LeishMANIAdb
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Putative ATPase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATPase
Gene product:
Cell division control protein 48, putative
Species:
Leishmania braziliensis
UniProt:
A4HGJ8_LEIBR
TriTrypDb:
LbrM.28.1620 , LBRM2903_280022300 *
Length:
770

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGJ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGJ8

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 1
GO:0051301 cell division 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 114 116 PF00675 0.478
CLV_NRD_NRD_1 142 144 PF00675 0.487
CLV_NRD_NRD_1 301 303 PF00675 0.524
CLV_NRD_NRD_1 400 402 PF00675 0.475
CLV_NRD_NRD_1 494 496 PF00675 0.303
CLV_NRD_NRD_1 533 535 PF00675 0.364
CLV_NRD_NRD_1 61 63 PF00675 0.370
CLV_NRD_NRD_1 622 624 PF00675 0.400
CLV_NRD_NRD_1 674 676 PF00675 0.508
CLV_NRD_NRD_1 725 727 PF00675 0.562
CLV_NRD_NRD_1 736 738 PF00675 0.507
CLV_PCSK_KEX2_1 114 116 PF00082 0.476
CLV_PCSK_KEX2_1 142 144 PF00082 0.487
CLV_PCSK_KEX2_1 301 303 PF00082 0.524
CLV_PCSK_KEX2_1 400 402 PF00082 0.475
CLV_PCSK_KEX2_1 494 496 PF00082 0.322
CLV_PCSK_KEX2_1 532 534 PF00082 0.362
CLV_PCSK_KEX2_1 61 63 PF00082 0.370
CLV_PCSK_KEX2_1 622 624 PF00082 0.393
CLV_PCSK_KEX2_1 674 676 PF00082 0.508
CLV_PCSK_KEX2_1 725 727 PF00082 0.546
CLV_PCSK_KEX2_1 736 738 PF00082 0.520
CLV_PCSK_SKI1_1 117 121 PF00082 0.354
CLV_PCSK_SKI1_1 142 146 PF00082 0.503
CLV_PCSK_SKI1_1 301 305 PF00082 0.426
CLV_PCSK_SKI1_1 428 432 PF00082 0.403
CLV_PCSK_SKI1_1 461 465 PF00082 0.279
CLV_PCSK_SKI1_1 665 669 PF00082 0.501
CLV_PCSK_SKI1_1 685 689 PF00082 0.277
CLV_PCSK_SKI1_1 737 741 PF00082 0.490
DEG_SCF_FBW7_2 171 178 PF00400 0.422
DOC_CDC14_PxL_1 478 486 PF14671 0.279
DOC_CKS1_1 293 298 PF01111 0.393
DOC_CYCLIN_yCln2_LP_2 592 598 PF00134 0.410
DOC_MAPK_gen_1 114 121 PF00069 0.417
DOC_MAPK_gen_1 400 408 PF00069 0.473
DOC_MAPK_gen_1 504 512 PF00069 0.279
DOC_MAPK_gen_1 599 609 PF00069 0.279
DOC_MAPK_MEF2A_6 401 410 PF00069 0.479
DOC_MAPK_MEF2A_6 504 512 PF00069 0.279
DOC_MAPK_MEF2A_6 602 611 PF00069 0.215
DOC_PP2B_LxvP_1 291 294 PF13499 0.419
DOC_PP2B_LxvP_1 321 324 PF13499 0.518
DOC_PP2B_LxvP_1 607 610 PF13499 0.418
DOC_USP7_MATH_1 130 134 PF00917 0.482
DOC_USP7_MATH_1 309 313 PF00917 0.417
DOC_USP7_MATH_1 387 391 PF00917 0.463
DOC_USP7_MATH_1 616 620 PF00917 0.376
DOC_USP7_MATH_1 79 83 PF00917 0.642
DOC_WW_Pin1_4 10 15 PF00397 0.595
DOC_WW_Pin1_4 16 21 PF00397 0.464
DOC_WW_Pin1_4 171 176 PF00397 0.600
DOC_WW_Pin1_4 292 297 PF00397 0.433
DOC_WW_Pin1_4 359 364 PF00397 0.671
DOC_WW_Pin1_4 504 509 PF00397 0.318
DOC_WW_Pin1_4 548 553 PF00397 0.317
