Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGJ7_LEIBR

TriTrypDb:

LbrM.28.1610 , LBRM2903_280022200

Length:

699

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.540
CLV_C14_Caspase3-7	52	56	PF00656	0.522
CLV_C14_Caspase3-7	678	682	PF00656	0.566
CLV_C14_Caspase3-7	687	691	PF00656	0.473
CLV_MEL_PAP_1	116	122	PF00089	0.524
CLV_NRD_NRD_1	144	146	PF00675	0.579
CLV_NRD_NRD_1	175	177	PF00675	0.641
CLV_NRD_NRD_1	20	22	PF00675	0.748
CLV_NRD_NRD_1	38	40	PF00675	0.477
CLV_NRD_NRD_1	439	441	PF00675	0.522
CLV_NRD_NRD_1	450	452	PF00675	0.604
CLV_NRD_NRD_1	53	55	PF00675	0.542
CLV_PCSK_KEX2_1	144	146	PF00082	0.579
CLV_PCSK_KEX2_1	175	177	PF00082	0.641
CLV_PCSK_KEX2_1	19	21	PF00082	0.744
CLV_PCSK_KEX2_1	206	208	PF00082	0.560
CLV_PCSK_KEX2_1	38	40	PF00082	0.471
CLV_PCSK_KEX2_1	439	441	PF00082	0.634
CLV_PCSK_KEX2_1	449	451	PF00082	0.494
CLV_PCSK_KEX2_1	519	521	PF00082	0.820
CLV_PCSK_KEX2_1	53	55	PF00082	0.542
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.560
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.703
CLV_PCSK_PC7_1	171	177	PF00082	0.659
CLV_PCSK_PC7_1	446	452	PF00082	0.674
CLV_PCSK_SKI1_1	171	175	PF00082	0.742
CLV_PCSK_SKI1_1	399	403	PF00082	0.486
CLV_PCSK_SKI1_1	474	478	PF00082	0.691
CLV_PCSK_SKI1_1	582	586	PF00082	0.572
CLV_PCSK_SKI1_1	606	610	PF00082	0.536
CLV_PCSK_SKI1_1	622	626	PF00082	0.643
DEG_APCC_DBOX_1	256	264	PF00400	0.659
DEG_APCC_DBOX_1	487	495	PF00400	0.623
DEG_Kelch_Keap1_1	198	203	PF01344	0.534
DEG_Nend_UBRbox_4	1	3	PF02207	0.497
DEG_SPOP_SBC_1	274	278	PF00917	0.626
DEG_SPOP_SBC_1	300	304	PF00917	0.454
DEG_SPOP_SBC_1	66	70	PF00917	0.527
DOC_CKS1_1	359	364	PF01111	0.488
DOC_MAPK_DCC_7	184	193	PF00069	0.623
DOC_MAPK_gen_1	38	45	PF00069	0.584
DOC_MAPK_MEF2A_6	184	193	PF00069	0.695
DOC_MAPK_RevD_3	436	451	PF00069	0.570
DOC_PP1_RVXF_1	353	360	PF00149	0.455
DOC_PP2B_LxvP_1	543	546	PF13499	0.689
DOC_PP2B_LxvP_1	694	697	PF13499	0.597
DOC_PP2B_PxIxI_1	672	678	PF00149	0.566
DOC_PP4_FxxP_1	595	598	PF00568	0.676
DOC_USP7_MATH_1	210	214	PF00917	0.555
DOC_USP7_MATH_1	216	220	PF00917	0.546
DOC_USP7_MATH_1	272	276	PF00917	0.613
DOC_USP7_MATH_1	284	288	PF00917	0.683
DOC_USP7_MATH_1	363	367	PF00917	0.610
DOC_USP7_MATH_1	403	407	PF00917	0.523
DOC_USP7_MATH_1	561	565	PF00917	0.589
