Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGJ6_LEIBR

TriTrypDb:

LbrM.28.1600 , LBRM2903_280022100

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.644
CLV_C14_Caspase3-7	349	353	PF00656	0.688
CLV_NRD_NRD_1	238	240	PF00675	0.507
CLV_NRD_NRD_1	270	272	PF00675	0.491
CLV_NRD_NRD_1	29	31	PF00675	0.627
CLV_NRD_NRD_1	320	322	PF00675	0.635
CLV_NRD_NRD_1	326	328	PF00675	0.683
CLV_NRD_NRD_1	503	505	PF00675	0.406
CLV_NRD_NRD_1	539	541	PF00675	0.742
CLV_NRD_NRD_1	689	691	PF00675	0.625
CLV_NRD_NRD_1	705	707	PF00675	0.562
CLV_NRD_NRD_1	89	91	PF00675	0.789
CLV_PCSK_KEX2_1	112	114	PF00082	0.467
CLV_PCSK_KEX2_1	175	177	PF00082	0.516
CLV_PCSK_KEX2_1	238	240	PF00082	0.573
CLV_PCSK_KEX2_1	270	272	PF00082	0.491
CLV_PCSK_KEX2_1	29	31	PF00082	0.627
CLV_PCSK_KEX2_1	320	322	PF00082	0.635
CLV_PCSK_KEX2_1	326	328	PF00082	0.683
CLV_PCSK_KEX2_1	448	450	PF00082	0.406
CLV_PCSK_KEX2_1	462	464	PF00082	0.501
CLV_PCSK_KEX2_1	503	505	PF00082	0.406
CLV_PCSK_KEX2_1	689	691	PF00082	0.588
CLV_PCSK_KEX2_1	707	709	PF00082	0.701
CLV_PCSK_KEX2_1	89	91	PF00082	0.789
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.467
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.618
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.406
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.501
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.660
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.789
CLV_PCSK_PC7_1	108	114	PF00082	0.465
CLV_PCSK_SKI1_1	20	24	PF00082	0.658
CLV_PCSK_SKI1_1	29	33	PF00082	0.583
CLV_PCSK_SKI1_1	321	325	PF00082	0.637
CLV_PCSK_SKI1_1	419	423	PF00082	0.572
CLV_PCSK_SKI1_1	448	452	PF00082	0.401
CLV_PCSK_SKI1_1	582	586	PF00082	0.601
CLV_PCSK_SKI1_1	643	647	PF00082	0.464
CLV_PCSK_SKI1_1	677	681	PF00082	0.617
CLV_PCSK_SKI1_1	90	94	PF00082	0.766
DEG_APCC_DBOX_1	539	547	PF00400	0.477
DEG_COP1_1	129	137	PF00400	0.634
DEG_ODPH_VHL_1	506	519	PF01847	0.625
DEG_SPOP_SBC_1	210	214	PF00917	0.801
DOC_CKS1_1	305	310	PF01111	0.649
DOC_CKS1_1	345	350	PF01111	0.579
DOC_CKS1_1	438	443	PF01111	0.566
DOC_CKS1_1	65	70	PF01111	0.534
DOC_MAPK_DCC_7	503	511	PF00069	0.543
DOC_MAPK_gen_1	126	134	PF00069	0.376
DOC_MAPK_gen_1	503	511	PF00069	0.388
DOC_MAPK_gen_1	667	674	PF00069	0.347
DOC_MAPK_gen_1	707	719	PF00069	0.517
DOC_MAPK_RevD_3	313	327	PF00069	0.380
DOC_PP1_RVXF_1	669	675	PF00149	0.594
DOC_PP2B_LxvP_1	132	135	PF13499	0.639
