Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGK5_LEIBR

TriTrypDb:

LbrM.28.1690 , LBRM2903_280023000

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.454
CLV_NRD_NRD_1	151	153	PF00675	0.520
CLV_NRD_NRD_1	216	218	PF00675	0.475
CLV_NRD_NRD_1	227	229	PF00675	0.466
CLV_NRD_NRD_1	273	275	PF00675	0.437
CLV_NRD_NRD_1	399	401	PF00675	0.509
CLV_NRD_NRD_1	426	428	PF00675	0.511
CLV_NRD_NRD_1	583	585	PF00675	0.709
CLV_NRD_NRD_1	610	612	PF00675	0.525
CLV_PCSK_FUR_1	149	153	PF00082	0.519
CLV_PCSK_KEX2_1	112	114	PF00082	0.454
CLV_PCSK_KEX2_1	151	153	PF00082	0.520
CLV_PCSK_KEX2_1	216	218	PF00082	0.486
CLV_PCSK_KEX2_1	227	229	PF00082	0.562
CLV_PCSK_KEX2_1	273	275	PF00082	0.437
CLV_PCSK_KEX2_1	32	34	PF00082	0.483
CLV_PCSK_KEX2_1	399	401	PF00082	0.509
CLV_PCSK_KEX2_1	426	428	PF00082	0.499
CLV_PCSK_KEX2_1	583	585	PF00082	0.703
CLV_PCSK_KEX2_1	610	612	PF00082	0.544
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.483
CLV_PCSK_PC7_1	223	229	PF00082	0.415
CLV_PCSK_SKI1_1	112	116	PF00082	0.402
CLV_PCSK_SKI1_1	151	155	PF00082	0.471
CLV_PCSK_SKI1_1	183	187	PF00082	0.434
CLV_PCSK_SKI1_1	290	294	PF00082	0.528
CLV_PCSK_SKI1_1	451	455	PF00082	0.527
CLV_PCSK_SKI1_1	477	481	PF00082	0.409
CLV_PCSK_SKI1_1	522	526	PF00082	0.546
CLV_PCSK_SKI1_1	557	561	PF00082	0.551
CLV_PCSK_SKI1_1	620	624	PF00082	0.496
CLV_PCSK_SKI1_1	91	95	PF00082	0.400
DOC_CYCLIN_RxL_1	625	639	PF00134	0.619
DOC_USP7_MATH_1	158	162	PF00917	0.515
DOC_USP7_MATH_1	185	189	PF00917	0.551
DOC_USP7_MATH_1	263	267	PF00917	0.364
DOC_USP7_UBL2_3	206	210	PF12436	0.460
DOC_USP7_UBL2_3	326	330	PF12436	0.559
LIG_14-3-3_CanoR_1	273	282	PF00244	0.471
LIG_14-3-3_CanoR_1	295	301	PF00244	0.557
LIG_14-3-3_CanoR_1	347	355	PF00244	0.531
LIG_14-3-3_CanoR_1	433	439	PF00244	0.465
LIG_14-3-3_CanoR_1	477	485	PF00244	0.679
LIG_14-3-3_CanoR_1	594	599	PF00244	0.631
LIG_14-3-3_CanoR_1	610	616	PF00244	0.438
LIG_Actin_WH2_2	282	299	PF00022	0.385
LIG_Actin_WH2_2	310	325	PF00022	0.388
LIG_APCC_ABBA_1	25	30	PF00400	0.430
LIG_APCC_ABBAyCdc20_2	620	626	PF00400	0.559
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_CaM_IQ_9	588	603	PF13499	0.651
LIG_Clathr_ClatBox_1	314	318	PF01394	0.385
LIG_Clathr_ClatBox_1	387	391	PF01394	0.510
LIG_eIF4E_1	138	144	PF01652	0.481
LIG_FHA_1	291	297	PF00498	0.472
LIG_FHA_1	399	405	PF00498	0.599
LIG_FHA_1	433	439	PF00498	0.510
LIG_FHA_1	53	59	PF00498	0.401
LIG_FHA_1	531	537	PF00498	0.525
LIG_FHA_1	630	636	PF00498	0.570
LIG_FHA_2	14	20	PF00498	0.449
LIG_FHA_2	198	204	PF00498	0.569
LIG_FHA_2	274	280	PF00498	0.500
LIG_FHA_2	297	303	PF00498	0.460
LIG_FHA_2	376	382	PF00498	0.480
LIG_FHA_2	553	559	PF00498	0.613
LIG_GBD_Chelix_1	58	66	PF00786	0.457
LIG_LIR_Nem_3	133	138	PF02991	0.445
LIG_NRBOX	266	272	PF00104	0.504
LIG_PCNA_yPIPBox_3	257	271	PF02747	0.511
LIG_PCNA_yPIPBox_3	26	38	PF02747	0.483
LIG_PDZ_Class_2	637	642	PF00595	0.650
LIG_SH2_PTP2	362	365	PF00017	0.493
LIG_SH2_STAT5	13	16	PF00017	0.490
LIG_SH2_STAT5	138	141	PF00017	0.455
LIG_SH2_STAT5	362	365	PF00017	0.493
LIG_SUMO_SIM_anti_2	266	272	PF11976	0.374
LIG_SUMO_SIM_par_1	284	291	PF11976	0.452
LIG_SUMO_SIM_par_1	313	318	PF11976	0.418
LIG_TRAF2_1	200	203	PF00917	0.475
