C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HGJ2_LEIBR

TriTrypDb:

LbrM.28.1560 , LBRM2903_280021600

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGJ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.757
CLV_NRD_NRD_1	69	71	PF00675	0.591
CLV_PCSK_KEX2_1	390	392	PF00082	0.669
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.669
CLV_PCSK_SKI1_1	149	153	PF00082	0.626
CLV_PCSK_SKI1_1	235	239	PF00082	0.543
CLV_PCSK_SKI1_1	36	40	PF00082	0.767
DOC_CDC14_PxL_1	38	46	PF14671	0.508
DOC_CKS1_1	137	142	PF01111	0.663
DOC_CKS1_1	143	148	PF01111	0.671
DOC_CKS1_1	150	155	PF01111	0.643
DOC_MAPK_DCC_7	183	191	PF00069	0.530
DOC_MAPK_MEF2A_6	20	27	PF00069	0.558
DOC_PP2B_LxvP_1	25	28	PF13499	0.582
DOC_PP2B_LxvP_1	269	272	PF13499	0.809
DOC_PP4_FxxP_1	128	131	PF00568	0.546
DOC_PP4_FxxP_1	205	208	PF00568	0.693
DOC_USP7_MATH_1	212	216	PF00917	0.789
DOC_USP7_MATH_1	249	253	PF00917	0.766
DOC_USP7_MATH_1	265	269	PF00917	0.644
DOC_USP7_MATH_1	276	280	PF00917	0.703
DOC_USP7_MATH_1	76	80	PF00917	0.735
DOC_WW_Pin1_4	136	141	PF00397	0.657
DOC_WW_Pin1_4	142	147	PF00397	0.672
DOC_WW_Pin1_4	149	154	PF00397	0.649
DOC_WW_Pin1_4	165	170	PF00397	0.660
DOC_WW_Pin1_4	182	187	PF00397	0.779
DOC_WW_Pin1_4	19	24	PF00397	0.690
DOC_WW_Pin1_4	204	209	PF00397	0.697
DOC_WW_Pin1_4	237	242	PF00397	0.587
DOC_WW_Pin1_4	245	250	PF00397	0.650
DOC_WW_Pin1_4	263	268	PF00397	0.523
DOC_WW_Pin1_4	300	305	PF00397	0.699
DOC_WW_Pin1_4	335	340	PF00397	0.761
DOC_WW_Pin1_4	356	361	PF00397	0.830
DOC_WW_Pin1_4	371	376	PF00397	0.563
DOC_WW_Pin1_4	384	389	PF00397	0.576
LIG_14-3-3_CanoR_1	122	131	PF00244	0.546
LIG_14-3-3_CanoR_1	174	182	PF00244	0.736
LIG_14-3-3_CanoR_1	220	228	PF00244	0.661
LIG_14-3-3_CanoR_1	36	44	PF00244	0.763
LIG_14-3-3_CanoR_1	91	99	PF00244	0.522
LIG_BRCT_BRCA1_1	124	128	PF00533	0.546
LIG_BRCT_BRCA1_1	220	224	PF00533	0.793
LIG_FHA_1	176	182	PF00498	0.781
LIG_FHA_1	231	237	PF00498	0.595
LIG_FHA_2	289	295	PF00498	0.746
LIG_IBAR_NPY_1	369	371	PF08397	0.805
LIG_LIR_Apic_2	125	131	PF02991	0.546
LIG_LIR_Apic_2	203	208	PF02991	0.702
LIG_LIR_Gen_1	222	232	PF02991	0.517
LIG_LIR_Nem_3	222	228	PF02991	0.618
LIG_LIR_Nem_3	347	352	PF02991	0.561
LIG_MLH1_MIPbox_1	221	225	PF16413	0.523
LIG_PCNA_PIPBox_1	1	10	PF02747	0.501
LIG_PTB_Apo_2	158	165	PF02174	0.481
LIG_SH2_NCK_1	63	67	PF00017	0.550
LIG_SH2_SRC	371	374	PF00017	0.811
LIG_SH2_STAT5	274	277	PF00017	0.814
LIG_SH2_STAT5	343	346	PF00017	0.561
LIG_SH2_STAT5	43	46	PF00017	0.663
LIG_SH3_1	333	339	PF00018	0.659
LIG_SH3_2	385	390	PF14604	0.798
LIG_SH3_3	134	140	PF00018	0.641
LIG_SH3_3	147	153	PF00018	0.654
LIG_SH3_3	298	304	PF00018	0.714
LIG_SH3_3	333	339	PF00018	0.659
LIG_SH3_3	379	385	PF00018	0.752
LIG_SUMO_SIM_par_1	293	299	PF11976	0.544
MOD_CDC14_SPxK_1	387	390	PF00782	0.636
MOD_CDK_SPK_2	169	174	PF00069	0.609
MOD_CDK_SPK_2	182	187	PF00069	0.734
MOD_CDK_SPK_2	356	361	PF00069	0.830
MOD_CDK_SPxK_1	136	142	PF00069	0.763
MOD_CDK_SPxK_1	384	390	PF00069	0.629