LIG_14-3-3_CanoR_1 117 122 PF00244 0.433
LIG_14-3-3_CanoR_1 264 269 PF00244 0.398
LIG_14-3-3_CanoR_1 358 363 PF00244 0.802
LIG_14-3-3_CanoR_1 400 408 PF00244 0.473
LIG_14-3-3_CanoR_1 428 433 PF00244 0.475
LIG_14-3-3_CanoR_1 547 552 PF00244 0.274
LIG_14-3-3_CanoR_1 561 570 PF00244 0.293
LIG_14-3-3_CanoR_1 685 691 PF00244 0.421
LIG_Actin_WH2_2 509 525 PF00022 0.410
LIG_Actin_WH2_2 585 601 PF00022 0.280
LIG_APCC_ABBAyCdc20_2 622 628 PF00400 0.445
LIG_BRCT_BRCA1_1 401 405 PF00533 0.496
LIG_BRCT_BRCA1_1 508 512 PF00533 0.279
LIG_BRCT_BRCA1_1 675 679 PF00533 0.453
LIG_Clathr_ClatBox_1 182 186 PF01394 0.406
LIG_Clathr_ClatBox_1 510 514 PF01394 0.410
LIG_deltaCOP1_diTrp_1 628 632 PF00928 0.388
LIG_eIF4E_1 755 761 PF01652 0.297
LIG_FHA_1 114 120 PF00498 0.409
LIG_FHA_1 161 167 PF00498 0.623
LIG_FHA_1 257 263 PF00498 0.505
LIG_FHA_1 270 276 PF00498 0.237
LIG_FHA_1 331 337 PF00498 0.398
LIG_FHA_1 429 435 PF00498 0.511
LIG_FHA_1 447 453 PF00498 0.264
LIG_FHA_1 585 591 PF00498 0.302
LIG_FHA_1 656 662 PF00498 0.579
LIG_FHA_1 73 79 PF00498 0.467
LIG_FHA_1 738 744 PF00498 0.495
LIG_FHA_2 293 299 PF00498 0.399
LIG_FHA_2 393 399 PF00498 0.513
LIG_FHA_2 409 415 PF00498 0.483
LIG_FHA_2 554 560 PF00498 0.355
LIG_FHA_2 603 609 PF00498 0.279
LIG_GBD_Chelix_1 562 570 PF00786 0.322
LIG_LIR_Gen_1 240 250 PF02991 0.374
LIG_LIR_Gen_1 402 410 PF02991 0.446
LIG_LIR_Gen_1 411 420 PF02991 0.402
LIG_LIR_Gen_1 475 485 PF02991 0.279
LIG_LIR_Gen_1 577 586 PF02991 0.314
LIG_LIR_Gen_1 754 763 PF02991 0.294
LIG_LIR_Nem_3 232 237 PF02991 0.420
LIG_LIR_Nem_3 240 245 PF02991 0.317
LIG_LIR_Nem_3 337 341 PF02991 0.410
LIG_LIR_Nem_3 402 408 PF02991 0.421
LIG_LIR_Nem_3 411 416 PF02991 0.383
LIG_LIR_Nem_3 438 443 PF02991 0.522
LIG_LIR_Nem_3 475 481 PF02991 0.279
LIG_LIR_Nem_3 498 502 PF02991 0.410
LIG_LIR_Nem_3 577 583 PF02991 0.314
LIG_LIR_Nem_3 754 758 PF02991 0.308
LIG_LYPXL_S_1 233 237 PF13949 0.465
LIG_NRBOX 140 146 PF00104 0.509
LIG_NRBOX 27 33 PF00104 0.466
LIG_NRBOX 565 571 PF00104 0.322
LIG_NRBOX 602 608 PF00104 0.355
LIG_Pex14_2 687 691 PF04695 0.349
LIG_Rb_LxCxE_1 712 730 PF01857 0.434
LIG_SH2_CRK 242 246 PF00017 0.353
LIG_SH2_CRK 338 342 PF00017 0.354
LIG_SH2_CRK 454 458 PF00017 0.201
LIG_SH2_CRK 755 759 PF00017 0.314
LIG_SH2_GRB2like 499 502 PF00017 0.197
LIG_SH2_GRB2like 524 527 PF00017 0.355
LIG_SH2_NCK_1 524 528 PF00017 0.258
LIG_SH2_SRC 37 40 PF00017 0.437
LIG_SH2_SRC 524 527 PF00017 0.258
LIG_SH2_STAP1 150 154 PF00017 0.419
LIG_SH2_STAP1 289 293 PF00017 0.529
LIG_SH2_STAP1 755 759 PF00017 0.314
LIG_SH2_STAT3 191 194 PF00017 0.324
LIG_SH2_STAT5 191 194 PF00017 0.559
LIG_SH2_STAT5 242 245 PF00017 0.485
