HAD-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

HAD-like protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGJ0_LEIBR

TriTrypDb:

LbrM.28.1530 , LBRM2903_280021300

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGJ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.420
CLV_NRD_NRD_1	74	76	PF00675	0.461
CLV_PCSK_KEX2_1	68	70	PF00082	0.350
CLV_PCSK_KEX2_1	74	76	PF00082	0.431
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.304
CLV_PCSK_SKI1_1	149	153	PF00082	0.584
CLV_PCSK_SKI1_1	213	217	PF00082	0.299
CLV_PCSK_SKI1_1	347	351	PF00082	0.210
CLV_PCSK_SKI1_1	369	373	PF00082	0.300
CLV_PCSK_SKI1_1	75	79	PF00082	0.483
DEG_Nend_UBRbox_4	1	3	PF02207	0.401
DEG_SPOP_SBC_1	271	275	PF00917	0.410
DOC_MAPK_gen_1	367	376	PF00069	0.417
DOC_MAPK_HePTP_8	364	376	PF00069	0.439
DOC_MAPK_MEF2A_6	367	376	PF00069	0.374
DOC_PP1_RVXF_1	240	246	PF00149	0.352
DOC_PP2B_LxvP_1	199	202	PF13499	0.285
DOC_PP4_FxxP_1	215	218	PF00568	0.325
DOC_USP7_MATH_1	141	145	PF00917	0.383
DOC_USP7_MATH_1	159	163	PF00917	0.394
DOC_USP7_MATH_1	218	222	PF00917	0.592
DOC_USP7_MATH_1	227	231	PF00917	0.373
DOC_USP7_MATH_1	271	275	PF00917	0.353
DOC_USP7_MATH_1	67	71	PF00917	0.483
DOC_USP7_MATH_1	95	99	PF00917	0.546
DOC_USP7_UBL2_3	174	178	PF12436	0.475
DOC_USP7_UBL2_3	331	335	PF12436	0.366
DOC_WW_Pin1_4	155	160	PF00397	0.544
LIG_14-3-3_CanoR_1	246	250	PF00244	0.410
LIG_14-3-3_CanoR_1	267	271	PF00244	0.410
LIG_14-3-3_CanoR_1	50	56	PF00244	0.418
LIG_14-3-3_CanoR_1	69	77	PF00244	0.242
LIG_14-3-3_CanoR_1	8	18	PF00244	0.255
LIG_Actin_WH2_2	317	333	PF00022	0.366
LIG_APCC_ABBA_1	36	41	PF00400	0.366
LIG_BRCT_BRCA1_1	3	7	PF00533	0.326
LIG_BRCT_BRCA1_1	62	66	PF00533	0.465
LIG_BRCT_BRCA1_2	62	68	PF00533	0.429
LIG_Clathr_ClatBox_1	216	220	PF01394	0.333
LIG_deltaCOP1_diTrp_1	192	200	PF00928	0.323
LIG_eIF4E_1	28	34	PF01652	0.410
LIG_FHA_1	273	279	PF00498	0.499
LIG_FHA_2	188	194	PF00498	0.251
LIG_GBD_Chelix_1	364	372	PF00786	0.217
LIG_IRF3_LxIS_1	368	375	PF10401	0.307
LIG_LIR_Gen_1	230	240	PF02991	0.357
LIG_LIR_Gen_1	31	42	PF02991	0.366
LIG_LIR_Nem_3	197	203	PF02991	0.362
LIG_LIR_Nem_3	230	235	PF02991	0.487
LIG_LIR_Nem_3	31	37	PF02991	0.366
LIG_LIR_Nem_3	4	10	PF02991	0.347
LIG_MLH1_MIPbox_1	62	66	PF16413	0.465
LIG_MYND_1	214	218	PF01753	0.375
LIG_PCNA_PIPBox_1	30	39	PF02747	0.366
LIG_Pex14_2	215	219	PF04695	0.500
LIG_PTB_Apo_2	129	136	PF02174	0.257
LIG_PTB_Phospho_1	129	135	PF10480	0.251
LIG_SH2_CRK	138	142	PF00017	0.385
LIG_SH2_STAP1	40	44	PF00017	0.433
LIG_SH2_STAT3	40	43	PF00017	0.366
LIG_SH2_STAT5	142	145	PF00017	0.495
LIG_SH2_STAT5	189	192	PF00017	0.318
LIG_SH2_STAT5	28	31	PF00017	0.466
LIG_SH2_STAT5	52	55	PF00017	0.484
LIG_SH2_STAT5	65	68	PF00017	0.282
LIG_SH2_STAT5	93	96	PF00017	0.519
LIG_TRAF2_1	290	293	PF00917	0.366
LIG_TRAF2_1	358	361	PF00917	0.366
LIG_TRAF2_1	58	61	PF00917	0.366
LIG_UBA3_1	199	208	PF00899	0.281
MOD_CK1_1	187	193	PF00069	0.317
MOD_CK1_1	248	254	PF00069	0.366
MOD_CK1_1	286	292	PF00069	0.371
MOD_CK1_1	299	305	PF00069	0.371
MOD_CK1_1	76	82	PF00069	0.590
MOD_CK2_1	18	24	PF00069	0.417