DOC_PP2B_LxvP_1	496	499	PF13499	0.668
DOC_PP2B_LxvP_1	5	8	PF13499	0.611
DOC_PP4_MxPP_1	657	660	PF00568	0.486
DOC_USP7_MATH_1	13	17	PF00917	0.514
DOC_USP7_MATH_1	190	194	PF00917	0.589
DOC_USP7_MATH_1	210	214	PF00917	0.806
DOC_USP7_MATH_1	407	411	PF00917	0.605
DOC_USP7_MATH_1	571	575	PF00917	0.601
DOC_USP7_MATH_1	701	705	PF00917	0.544
DOC_USP7_UBL2_3	287	291	PF12436	0.441
DOC_USP7_UBL2_3	667	671	PF12436	0.441
DOC_WW_Pin1_4	304	309	PF00397	0.565
DOC_WW_Pin1_4	344	349	PF00397	0.677
DOC_WW_Pin1_4	365	370	PF00397	0.505
DOC_WW_Pin1_4	437	442	PF00397	0.476
DOC_WW_Pin1_4	64	69	PF00397	0.576
LIG_14-3-3_CanoR_1	186	190	PF00244	0.674
LIG_14-3-3_CanoR_1	20	26	PF00244	0.633
LIG_14-3-3_CanoR_1	270	280	PF00244	0.475
LIG_14-3-3_CanoR_1	340	348	PF00244	0.590
LIG_14-3-3_CanoR_1	416	422	PF00244	0.546
LIG_14-3-3_CanoR_1	557	564	PF00244	0.566
LIG_14-3-3_CanoR_1	590	594	PF00244	0.604
LIG_14-3-3_CanoR_1	643	648	PF00244	0.591
LIG_Actin_WH2_1	113	128	PF00022	0.412
LIG_Actin_WH2_2	489	505	PF00022	0.515
LIG_BIR_III_4	206	210	PF00653	0.781
LIG_BRCT_BRCA1_1	192	196	PF00533	0.553
LIG_BRCT_BRCA1_1	423	427	PF00533	0.589
LIG_BRCT_BRCA1_1	73	77	PF00533	0.668
LIG_BRCT_BRCA1_1	99	103	PF00533	0.749
LIG_CtBP_PxDLS_1	499	503	PF00389	0.642
LIG_FHA_1	137	143	PF00498	0.612
LIG_FHA_1	35	41	PF00498	0.540
LIG_FHA_1	354	360	PF00498	0.553
LIG_FHA_1	365	371	PF00498	0.353
LIG_FHA_1	492	498	PF00498	0.460
LIG_FHA_1	579	585	PF00498	0.571
LIG_FHA_1	644	650	PF00498	0.481
LIG_FHA_1	78	84	PF00498	0.558
LIG_FHA_2	145	151	PF00498	0.627
LIG_FHA_2	178	184	PF00498	0.637
LIG_FHA_2	453	459	PF00498	0.407
LIG_FHA_2	607	613	PF00498	0.619
LIG_FHA_2	91	97	PF00498	0.755
LIG_LIR_Apic_2	136	141	PF02991	0.635
LIG_LIR_Gen_1	193	204	PF02991	0.502
LIG_LIR_Gen_1	440	451	PF02991	0.458
LIG_LIR_Gen_1	641	652	PF02991	0.509
LIG_LIR_Nem_3	100	106	PF02991	0.738
LIG_LIR_Nem_3	193	199	PF02991	0.454
LIG_LIR_Nem_3	257	262	PF02991	0.467
LIG_LIR_Nem_3	440	446	PF02991	0.457
LIG_LIR_Nem_3	461	467	PF02991	0.434
LIG_LIR_Nem_3	585	589	PF02991	0.556
LIG_LIR_Nem_3	641	647	PF02991	0.526
LIG_MLH1_MIPbox_1	192	196	PF16413	0.553
LIG_PCNA_PIPBox_1	70	79	PF02747	0.472
LIG_PCNA_yPIPBox_3	524	535	PF02747	0.466
LIG_PDZ_Class_2	714	719	PF00595	0.654
LIG_Pex14_2	427	431	PF04695	0.548
LIG_Pex14_2	439	443	PF04695	0.384
LIG_SH2_CRK	138	142	PF00017	0.622
LIG_SH2_CRK	586	590	PF00017	0.580