DOC_USP7_MATH_1	620	624	PF00917	0.538
DOC_USP7_MATH_1	66	70	PF00917	0.567
DOC_USP7_MATH_1	82	86	PF00917	0.545
DOC_USP7_MATH_1	95	99	PF00917	0.539
DOC_WW_Pin1_4	358	363	PF00397	0.466
DOC_WW_Pin1_4	467	472	PF00397	0.670
DOC_WW_Pin1_4	545	550	PF00397	0.692
DOC_WW_Pin1_4	557	562	PF00397	0.632
DOC_WW_Pin1_4	594	599	PF00397	0.678
DOC_WW_Pin1_4	60	65	PF00397	0.578
DOC_WW_Pin1_4	645	650	PF00397	0.721
DOC_WW_Pin1_4	669	674	PF00397	0.597
LIG_14-3-3_CanoR_1	144	148	PF00244	0.570
LIG_14-3-3_CanoR_1	273	279	PF00244	0.533
LIG_14-3-3_CanoR_1	283	291	PF00244	0.503
LIG_14-3-3_CanoR_1	364	369	PF00244	0.634
LIG_14-3-3_CanoR_1	38	43	PF00244	0.536
LIG_14-3-3_CanoR_1	399	407	PF00244	0.542
LIG_14-3-3_CanoR_1	474	483	PF00244	0.711
LIG_14-3-3_CanoR_1	606	616	PF00244	0.592
LIG_14-3-3_CanoR_1	74	80	PF00244	0.522
LIG_Actin_WH2_2	113	128	PF00022	0.507
LIG_AP2alpha_1	416	420	PF02296	0.530
LIG_BIR_III_4	428	432	PF00653	0.498
LIG_BRCT_BRCA1_1	266	270	PF00533	0.537
LIG_BRCT_BRCA1_1	40	44	PF00533	0.568
LIG_Clathr_ClatBox_1	683	687	PF01394	0.462
LIG_EVH1_1	543	547	PF00568	0.612
LIG_FHA_1	115	121	PF00498	0.681
LIG_FHA_1	183	189	PF00498	0.715
LIG_FHA_1	301	307	PF00498	0.560
LIG_FHA_1	351	357	PF00498	0.511
LIG_FHA_1	495	501	PF00498	0.492
LIG_FHA_1	568	574	PF00498	0.625
LIG_FHA_1	624	630	PF00498	0.528
LIG_FHA_1	646	652	PF00498	0.510
LIG_FHA_1	691	697	PF00498	0.420
LIG_FHA_1	76	82	PF00498	0.556
LIG_FHA_2	199	205	PF00498	0.534
LIG_FHA_2	333	339	PF00498	0.388
LIG_FHA_2	450	456	PF00498	0.636
LIG_GSK3_LRP6_1	545	551	PF00069	0.614
LIG_LIR_Apic_2	358	362	PF02991	0.519
LIG_LIR_Apic_2	593	598	PF02991	0.671
LIG_LIR_Gen_1	297	306	PF02991	0.532
LIG_LIR_Gen_1	548	556	PF02991	0.676
LIG_LIR_Gen_1	672	680	PF02991	0.427
LIG_LIR_Gen_1	89	96	PF02991	0.521
LIG_LIR_Nem_3	297	301	PF02991	0.542
LIG_LIR_Nem_3	417	423	PF02991	0.466
LIG_LIR_Nem_3	484	489	PF02991	0.545
LIG_LIR_Nem_3	548	553	PF02991	0.688
LIG_LIR_Nem_3	672	677	PF02991	0.427
LIG_LIR_Nem_3	89	93	PF02991	0.521
LIG_MYND_1	541	545	PF01753	0.637
LIG_Pex14_2	416	420	PF04695	0.530
LIG_SH2_STAT5	14	17	PF00017	0.516
LIG_SH3_3	385	391	PF00018	0.513
LIG_SH3_3	535	541	PF00018	0.742
LIG_SH3_3	543	549	PF00018	0.690
LIG_SUMO_SIM_anti_2	302	311	PF11976	0.507
LIG_SUMO_SIM_par_1	160	170	PF11976	0.660
LIG_TRAF2_1	201	204	PF00917	0.537
