MOD_NEK2_1	225	230	PF00069	0.370
MOD_NEK2_1	254	259	PF00069	0.264
MOD_NEK2_1	336	341	PF00069	0.283
MOD_NEK2_1	47	52	PF00069	0.300
MOD_NEK2_1	84	89	PF00069	0.251
MOD_NEK2_2	232	237	PF00069	0.238
MOD_NEK2_2	73	78	PF00069	0.382
MOD_NEK2_2	95	100	PF00069	0.382
MOD_PKA_2	134	140	PF00069	0.337
MOD_PKA_2	26	32	PF00069	0.264
MOD_PKA_2	271	277	PF00069	0.402
MOD_PKB_1	25	33	PF00069	0.211
MOD_Plk_1	11	17	PF00069	0.258
MOD_Plk_1	336	342	PF00069	0.251
MOD_Plk_4	146	152	PF00069	0.354
MOD_Plk_4	184	190	PF00069	0.267
MOD_Plk_4	42	48	PF00069	0.297
MOD_Plk_4	95	101	PF00069	0.382
MOD_ProDKin_1	13	19	PF00069	0.396
MOD_ProDKin_1	174	180	PF00069	0.311
MOD_ProDKin_1	76	82	PF00069	0.254
MOD_SUMO_rev_2	387	395	PF00179	0.621
TRG_DiLeu_BaEn_1	184	189	PF01217	0.257
TRG_DiLeu_BaEn_1	359	364	PF01217	0.382
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.269
TRG_ENDOCYTIC_2	148	151	PF00928	0.341
TRG_ENDOCYTIC_2	169	172	PF00928	0.410
TRG_ENDOCYTIC_2	349	352	PF00928	0.386
TRG_ER_diArg_1	194	196	PF00400	0.522
TRG_ER_diArg_1	395	397	PF00400	0.611
TRG_ER_diArg_1	404	406	PF00400	0.328
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I285	Leptomonas seymouri	67%	100%
A0A1X0NSM8	Trypanosomatidae	42%	100%
A0A3S7X1I1	Leishmania donovani	85%	100%
A0A422NZ60	Trypanosoma rangeli	41%	100%
A4I3N7	Leishmania infantum	85%	100%
D0A8C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AZX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O86938	Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494)	29%	100%
Q4Q8A7	Leishmania major	84%	100%
Q54271	Streptomyces hygroscopicus	28%	100%
V5DBD1	Trypanosoma cruzi	43%	92%