LIG_SH2_NCK_1	479	483	PF00017	0.545
LIG_SH2_PTP2	644	647	PF00017	0.546
LIG_SH2_STAP1	259	263	PF00017	0.606
LIG_SH2_STAP1	460	464	PF00017	0.567
LIG_SH2_STAP1	479	483	PF00017	0.231
LIG_SH2_STAP1	78	82	PF00017	0.641
LIG_SH2_STAT3	58	61	PF00017	0.823
LIG_SH2_STAT5	119	122	PF00017	0.644
LIG_SH2_STAT5	138	141	PF00017	0.322
LIG_SH2_STAT5	172	175	PF00017	0.615
LIG_SH2_STAT5	195	198	PF00017	0.393
LIG_SH2_STAT5	240	243	PF00017	0.487
LIG_SH2_STAT5	262	265	PF00017	0.598
LIG_SH2_STAT5	283	286	PF00017	0.445
LIG_SH2_STAT5	468	471	PF00017	0.476
LIG_SH2_STAT5	487	490	PF00017	0.315
LIG_SH2_STAT5	580	583	PF00017	0.530
LIG_SH2_STAT5	644	647	PF00017	0.585
LIG_SH2_STAT5	673	676	PF00017	0.586
LIG_SH3_3	302	308	PF00018	0.588
LIG_SH3_3	435	441	PF00018	0.486
LIG_SH3_3	54	60	PF00018	0.824
LIG_SH3_3	653	659	PF00018	0.595
LIG_SH3_4	287	294	PF00018	0.438
LIG_SUMO_SIM_anti_2	379	385	PF11976	0.588
LIG_SUMO_SIM_par_1	129	136	PF11976	0.639
LIG_SUMO_SIM_par_1	407	413	PF11976	0.501
LIG_SUMO_SIM_par_1	659	665	PF11976	0.595
LIG_SUMO_SIM_par_1	79	86	PF11976	0.502
LIG_TRAF2_1	609	612	PF00917	0.601
LIG_TYR_ITIM	584	589	PF00017	0.581
LIG_UBA3_1	535	541	PF00899	0.721
LIG_WRC_WIRS_1	411	416	PF05994	0.610
MOD_CK1_1	212	218	PF00069	0.656
MOD_CK1_1	332	338	PF00069	0.587
MOD_CK1_1	394	400	PF00069	0.702
MOD_CK1_1	410	416	PF00069	0.486
MOD_CK1_1	471	477	PF00069	0.470
MOD_CK2_1	144	150	PF00069	0.530
MOD_CK2_1	296	302	PF00069	0.639
MOD_CK2_1	327	333	PF00069	0.564
MOD_CK2_1	606	612	PF00069	0.608
MOD_Cter_Amidation	704	707	PF01082	0.784
MOD_GlcNHglycan	329	332	PF01048	0.721
MOD_GlcNHglycan	333	337	PF01048	0.736
MOD_GlcNHglycan	349	352	PF01048	0.524
MOD_GlcNHglycan	403	406	PF01048	0.646
MOD_GlcNHglycan	703	706	PF01048	0.547
MOD_GSK3_1	20	27	PF00069	0.707
MOD_GSK3_1	208	215	PF00069	0.756
MOD_GSK3_1	254	261	PF00069	0.490
MOD_GSK3_1	332	339	PF00069	0.639
MOD_GSK3_1	417	424	PF00069	0.577
MOD_GSK3_1	427	434	PF00069	0.426
MOD_GSK3_1	49	56	PF00069	0.724
MOD_GSK3_1	511	518	PF00069	0.517
MOD_GSK3_1	578	585	PF00069	0.539
MOD_GSK3_1	589	596	PF00069	0.610
MOD_N-GLC_1	266	271	PF02516	0.499
MOD_N-GLC_1	527	532	PF02516	0.513
MOD_NEK2_1	14	19	PF00069	0.727
MOD_NEK2_1	185	190	PF00069	0.585
MOD_NEK2_1	25	30	PF00069	0.716
MOD_NEK2_1	266	271	PF00069	0.468
MOD_NEK2_1	34	39	PF00069	0.671
MOD_NEK2_1	427	432	PF00069	0.547
MOD_NEK2_1	502	507	PF00069	0.527
MOD_NEK2_1	511	516	PF00069	0.492
