Putative DNA polymerase kappa

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase kappa, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HGJ4_LEIBR

TriTrypDb:

LbrM.28.1580 , LBRM2903_280021900

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGJ4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006259	DNA metabolic process	4	4
GO:0006281	DNA repair	5	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0006950	response to stress	2	4
GO:0006974	DNA damage response	4	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0033554	cellular response to stress	3	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	4
GO:0046483	heterocycle metabolic process	3	4
GO:0050896	response to stimulus	1	4
GO:0051716	cellular response to stimulus	2	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0003887	DNA-directed DNA polymerase activity	5	4
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0016779	nucleotidyltransferase activity	4	4
GO:0034061	DNA polymerase activity	4	4
GO:0140097	catalytic activity, acting on DNA	3	4
GO:0140640	catalytic activity, acting on a nucleic acid	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.494
CLV_NRD_NRD_1	200	202	PF00675	0.290
CLV_PCSK_KEX2_1	156	158	PF00082	0.369
CLV_PCSK_KEX2_1	199	201	PF00082	0.299
CLV_PCSK_KEX2_1	26	28	PF00082	0.512
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.512
CLV_PCSK_PC7_1	196	202	PF00082	0.300
DEG_Nend_Nbox_1	1	3	PF02207	0.406
DOC_CKS1_1	45	50	PF01111	0.477
DOC_MAPK_gen_1	196	205	PF00069	0.292
DOC_MAPK_gen_1	257	265	PF00069	0.366
DOC_MAPK_MEF2A_6	199	207	PF00069	0.262
DOC_MAPK_MEF2A_6	257	265	PF00069	0.366
DOC_MAPK_RevD_3	203	218	PF00069	0.179
DOC_PP1_RVXF_1	112	118	PF00149	0.387
DOC_USP7_MATH_1	18	22	PF00917	0.606
DOC_USP7_MATH_1	311	315	PF00917	0.414
DOC_USP7_MATH_1	89	93	PF00917	0.640
DOC_USP7_UBL2_3	178	182	PF12436	0.356
DOC_USP7_UBL2_3	22	26	PF12436	0.512
DOC_WW_Pin1_4	216	221	PF00397	0.400
DOC_WW_Pin1_4	44	49	PF00397	0.586
DOC_WW_Pin1_4	52	57	PF00397	0.480
LIG_APCC_ABBAyCdc20_2	200	206	PF00400	0.259
LIG_DCNL_PONY_1	1	4	PF03556	0.394
LIG_FHA_1	193	199	PF00498	0.431
LIG_FHA_1	217	223	PF00498	0.371
LIG_FHA_1	236	242	PF00498	0.428
LIG_FHA_1	298	304	PF00498	0.366
LIG_FHA_2	185	191	PF00498	0.307
LIG_LIR_Gen_1	169	176	PF02991	0.361
LIG_LIR_Gen_1	208	216	PF02991	0.366
LIG_LIR_Gen_1	288	299	PF02991	0.366
LIG_LIR_Nem_3	169	173	PF02991	0.367
LIG_LIR_Nem_3	208	214	PF02991	0.409
LIG_LIR_Nem_3	269	273	PF02991	0.368
LIG_LIR_Nem_3	288	294	PF02991	0.335
LIG_LIR_Nem_3	309	313	PF02991	0.371
LIG_PDZ_Class_3	321	326	PF00595	0.352
LIG_SH2_GRB2like	66	69	PF00017	0.498
LIG_SH2_NCK_1	211	215	PF00017	0.366
LIG_SH2_PTP2	202	205	PF00017	0.264
LIG_SH2_SRC	131	134	PF00017	0.296
LIG_SH2_SRC	202	205	PF00017	0.246
LIG_SH2_STAP1	287	291	PF00017	0.371
LIG_SH2_STAT3	287	290	PF00017	0.371
LIG_SH2_STAT5	131	134	PF00017	0.318
LIG_SH2_STAT5	202	205	PF00017	0.264
LIG_SH2_STAT5	240	243	PF00017	0.366
LIG_SH2_STAT5	306	309	PF00017	0.397
LIG_SH3_3	42	48	PF00018	0.493
LIG_SUMO_SIM_anti_2	262	267	PF11976	0.366
LIG_TRAF2_1	213	216	PF00917	0.371
MOD_CDK_SPxxK_3	216	223	PF00069	0.371
MOD_CDK_SPxxK_3	56	63	PF00069	0.506
MOD_CK1_1	10	16	PF00069	0.467
MOD_CK1_1	140	146	PF00069	0.304
MOD_CK1_1	169	175	PF00069	0.356
MOD_CK1_1	21	27	PF00069	0.566
MOD_CK1_1	282	288	PF00069	0.381
MOD_CK1_1	38	44	PF00069	0.635
MOD_CK2_1	171	177	PF00069	0.395
MOD_CK2_1	218	224	PF00069	0.535
MOD_Cter_Amidation	255	258	PF01082	0.166
MOD_GlcNHglycan	110	113	PF01048	0.680
MOD_GlcNHglycan	142	145	PF01048	0.326
MOD_GlcNHglycan	248	251	PF01048	0.192
MOD_GlcNHglycan	313	316	PF01048	0.287
MOD_GlcNHglycan	37	40	PF01048	0.488
MOD_GlcNHglycan	48	51	PF01048	0.440
MOD_GlcNHglycan	77	80	PF01048	0.488
MOD_GSK3_1	297	304	PF00069	0.366
MOD_GSK3_1	52	59	PF00069	0.686
MOD_GSK3_1	7	14	PF00069	0.450
MOD_NEK2_1	117	122	PF00069	0.502
MOD_NEK2_1	152	157	PF00069	0.588
MOD_NEK2_1	184	189	PF00069	0.517
MOD_NEK2_1	2	7	PF00069	0.397
MOD_NEK2_1	234	239	PF00069	0.366
MOD_NEK2_1	301	306	PF00069	0.366
MOD_PIKK_1	228	234	PF00454	0.371
MOD_PK_1	279	285	PF00069	0.371
MOD_PKA_1	35	41	PF00069	0.493
MOD_PKA_2	18	24	PF00069	0.469
MOD_PKA_2	2	8	PF00069	0.407
MOD_Plk_1	297	303	PF00069	0.384
MOD_Plk_2-3	297	303	PF00069	0.366
MOD_Plk_4	184	190	PF00069	0.308
MOD_Plk_4	41	47	PF00069	0.645
MOD_ProDKin_1	216	222	PF00069	0.400
MOD_ProDKin_1	44	50	PF00069	0.585
MOD_ProDKin_1	52	58	PF00069	0.493
MOD_SUMO_rev_2	215	220	PF00179	0.371
TRG_ENDOCYTIC_2	202	205	PF00928	0.246
TRG_ENDOCYTIC_2	211	214	PF00928	0.366
TRG_ER_diArg_1	156	158	PF00400	0.351
TRG_ER_diArg_1	198	201	PF00400	0.303
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.171

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7LZ62	Trypanosoma rangeli	53%	100%
A0A422MX83	Trypanosoma rangeli	52%	100%