Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HGK7_LEIBR

TriTrypDb:

LbrM.28.1710 , LBRM2903_280023200

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.602
CLV_C14_Caspase3-7	259	263	PF00656	0.618
CLV_C14_Caspase3-7	721	725	PF00656	0.678
CLV_NRD_NRD_1	116	118	PF00675	0.715
CLV_NRD_NRD_1	483	485	PF00675	0.457
CLV_NRD_NRD_1	608	610	PF00675	0.580
CLV_NRD_NRD_1	834	836	PF00675	0.576
CLV_PCSK_FUR_1	832	836	PF00082	0.586
CLV_PCSK_KEX2_1	116	118	PF00082	0.715
CLV_PCSK_KEX2_1	483	485	PF00082	0.457
CLV_PCSK_KEX2_1	665	667	PF00082	0.686
CLV_PCSK_KEX2_1	834	836	PF00082	0.568
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.715
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.686
CLV_PCSK_SKI1_1	121	125	PF00082	0.763
CLV_PCSK_SKI1_1	216	220	PF00082	0.591
CLV_PCSK_SKI1_1	4	8	PF00082	0.542
CLV_PCSK_SKI1_1	484	488	PF00082	0.557
CLV_PCSK_SKI1_1	665	669	PF00082	0.642
CLV_PCSK_SKI1_1	672	676	PF00082	0.628
CLV_PCSK_SKI1_1	712	716	PF00082	0.670
CLV_PCSK_SKI1_1	746	750	PF00082	0.444
DEG_Nend_Nbox_1	1	3	PF02207	0.538
DEG_SCF_TRCP1_1	696	702	PF00400	0.562
DEG_SPOP_SBC_1	40	44	PF00917	0.564
DOC_CKS1_1	109	114	PF01111	0.571
DOC_MAPK_DCC_7	687	695	PF00069	0.539
DOC_MAPK_gen_1	216	225	PF00069	0.590
DOC_MAPK_gen_1	425	433	PF00069	0.514
DOC_MAPK_gen_1	832	842	PF00069	0.541
DOC_MAPK_MEF2A_6	835	844	PF00069	0.534
DOC_PP1_RVXF_1	2	8	PF00149	0.541
DOC_PP1_RVXF_1	710	717	PF00149	0.708
DOC_USP7_MATH_1	15	19	PF00917	0.566
DOC_USP7_MATH_1	267	271	PF00917	0.751
DOC_USP7_MATH_1	276	280	PF00917	0.674
DOC_USP7_MATH_1	328	332	PF00917	0.820
DOC_USP7_MATH_1	563	567	PF00917	0.585
DOC_USP7_MATH_1	605	609	PF00917	0.633
DOC_USP7_MATH_1	612	616	PF00917	0.628
DOC_USP7_MATH_1	637	641	PF00917	0.551
DOC_USP7_MATH_1	643	647	PF00917	0.537
DOC_USP7_MATH_1	81	85	PF00917	0.833
DOC_USP7_MATH_1	812	816	PF00917	0.687
DOC_USP7_UBL2_3	227	231	PF12436	0.684
DOC_USP7_UBL2_3	508	512	PF12436	0.396
DOC_WW_Pin1_4	108	113	PF00397	0.735
DOC_WW_Pin1_4	163	168	PF00397	0.768
DOC_WW_Pin1_4	239	244	PF00397	0.667
DOC_WW_Pin1_4	272	277	PF00397	0.586
DOC_WW_Pin1_4	326	331	PF00397	0.741
DOC_WW_Pin1_4	473	478	PF00397	0.608
DOC_WW_Pin1_4	486	491	PF00397	0.421
DOC_WW_Pin1_4	639	644	PF00397	0.636
DOC_WW_Pin1_4	654	659	PF00397	0.602
DOC_WW_Pin1_4	781	786	PF00397	0.704
DOC_WW_Pin1_4	82	87	PF00397	0.767
DOC_WW_Pin1_4	822	827	PF00397	0.695
LIG_14-3-3_CanoR_1	148	153	PF00244	0.616
LIG_14-3-3_CanoR_1	162	169	PF00244	0.544
LIG_14-3-3_CanoR_1	180	186	PF00244	0.712
LIG_14-3-3_CanoR_1	190	195	PF00244	0.719
LIG_14-3-3_CanoR_1	333	339	PF00244	0.598
LIG_14-3-3_CanoR_1	383	391	PF00244	0.541
