Haloacid dehalogenase-like hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

haloacid dehalogenase-like hydrolase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HGI8_LEIBR

TriTrypDb:

LbrM.28.1510 , LBRM2903_280020900

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGI8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0016787	hydrolase activity	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	116	120	PF00082	0.318
CLV_PCSK_SKI1_1	127	131	PF00082	0.270
CLV_PCSK_SKI1_1	138	142	PF00082	0.300
CLV_PCSK_SKI1_1	27	31	PF00082	0.321
CLV_PCSK_SKI1_1	7	11	PF00082	0.365
DEG_APCC_DBOX_1	115	123	PF00400	0.580
DOC_MAPK_gen_1	5	13	PF00069	0.409
DOC_MAPK_MEF2A_6	257	265	PF00069	0.458
DOC_MAPK_MEF2A_6	5	13	PF00069	0.302
DOC_PP1_RVXF_1	114	121	PF00149	0.436
DOC_PP1_RVXF_1	36	43	PF00149	0.572
DOC_PP4_FxxP_1	194	197	PF00568	0.500
DOC_USP7_MATH_1	296	300	PF00917	0.638
DOC_USP7_UBL2_3	205	209	PF12436	0.534
DOC_WW_Pin1_4	60	65	PF00397	0.364
DOC_WW_Pin1_4	97	102	PF00397	0.526
LIG_14-3-3_CanoR_1	214	224	PF00244	0.364
LIG_14-3-3_CanoR_1	27	32	PF00244	0.443
LIG_14-3-3_CanoR_1	79	84	PF00244	0.408
LIG_AP2alpha_1	50	54	PF02296	0.500
LIG_BIR_II_1	1	5	PF00653	0.458
LIG_BIR_III_3	1	5	PF00653	0.322
LIG_BRCT_BRCA1_1	19	23	PF00533	0.406
LIG_BRCT_BRCA1_1	62	66	PF00533	0.561
LIG_FHA_1	155	161	PF00498	0.573
LIG_FHA_1	191	197	PF00498	0.526
LIG_FHA_1	26	32	PF00498	0.508
LIG_FHA_1	88	94	PF00498	0.406
LIG_GBD_Chelix_1	274	282	PF00786	0.337
LIG_LIR_Apic_2	191	197	PF02991	0.488
LIG_LIR_Gen_1	144	153	PF02991	0.493
LIG_LIR_Gen_1	20	31	PF02991	0.491
LIG_LIR_Nem_3	144	150	PF02991	0.495
LIG_LIR_Nem_3	20	26	PF02991	0.468
LIG_LIR_Nem_3	52	57	PF02991	0.486
LIG_NRBOX	277	283	PF00104	0.478
LIG_Pex14_2	141	145	PF04695	0.534
LIG_Pex14_2	50	54	PF04695	0.500
LIG_SH2_NCK_1	147	151	PF00017	0.500
LIG_SH2_STAT5	181	184	PF00017	0.507
LIG_SH3_3	105	111	PF00018	0.504
LIG_SH3_3	258	264	PF00018	0.454
LIG_SH3_3	295	301	PF00018	0.414
LIG_TRFH_1	97	101	PF08558	0.534
MOD_CK1_1	25	31	PF00069	0.468
MOD_CK2_1	265	271	PF00069	0.444
MOD_GSK3_1	13	20	PF00069	0.468
MOD_GSK3_1	156	163	PF00069	0.510
MOD_GSK3_1	184	191	PF00069	0.468
MOD_GSK3_1	97	104	PF00069	0.510
MOD_N-GLC_1	60	65	PF02516	0.254
MOD_N-GLC_2	131	133	PF02516	0.334
MOD_NEK2_1	13	18	PF00069	0.464
MOD_NEK2_1	160	165	PF00069	0.497
MOD_NEK2_1	224	229	PF00069	0.549
MOD_NEK2_1	66	71	PF00069	0.436
MOD_PIKK_1	151	157	PF00454	0.364
MOD_PIKK_1	296	302	PF00454	0.430
MOD_PKB_1	125	133	PF00069	0.399
MOD_Plk_4	13	19	PF00069	0.470
MOD_Plk_4	141	147	PF00069	0.534
MOD_Plk_4	162	168	PF00069	0.477
MOD_Plk_4	27	33	PF00069	0.413
MOD_Plk_4	79	85	PF00069	0.563
MOD_ProDKin_1	60	66	PF00069	0.364
MOD_ProDKin_1	97	103	PF00069	0.526
TRG_ENDOCYTIC_2	147	150	PF00928	0.436
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I9	Leptomonas seymouri	30%	92%
A0A0N0P7W9	Leptomonas seymouri	28%	100%
A0A0N1I1D8	Leptomonas seymouri	30%	91%
A0A0N1I836	Leptomonas seymouri	60%	100%
A0A0N1I9R7	Leptomonas seymouri	69%	100%
A0A0N1ILU0	Leptomonas seymouri	24%	80%
A0A0N1IM34	Leptomonas seymouri	41%	100%
A0A1X0NRL0	Trypanosomatidae	33%	100%
A0A1X0NYN3	Trypanosomatidae	27%	92%
A0A1X0NYY3	Trypanosomatidae	37%	100%
A0A1X0P2Q4	Trypanosomatidae	27%	87%
A0A3Q8IAZ9	Leishmania donovani	79%	100%
A0A3Q8IDX0	Leishmania donovani	29%	99%
A0A3Q8IGR3	Leishmania donovani	27%	90%
A0A3R7M7Z1	Trypanosoma rangeli	33%	100%
A0A3S7X1G8	Leishmania donovani	40%	100%
A0A422MX56	Trypanosoma rangeli	36%	100%
A0A422N4F0	Trypanosoma rangeli	23%	79%
A1A8B5	Escherichia coli O1:K1 / APEC	29%	100%
A1JNL2	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	30%	100%
A4HGI1	Leishmania braziliensis	28%	100%
A4HGI6	Leishmania braziliensis	29%	99%
A4HGI9	Leishmania braziliensis	39%	100%
A4HGJ0	Leishmania braziliensis	25%	80%
A4I3L4	Leishmania infantum	29%	99%
A4I3L5	Leishmania infantum	79%	100%
A4I3L6	Leishmania infantum	40%	100%
