Putative hydrolase, alpha/beta fold family

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase, alpha/beta fold family, putative

Species:

Leishmania braziliensis

UniProt:

A4HGL0_LEIBR

TriTrypDb:

LbrM.28.1740 , LBRM2903_280023600

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HGL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGL0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	27
GO:0016787	hydrolase activity	2	27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	266	268	PF00675	0.361
CLV_PCSK_KEX2_1	331	333	PF00082	0.404
CLV_PCSK_KEX2_1	41	43	PF00082	0.424
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.522
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.451
CLV_PCSK_SKI1_1	110	114	PF00082	0.240
CLV_PCSK_SKI1_1	20	24	PF00082	0.495
CLV_PCSK_SKI1_1	232	236	PF00082	0.269
CLV_PCSK_SKI1_1	267	271	PF00082	0.248
CLV_PCSK_SKI1_1	41	45	PF00082	0.420
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.156
DOC_MAPK_MEF2A_6	168	176	PF00069	0.365
DOC_MAPK_MEF2A_6	267	276	PF00069	0.269
DOC_PP1_RVXF_1	298	305	PF00149	0.362
DOC_PP2B_LxvP_1	111	114	PF13499	0.303
DOC_PP4_FxxP_1	103	106	PF00568	0.419
DOC_PP4_FxxP_1	50	53	PF00568	0.353
DOC_SPAK_OSR1_1	194	198	PF12202	0.208
DOC_USP7_UBL2_3	264	268	PF12436	0.219
DOC_WW_Pin1_4	13	18	PF00397	0.465
LIG_14-3-3_CanoR_1	122	128	PF00244	0.223
LIG_14-3-3_CanoR_1	168	173	PF00244	0.270
LIG_14-3-3_CanoR_1	267	272	PF00244	0.301
LIG_14-3-3_CanoR_1	42	46	PF00244	0.377
LIG_14-3-3_CanoR_1	65	69	PF00244	0.156
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BIR_III_4	133	137	PF00653	0.396
LIG_BRCT_BRCA1_1	96	100	PF00533	0.364
LIG_DLG_GKlike_1	168	175	PF00625	0.403
LIG_eIF4E_1	290	296	PF01652	0.395
LIG_FHA_2	124	130	PF00498	0.290
LIG_FHA_2	96	102	PF00498	0.319
LIG_GBD_Chelix_1	60	68	PF00786	0.435
LIG_LIR_Apic_2	101	106	PF02991	0.406
LIG_LIR_Apic_2	49	53	PF02991	0.388
LIG_LIR_Gen_1	44	53	PF02991	0.325
LIG_LIR_Gen_1	97	108	PF02991	0.222
LIG_LIR_Nem_3	44	50	PF02991	0.312
LIG_LIR_Nem_3	81	87	PF02991	0.295
LIG_LIR_Nem_3	97	103	PF02991	0.394
LIG_MYND_1	13	17	PF01753	0.288
LIG_Pex14_1	213	217	PF04695	0.395
LIG_Pex14_2	75	79	PF04695	0.330
LIG_SH2_GRB2like	89	92	PF00017	0.307
LIG_SH2_STAP1	192	196	PF00017	0.395
LIG_SH2_STAT3	217	220	PF00017	0.395
LIG_SH2_STAT5	125	128	PF00017	0.303
LIG_SH2_STAT5	217	220	PF00017	0.376
LIG_SH2_STAT5	233	236	PF00017	0.204
LIG_SH2_STAT5	78	81	PF00017	0.307
LIG_SH2_STAT5	85	88	PF00017	0.282
LIG_SH3_3	181	187	PF00018	0.390
LIG_SH3_3	279	285	PF00018	0.268
LIG_SH3_3	299	305	PF00018	0.334
LIG_SH3_3	50	56	PF00018	0.418
LIG_SUMO_SIM_par_1	27	35	PF11976	0.221
LIG_UBA3_1	137	142	PF00899	0.262
LIG_UBA3_1	324	331	PF00899	0.285
LIG_WRC_WIRS_1	47	52	PF05994	0.304
MOD_CDK_SPxxK_3	13	20	PF00069	0.454
MOD_CK1_1	2	8	PF00069	0.710
MOD_CK2_1	115	121	PF00069	0.320