LIG_14-3-3_CanoR_1	425	434	PF00244	0.404
LIG_14-3-3_CanoR_1	464	473	PF00244	0.727
LIG_14-3-3_CanoR_1	483	487	PF00244	0.389
LIG_14-3-3_CanoR_1	672	677	PF00244	0.545
LIG_14-3-3_CanoR_1	682	687	PF00244	0.499
LIG_14-3-3_CanoR_1	707	716	PF00244	0.686
LIG_14-3-3_CanoR_1	726	736	PF00244	0.450
LIG_14-3-3_CanoR_1	788	796	PF00244	0.595
LIG_14-3-3_CanoR_1	832	842	PF00244	0.559
LIG_Actin_WH2_2	374	391	PF00022	0.405
LIG_BIR_III_2	724	728	PF00653	0.675
LIG_BIR_III_2	801	805	PF00653	0.528
LIG_BIR_III_4	266	270	PF00653	0.613
LIG_BIR_III_4	613	617	PF00653	0.572
LIG_CtBP_PxDLS_1	33	37	PF00389	0.555
LIG_FHA_1	109	115	PF00498	0.570
LIG_FHA_1	180	186	PF00498	0.837
LIG_FHA_1	275	281	PF00498	0.572
LIG_FHA_1	29	35	PF00498	0.764
LIG_FHA_1	383	389	PF00498	0.537
LIG_FHA_1	40	46	PF00498	0.583
LIG_FHA_1	410	416	PF00498	0.724
LIG_FHA_1	577	583	PF00498	0.789
LIG_FHA_1	649	655	PF00498	0.595
LIG_FHA_1	713	719	PF00498	0.663
LIG_FHA_1	733	739	PF00498	0.584
LIG_FHA_1	74	80	PF00498	0.616
LIG_FHA_1	788	794	PF00498	0.771
LIG_FHA_1	823	829	PF00498	0.819
LIG_FHA_2	589	595	PF00498	0.552
LIG_FHA_2	61	67	PF00498	0.545
LIG_FHA_2	776	782	PF00498	0.491
LIG_FHA_2	822	828	PF00498	0.591
LIG_LIR_Apic_2	244	249	PF02991	0.694
LIG_LIR_Gen_1	362	372	PF02991	0.546
LIG_LIR_Gen_1	435	445	PF02991	0.515
LIG_LIR_Gen_1	646	654	PF02991	0.537
LIG_LIR_Nem_3	362	367	PF02991	0.549
LIG_LIR_Nem_3	435	441	PF02991	0.597
LIG_LIR_Nem_3	646	650	PF02991	0.537
LIG_LYPXL_yS_3	119	122	PF13949	0.777
LIG_MYND_1	632	636	PF01753	0.554
LIG_MYND_3	753	757	PF01753	0.405
LIG_REV1ctd_RIR_1	365	374	PF16727	0.386
LIG_SH2_CRK	246	250	PF00017	0.655
LIG_SH2_CRK	438	442	PF00017	0.355
LIG_SH2_GRB2like	438	441	PF00017	0.388
LIG_SH2_GRB2like	647	650	PF00017	0.540
LIG_SH2_NCK_1	246	250	PF00017	0.655
LIG_SH2_NCK_1	807	811	PF00017	0.553
LIG_SH2_PTP2	647	650	PF00017	0.540
LIG_SH2_SRC	246	249	PF00017	0.797
LIG_SH2_SRC	807	810	PF00017	0.554
LIG_SH2_STAP1	308	312	PF00017	0.570
LIG_SH2_STAT5	194	197	PF00017	0.584
LIG_SH2_STAT5	253	256	PF00017	0.646
LIG_SH2_STAT5	647	650	PF00017	0.540
LIG_SH2_STAT5	669	672	PF00017	0.695
LIG_SH3_2	112	117	PF14604	0.730
LIG_SH3_2	661	666	PF14604	0.693
LIG_SH3_3	106	112	PF00018	0.821
LIG_SH3_3	242	248	PF00018	0.699
LIG_SH3_3	27	33	PF00018	0.559
LIG_SH3_3	526	532	PF00018	0.613
LIG_SH3_3	626	632	PF00018	0.706
LIG_SH3_3	655	661	PF00018	0.557
LIG_SUMO_SIM_anti_2	735	740	PF11976	0.598
LIG_SUMO_SIM_par_1	491	497	PF11976	0.599
LIG_SUMO_SIM_par_1	733	740	PF11976	0.609
LIG_TRAF2_1	494	497	PF00917	0.636
LIG_TRAF2_1	759	762	PF00917	0.615
LIG_TRFH_1	58	62	PF08558	0.535