MOD_CDK_SPxK_1	358	364	PF00069	0.477
MOD_CDK_SPxxK_3	467	474	PF00069	0.682
MOD_CK1_1	164	170	PF00069	0.647
MOD_CK1_1	177	183	PF00069	0.568
MOD_CK1_1	23	29	PF00069	0.537
MOD_CK1_1	230	236	PF00069	0.533
MOD_CK1_1	275	281	PF00069	0.618
MOD_CK1_1	287	293	PF00069	0.571
MOD_CK1_1	302	308	PF00069	0.676
MOD_CK1_1	350	356	PF00069	0.458
MOD_CK1_1	367	373	PF00069	0.730
MOD_CK1_1	4	10	PF00069	0.476
MOD_CK1_1	47	53	PF00069	0.615
MOD_CK1_1	532	538	PF00069	0.646
MOD_CK1_1	548	554	PF00069	0.562
MOD_CK1_1	597	603	PF00069	0.640
MOD_CK1_1	623	629	PF00069	0.513
MOD_CK1_1	643	649	PF00069	0.596
MOD_CK1_1	661	667	PF00069	0.554
MOD_CK1_1	70	76	PF00069	0.656
MOD_CK1_1	98	104	PF00069	0.698
MOD_CK2_1	198	204	PF00069	0.536
MOD_CK2_1	449	455	PF00069	0.646
MOD_CK2_1	548	554	PF00069	0.738
MOD_Cter_Amidation	36	39	PF01082	0.474
MOD_Cter_Amidation	447	450	PF01082	0.627
MOD_GlcNHglycan	176	179	PF01048	0.719
MOD_GlcNHglycan	22	25	PF01048	0.499
MOD_GlcNHglycan	233	236	PF01048	0.686
MOD_GlcNHglycan	266	269	PF01048	0.771
MOD_GlcNHglycan	270	273	PF01048	0.677
MOD_GlcNHglycan	3	6	PF01048	0.495
MOD_GlcNHglycan	32	35	PF01048	0.529
MOD_GlcNHglycan	399	402	PF01048	0.525
MOD_GlcNHglycan	428	432	PF01048	0.498
MOD_GlcNHglycan	442	445	PF01048	0.660
MOD_GlcNHglycan	48	52	PF01048	0.609
MOD_GlcNHglycan	512	515	PF01048	0.657
MOD_GlcNHglycan	565	568	PF01048	0.595
MOD_GlcNHglycan	663	666	PF01048	0.549
MOD_GlcNHglycan	69	72	PF01048	0.576
MOD_GlcNHglycan	84	87	PF01048	0.546
MOD_GlcNHglycan	97	100	PF01048	0.502
MOD_GSK3_1	143	150	PF00069	0.692
MOD_GSK3_1	174	181	PF00069	0.724
MOD_GSK3_1	227	234	PF00069	0.587
MOD_GSK3_1	23	30	PF00069	0.627
MOD_GSK3_1	235	242	PF00069	0.593
MOD_GSK3_1	264	271	PF00069	0.657
MOD_GSK3_1	285	292	PF00069	0.657
MOD_GSK3_1	300	307	PF00069	0.505
MOD_GSK3_1	363	370	PF00069	0.543
MOD_GSK3_1	399	406	PF00069	0.478
MOD_GSK3_1	463	470	PF00069	0.495
MOD_GSK3_1	494	501	PF00069	0.607
MOD_GSK3_1	528	535	PF00069	0.625
MOD_GSK3_1	555	562	PF00069	0.597
MOD_GSK3_1	563	570	PF00069	0.593
MOD_GSK3_1	58	65	PF00069	0.569
MOD_GSK3_1	641	648	PF00069	0.513
MOD_GSK3_1	657	664	PF00069	0.493
MOD_GSK3_1	66	73	PF00069	0.619
MOD_LATS_1	25	31	PF00433	0.580
MOD_N-GLC_1	230	235	PF02516	0.515
MOD_N-GLC_1	332	337	PF02516	0.380
MOD_N-GLC_2	223	225	PF02516	0.515