MOD_CK2_1	187	193	PF00069	0.408
MOD_CK2_1	348	354	PF00069	0.437
MOD_CK2_1	355	361	PF00069	0.385
MOD_GlcNHglycan	161	164	PF01048	0.473
MOD_GlcNHglycan	186	189	PF01048	0.306
MOD_GlcNHglycan	225	228	PF01048	0.392
MOD_GlcNHglycan	288	291	PF01048	0.260
MOD_GlcNHglycan	3	6	PF01048	0.373
MOD_GlcNHglycan	301	304	PF01048	0.260
MOD_GSK3_1	14	21	PF00069	0.447
MOD_GSK3_1	151	158	PF00069	0.563
MOD_GSK3_1	183	190	PF00069	0.301
MOD_GSK3_1	223	230	PF00069	0.431
MOD_GSK3_1	266	273	PF00069	0.371
MOD_GSK3_1	95	102	PF00069	0.377
MOD_N-GLC_1	283	288	PF02516	0.166
MOD_NEK2_1	1	6	PF00069	0.479
MOD_NEK2_1	104	109	PF00069	0.294
MOD_NEK2_1	14	19	PF00069	0.407
MOD_NEK2_1	256	261	PF00069	0.528
MOD_NEK2_1	272	277	PF00069	0.431
MOD_NEK2_1	320	325	PF00069	0.393
MOD_NEK2_1	329	334	PF00069	0.446
MOD_NEK2_2	227	232	PF00069	0.427
MOD_NEK2_2	73	78	PF00069	0.356
MOD_PIKK_1	96	102	PF00454	0.370
MOD_PKA_1	68	74	PF00069	0.368
MOD_PKA_2	245	251	PF00069	0.410
MOD_PKA_2	266	272	PF00069	0.371
MOD_PKA_2	68	74	PF00069	0.368
MOD_PKA_2	87	93	PF00069	0.372
MOD_Plk_1	256	262	PF00069	0.366
MOD_Plk_1	26	32	PF00069	0.366
MOD_Plk_1	60	66	PF00069	0.366
MOD_Plk_4	14	20	PF00069	0.420
MOD_Plk_4	227	233	PF00069	0.566
MOD_Plk_4	248	254	PF00069	0.437
MOD_Plk_4	29	35	PF00069	0.420
MOD_Plk_4	61	67	PF00069	0.469
MOD_Plk_4	99	105	PF00069	0.301
MOD_ProDKin_1	155	161	PF00069	0.544
MOD_SUMO_rev_2	205	210	PF00179	0.306
TRG_DiLeu_BaEn_1	293	298	PF01217	0.366
TRG_ENDOCYTIC_2	52	55	PF00928	0.533
TRG_ER_diArg_1	73	75	PF00400	0.326
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.166
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I9	Leptomonas seymouri	29%	100%
A0A0N0P7W9	Leptomonas seymouri	28%	100%
A0A0N1I1D8	Leptomonas seymouri	28%	100%
A0A0N1I836	Leptomonas seymouri	23%	100%
A0A0N1I9R7	Leptomonas seymouri	25%	100%
A0A0N1ILU0	Leptomonas seymouri	56%	100%
A0A0N1IM34	Leptomonas seymouri	28%	100%
A0A0N1PEM6	Leptomonas seymouri	30%	97%
A0A1X0NRL0	Trypanosomatidae	26%	100%
A0A1X0NYN3	Trypanosomatidae	27%	100%
A0A1X0NYY3	Trypanosomatidae	31%	100%
A0A1X0P2Q4	Trypanosomatidae	29%	100%
A0A3Q8IAZ9	Leishmania donovani	24%	100%
A0A3Q8IDX0	Leishmania donovani	27%	100%
A0A3Q8IEU6	Leishmania donovani	31%	94%
A0A3Q8IGR3	Leishmania donovani	29%	100%
A0A3R7M7Z1	Trypanosoma rangeli	28%	100%
A0A3S7X1G8	Leishmania donovani	25%	100%
A0A422MX56	Trypanosoma rangeli	30%	100%
A0A422N4F0	Trypanosoma rangeli	33%	99%
A1A8B5	Escherichia coli O1:K1 / APEC	26%	100%
A1JNL2	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	25%	100%
A4HGI1	Leishmania braziliensis	28%	95%
A4HGI6	Leishmania braziliensis	29%	86%
A4HGI8	Leishmania braziliensis	25%	82%
A4HGI9	Leishmania braziliensis	24%	77%
A4I3L4	Leishmania infantum	27%	100%
A4I3L5	Leishmania infantum	24%	100%
A4I3L6	Leishmania infantum	25%	100%
A4I3L7	Leishmania infantum	31%	94%
A6T5I9	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	25%	100%
A7ZIK4	Escherichia coli O139:H28 (strain E24377A / ETEC)	26%	100%
A7ZXA4	Escherichia coli O9:H4 (strain HS)	26%	100%
A8GAR8	Serratia proteamaculans (strain 568)	26%	100%
