Similar to Prokaryotic YgdD inner membrane proteins.. Topology is somewhat unclear but likely to start / end in cytoplasm. Might have been acquired by horizontal gene transfer.
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 12 |
| NetGPI | no | yes: 0, no: 12 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 13 |
| GO:0110165 | cellular anatomical entity | 1 | 13 |
Related structures:
AlphaFold database: A4HGK2
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 40 | 42 | PF00675 | 0.273 |
| CLV_PCSK_FUR_1 | 38 | 42 | PF00082 | 0.308 |
| CLV_PCSK_KEX2_1 | 40 | 42 | PF00082 | 0.273 |
| DOC_CKS1_1 | 109 | 114 | PF01111 | 0.260 |
| DOC_MAPK_DCC_7 | 5 | 14 | PF00069 | 0.228 |
| DOC_MAPK_gen_1 | 76 | 85 | PF00069 | 0.290 |
| DOC_MAPK_MEF2A_6 | 5 | 14 | PF00069 | 0.233 |
| DOC_PP2B_PxIxI_1 | 9 | 15 | PF00149 | 0.304 |
| DOC_PP4_FxxP_1 | 106 | 109 | PF00568 | 0.523 |
| DOC_USP7_MATH_1 | 71 | 75 | PF00917 | 0.251 |
| DOC_WW_Pin1_4 | 108 | 113 | PF00397 | 0.417 |
| DOC_WW_Pin1_4 | 67 | 72 | PF00397 | 0.340 |
| LIG_14-3-3_CanoR_1 | 38 | 44 | PF00244 | 0.479 |
| LIG_BIR_III_4 | 25 | 29 | PF00653 | 0.275 |
| LIG_DCNL_PONY_1 | 1 | 4 | PF03556 | 0.384 |
| LIG_FHA_1 | 111 | 117 | PF00498 | 0.272 |
| LIG_FHA_1 | 52 | 58 | PF00498 | 0.329 |
| LIG_FHA_1 | 84 | 90 | PF00498 | 0.274 |
| LIG_PCNA_PIPBox_1 | 24 | 33 | PF02747 | 0.154 |
| LIG_SH2_CRK | 49 | 53 | PF00017 | 0.387 |
| LIG_SH2_STAP1 | 96 | 100 | PF00017 | 0.309 |
| LIG_SH2_STAT5 | 82 | 85 | PF00017 | 0.304 |
| LIG_SH3_3 | 106 | 112 | PF00018 | 0.408 |
| LIG_Sin3_3 | 56 | 63 | PF02671 | 0.154 |
| LIG_SUMO_SIM_anti_2 | 113 | 120 | PF11976 | 0.387 |
| LIG_UBA3_1 | 1 | 5 | PF00899 | 0.382 |
| LIG_UBA3_1 | 63 | 68 | PF00899 | 0.301 |
| LIG_WRC_WIRS_1 | 19 | 24 | PF05994 | 0.297 |
| MOD_CK1_1 | 42 | 48 | PF00069 | 0.475 |
| MOD_CK1_1 | 94 | 100 | PF00069 | 0.360 |
| MOD_GlcNHglycan | 113 | 116 | PF01048 | 0.360 |
| MOD_GSK3_1 | 67 | 74 | PF00069 | 0.346 |
| MOD_NEK2_1 | 120 | 125 | PF00069 | 0.286 |
| MOD_NEK2_1 | 51 | 56 | PF00069 | 0.324 |
| MOD_NEK2_1 | 83 | 88 | PF00069 | 0.290 |
| MOD_NEK2_1 | 91 | 96 | PF00069 | 0.313 |
| MOD_PKA_2 | 39 | 45 | PF00069 | 0.482 |
| MOD_Plk_4 | 91 | 97 | PF00069 | 0.285 |
| MOD_ProDKin_1 | 108 | 114 | PF00069 | 0.417 |
| MOD_ProDKin_1 | 67 | 73 | PF00069 | 0.340 |
| TRG_ENDOCYTIC_2 | 49 | 52 | PF00928 | 0.414 |
| TRG_ENDOCYTIC_2 | 82 | 85 | PF00928 | 0.314 |
| TRG_ER_diArg_1 | 37 | 40 | PF00400 | 0.508 |
| TRG_NES_CRM1_1 | 25 | 39 | PF08389 | 0.297 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1HUH3 | Leptomonas seymouri | 31% | 96% |
| A0A0N1I149 | Leptomonas seymouri | 78% | 100% |
| A0A0N1I2H5 | Leptomonas seymouri | 27% | 100% |
| A0A0S4JA03 | Bodo saltans | 36% | 100% |
| A0A1X0NW75 | Trypanosomatidae | 43% | 100% |
| A0A1X0NYR3 | Trypanosomatidae | 45% | 100% |
| A0A3Q8IGS2 | Leishmania donovani | 93% | 100% |
| A0A3R7NJS9 | Trypanosoma rangeli | 40% | 100% |
| A0A3S7X1H0 | Leishmania donovani | 29% | 100% |
| A0A3S7X1J0 | Leishmania donovani | 31% | 96% |
| A4HGK1 | Leishmania braziliensis | 31% | 100% |
| A4HGK3 | Leishmania braziliensis | 25% | 100% |
| A4I3M7 | Leishmania infantum | 31% | 96% |
| A4I3M8 | Leishmania infantum | 93% | 100% |
| A4I3M9 | Leishmania infantum | 29% | 100% |
| D0A7U8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 34% | 100% |
| D0A857 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 35% | 100% |
| E9AZW8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 96% |
| E9AZW9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 90% | 100% |
| E9AZX0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 100% |
| P39619 | Bacillus subtilis (strain 168) | 31% | 100% |
| Q2FJ60 | Staphylococcus aureus (strain USA300) | 33% | 100% |
| Q2G0J5 | Staphylococcus aureus (strain NCTC 8325 / PS 47) | 33% | 100% |
| Q2YS64 | Staphylococcus aureus (strain bovine RF122 / ET3-1) | 33% | 100% |
| Q49VD3 | Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) | 30% | 100% |
| Q4L3Q9 | Staphylococcus haemolyticus (strain JCSC1435) | 32% | 100% |
| Q4Q8B5 | Leishmania major | 28% | 100% |
| Q4Q8B6 | Leishmania major | 92% | 100% |
| Q4Q8B7 | Leishmania major | 32% | 100% |
| Q5HI93 | Staphylococcus aureus (strain COL) | 33% | 100% |
| Q5HRG3 | Staphylococcus epidermidis (strain ATCC 35984 / RP62A) | 31% | 100% |
| Q6GBQ4 | Staphylococcus aureus (strain MSSA476) | 33% | 100% |
| Q6GJ86 | Staphylococcus aureus (strain MRSA252) | 33% | 100% |
| Q7A1P4 | Staphylococcus aureus (strain MW2) | 33% | 100% |
| Q7A763 | Staphylococcus aureus (strain N315) | 33% | 100% |
| Q8CTQ5 | Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) | 31% | 100% |
| Q99W28 | Staphylococcus aureus (strain Mu50 / ATCC 700699) | 33% | 100% |
| Q9P7G8 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 32% | 100% |