Similar to Prokaryotic YgdD inner membrane proteins.. Topology is somewhat unclear but likely to start / end in cytoplasm. Might have been acquired by horizontal gene transfer.
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 10 |
| NetGPI | no | yes: 0, no: 10 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 11 |
| GO:0110165 | cellular anatomical entity | 1 | 11 |
Related structures:
AlphaFold database: A4HGK3
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_PCSK_KEX2_1 | 71 | 73 | PF00082 | 0.264 |
| CLV_PCSK_PC1ET2_1 | 71 | 73 | PF00082 | 0.303 |
| CLV_PCSK_SKI1_1 | 35 | 39 | PF00082 | 0.503 |
| DOC_PP4_FxxP_1 | 96 | 99 | PF00568 | 0.322 |
| DOC_USP7_MATH_1 | 21 | 25 | PF00917 | 0.276 |
| DOC_USP7_MATH_1 | 39 | 43 | PF00917 | 0.221 |
| LIG_CaM_NSCaTE_8 | 117 | 124 | PF13499 | 0.376 |
| LIG_FHA_1 | 13 | 19 | PF00498 | 0.318 |
| LIG_FHA_2 | 29 | 35 | PF00498 | 0.207 |
| LIG_LIR_Gen_1 | 42 | 52 | PF02991 | 0.302 |
| LIG_LIR_Gen_1 | 90 | 99 | PF02991 | 0.436 |
| LIG_LIR_Nem_3 | 90 | 95 | PF02991 | 0.361 |
| LIG_PDZ_Class_2 | 122 | 127 | PF00595 | 0.451 |
| LIG_SH2_CRK | 8 | 12 | PF00017 | 0.376 |
| LIG_SH2_CRK | 92 | 96 | PF00017 | 0.376 |
| LIG_SH2_NCK_1 | 92 | 96 | PF00017 | 0.308 |
| LIG_SH2_STAP1 | 92 | 96 | PF00017 | 0.335 |
| LIG_SH2_STAT5 | 111 | 114 | PF00017 | 0.376 |
| LIG_TRAF2_1 | 31 | 34 | PF00917 | 0.254 |
| LIG_TYR_ITIM | 6 | 11 | PF00017 | 0.376 |
| LIG_TYR_ITSM | 88 | 95 | PF00017 | 0.308 |
| MOD_CK2_1 | 28 | 34 | PF00069 | 0.308 |
| MOD_GlcNHglycan | 8 | 11 | PF01048 | 0.395 |
| MOD_GlcNHglycan | 87 | 90 | PF01048 | 0.286 |
| MOD_GSK3_1 | 61 | 68 | PF00069 | 0.374 |
| MOD_GSK3_1 | 81 | 88 | PF00069 | 0.288 |
| MOD_NEK2_1 | 12 | 17 | PF00069 | 0.323 |
| MOD_NEK2_1 | 46 | 51 | PF00069 | 0.311 |
| MOD_NEK2_1 | 58 | 63 | PF00069 | 0.310 |
| MOD_NEK2_1 | 6 | 11 | PF00069 | 0.324 |
| MOD_NEK2_1 | 81 | 86 | PF00069 | 0.316 |
| MOD_NEK2_1 | 87 | 92 | PF00069 | 0.325 |
| MOD_PIKK_1 | 39 | 45 | PF00454 | 0.358 |
| MOD_PIKK_1 | 56 | 62 | PF00454 | 0.221 |
| MOD_Plk_4 | 82 | 88 | PF00069 | 0.292 |
| TRG_ENDOCYTIC_2 | 111 | 114 | PF00928 | 0.122 |
| TRG_ENDOCYTIC_2 | 44 | 47 | PF00928 | 0.367 |
| TRG_ENDOCYTIC_2 | 8 | 11 | PF00928 | 0.376 |
| TRG_ENDOCYTIC_2 | 92 | 95 | PF00928 | 0.372 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I2H5 | Leptomonas seymouri | 68% | 98% |
| A0A0S4JA03 | Bodo saltans | 41% | 100% |
| A0A1X0NW75 | Trypanosomatidae | 35% | 98% |
| A0A1X0NYR3 | Trypanosomatidae | 41% | 98% |
| A0A3Q8IGS2 | Leishmania donovani | 26% | 96% |
| A0A3R7NJS9 | Trypanosoma rangeli | 38% | 98% |
| A0A3S7X1H0 | Leishmania donovani | 83% | 100% |
| A0A3S7X1J0 | Leishmania donovani | 29% | 92% |
| A4HGK1 | Leishmania braziliensis | 32% | 100% |
| A4HGK2 | Leishmania braziliensis | 25% | 100% |
| A4I3M7 | Leishmania infantum | 29% | 92% |
| A4I3M8 | Leishmania infantum | 26% | 96% |
| A4I3M9 | Leishmania infantum | 83% | 100% |
| A4K526 | Bufo gargarizans | 32% | 100% |
| D0A7U8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 38% | 98% |
| D0A857 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 35% | 98% |
| E9AZW8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 92% |
| E9AZW9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 96% |
| E9AZX0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 86% | 100% |
| P45019 | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) | 36% | 100% |
| Q2FJ60 | Staphylococcus aureus (strain USA300) | 29% | 100% |
| Q2G0J5 | Staphylococcus aureus (strain NCTC 8325 / PS 47) | 29% | 100% |
| Q2YS64 | Staphylococcus aureus (strain bovine RF122 / ET3-1) | 29% | 100% |
| Q4L3Q9 | Staphylococcus haemolyticus (strain JCSC1435) | 28% | 100% |
| Q4Q8B5 | Leishmania major | 84% | 100% |
| Q4Q8B6 | Leishmania major | 26% | 100% |
| Q4Q8B7 | Leishmania major | 29% | 100% |
| Q568J8 | Danio rerio | 31% | 100% |
| Q5HI93 | Staphylococcus aureus (strain COL) | 29% | 100% |
| Q5HRG3 | Staphylococcus epidermidis (strain ATCC 35984 / RP62A) | 31% | 100% |
| Q6GBQ4 | Staphylococcus aureus (strain MSSA476) | 29% | 100% |
| Q6GJ86 | Staphylococcus aureus (strain MRSA252) | 29% | 100% |
| Q7A1P4 | Staphylococcus aureus (strain MW2) | 29% | 100% |
| Q7A763 | Staphylococcus aureus (strain N315) | 29% | 100% |
| Q8CTQ5 | Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) | 31% | 100% |
| Q99W28 | Staphylococcus aureus (strain Mu50 / ATCC 700699) | 29% | 100% |
| Q9P7G8 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 29% | 100% |