MOD_NEK2_1	1	6	PF00069	0.571
MOD_NEK2_1	174	179	PF00069	0.683
MOD_NEK2_1	253	258	PF00069	0.532
MOD_NEK2_1	301	306	PF00069	0.458
MOD_NEK2_1	416	421	PF00069	0.470
MOD_NEK2_1	463	468	PF00069	0.485
MOD_NEK2_1	494	499	PF00069	0.538
MOD_NEK2_1	533	538	PF00069	0.764
MOD_NEK2_1	625	630	PF00069	0.604
MOD_NEK2_1	640	645	PF00069	0.544
MOD_NEK2_1	658	663	PF00069	0.443
MOD_NEK2_1	67	72	PF00069	0.535
MOD_NEK2_1	75	80	PF00069	0.513
MOD_PIKK_1	114	120	PF00454	0.525
MOD_PK_1	364	370	PF00069	0.529
MOD_PK_1	38	44	PF00069	0.584
MOD_PKA_1	20	26	PF00069	0.591
MOD_PKA_1	38	44	PF00069	0.483
MOD_PKA_1	449	455	PF00069	0.578
MOD_PKA_2	143	149	PF00069	0.559
MOD_PKA_2	174	180	PF00069	0.712
MOD_PKA_2	20	26	PF00069	0.616
MOD_PKA_2	256	262	PF00069	0.657
MOD_PKA_2	272	278	PF00069	0.529
MOD_PKA_2	363	369	PF00069	0.649
MOD_PKA_2	38	44	PF00069	0.554
MOD_PKA_2	449	455	PF00069	0.727
MOD_PKA_2	73	79	PF00069	0.523
MOD_PKB_1	262	270	PF00069	0.597
MOD_Plk_1	167	173	PF00069	0.569
MOD_Plk_1	216	222	PF00069	0.536
MOD_Plk_1	247	253	PF00069	0.577
MOD_Plk_1	332	338	PF00069	0.479
MOD_Plk_1	416	422	PF00069	0.446
MOD_Plk_4	247	253	PF00069	0.595
MOD_Plk_4	304	310	PF00069	0.514
MOD_Plk_4	321	327	PF00069	0.504
MOD_Plk_4	342	348	PF00069	0.460
MOD_Plk_4	38	44	PF00069	0.584
MOD_Plk_4	568	574	PF00069	0.625
MOD_Plk_4	620	626	PF00069	0.490
MOD_ProDKin_1	358	364	PF00069	0.477
MOD_ProDKin_1	467	473	PF00069	0.676
MOD_ProDKin_1	545	551	PF00069	0.688
MOD_ProDKin_1	557	563	PF00069	0.631
MOD_ProDKin_1	594	600	PF00069	0.675
MOD_ProDKin_1	60	66	PF00069	0.577
MOD_ProDKin_1	645	651	PF00069	0.719
MOD_ProDKin_1	669	675	PF00069	0.592
MOD_SUMO_rev_2	199	208	PF00179	0.542
MOD_SUMO_rev_2	372	382	PF00179	0.484
TRG_DiLeu_BaEn_1	248	253	PF01217	0.574
TRG_ER_diArg_1	174	176	PF00400	0.640
TRG_ER_diArg_1	19	21	PF00400	0.593
TRG_ER_diArg_1	262	265	PF00400	0.593
TRG_ER_diArg_1	38	40	PF00400	0.508
TRG_ER_diArg_1	438	440	PF00400	0.561
TRG_ER_diArg_1	449	451	PF00400	0.486
TRG_ER_diArg_1	540	543	PF00400	0.642
TRG_ER_diArg_1	603	606	PF00400	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I813	Leptomonas seymouri	39%	100%
A0A3Q8ID48	Leishmania donovani	73%	94%
A4I3M4	Leishmania infantum	74%	94%
E9AZW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q8C1	Leishmania major	73%	100%