Putative haloacid dehalogenase-like hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

haloacid dehalogenase-like hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HGI9_LEIBR

TriTrypDb:

LbrM.28.1520 , LBRM2903_280021100

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGI9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0016787	hydrolase activity	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.465
CLV_NRD_NRD_1	54	56	PF00675	0.167
CLV_PCSK_KEX2_1	30	32	PF00082	0.252
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.252
CLV_PCSK_SKI1_1	111	115	PF00082	0.335
CLV_PCSK_SKI1_1	27	31	PF00082	0.298
CLV_PCSK_SKI1_1	97	101	PF00082	0.324
DEG_APCC_DBOX_1	144	152	PF00400	0.556
DOC_MAPK_gen_1	272	279	PF00069	0.579
DOC_MAPK_gen_1	30	39	PF00069	0.422
DOC_PP1_RVXF_1	33	40	PF00149	0.575
DOC_PP4_FxxP_1	190	193	PF00568	0.502
LIG_14-3-3_CanoR_1	45	54	PF00244	0.380
LIG_AP2alpha_1	135	139	PF02296	0.367
LIG_BRCT_BRCA1_1	131	135	PF00533	0.524
LIG_BRCT_BRCA1_1	186	190	PF00533	0.406
LIG_Clathr_ClatBox_1	171	175	PF01394	0.460
LIG_FHA_1	187	193	PF00498	0.514
LIG_FHA_1	23	29	PF00498	0.483
LIG_FHA_1	239	245	PF00498	0.415
LIG_FHA_2	102	108	PF00498	0.546
LIG_FHA_2	217	223	PF00498	0.380
LIG_FHA_2	262	268	PF00498	0.401
LIG_FHA_2	6	12	PF00498	0.479
LIG_GBD_Chelix_1	212	220	PF00786	0.264
LIG_GBD_Chelix_1	6	14	PF00786	0.324
LIG_LIR_Apic_2	187	193	PF02991	0.491
LIG_LIR_Gen_1	74	85	PF02991	0.457
LIG_LIR_Nem_3	48	54	PF02991	0.486
LIG_LIR_Nem_3	74	80	PF02991	0.524
LIG_Pex14_2	135	139	PF04695	0.524
LIG_SH2_NCK_1	47	51	PF00017	0.457
LIG_SH2_STAP1	149	153	PF00017	0.457
LIG_SH2_STAP1	24	28	PF00017	0.524
LIG_SH2_STAP1	47	51	PF00017	0.457
LIG_SH2_STAT3	149	152	PF00017	0.457
LIG_SH2_STAT5	194	197	PF00017	0.516
LIG_SH2_STAT5	24	27	PF00017	0.407
LIG_SH2_STAT5	47	50	PF00017	0.436
LIG_SH2_STAT5	63	66	PF00017	0.436
MOD_CK1_1	22	28	PF00069	0.453
MOD_CK1_1	242	248	PF00069	0.367
MOD_CK2_1	101	107	PF00069	0.539
MOD_CK2_1	124	130	PF00069	0.457
MOD_CK2_1	205	211	PF00069	0.500
MOD_CK2_1	216	222	PF00069	0.436
MOD_GlcNHglycan	101	104	PF01048	0.255
MOD_GlcNHglycan	130	134	PF01048	0.190
MOD_GlcNHglycan	175	178	PF01048	0.347
MOD_GlcNHglycan	182	185	PF01048	0.376
MOD_GSK3_1	180	187	PF00069	0.452
MOD_GSK3_1	238	245	PF00069	0.367
MOD_GSK3_1	95	102	PF00069	0.467
MOD_NEK2_1	10	15	PF00069	0.460
MOD_NEK2_1	186	191	PF00069	0.474
MOD_NEK2_1	236	241	PF00069	0.480
MOD_NEK2_1	89	94	PF00069	0.572
MOD_Plk_1	124	130	PF00069	0.457
MOD_Plk_1	22	28	PF00069	0.392
MOD_Plk_1	231	237	PF00069	0.524
MOD_Plk_4	10	16	PF00069	0.466
MOD_Plk_4	231	237	PF00069	0.527
MOD_Plk_4	239	245	PF00069	0.532
MOD_Plk_4	89	95	PF00069	0.558
TRG_DiLeu_BaEn_1	167	172	PF01217	0.367
TRG_ENDOCYTIC_2	47	50	PF00928	0.470
TRG_ER_diArg_1	52	55	PF00400	0.367
TRG_ER_diArg_1	94	97	PF00400	0.560
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.234
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.261
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.239