LIG_SH2_STAT5 286 289 PF00017 0.432
LIG_SH2_STAT5 499 502 PF00017 0.410
LIG_SH3_1 33 39 PF00018 0.430
LIG_SH3_3 118 124 PF00018 0.452
LIG_SH3_3 214 220 PF00018 0.759
LIG_SH3_3 33 39 PF00018 0.537
LIG_SH3_3 427 433 PF00018 0.376
LIG_SH3_3 606 612 PF00018 0.302
LIG_SH3_3 647 653 PF00018 0.565
LIG_Sin3_3 757 764 PF02671 0.431
LIG_SUMO_SIM_anti_2 177 183 PF11976 0.431
LIG_SUMO_SIM_anti_2 276 283 PF11976 0.308
LIG_SUMO_SIM_anti_2 756 762 PF11976 0.444
LIG_SUMO_SIM_par_1 180 186 PF11976 0.368
LIG_SUMO_SIM_par_1 25 30 PF11976 0.350
LIG_SxIP_EBH_1 114 128 PF03271 0.467
LIG_TYR_ITIM 336 341 PF00017 0.341
LIG_TYR_ITIM 753 758 PF00017 0.305
MOD_CK1_1 157 163 PF00069 0.528
MOD_CK1_1 203 209 PF00069 0.753
MOD_CK1_1 292 298 PF00069 0.369
MOD_CK1_1 354 360 PF00069 0.676
MOD_CK1_1 361 367 PF00069 0.697
MOD_CK1_1 390 396 PF00069 0.507
MOD_CK1_1 746 752 PF00069 0.614
MOD_CK2_1 16 22 PF00069 0.568
MOD_CK2_1 250 256 PF00069 0.517
MOD_CK2_1 292 298 PF00069 0.398
MOD_CK2_1 392 398 PF00069 0.523
MOD_CK2_1 602 608 PF00069 0.279
MOD_CK2_1 677 683 PF00069 0.445
MOD_CK2_1 79 85 PF00069 0.622
MOD_CMANNOS 629 632 PF00535 0.386
MOD_DYRK1A_RPxSP_1 12 16 PF00069 0.596
MOD_GlcNHglycan 132 135 PF01048 0.414
MOD_GlcNHglycan 159 162 PF01048 0.488
MOD_GlcNHglycan 203 206 PF01048 0.759
MOD_GlcNHglycan 311 314 PF01048 0.464
MOD_GlcNHglycan 390 393 PF01048 0.385
MOD_GlcNHglycan 401 404 PF01048 0.431
MOD_GlcNHglycan 6 9 PF01048 0.517
MOD_GlcNHglycan 641 644 PF01048 0.689
MOD_GlcNHglycan 679 682 PF01048 0.397
MOD_GlcNHglycan 745 748 PF01048 0.595
MOD_GSK3_1 10 17 PF00069 0.612
MOD_GSK3_1 113 120 PF00069 0.538
MOD_GSK3_1 167 174 PF00069 0.613
MOD_GSK3_1 199 206 PF00069 0.681
MOD_GSK3_1 218 225 PF00069 0.489
MOD_GSK3_1 240 247 PF00069 0.511
MOD_GSK3_1 256 263 PF00069 0.448
MOD_GSK3_1 307 314 PF00069 0.464
MOD_GSK3_1 330 337 PF00069 0.466
MOD_GSK3_1 350 357 PF00069 0.333
MOD_GSK3_1 358 365 PF00069 0.783
MOD_GSK3_1 388 395 PF00069 0.467
MOD_GSK3_1 50 57 PF00069 0.492
MOD_GSK3_1 547 554 PF00069 0.381
MOD_GSK3_1 673 680 PF00069 0.358
MOD_GSK3_1 68 75 PF00069 0.597
MOD_GSK3_1 737 744 PF00069 0.524
MOD_LATS_1 444 450 PF00433 0.427
MOD_N-GLC_1 167 172 PF02516 0.550
MOD_N-GLC_1 472 477 PF02516 0.279
MOD_N-GLC_1 525 530 PF02516 0.197
MOD_N-GLC_1 637 642 PF02516 0.626
MOD_N-GLC_1 685 690 PF02516 0.429
MOD_N-GLC_2 68 70 PF02516 0.468
MOD_NEK2_1 1 6 PF00069 0.529
MOD_NEK2_1 260 265 PF00069 0.272
MOD_NEK2_1 27 32 PF00069 0.460
MOD_NEK2_1 472 477 PF00069 0.279
MOD_NEK2_1 655 660 PF00069 0.378
MOD_NEK2_1 742 747 PF00069 0.582
MOD_NEK2_2 167 172 PF00069 0.455
MOD_NEK2_2 229 234 PF00069 0.366
MOD_PIKK_1 250 256 PF00454 0.462
MOD_PK_1 264 270 PF00069 0.452