A9MM14	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	26%	100%
A9MWC0	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	25%	100%
B1LJK3	Escherichia coli (strain SMS-3-5 / SECEC)	26%	100%
B1XFN4	Escherichia coli (strain K12 / DH10B)	26%	100%
B2U4Q1	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	26%	100%
B4SWV0	Salmonella newport (strain SL254)	25%	100%
B4T9F2	Salmonella heidelberg (strain SL476)	25%	100%
B4TMD5	Salmonella schwarzengrund (strain CVM19633)	25%	100%
B5BD74	Salmonella paratyphi A (strain AKU_12601)	25%	100%
B5EXJ7	Salmonella agona (strain SL483)	25%	100%
B5FKW1	Salmonella dublin (strain CT_02021853)	25%	100%
B5QU47	Salmonella enteritidis PT4 (strain P125109)	25%	100%
B5R6V8	Salmonella gallinarum (strain 287/91 / NCTC 13346)	25%	100%
B5Y0T3	Klebsiella pneumoniae (strain 342)	26%	100%
B5Z3V4	Escherichia coli O157:H7 (strain EC4115 / EHEC)	26%	100%
B6HZQ3	Escherichia coli (strain SE11)	26%	100%
B7L683	Escherichia coli (strain 55989 / EAEC)	25%	100%
B7LMD3	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	26%	100%
B7M3T9	Escherichia coli O8 (strain IAI1)	25%	100%
B7MDA5	Escherichia coli O45:K1 (strain S88 / ExPEC)	26%	100%
B7MQG2	Escherichia coli O81 (strain ED1a)	25%	100%
B7N900	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	25%	100%
B7NJ48	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	26%	100%
B7UJR9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	26%	100%
C4ZTK3	Escherichia coli (strain K12 / MC4100 / BW2952)	26%	100%
D0A7S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A841	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AZV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AZV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AZV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AZV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	94%
P27848	Escherichia coli (strain K12)	32%	100%
P44771	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	31%	100%
P46891	Escherichia coli (strain K12)	26%	100%
P57140	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	26%	100%
Q0T7D7	Shigella flexneri serotype 5b (strain 8401)	26%	100%
Q0TKJ5	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	26%	100%
Q1RF89	Escherichia coli (strain UTI89 / UPEC)	26%	100%
Q325F5	Shigella boydii serotype 4 (strain Sb227)	26%	100%
Q3Z4V2	Shigella sonnei (strain Ss046)	26%	100%
Q4Q8C8	Leishmania major	31%	98%
Q4Q8C9	Leishmania major	25%	77%
Q4Q8D0	Leishmania major	25%	78%
Q4Q8D1	Leishmania major	28%	85%
Q57SA6	Salmonella choleraesuis (strain SC-B67)	25%	100%
Q5PFM4	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	25%	100%
Q83M49	Shigella flexneri	26%	100%
Q8FKA2	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	25%	100%
Q8KA73	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	29%	100%
Q8X8L6	Escherichia coli O157:H7	32%	100%
Q8XE50	Escherichia coli O157:H7	26%	100%
Q8Z8U7	Salmonella typhi	25%	100%
Q8ZRB6	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	25%	100%
V5BGL5	Trypanosoma cruzi	37%	100%
V5D8D2	Trypanosoma cruzi	29%	100%