MOD_NEK2_1	593	598	PF00069	0.529
MOD_NEK2_1	650	655	PF00069	0.545
MOD_NEK2_1	672	677	PF00069	0.593
MOD_NEK2_1	693	698	PF00069	0.536
MOD_NEK2_1	77	82	PF00069	0.733
MOD_NEK2_2	190	195	PF00069	0.581
MOD_NEK2_2	407	412	PF00069	0.504
MOD_NEK2_2	452	457	PF00069	0.313
MOD_NEK2_2	527	532	PF00069	0.557
MOD_NEK2_2	571	576	PF00069	0.597
MOD_PIKK_1	271	277	PF00454	0.470
MOD_PIKK_1	49	55	PF00454	0.814
MOD_PIKK_1	548	554	PF00454	0.661
MOD_PK_1	712	718	PF00069	0.511
MOD_PKA_1	126	132	PF00069	0.372
MOD_PKA_1	90	96	PF00069	0.760
MOD_PKA_2	185	191	PF00069	0.635
MOD_PKA_2	339	345	PF00069	0.719
MOD_PKA_2	35	41	PF00069	0.701
MOD_PKA_2	471	477	PF00069	0.572
MOD_PKA_2	502	508	PF00069	0.579
MOD_PKA_2	515	521	PF00069	0.492
MOD_PKA_2	556	562	PF00069	0.587
MOD_PKA_2	589	595	PF00069	0.507
MOD_Plk_1	254	260	PF00069	0.486
MOD_Plk_1	271	277	PF00069	0.504
MOD_Plk_1	527	533	PF00069	0.464
MOD_Plk_1	71	77	PF00069	0.713
MOD_Plk_1	78	84	PF00069	0.633
MOD_Plk_4	190	196	PF00069	0.415
MOD_Plk_4	258	264	PF00069	0.602
MOD_Plk_4	492	498	PF00069	0.621
MOD_Plk_4	53	59	PF00069	0.795
MOD_Plk_4	712	718	PF00069	0.764
MOD_Plk_4	72	78	PF00069	0.677
MOD_Plk_4	97	103	PF00069	0.705
MOD_ProDKin_1	304	310	PF00069	0.560
MOD_ProDKin_1	344	350	PF00069	0.676
MOD_ProDKin_1	365	371	PF00069	0.503
MOD_ProDKin_1	437	443	PF00069	0.468
MOD_ProDKin_1	64	70	PF00069	0.574
MOD_SUMO_for_1	111	114	PF00179	0.613
MOD_SUMO_for_1	41	44	PF00179	0.763
MOD_SUMO_rev_2	121	128	PF00179	0.385
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.598
TRG_ENDOCYTIC_2	119	122	PF00928	0.661
TRG_ENDOCYTIC_2	165	168	PF00928	0.512
TRG_ENDOCYTIC_2	195	198	PF00928	0.452
TRG_ENDOCYTIC_2	262	265	PF00928	0.481
TRG_ENDOCYTIC_2	467	470	PF00928	0.550
TRG_ENDOCYTIC_2	586	589	PF00928	0.520
TRG_ENDOCYTIC_2	644	647	PF00928	0.585
TRG_ER_diArg_1	237	239	PF00400	0.495
TRG_ER_diArg_1	319	321	PF00400	0.515
TRG_ER_diArg_1	326	328	PF00400	0.680
TRG_ER_diArg_1	502	504	PF00400	0.399
TRG_ER_diArg_1	688	690	PF00400	0.529
TRG_NLS_Bipartite_1	689	711	PF00514	0.602
TRG_NLS_MonoCore_2	705	710	PF00514	0.539
TRG_NLS_MonoExtC_3	705	710	PF00514	0.591
TRG_NLS_MonoExtN_4	706	711	PF00514	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D3	Leptomonas seymouri	36%	86%
A0A3S5H7J3	Leishmania donovani	79%	99%
A4I3M3	Leishmania infantum	78%	99%
E9AZW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4Q8C2	Leishmania major	77%	100%