MOD_PK_1 534 540 PF00069 0.476
MOD_PKA_2 113 119 PF00069 0.478
MOD_PKA_2 157 163 PF00069 0.549
MOD_PKA_2 211 217 PF00069 0.736
MOD_PKA_2 357 363 PF00069 0.663
MOD_PKA_2 399 405 PF00069 0.441
MOD_PKA_2 436 442 PF00069 0.495
MOD_PKA_2 445 451 PF00069 0.377
MOD_PKA_2 616 622 PF00069 0.380
MOD_PKA_2 673 679 PF00069 0.446
MOD_PKB_1 115 123 PF00069 0.302
MOD_PKB_1 504 512 PF00069 0.279
MOD_PKB_1 532 540 PF00069 0.444
MOD_Plk_1 167 173 PF00069 0.654
MOD_Plk_1 472 478 PF00069 0.279
MOD_Plk_1 685 691 PF00069 0.424
MOD_Plk_2-3 366 372 PF00069 0.692
MOD_Plk_2-3 72 78 PF00069 0.456
MOD_Plk_4 117 123 PF00069 0.586
MOD_Plk_4 229 235 PF00069 0.558
MOD_Plk_4 240 246 PF00069 0.375
MOD_Plk_4 27 33 PF00069 0.405
MOD_Plk_4 277 283 PF00069 0.334
MOD_Plk_4 316 322 PF00069 0.633
MOD_Plk_4 42 48 PF00069 0.319
MOD_Plk_4 459 465 PF00069 0.279
MOD_Plk_4 472 478 PF00069 0.279
MOD_Plk_4 506 512 PF00069 0.279
MOD_Plk_4 602 608 PF00069 0.308
MOD_Plk_4 616 622 PF00069 0.441
MOD_Plk_4 686 692 PF00069 0.471
MOD_ProDKin_1 10 16 PF00069 0.591
MOD_ProDKin_1 171 177 PF00069 0.589
MOD_ProDKin_1 292 298 PF00069 0.434
MOD_ProDKin_1 359 365 PF00069 0.670
MOD_ProDKin_1 504 510 PF00069 0.318
MOD_ProDKin_1 548 554 PF00069 0.317
TRG_DiLeu_BaEn_1 178 183 PF01217 0.469
TRG_DiLeu_BaEn_1 22 27 PF01217 0.407
TRG_DiLeu_BaLyEn_6 140 145 PF01217 0.510
TRG_DiLeu_BaLyEn_6 592 597 PF01217 0.410
TRG_ENDOCYTIC_2 234 237 PF00928 0.508
TRG_ENDOCYTIC_2 242 245 PF00928 0.354
TRG_ENDOCYTIC_2 338 341 PF00928 0.378
TRG_ENDOCYTIC_2 440 443 PF00928 0.453
TRG_ENDOCYTIC_2 478 481 PF00928 0.279
TRG_ENDOCYTIC_2 499 502 PF00928 0.410
TRG_ENDOCYTIC_2 755 758 PF00928 0.315
TRG_ER_diArg_1 114 117 PF00400 0.394
TRG_ER_diArg_1 141 143 PF00400 0.484
TRG_ER_diArg_1 282 285 PF00400 0.545
TRG_ER_diArg_1 399 401 PF00400 0.459
TRG_ER_diArg_1 434 437 PF00400 0.486
TRG_ER_diArg_1 494 496 PF00400 0.320
TRG_ER_diArg_1 532 534 PF00400 0.424
TRG_ER_diArg_1 60 62 PF00400 0.370
TRG_ER_diArg_1 621 623 PF00400 0.525
TRG_ER_diArg_1 673 675 PF00400 0.525
TRG_ER_diArg_1 724 726 PF00400 0.621
TRG_ER_diArg_1 735 737 PF00400 0.564
TRG_ER_diLys_1 766 770 PF00400 0.477
TRG_NES_CRM1_1 660 670 PF08389 0.293
TRG_Pf-PMV_PEXEL_1 494 498 PF00026 0.322

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9Q8 Leptomonas seymouri 56% 100%
A0A1X0NZ99 Trypanosomatidae 41% 100%
A0A3Q8II41 Leishmania donovani 77% 100%
A0A422MTD5 Trypanosoma rangeli 41% 100%
A4I3M5 Leishmania infantum 77% 100%
D0A856 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AZW6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
Q4Q8C0 Leishmania major 76% 100%
V5BCT3 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS