Qa-SNARE protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Qa-SNARE protein

Gene product:

Qa-SNARE protein

Species:

Leishmania braziliensis

UniProt:

A4HGJ9_LEIBR

TriTrypDb:

LbrM.28.1630 , LBRM2903_280022500

Length:

250

Annotations

LeishMANIAdb annotations

Homologous to animal syntaxin proteins, involved in vesulcular fusion to membranes. Although most proteins appear to be membrane-embedded, some Lesihmaniid members are likely not.. For some reason, multiple copies are seen in Leptomonas

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	2
GO:0012505	endomembrane system	2	2
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2

Expansion

Sequence features

A4HGJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGJ9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	14
GO:0016192	vesicle-mediated transport	4	14
GO:0051179	localization	1	14
GO:0051234	establishment of localization	2	14
GO:0006886	intracellular protein transport	4	2
GO:0006887	exocytosis	4	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0022406	membrane docking	2	2
GO:0032940	secretion by cell	3	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046903	secretion	4	2
GO:0046907	intracellular transport	3	2
GO:0048278	vesicle docking	4	2
GO:0048284	organelle fusion	5	2
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0140056	organelle localization by membrane tethering	3	2
GO:0140352	export from cell	2	2

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.479
CLV_C14_Caspase3-7	43	47	PF00656	0.584
CLV_NRD_NRD_1	212	214	PF00675	0.312
CLV_NRD_NRD_1	219	221	PF00675	0.328
CLV_PCSK_SKI1_1	107	111	PF00082	0.277
CLV_PCSK_SKI1_1	147	151	PF00082	0.288
CLV_PCSK_SKI1_1	39	43	PF00082	0.357
CLV_PCSK_SKI1_1	82	86	PF00082	0.209
DEG_Nend_UBRbox_2	1	3	PF02207	0.482
DOC_CYCLIN_RxL_1	18	29	PF00134	0.405
DOC_MAPK_gen_1	19	27	PF00069	0.405
DOC_MAPK_gen_1	217	226	PF00069	0.415
DOC_MAPK_MEF2A_6	19	27	PF00069	0.405
DOC_PP1_RVXF_1	220	227	PF00149	0.370
DOC_USP7_UBL2_3	210	214	PF12436	0.489
DOC_USP7_UBL2_3	217	221	PF12436	0.533
DOC_WW_Pin1_4	55	60	PF00397	0.416
LIG_14-3-3_CanoR_1	92	101	PF00244	0.504
LIG_Actin_WH2_2	195	212	PF00022	0.511
LIG_Actin_WH2_2	41	58	PF00022	0.492
LIG_BRCT_BRCA1_1	139	143	PF00533	0.519
LIG_FHA_1	244	250	PF00498	0.437
LIG_FHA_1	50	56	PF00498	0.479
LIG_FHA_2	112	118	PF00498	0.509
LIG_FHA_2	12	18	PF00498	0.532
LIG_FHA_2	154	160	PF00498	0.477
LIG_GBD_Chelix_1	79	87	PF00786	0.377
LIG_PCNA_PIPBox_1	167	176	PF02747	0.517
LIG_PCNA_yPIPBox_3	184	197	PF02747	0.413
LIG_SH2_GRB2like	113	116	PF00017	0.479
LIG_SH2_STAT3	101	104	PF00017	0.480
LIG_SH2_STAT3	141	144	PF00017	0.560
LIG_SH2_STAT5	113	116	PF00017	0.490
LIG_SH2_STAT5	141	144	PF00017	0.551
LIG_SH2_STAT5	201	204	PF00017	0.517
LIG_SH2_STAT5	78	81	PF00017	0.526
LIG_SUMO_SIM_anti_2	176	181	PF11976	0.484
LIG_TYR_ITIM	111	116	PF00017	0.405
MOD_CK1_1	49	55	PF00069	0.519
MOD_CK2_1	11	17	PF00069	0.550
MOD_CK2_1	149	155	PF00069	0.577
MOD_CK2_1	163	169	PF00069	0.414
MOD_CK2_1	92	98	PF00069	0.522
MOD_Cter_Amidation	211	214	PF01082	0.200
MOD_GlcNHglycan	117	121	PF01048	0.319
MOD_GlcNHglycan	205	208	PF01048	0.205
MOD_GlcNHglycan	65	68	PF01048	0.375
MOD_GlcNHglycan	94	97	PF01048	0.389
MOD_GSK3_1	149	156	PF00069	0.577
MOD_GSK3_1	28	35	PF00069	0.516
MOD_N-GLC_1	135	140	PF02516	0.282
MOD_NEK2_1	116	121	PF00069	0.405
MOD_NEK2_1	243	248	PF00069	0.520
MOD_PIKK_1	102	108	PF00454	0.531
MOD_PKA_2	49	55	PF00069	0.445
MOD_Plk_1	121	127	PF00069	0.572
MOD_Plk_1	136	142	PF00069	0.540
MOD_Plk_1	163	169	PF00069	0.477
MOD_Plk_4	137	143	PF00069	0.519
MOD_Plk_4	149	155	PF00069	0.492
MOD_Plk_4	82	88	PF00069	0.405
MOD_ProDKin_1	55	61	PF00069	0.416
TRG_ENDOCYTIC_2	113	116	PF00928	0.538
TRG_ENDOCYTIC_2	78	81	PF00928	0.569
TRG_NES_CRM1_1	169	183	PF08389	0.405
TRG_NLS_Bipartite_1	210	224	PF00514	0.501
TRG_NLS_MonoExtC_3	209	214	PF00514	0.484
TRG_NLS_MonoExtC_3	216	221	PF00514	0.484
TRG_NLS_MonoExtN_4	214	221	PF00514	0.514
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN0	Leptomonas seymouri	27%	83%
A0A0S4JI44	Bodo saltans	25%	98%
A0A0S4JKJ1	Bodo saltans	27%	83%
A0A1X0NYQ5	Trypanosomatidae	58%	76%
A0A1X0P5S4	Trypanosomatidae	24%	83%
A0A1X0P6I0	Trypanosomatidae	26%	84%
A0A3Q8IDT6	Leishmania donovani	84%	97%
A0A3R7L4L2	Trypanosoma rangeli	52%	79%
A0A3R7NXH1	Trypanosoma rangeli	26%	96%
A0A3S7X1I6	Leishmania donovani	84%	95%
A4HGK0	Leishmania braziliensis	94%	100%
A4I3M6	Leishmania infantum	85%	100%
A8WVD0	Caenorhabditis briggsae	30%	85%
D0A863	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	79%
E9AHG5	Leishmania infantum	84%	95%
E9AZW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	73%
O16000	Caenorhabditis elegans	30%	86%
O35526	Mus musculus	33%	87%
O64791	Arabidopsis thaliana	28%	83%
O75558	Homo sapiens	26%	87%
P32850	Bos taurus	33%	87%
P32851	Rattus norvegicus	33%	87%
P32856	Homo sapiens	30%	87%
P50279	Rattus norvegicus	30%	86%
P61264	Mus musculus	31%	87%
P61265	Rattus norvegicus	31%	87%
P61266	Homo sapiens	31%	87%
P61267	Bos taurus	31%	87%
P61268	Ovis aries	31%	87%
P70452	Mus musculus	27%	84%
Q00262	Mus musculus	30%	87%
Q08849	Rattus norvegicus	33%	87%
Q08850	Rattus norvegicus	27%	84%
Q12846	Homo sapiens	28%	84%
Q13277	Homo sapiens	34%	87%
Q16623	Homo sapiens	32%	87%
Q16932	Aplysia californica	30%	86%
Q20024	Caenorhabditis elegans	24%	82%
Q24547	Drosophila melanogaster	34%	86%
Q3SWZ3	Bos taurus	29%	84%
Q42374	Arabidopsis thaliana	28%	81%
Q4Q8B8	Leishmania major	83%	100%
Q4Q8B9	Leishmania major	83%	100%
Q5R4L2	Pongo abelii	32%	87%
Q64704	Mus musculus	33%	87%
Q8VZU2	Arabidopsis thaliana	28%	82%
Q9D3G5	Mus musculus	27%	87%
Q9SRV7	Arabidopsis thaliana	26%	82%
Q9SXB0	Arabidopsis thaliana	28%	84%
Q9ZQZ8	Arabidopsis thaliana	26%	82%
Q9ZSD4	Arabidopsis thaliana	29%	72%
V5B7Y5	Trypanosoma cruzi	56%	79%
V5BNX1	Trypanosoma cruzi	24%	85%
V5C306	Trypanosoma cruzi	25%	83%