Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGK9_LEIBR

TriTrypDb:

LbrM.28.1730 , LBRM2903_280023400

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.656
CLV_C14_Caspase3-7	554	558	PF00656	0.692
CLV_NRD_NRD_1	22	24	PF00675	0.650
CLV_NRD_NRD_1	223	225	PF00675	0.538
CLV_NRD_NRD_1	386	388	PF00675	0.511
CLV_NRD_NRD_1	409	411	PF00675	0.681
CLV_NRD_NRD_1	423	425	PF00675	0.623
CLV_PCSK_FUR_1	384	388	PF00082	0.442
CLV_PCSK_KEX2_1	109	111	PF00082	0.721
CLV_PCSK_KEX2_1	22	24	PF00082	0.526
CLV_PCSK_KEX2_1	223	225	PF00082	0.538
CLV_PCSK_KEX2_1	386	388	PF00082	0.511
CLV_PCSK_KEX2_1	423	425	PF00082	0.768
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.721
DEG_APCC_DBOX_1	47	55	PF00400	0.626
DEG_Nend_UBRbox_2	1	3	PF02207	0.621
DEG_SCF_FBW7_1	148	154	PF00400	0.658
DEG_SPOP_SBC_1	512	516	PF00917	0.638
DEG_SPOP_SBC_1	546	550	PF00917	0.580
DOC_CKS1_1	148	153	PF01111	0.659
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.524
DOC_MAPK_gen_1	344	351	PF00069	0.535
DOC_MAPK_gen_1	384	394	PF00069	0.608
DOC_MAPK_gen_1	489	498	PF00069	0.425
DOC_MAPK_MEF2A_6	344	351	PF00069	0.535
DOC_MAPK_MEF2A_6	387	396	PF00069	0.581
DOC_PP2B_LxvP_1	116	119	PF13499	0.571
DOC_USP7_MATH_1	121	125	PF00917	0.676
DOC_USP7_MATH_1	367	371	PF00917	0.548
DOC_USP7_MATH_1	455	459	PF00917	0.534
DOC_USP7_MATH_1	512	516	PF00917	0.661
DOC_USP7_MATH_1	93	97	PF00917	0.553
DOC_WW_Pin1_4	117	122	PF00397	0.567
DOC_WW_Pin1_4	130	135	PF00397	0.590
DOC_WW_Pin1_4	144	149	PF00397	0.685
DOC_WW_Pin1_4	162	167	PF00397	0.517
DOC_WW_Pin1_4	250	255	PF00397	0.675
DOC_WW_Pin1_4	77	82	PF00397	0.675
LIG_14-3-3_CanoR_1	196	201	PF00244	0.449
LIG_14-3-3_CanoR_1	249	253	PF00244	0.514
LIG_14-3-3_CanoR_1	387	393	PF00244	0.459
LIG_14-3-3_CanoR_1	48	58	PF00244	0.624
LIG_14-3-3_CanoR_1	517	527	PF00244	0.708
LIG_14-3-3_CanoR_1	91	101	PF00244	0.632
LIG_Actin_WH2_2	218	233	PF00022	0.407
LIG_BIR_III_2	28	32	PF00653	0.574
LIG_BRCT_BRCA1_1	445	449	PF00533	0.677
LIG_FHA_1	156	162	PF00498	0.548
LIG_FHA_1	197	203	PF00498	0.482
LIG_FHA_1	230	236	PF00498	0.410
LIG_FHA_1	454	460	PF00498	0.574
LIG_FHA_1	462	468	PF00498	0.613
LIG_FHA_1	482	488	PF00498	0.530
LIG_FHA_2	173	179	PF00498	0.603
LIG_FHA_2	217	223	PF00498	0.392
LIG_FHA_2	548	554	PF00498	0.730
LIG_GBD_Chelix_1	217	225	PF00786	0.382
LIG_Integrin_RGD_1	435	437	PF01839	0.545
LIG_LIR_Gen_1	150	160	PF02991	0.562
LIG_LIR_Gen_1	446	455	PF02991	0.679
LIG_LIR_Nem_3	150	155	PF02991	0.571
LIG_LIR_Nem_3	370	376	PF02991	0.661
LIG_LIR_Nem_3	446	452	PF02991	0.679
LIG_SH2_GRB2like	11	14	PF00017	0.559
LIG_SH2_STAP1	11	15	PF00017	0.584
LIG_SH2_STAP1	527	531	PF00017	0.657
LIG_SH2_STAT5	19	22	PF00017	0.610
LIG_SH2_STAT5	38	41	PF00017	0.477
LIG_SH2_STAT5	444	447	PF00017	0.525
LIG_SH3_1	157	163	PF00018	0.703
LIG_SH3_3	128	134	PF00018	0.670
LIG_SH3_3	142	148	PF00018	0.628
LIG_SH3_3	157	163	PF00018	0.547
LIG_SH3_3	251	257	PF00018	0.587
LIG_SH3_3	260	266	PF00018	0.607
LIG_SUMO_SIM_par_1	231	237	PF11976	0.529
LIG_TRAF2_1	483	486	PF00917	0.624
LIG_TYR_ITSM	369	376	PF00017	0.524
LIG_Vh1_VBS_1	214	232	PF01044	0.387
LIG_WRC_WIRS_1	152	157	PF05994	0.573
MOD_CDK_SPK_2	117	122	PF00069	0.567