MOD_CDK_SPxxK_3	142	149	PF00069	0.671
MOD_CDK_SPxxK_3	19	26	PF00069	0.656
MOD_CDK_SPxxK_3	384	391	PF00069	0.660
MOD_CK1_1	172	178	PF00069	0.599
MOD_CK1_1	197	203	PF00069	0.712
MOD_CK1_1	204	210	PF00069	0.718
MOD_CK1_1	239	245	PF00069	0.781
MOD_CK1_1	248	254	PF00069	0.769
MOD_CK1_1	279	285	PF00069	0.757
MOD_CK1_1	303	309	PF00069	0.696
MOD_CK1_1	324	330	PF00069	0.822
MOD_CK1_1	345	351	PF00069	0.710
MOD_CK1_1	86	92	PF00069	0.609
MOD_CK2_1	197	203	PF00069	0.760
MOD_CK2_1	279	285	PF00069	0.621
MOD_Cter_Amidation	106	109	PF01082	0.576
MOD_DYRK1A_RPxSP_1	142	146	PF00069	0.698
MOD_DYRK1A_RPxSP_1	149	153	PF00069	0.596
MOD_DYRK1A_RPxSP_1	300	304	PF00069	0.802
MOD_GlcNHglycan	161	164	PF01048	0.737
MOD_GlcNHglycan	192	195	PF01048	0.795
MOD_GlcNHglycan	196	199	PF01048	0.735
MOD_GlcNHglycan	214	217	PF01048	0.494
MOD_GlcNHglycan	221	224	PF01048	0.688
MOD_GlcNHglycan	326	329	PF01048	0.838
MOD_GlcNHglycan	344	347	PF01048	0.541
MOD_GlcNHglycan	45	48	PF01048	0.542
MOD_GlcNHglycan	78	81	PF01048	0.737
MOD_GlcNHglycan	88	91	PF01048	0.531
MOD_GlcNHglycan	93	96	PF01048	0.655
MOD_GSK3_1	138	145	PF00069	0.674
MOD_GSK3_1	14	21	PF00069	0.672
MOD_GSK3_1	165	172	PF00069	0.669
MOD_GSK3_1	177	184	PF00069	0.600
MOD_GSK3_1	190	197	PF00069	0.586
MOD_GSK3_1	204	211	PF00069	0.729
MOD_GSK3_1	214	221	PF00069	0.672
MOD_GSK3_1	245	252	PF00069	0.667
MOD_GSK3_1	276	283	PF00069	0.608
MOD_GSK3_1	296	303	PF00069	0.697
MOD_GSK3_1	322	329	PF00069	0.630
MOD_GSK3_1	389	396	PF00069	0.685
MOD_N-GLC_1	116	121	PF02516	0.265
MOD_N-GLC_1	276	281	PF02516	0.760
MOD_N-GLC_1	29	34	PF02516	0.650
MOD_N-GLC_2	110	112	PF02516	0.411
MOD_NEK2_1	116	121	PF00069	0.438
MOD_NEK2_1	159	164	PF00069	0.527
MOD_NEK2_1	177	182	PF00069	0.793
MOD_NEK2_1	224	229	PF00069	0.530
MOD_NEK2_1	236	241	PF00069	0.574
MOD_NEK2_1	321	326	PF00069	0.813
MOD_NEK2_1	344	349	PF00069	0.562
MOD_NEK2_1	389	394	PF00069	0.669
MOD_OFUCOSY	120	126	PF10250	0.346
MOD_PIKK_1	6	12	PF00454	0.514
MOD_PIKK_1	93	99	PF00454	0.551
MOD_PKA_2	121	127	PF00069	0.546
MOD_PKA_2	219	225	PF00069	0.664
MOD_Plk_1	279	285	PF00069	0.577
MOD_Plk_2-3	280	286	PF00069	0.551
MOD_Plk_4	177	183	PF00069	0.745
MOD_Plk_4	310	316	PF00069	0.546
MOD_ProDKin_1	136	142	PF00069	0.661
MOD_ProDKin_1	149	155	PF00069	0.645
MOD_ProDKin_1	165	171	PF00069	0.664
MOD_ProDKin_1	182	188	PF00069	0.775
MOD_ProDKin_1	19	25	PF00069	0.692
MOD_ProDKin_1	204	210	PF00069	0.698
MOD_ProDKin_1	237	243	PF00069	0.586
MOD_ProDKin_1	245	251	PF00069	0.650
MOD_ProDKin_1	263	269	PF00069	0.527
MOD_ProDKin_1	300	306	PF00069	0.701
MOD_ProDKin_1	335	341	PF00069	0.761
MOD_ProDKin_1	356	362	PF00069	0.829
MOD_ProDKin_1	371	377	PF00069	0.563
MOD_ProDKin_1	384	390	PF00069	0.579
TRG_DiLeu_BaEn_1	293	298	PF01217	0.542
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W6	Leptomonas seymouri	38%	100%
A0A3S7X1G7	Leishmania donovani	69%	100%
E9ADK0	Leishmania major	68%	100%
E9AHG4	Leishmania infantum	69%	100%
E9AZW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%