Similar to Prokaryotic YgdD inner membrane proteins.. Topology is somewhat unclear but likely to start / end in cytoplasm. Might have been acquired by horizontal gene transfer.
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 12 |
| GO:0110165 | cellular anatomical entity | 1 | 12 |
Related structures:
AlphaFold database: A4HGK1
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 82 | 84 | PF00675 | 0.289 |
| CLV_PCSK_KEX2_1 | 82 | 84 | PF00082 | 0.283 |
| CLV_PCSK_SKI1_1 | 6 | 10 | PF00082 | 0.403 |
| DOC_MAPK_gen_1 | 82 | 88 | PF00069 | 0.447 |
| DOC_USP7_MATH_1 | 31 | 35 | PF00917 | 0.373 |
| LIG_14-3-3_CanoR_1 | 72 | 76 | PF00244 | 0.570 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.665 |
| LIG_BRCT_BRCA1_1 | 33 | 37 | PF00533 | 0.319 |
| LIG_EH1_1 | 58 | 66 | PF00400 | 0.367 |
| LIG_GBD_Chelix_1 | 17 | 25 | PF00786 | 0.256 |
| LIG_LIR_Gen_1 | 34 | 41 | PF02991 | 0.311 |
| LIG_LIR_Nem_3 | 112 | 117 | PF02991 | 0.206 |
| LIG_LIR_Nem_3 | 34 | 40 | PF02991 | 0.311 |
| LIG_LIR_Nem_3 | 43 | 49 | PF02991 | 0.263 |
| LIG_Pex14_2 | 110 | 114 | PF04695 | 0.173 |
| LIG_SH2_CRK | 55 | 59 | PF00017 | 0.319 |
| LIG_SH2_NCK_1 | 49 | 53 | PF00017 | 0.311 |
| LIG_SH2_STAT5 | 100 | 103 | PF00017 | 0.445 |
| LIG_SH2_STAT5 | 80 | 83 | PF00017 | 0.419 |
| LIG_SH2_STAT5 | 85 | 88 | PF00017 | 0.284 |
| LIG_SH3_3 | 102 | 108 | PF00018 | 0.277 |
| LIG_SH3_3 | 70 | 76 | PF00018 | 0.323 |
| MOD_CK2_1 | 132 | 138 | PF00069 | 0.281 |
| MOD_GlcNHglycan | 1 | 4 | PF01048 | 0.473 |
| MOD_GlcNHglycan | 21 | 24 | PF01048 | 0.296 |
| MOD_GlcNHglycan | 9 | 12 | PF01048 | 0.432 |
| MOD_GlcNHglycan | 95 | 98 | PF01048 | 0.302 |
| MOD_GSK3_1 | 89 | 96 | PF00069 | 0.356 |
| MOD_NEK2_1 | 131 | 136 | PF00069 | 0.442 |
| MOD_NEK2_1 | 40 | 45 | PF00069 | 0.298 |
| MOD_NEK2_1 | 57 | 62 | PF00069 | 0.388 |
| MOD_NEK2_1 | 9 | 14 | PF00069 | 0.621 |
| MOD_NEK2_1 | 95 | 100 | PF00069 | 0.381 |
| MOD_NEK2_2 | 132 | 137 | PF00069 | 0.264 |
| MOD_PKA_2 | 71 | 77 | PF00069 | 0.570 |
| MOD_Plk_4 | 76 | 82 | PF00069 | 0.505 |
| MOD_Plk_4 | 89 | 95 | PF00069 | 0.327 |
| TRG_ENDOCYTIC_2 | 55 | 58 | PF00928 | 0.373 |
| TRG_ENDOCYTIC_2 | 85 | 88 | PF00928 | 0.392 |
| TRG_ER_diArg_1 | 81 | 83 | PF00400 | 0.530 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1HUH3 | Leptomonas seymouri | 77% | 100% |
| A0A0N1I149 | Leptomonas seymouri | 25% | 100% |
| A0A0N1I2H5 | Leptomonas seymouri | 38% | 100% |
| A0A0S4JA03 | Bodo saltans | 35% | 100% |
| A0A1X0NW75 | Trypanosomatidae | 34% | 100% |
| A0A1X0NYR3 | Trypanosomatidae | 39% | 100% |
| A0A3Q8IGS2 | Leishmania donovani | 30% | 100% |
| A0A3R7NJS9 | Trypanosoma rangeli | 33% | 100% |
| A0A3S7X1H0 | Leishmania donovani | 36% | 100% |
| A0A3S7X1J0 | Leishmania donovani | 83% | 100% |
| A4HGK2 | Leishmania braziliensis | 31% | 100% |
| A4HGK3 | Leishmania braziliensis | 32% | 100% |
| A4I3M7 | Leishmania infantum | 83% | 100% |
| A4I3M8 | Leishmania infantum | 30% | 100% |
| A4I3M9 | Leishmania infantum | 36% | 100% |
| A4K526 | Bufo gargarizans | 35% | 100% |
| D0A7U8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 34% | 100% |
| D0A857 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 29% | 100% |
| E9AZW8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 80% | 100% |
| E9AZW9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 100% |
| E9AZX0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 36% | 100% |
| P0ADR2 | Escherichia coli (strain K12) | 29% | 100% |
| P0ADR3 | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) | 29% | 100% |
| P0ADR4 | Escherichia coli O157:H7 | 29% | 100% |
| P0ADR5 | Shigella flexneri | 29% | 100% |
| P39619 | Bacillus subtilis (strain 168) | 28% | 100% |
| Q4Q8B5 | Leishmania major | 35% | 100% |
| Q4Q8B6 | Leishmania major | 29% | 100% |
| Q4Q8B7 | Leishmania major | 82% | 100% |
| Q568J8 | Danio rerio | 35% | 100% |