MOD_CDK_SPK_2	130	135	PF00069	0.551
MOD_CK1_1	133	139	PF00069	0.626
MOD_CK1_1	147	153	PF00069	0.687
MOD_CK1_1	250	256	PF00069	0.685
MOD_CK1_1	297	303	PF00069	0.548
MOD_CK1_1	37	43	PF00069	0.633
MOD_CK1_1	440	446	PF00069	0.622
MOD_CK1_1	454	460	PF00069	0.567
MOD_CK1_1	477	483	PF00069	0.649
MOD_CK1_1	521	527	PF00069	0.713
MOD_CK1_1	544	550	PF00069	0.612
MOD_CK1_1	57	63	PF00069	0.574
MOD_CK1_1	77	83	PF00069	0.469
MOD_CK2_1	172	178	PF00069	0.610
MOD_CK2_1	216	222	PF00069	0.387
MOD_CK2_1	264	270	PF00069	0.555
MOD_CK2_1	360	366	PF00069	0.399
MOD_CK2_1	479	485	PF00069	0.693
MOD_GlcNHglycan	178	181	PF01048	0.583
MOD_GlcNHglycan	275	278	PF01048	0.642
MOD_GlcNHglycan	306	309	PF01048	0.654
MOD_GlcNHglycan	330	333	PF01048	0.596
MOD_GlcNHglycan	429	432	PF01048	0.642
MOD_GlcNHglycan	453	456	PF01048	0.711
MOD_GlcNHglycan	74	77	PF01048	0.562
MOD_GSK3_1	117	124	PF00069	0.691
MOD_GSK3_1	147	154	PF00069	0.677
MOD_GSK3_1	168	175	PF00069	0.531
MOD_GSK3_1	273	280	PF00069	0.584
MOD_GSK3_1	290	297	PF00069	0.691
MOD_GSK3_1	30	37	PF00069	0.578
MOD_GSK3_1	328	335	PF00069	0.593
MOD_GSK3_1	443	450	PF00069	0.726
MOD_GSK3_1	451	458	PF00069	0.720
MOD_GSK3_1	461	468	PF00069	0.574
MOD_GSK3_1	475	482	PF00069	0.750
MOD_GSK3_1	50	57	PF00069	0.489
MOD_GSK3_1	518	525	PF00069	0.694
MOD_GSK3_1	527	534	PF00069	0.614
MOD_GSK3_1	535	542	PF00069	0.551
MOD_GSK3_1	544	551	PF00069	0.555
MOD_N-GLC_1	332	337	PF02516	0.710
MOD_N-GLC_1	427	432	PF02516	0.557
MOD_N-GLC_1	60	65	PF02516	0.639
MOD_NEK2_1	155	160	PF00069	0.711
MOD_NEK2_1	248	253	PF00069	0.526
MOD_NEK2_1	272	277	PF00069	0.683
MOD_NEK2_1	36	41	PF00069	0.535
MOD_NEK2_1	520	525	PF00069	0.645
MOD_NEK2_1	531	536	PF00069	0.635
MOD_NEK2_1	54	59	PF00069	0.573
MOD_NEK2_1	72	77	PF00069	0.470
MOD_OFUCOSY	27	34	PF10250	0.508
MOD_PIKK_1	168	174	PF00454	0.528
MOD_PK_1	109	115	PF00069	0.564
MOD_PKA_1	109	115	PF00069	0.564
MOD_PKA_2	109	115	PF00069	0.583
MOD_PKA_2	121	127	PF00069	0.541
MOD_PKA_2	248	254	PF00069	0.511
MOD_PKA_2	465	471	PF00069	0.640
MOD_PKA_2	518	524	PF00069	0.706
MOD_PKA_2	540	546	PF00069	0.605
MOD_Plk_1	172	178	PF00069	0.656
MOD_Plk_1	335	341	PF00069	0.690
MOD_Plk_1	34	40	PF00069	0.519
MOD_Plk_1	368	374	PF00069	0.527
MOD_Plk_1	440	446	PF00069	0.613
MOD_Plk_2-3	437	443	PF00069	0.526
MOD_Plk_2-3	553	559	PF00069	0.635
MOD_Plk_4	440	446	PF00069	0.561
MOD_Plk_4	455	461	PF00069	0.654
MOD_Plk_4	50	56	PF00069	0.600
MOD_Plk_4	74	80	PF00069	0.631
MOD_ProDKin_1	117	123	PF00069	0.567
MOD_ProDKin_1	130	136	PF00069	0.590
MOD_ProDKin_1	144	150	PF00069	0.686
MOD_ProDKin_1	162	168	PF00069	0.518
MOD_ProDKin_1	250	256	PF00069	0.679
MOD_ProDKin_1	77	83	PF00069	0.677
MOD_SUMO_for_1	343	346	PF00179	0.537
TRG_ENDOCYTIC_2	373	376	PF00928	0.554
TRG_ER_diArg_1	223	226	PF00400	0.537
TRG_ER_diArg_1	384	387	PF00400	0.491
TRG_ER_diArg_1	488	491	PF00400	0.583
TRG_ER_diArg_1	496	499	PF00400	0.455
TRG_ER_diArg_1	5	8	PF00400	0.593
TRG_ER_diArg_1	517	520	PF00400	0.700
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X1K0	Leishmania donovani	69%	100%
A4I3N5	Leishmania infantum	69%	100%
E9AZX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q8A9	Leishmania major	69%	100%