LIG_TRAF2_1	299	302	PF00917	0.539
LIG_TRAF2_1	350	353	PF00917	0.517
LIG_TRAF2_1	410	413	PF00917	0.547
LIG_TRAF2_1	44	47	PF00917	0.463
MOD_CK1_1	304	310	PF00069	0.545
MOD_CK1_1	325	331	PF00069	0.466
MOD_CK1_1	377	383	PF00069	0.498
MOD_CK1_1	566	572	PF00069	0.636
MOD_CK1_1	61	67	PF00069	0.319
MOD_CK2_1	13	19	PF00069	0.451
MOD_CK2_1	197	203	PF00069	0.609
MOD_CK2_1	273	279	PF00069	0.490
MOD_CK2_1	296	302	PF00069	0.457
MOD_CK2_1	336	342	PF00069	0.612
MOD_CK2_1	347	353	PF00069	0.537
MOD_CK2_1	375	381	PF00069	0.523
MOD_CK2_1	552	558	PF00069	0.704
MOD_CK2_1	561	567	PF00069	0.716
MOD_CK2_1	570	576	PF00069	0.493
MOD_CK2_1	83	89	PF00069	0.409
MOD_CMANNOS	193	196	PF00535	0.594
MOD_GlcNHglycan	301	306	PF01048	0.564
MOD_GlcNHglycan	611	614	PF01048	0.520
MOD_GSK3_1	139	146	PF00069	0.598
MOD_GSK3_1	561	568	PF00069	0.658
MOD_GSK3_1	57	64	PF00069	0.342
MOD_GSK3_1	590	597	PF00069	0.503
MOD_GSK3_1	629	636	PF00069	0.537
MOD_N-GLC_2	281	283	PF02516	0.384
MOD_NEK2_1	121	126	PF00069	0.319
MOD_NEK2_1	317	322	PF00069	0.520
MOD_NEK2_1	439	444	PF00069	0.536
MOD_NEK2_1	52	57	PF00069	0.472
MOD_NEK2_1	58	63	PF00069	0.444
MOD_NEK2_1	633	638	PF00069	0.483
MOD_NEK2_2	459	464	PF00069	0.379
MOD_PIKK_1	197	203	PF00454	0.564
MOD_PIKK_1	304	310	PF00454	0.405
MOD_PIKK_1	347	353	PF00454	0.529
MOD_PIKK_1	439	445	PF00454	0.558
MOD_PIKK_1	492	498	PF00454	0.577
MOD_PIKK_1	52	58	PF00454	0.475
MOD_PKA_1	273	279	PF00069	0.506
MOD_PKA_2	273	279	PF00069	0.490
MOD_PKA_2	322	328	PF00069	0.501
MOD_PKA_2	346	352	PF00069	0.546
MOD_PKA_2	398	404	PF00069	0.463
MOD_PKA_2	432	438	PF00069	0.480
MOD_PKA_2	446	452	PF00069	0.578
MOD_PKA_2	609	615	PF00069	0.515
MOD_PKA_2	633	639	PF00069	0.483
MOD_PKA_2	95	101	PF00069	0.495
MOD_PKB_1	475	483	PF00069	0.409
MOD_Plk_1	317	323	PF00069	0.591
MOD_Plk_1	368	374	PF00069	0.348
MOD_Plk_1	38	44	PF00069	0.479
MOD_Plk_1	390	396	PF00069	0.546
MOD_Plk_1	514	520	PF00069	0.418
MOD_Plk_1	566	572	PF00069	0.657
MOD_Plk_1	575	581	PF00069	0.676
MOD_Plk_2-3	336	342	PF00069	0.628
MOD_Plk_4	139	145	PF00069	0.596
MOD_Plk_4	263	269	PF00069	0.348
MOD_Plk_4	566	572	PF00069	0.620
MOD_Plk_4	77	83	PF00069	0.326
MOD_SUMO_for_1	410	413	PF00179	0.370
MOD_SUMO_for_1	463	466	PF00179	0.530
MOD_SUMO_for_1	539	542	PF00179	0.548
MOD_SUMO_rev_2	29	34	PF00179	0.426
TRG_DiLeu_BaEn_1	238	243	PF01217	0.593
TRG_DiLeu_BaEn_1	68	73	PF01217	0.337
TRG_DiLeu_BaEn_4	301	307	PF01217	0.544
TRG_DiLeu_BaEn_4	353	359	PF01217	0.455
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.634
TRG_ENDOCYTIC_2	362	365	PF00928	0.493
TRG_ER_diArg_1	111	113	PF00400	0.450
TRG_ER_diArg_1	151	153	PF00400	0.363
TRG_ER_diArg_1	215	217	PF00400	0.428
TRG_ER_diArg_1	272	274	PF00400	0.630
TRG_ER_diArg_1	321	324	PF00400	0.527
TRG_ER_diArg_1	425	427	PF00400	0.517
TRG_ER_diArg_1	601	604	PF00400	0.636
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	370	375	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9P5	Leptomonas seymouri	49%	100%
A0A1X0P087	Trypanosomatidae	26%	100%
A0A3S7X1I5	Leishmania donovani	80%	100%
A4I3N1	Leishmania infantum	80%	100%
E9AZX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q8B3	Leishmania major	80%	100%