MOD_CK2_1	233	239	PF00069	0.446
MOD_Cter_Amidation	39	42	PF01082	0.442
MOD_GlcNHglycan	1	4	PF01048	0.669
MOD_GlcNHglycan	202	205	PF01048	0.334
MOD_GSK3_1	3	10	PF00069	0.683
MOD_GSK3_1	32	39	PF00069	0.478
MOD_GSK3_1	91	98	PF00069	0.346
MOD_N-GLC_1	325	330	PF02516	0.408
MOD_NEK2_1	123	128	PF00069	0.335
MOD_NEK2_1	149	154	PF00069	0.347
MOD_NEK2_1	307	312	PF00069	0.311
MOD_NEK2_1	325	330	PF00069	0.427
MOD_NEK2_1	64	69	PF00069	0.387
MOD_NEK2_1	7	12	PF00069	0.612
MOD_PIKK_1	216	222	PF00454	0.395
MOD_PIKK_1	246	252	PF00454	0.164
MOD_PKA_1	267	273	PF00069	0.379
MOD_PKA_1	41	47	PF00069	0.443
MOD_PKA_2	121	127	PF00069	0.397
MOD_PKA_2	246	252	PF00069	0.335
MOD_PKA_2	41	47	PF00069	0.440
MOD_PKA_2	64	70	PF00069	0.156
MOD_PKA_2	91	97	PF00069	0.365
MOD_Plk_1	325	331	PF00069	0.482
MOD_Plk_4	270	276	PF00069	0.228
MOD_Plk_4	325	331	PF00069	0.533
MOD_Plk_4	64	70	PF00069	0.424
MOD_ProDKin_1	13	19	PF00069	0.454
MOD_SUMO_rev_2	25	31	PF00179	0.358
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.399
TRG_ENDOCYTIC_2	192	195	PF00928	0.395
TRG_ENDOCYTIC_2	47	50	PF00928	0.327
TRG_ENDOCYTIC_2	84	87	PF00928	0.298
TRG_NES_CRM1_1	133	145	PF08389	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	30%	77%
A0A0N0P3S4	Leptomonas seymouri	40%	92%
A0A0N1PA10	Leptomonas seymouri	71%	98%
A0A0N1PCQ2	Leptomonas seymouri	45%	100%
A0A0S4JQB3	Bodo saltans	37%	98%
A0A1X0NSR3	Trypanosomatidae	40%	75%
A0A1X0NSS6	Trypanosomatidae	43%	100%
A0A1X0NT85	Trypanosomatidae	30%	68%
A0A3Q8IAY1	Leishmania donovani	38%	86%
A0A3R7KKJ0	Trypanosoma rangeli	41%	100%
A0A3S5IRR1	Trypanosoma rangeli	33%	82%
A0A3S7WUJ3	Leishmania donovani	42%	99%
A0A3S7WUK0	Leishmania donovani	29%	77%
A0A3S7X1K2	Leishmania donovani	81%	97%
A0A422NS41	Trypanosoma rangeli	39%	78%
A1JMX1	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	26%	100%
A4H956	Leishmania braziliensis	46%	100%
A4H959	Leishmania braziliensis	31%	100%
A4H960	Leishmania braziliensis	41%	100%
A4HXH8	Leishmania infantum	42%	99%
A4HXI1	Leishmania infantum	29%	77%
A4HXI2	Leishmania infantum	38%	86%
A4I3N6	Leishmania infantum	81%	97%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	83%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	77%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	86%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	97%
P00632	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	26%	100%
Q4Q8A8	Leishmania major	79%	100%
Q4QE86	Leishmania major	39%	100%
Q4QE87	Leishmania major	31%	100%
Q4QE90	Leishmania major	42%	100%
Q54528	Streptomyces purpurascens	32%	100%
Q54809	Streptomyces peucetius	27%	100%
Q55217	Streptomyces sp. (strain C5)	27%	100%
Q83WC8	Acinetobacter calcoaceticus	22%	100%
V5AZB9	Trypanosoma cruzi	40%	78%
V5BER0	Trypanosoma cruzi	42%	100%
V5BNU9	Trypanosoma cruzi	30%	82%