LIG_TRFH_1	716	720	PF08558	0.692
LIG_UBA3_1	738	746	PF00899	0.592
LIG_WW_3	550	554	PF00397	0.610
MOD_CAAXbox	848	851	PF01239	0.537
MOD_CDC14_SPxK_1	85	88	PF00782	0.650
MOD_CDK_SPxK_1	82	88	PF00069	0.657
MOD_CDK_SPxxK_3	326	333	PF00069	0.571
MOD_CDK_SPxxK_3	781	788	PF00069	0.534
MOD_CDK_SPxxK_3	822	829	PF00069	0.567
MOD_CK1_1	153	159	PF00069	0.787
MOD_CK1_1	160	166	PF00069	0.615
MOD_CK1_1	184	190	PF00069	0.801
MOD_CK1_1	205	211	PF00069	0.779
MOD_CK1_1	23	29	PF00069	0.745
MOD_CK1_1	35	41	PF00069	0.669
MOD_CK1_1	360	366	PF00069	0.631
MOD_CK1_1	465	471	PF00069	0.683
MOD_CK1_1	561	567	PF00069	0.634
MOD_CK1_1	570	576	PF00069	0.667
MOD_CK1_1	589	595	PF00069	0.474
MOD_CK1_1	623	629	PF00069	0.814
MOD_CK1_1	652	658	PF00069	0.659
MOD_CK1_1	681	687	PF00069	0.683
MOD_CK1_1	697	703	PF00069	0.758
MOD_CK1_1	730	736	PF00069	0.633
MOD_CK1_1	816	822	PF00069	0.777
MOD_CK1_1	833	839	PF00069	0.516
MOD_CK1_1	95	101	PF00069	0.562
MOD_CK2_1	23	29	PF00069	0.810
MOD_CK2_1	315	321	PF00069	0.712
MOD_CK2_1	499	505	PF00069	0.453
MOD_CK2_1	755	761	PF00069	0.559
MOD_CK2_1	775	781	PF00069	0.399
MOD_CK2_1	821	827	PF00069	0.765
MOD_GlcNHglycan	428	431	PF01048	0.375
MOD_GlcNHglycan	465	468	PF01048	0.667
MOD_GlcNHglycan	575	578	PF01048	0.737
MOD_GlcNHglycan	613	617	PF01048	0.712
MOD_GlcNHglycan	639	642	PF01048	0.630
MOD_GlcNHglycan	672	675	PF01048	0.581
MOD_GlcNHglycan	696	699	PF01048	0.555
MOD_GlcNHglycan	729	732	PF01048	0.661
MOD_GlcNHglycan	750	753	PF01048	0.479
MOD_GlcNHglycan	757	760	PF01048	0.592
MOD_GlcNHglycan	8	11	PF01048	0.535
MOD_GlcNHglycan	95	98	PF01048	0.649
MOD_GSK3_1	153	160	PF00069	0.693
MOD_GSK3_1	161	168	PF00069	0.751
MOD_GSK3_1	180	187	PF00069	0.703
MOD_GSK3_1	190	197	PF00069	0.718
MOD_GSK3_1	198	205	PF00069	0.702
MOD_GSK3_1	272	279	PF00069	0.686
MOD_GSK3_1	28	35	PF00069	0.695
MOD_GSK3_1	324	331	PF00069	0.587
MOD_GSK3_1	40	47	PF00069	0.653
MOD_GSK3_1	407	414	PF00069	0.647
MOD_GSK3_1	482	489	PF00069	0.594
MOD_GSK3_1	56	63	PF00069	0.794
MOD_GSK3_1	563	570	PF00069	0.651
MOD_GSK3_1	586	593	PF00069	0.684
MOD_GSK3_1	594	601	PF00069	0.692
MOD_GSK3_1	623	630	PF00069	0.657
MOD_GSK3_1	639	646	PF00069	0.592
MOD_GSK3_1	648	655	PF00069	0.646
MOD_GSK3_1	678	685	PF00069	0.654
MOD_GSK3_1	694	701	PF00069	0.790
MOD_GSK3_1	703	710	PF00069	0.728
MOD_GSK3_1	812	819	PF00069	0.700
MOD_GSK3_1	830	837	PF00069	0.686
MOD_GSK3_1	93	100	PF00069	0.730
MOD_N-GLC_1	20	25	PF02516	0.773
MOD_N-GLC_1	586	591	PF02516	0.695
MOD_N-GLC_1	605	610	PF02516	0.730
MOD_N-GLC_1	648	653	PF02516	0.584
MOD_N-GLC_2	620	622	PF02516	0.584
MOD_NEK2_1	179	184	PF00069	0.719