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I9	Leptomonas seymouri	28%	86%
A0A0N0P7W9	Leptomonas seymouri	31%	96%
A0A0N1I1D8	Leptomonas seymouri	26%	85%
A0A0N1I836	Leptomonas seymouri	34%	96%
A0A0N1I9R7	Leptomonas seymouri	36%	99%
A0A0N1ILU0	Leptomonas seymouri	24%	74%
A0A0N1IM34	Leptomonas seymouri	62%	100%
A0A1X0NRL0	Trypanosomatidae	33%	97%
A0A1X0NYN3	Trypanosomatidae	28%	86%
A0A1X0NYY3	Trypanosomatidae	41%	96%
A0A1X0P2Q4	Trypanosomatidae	29%	81%
A0A3Q8IAZ9	Leishmania donovani	38%	97%
A0A3Q8IDX0	Leishmania donovani	25%	84%
A0A3Q8IEU6	Leishmania donovani	27%	70%
A0A3Q8IGR3	Leishmania donovani	27%	84%
A0A3R7M7Z1	Trypanosoma rangeli	34%	97%
A0A3S7X1G8	Leishmania donovani	79%	99%
A0A422MX56	Trypanosoma rangeli	41%	100%
A0A422N4F0	Trypanosoma rangeli	24%	74%
A1A8B5	Escherichia coli O1:K1 / APEC	30%	100%
A1JNL2	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	30%	100%
A4HGI1	Leishmania braziliensis	27%	96%
A4HGI6	Leishmania braziliensis	27%	100%
A4HGI8	Leishmania braziliensis	39%	100%
A4HGJ0	Leishmania braziliensis	24%	74%
A4I3L3	Leishmania infantum	30%	100%
A4I3L4	Leishmania infantum	26%	84%
A4I3L5	Leishmania infantum	38%	97%
A4I3L6	Leishmania infantum	78%	99%
A4I3L7	Leishmania infantum	27%	70%
A4TPD3	Yersinia pestis (strain Pestoides F)	32%	100%
A4W7B7	Enterobacter sp. (strain 638)	31%	100%
A6T5I9	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	30%	100%
A7FLB5	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	32%	100%
A7MFJ6	Cronobacter sakazakii (strain ATCC BAA-894)	30%	100%
A7ZIK4	Escherichia coli O139:H28 (strain E24377A / ETEC)	30%	100%
A7ZXA4	Escherichia coli O9:H4 (strain HS)	30%	100%
A8AK07	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	28%	100%
A8GAR8	Serratia proteamaculans (strain 568)	28%	100%
A9MM14	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	29%	100%
A9MWC0	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	28%	100%
A9QZP3	Yersinia pestis bv. Antiqua (strain Angola)	32%	100%
B1IZE7	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	29%	100%
B1JHR2	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	32%	100%
B1LJK3	Escherichia coli (strain SMS-3-5 / SECEC)	30%	100%
B1XFN4	Escherichia coli (strain K12 / DH10B)	30%	100%
B2K6W6	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	32%	100%
B2U4Q1	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	30%	100%
B4SWV0	Salmonella newport (strain SL254)	28%	100%
B4T9F2	Salmonella heidelberg (strain SL476)	28%	100%
B4TMD5	Salmonella schwarzengrund (strain CVM19633)	28%	100%
B5BD74	Salmonella paratyphi A (strain AKU_12601)	28%	100%
B5EXJ7	Salmonella agona (strain SL483)	28%	100%
B5FKW1	Salmonella dublin (strain CT_02021853)	28%	100%
B5QU47	Salmonella enteritidis PT4 (strain P125109)	28%	100%
B5R6V8	Salmonella gallinarum (strain 287/91 / NCTC 13346)	28%	100%
B5Y0T3	Klebsiella pneumoniae (strain 342)	31%	100%
B5Z3V4	Escherichia coli O157:H7 (strain EC4115 / EHEC)	30%	100%
B6HZQ3	Escherichia coli (strain SE11)	30%	100%
B7L683	Escherichia coli (strain 55989 / EAEC)	30%	100%
B7LMD3	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	30%	100%
B7M3T9	Escherichia coli O8 (strain IAI1)	30%	100%
B7MDA5	Escherichia coli O45:K1 (strain S88 / ExPEC)	30%	100%
B7MQG2	Escherichia coli O81 (strain ED1a)	30%	100%
B7N900	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	30%	100%
B7NJ48	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	30%	100%
B7UJR9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	30%	100%
C4ZTK3	Escherichia coli (strain K12 / MC4100 / BW2952)	30%	100%
D0A7S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	90%
D0A841	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	98%
E9AZV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AZV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	84%
E9AZV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	97%
E9AZV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
E9AZV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	70%
P0A8Y5	Escherichia coli (strain K12)	25%	100%
P0A8Y6	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	25%	100%
P0A8Y7	Shigella flexneri	25%	100%
P27848	Escherichia coli (strain K12)	35%	100%
P42962	Bacillus subtilis (strain 168)	28%	100%
P44447	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	26%	100%
P44771	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	31%	100%
P46891	Escherichia coli (strain K12)	30%	100%
P54947	Bacillus subtilis (strain 168)	26%	100%
P57140	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	28%	100%
P70947	Bacillus subtilis (strain 168)	27%	100%
Q0T7D7	Shigella flexneri serotype 5b (strain 8401)	29%	100%
Q0TKJ5	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	30%	100%
Q1C4L7	Yersinia pestis bv. Antiqua (strain Antiqua)	32%	100%
Q1CL56	Yersinia pestis bv. Antiqua (strain Nepal516)	32%	100%
Q1RF89	Escherichia coli (strain UTI89 / UPEC)	30%	100%
Q325F5	Shigella boydii serotype 4 (strain Sb227)	30%	100%
Q3Z4V2	Shigella sonnei (strain Ss046)	30%	100%
Q4Q8C8	Leishmania major	28%	70%
Q4Q8C9	Leishmania major	77%	100%
Q4Q8D0	Leishmania major	39%	100%
Q4Q8D1	Leishmania major	28%	98%
Q4Q8D2	Leishmania major	29%	100%
Q57SA6	Salmonella choleraesuis (strain SC-B67)	28%	100%
Q5PFM4	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	28%	100%
Q5XD45	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	26%	100%
Q66DS5	Yersinia pseudotuberculosis serotype I (strain IP32953)	32%	100%
Q7CK25	Yersinia pestis	32%	100%
Q83M49	Shigella flexneri	29%	100%
Q89B25	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	30%	100%
Q8FKA2	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	30%	100%
Q8KA73	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	31%	100%
Q8X8L6	Escherichia coli O157:H7	35%	100%
Q8XE50	Escherichia coli O157:H7	30%	100%
Q8Z8U7	Salmonella typhi	28%	100%
Q8ZRB6	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	28%	100%
Q9UTA6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	93%
V5BGL5	Trypanosoma cruzi	29%	89%
V5D8D2	Trypanosoma cruzi	42%	90%