Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGK8_LEIBR

TriTrypDb:

LbrM.28.1720 , LBRM2903_280023300

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HGK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	64	70	PF00089	0.633
CLV_NRD_NRD_1	148	150	PF00675	0.408
CLV_NRD_NRD_1	166	168	PF00675	0.220
CLV_NRD_NRD_1	189	191	PF00675	0.341
CLV_NRD_NRD_1	97	99	PF00675	0.341
CLV_PCSK_KEX2_1	148	150	PF00082	0.408
CLV_PCSK_KEX2_1	166	168	PF00082	0.220
CLV_PCSK_KEX2_1	97	99	PF00082	0.341
DEG_APCC_DBOX_1	66	74	PF00400	0.345
DEG_Nend_UBRbox_2	1	3	PF02207	0.722
DOC_MAPK_gen_1	164	174	PF00069	0.530
DOC_MAPK_MEF2A_6	166	174	PF00069	0.647
DOC_MAPK_NFAT4_5	167	175	PF00069	0.612
DOC_PP1_RVXF_1	73	79	PF00149	0.277
DOC_PP4_FxxP_1	142	145	PF00568	0.607
DOC_PP4_FxxP_1	31	34	PF00568	0.620
DOC_PP4_FxxP_1	5	8	PF00568	0.551
LIG_14-3-3_CanoR_1	67	71	PF00244	0.364
LIG_APCC_ABBA_1	208	213	PF00400	0.623
LIG_BRCT_BRCA1_1	192	196	PF00533	0.618
LIG_eIF4E_1	155	161	PF01652	0.589
LIG_FHA_1	192	198	PF00498	0.594
LIG_FHA_1	219	225	PF00498	0.566
LIG_FHA_1	49	55	PF00498	0.340
LIG_FHA_1	88	94	PF00498	0.339
LIG_LIR_Apic_2	139	145	PF02991	0.616
LIG_LIR_Apic_2	2	8	PF02991	0.640
LIG_LIR_Apic_2	29	34	PF02991	0.638
LIG_LIR_Gen_1	48	57	PF02991	0.441
LIG_LIR_LC3C_4	51	54	PF02991	0.210
LIG_LIR_Nem_3	130	136	PF02991	0.576
LIG_LIR_Nem_3	200	206	PF02991	0.524
LIG_LIR_Nem_3	230	236	PF02991	0.585
LIG_LIR_Nem_3	48	52	PF02991	0.441
LIG_NRBOX	156	162	PF00104	0.584
LIG_NRBOX	167	173	PF00104	0.530
LIG_Pex14_2	78	82	PF04695	0.302
LIG_REV1ctd_RIR_1	56	64	PF16727	0.464
LIG_SH2_CRK	203	207	PF00017	0.607
LIG_SH2_CRK	233	237	PF00017	0.561
LIG_SH2_CRK	41	45	PF00017	0.393
LIG_SH2_NCK_1	41	45	PF00017	0.362
LIG_SH2_PTP2	62	65	PF00017	0.398
LIG_SH2_STAP1	19	23	PF00017	0.693
LIG_SH2_STAP1	41	45	PF00017	0.426
LIG_SH2_STAP1	89	93	PF00017	0.318
LIG_SH2_STAT5	56	59	PF00017	0.376
LIG_SH2_STAT5	62	65	PF00017	0.373
LIG_SH2_STAT5	89	92	PF00017	0.328
LIG_SUMO_SIM_anti_2	110	115	PF11976	0.534
LIG_SUMO_SIM_anti_2	220	226	PF11976	0.578
LIG_SUMO_SIM_anti_2	51	56	PF11976	0.210
LIG_SUMO_SIM_par_1	88	94	PF11976	0.418
LIG_TYR_ITIM	231	236	PF00017	0.544
LIG_TYR_ITIM	39	44	PF00017	0.393
LIG_UBA3_1	160	164	PF00899	0.576
LIG_UBA3_1	170	175	PF00899	0.531
LIG_UBA3_1	222	227	PF00899	0.645
MOD_CK1_1	66	72	PF00069	0.360
MOD_CK2_1	176	182	PF00069	0.640
MOD_GlcNHglycan	151	154	PF01048	0.412
MOD_GlcNHglycan	178	181	PF01048	0.441
MOD_GlcNHglycan	20	24	PF01048	0.478
MOD_GlcNHglycan	26	29	PF01048	0.422
MOD_GlcNHglycan	79	82	PF01048	0.337
MOD_GSK3_1	123	130	PF00069	0.581
MOD_GSK3_1	132	139	PF00069	0.609
MOD_GSK3_1	151	158	PF00069	0.484
MOD_GSK3_1	191	198	PF00069	0.576
MOD_GSK3_1	202	209	PF00069	0.493
MOD_GSK3_1	87	94	PF00069	0.440
MOD_N-GLC_1	107	112	PF02516	0.317
MOD_N-GLC_1	136	141	PF02516	0.478
MOD_NEK2_1	170	175	PF00069	0.615
MOD_NEK2_1	196	201	PF00069	0.574
MOD_NEK2_1	206	211	PF00069	0.506
MOD_NEK2_2	26	31	PF00069	0.563
MOD_PK_1	204	210	PF00069	0.607
MOD_PKA_1	190	196	PF00069	0.570
MOD_PKA_2	66	72	PF00069	0.361
MOD_PKB_1	149	157	PF00069	0.586
MOD_Plk_1	107	113	PF00069	0.518
MOD_Plk_4	102	108	PF00069	0.566
MOD_Plk_4	218	224	PF00069	0.596
MOD_Plk_4	26	32	PF00069	0.567
MOD_Plk_4	48	54	PF00069	0.350
MOD_Plk_4	91	97	PF00069	0.410
MOD_SUMO_rev_2	207	217	PF00179	0.656
TRG_DiLeu_BaEn_1	156	161	PF01217	0.588
TRG_DiLeu_BaEn_1	220	225	PF01217	0.619
TRG_DiLeu_BaEn_2	191	197	PF01217	0.563
TRG_ENDOCYTIC_2	203	206	PF00928	0.608
TRG_ENDOCYTIC_2	233	236	PF00928	0.617
TRG_ENDOCYTIC_2	41	44	PF00928	0.381
TRG_ENDOCYTIC_2	56	59	PF00928	0.272
TRG_ENDOCYTIC_2	62	65	PF00928	0.328
TRG_ER_diArg_1	147	149	PF00400	0.613
TRG_ER_diArg_1	166	168	PF00400	0.578
TRG_ER_diArg_1	96	98	PF00400	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N3	Leptomonas seymouri	79%	82%
A0A0S4J943	Bodo saltans	55%	76%
A0A1X0NYS0	Trypanosomatidae	61%	86%
A0A3Q8IB08	Leishmania donovani	93%	100%
A0A3R7KJ52	Trypanosoma rangeli	65%	85%
A4I3N4	Leishmania infantum	93%	100%
D0A864	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	86%
E9AZX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8B0	Leishmania major	92%	100%
V5ASF1	Trypanosoma cruzi	65%	85%