MOD_NEK2_1	185	190	PF00069	0.707
MOD_NEK2_1	296	301	PF00069	0.762
MOD_NEK2_1	409	414	PF00069	0.637
MOD_NEK2_1	462	467	PF00069	0.528
MOD_NEK2_1	546	551	PF00069	0.580
MOD_NEK2_1	581	586	PF00069	0.669
MOD_NEK2_1	588	593	PF00069	0.683
MOD_NEK2_1	6	11	PF00069	0.654
MOD_NEK2_1	755	760	PF00069	0.545
MOD_NEK2_1	820	825	PF00069	0.633
MOD_NEK2_2	267	272	PF00069	0.576
MOD_NEK2_2	417	422	PF00069	0.562
MOD_NEK2_2	56	61	PF00069	0.540
MOD_PIKK_1	121	127	PF00454	0.758
MOD_PIKK_1	153	159	PF00454	0.603
MOD_PIKK_1	576	582	PF00454	0.540
MOD_PIKK_1	701	707	PF00454	0.836
MOD_PIKK_1	813	819	PF00454	0.624
MOD_PK_1	148	154	PF00069	0.599
MOD_PKA_1	834	840	PF00069	0.538
MOD_PKA_2	157	163	PF00069	0.682
MOD_PKA_2	179	185	PF00069	0.746
MOD_PKA_2	189	195	PF00069	0.713
MOD_PKA_2	382	388	PF00069	0.536
MOD_PKA_2	463	469	PF00069	0.557
MOD_PKA_2	482	488	PF00069	0.492
MOD_PKA_2	681	687	PF00069	0.720
MOD_PKA_2	727	733	PF00069	0.511
MOD_PKA_2	787	793	PF00069	0.548
MOD_PKA_2	833	839	PF00069	0.697
MOD_PKB_1	399	407	PF00069	0.497
MOD_PKB_1	832	840	PF00069	0.544
MOD_Plk_1	586	592	PF00069	0.726
MOD_Plk_1	648	654	PF00069	0.539
MOD_Plk_2-3	315	321	PF00069	0.814
MOD_Plk_2-3	594	600	PF00069	0.559
MOD_Plk_4	190	196	PF00069	0.661
MOD_Plk_4	276	282	PF00069	0.723
MOD_Plk_4	41	47	PF00069	0.633
MOD_Plk_4	512	518	PF00069	0.393
MOD_Plk_4	643	649	PF00069	0.557
MOD_ProDKin_1	108	114	PF00069	0.736
MOD_ProDKin_1	163	169	PF00069	0.766
MOD_ProDKin_1	239	245	PF00069	0.664
MOD_ProDKin_1	272	278	PF00069	0.587
MOD_ProDKin_1	326	332	PF00069	0.740
MOD_ProDKin_1	473	479	PF00069	0.604
MOD_ProDKin_1	486	492	PF00069	0.417
MOD_ProDKin_1	639	645	PF00069	0.635
MOD_ProDKin_1	654	660	PF00069	0.602
MOD_ProDKin_1	781	787	PF00069	0.703
MOD_ProDKin_1	82	88	PF00069	0.769
MOD_ProDKin_1	822	828	PF00069	0.693
MOD_SUMO_for_1	226	229	PF00179	0.578
MOD_SUMO_for_1	828	831	PF00179	0.570
MOD_SUMO_rev_2	821	830	PF00179	0.572
TRG_DiLeu_BaEn_1	578	583	PF01217	0.788
TRG_ENDOCYTIC_2	119	122	PF00928	0.777
TRG_ENDOCYTIC_2	364	367	PF00928	0.540
TRG_ENDOCYTIC_2	438	441	PF00928	0.509
TRG_ENDOCYTIC_2	647	650	PF00928	0.540
TRG_ER_diArg_1	137	140	PF00400	0.585
TRG_ER_diArg_1	726	729	PF00400	0.568
TRG_ER_diArg_1	832	835	PF00400	0.549
TRG_NLS_MonoExtC_3	115	120	PF00514	0.702
TRG_NLS_MonoExtN_4	115	120	PF00514	0.649
TRG_NLS_MonoExtN_4	664	669	PF00514	0.662
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK2	Leptomonas seymouri	37%	100%
A0A3Q8IQL8	Leishmania donovani	57%	99%
A4I3N3	Leishmania infantum	58%	99%
E9AZX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	98%
Q4Q8B1	Leishmania major	57%	99%