A4TPD3	Yersinia pestis (strain Pestoides F)	31%	100%
A4W7B7	Enterobacter sp. (strain 638)	29%	100%
A6T5I9	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	30%	100%
A7FLB5	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	32%	100%
A7MFJ6	Cronobacter sakazakii (strain ATCC BAA-894)	31%	100%
A7ZIK4	Escherichia coli O139:H28 (strain E24377A / ETEC)	29%	100%
A7ZXA4	Escherichia coli O9:H4 (strain HS)	29%	100%
A8AK07	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	30%	100%
A8GAR8	Serratia proteamaculans (strain 568)	31%	100%
A9MM14	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	29%	100%
A9MWC0	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	30%	100%
A9QZP3	Yersinia pestis bv. Antiqua (strain Angola)	31%	100%
B1IZE7	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	28%	100%
B1JHR2	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	32%	100%
B1LJK3	Escherichia coli (strain SMS-3-5 / SECEC)	29%	100%
B1XFN4	Escherichia coli (strain K12 / DH10B)	29%	100%
B2K6W6	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	31%	100%
B2U4Q1	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	29%	100%
B4SWV0	Salmonella newport (strain SL254)	30%	100%
B4T9F2	Salmonella heidelberg (strain SL476)	30%	100%
B4TMD5	Salmonella schwarzengrund (strain CVM19633)	29%	100%
B5BD74	Salmonella paratyphi A (strain AKU_12601)	30%	100%
B5EXJ7	Salmonella agona (strain SL483)	30%	100%
B5FKW1	Salmonella dublin (strain CT_02021853)	30%	100%
B5QU47	Salmonella enteritidis PT4 (strain P125109)	30%	100%
B5R6V8	Salmonella gallinarum (strain 287/91 / NCTC 13346)	30%	100%
B5Y0T3	Klebsiella pneumoniae (strain 342)	30%	100%
B5Z3V4	Escherichia coli O157:H7 (strain EC4115 / EHEC)	29%	100%
B6HZQ3	Escherichia coli (strain SE11)	29%	100%
B7L683	Escherichia coli (strain 55989 / EAEC)	29%	100%
B7LMD3	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	29%	100%
B7M3T9	Escherichia coli O8 (strain IAI1)	29%	100%
B7MDA5	Escherichia coli O45:K1 (strain S88 / ExPEC)	29%	100%
B7MQG2	Escherichia coli O81 (strain ED1a)	29%	100%
B7N900	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	29%	100%
B7NJ48	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	29%	100%
B7UJR9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	29%	100%
C4ZTK3	Escherichia coli (strain K12 / MC4100 / BW2952)	29%	100%
D0A7S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	97%
D0A841	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AZV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	91%
E9AZV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9AZV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
O07539	Bacillus subtilis (strain 168)	24%	100%
P0A8Y5	Escherichia coli (strain K12)	29%	100%
P0A8Y6	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	29%	100%
P0A8Y7	Shigella flexneri	29%	100%
P21829	Escherichia coli (strain K12)	26%	100%
P27848	Escherichia coli (strain K12)	32%	100%
P42962	Bacillus subtilis (strain 168)	27%	100%
P44447	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	100%
P44771	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	35%	100%
P46891	Escherichia coli (strain K12)	29%	100%
P54947	Bacillus subtilis (strain 168)	27%	100%
P57140	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	27%	100%
P70947	Bacillus subtilis (strain 168)	25%	100%
P75360	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	22%	100%
P75809	Escherichia coli (strain K12)	23%	100%
P94592	Bacillus subtilis (strain 168)	27%	100%
P96741	Bacillus subtilis (strain 168)	24%	100%
Q0T7D7	Shigella flexneri serotype 5b (strain 8401)	28%	100%
Q0TKJ5	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	29%	100%
Q1C4L7	Yersinia pestis bv. Antiqua (strain Antiqua)	31%	100%
Q1CL56	Yersinia pestis bv. Antiqua (strain Nepal516)	31%	100%
Q1RF89	Escherichia coli (strain UTI89 / UPEC)	29%	100%
Q325F5	Shigella boydii serotype 4 (strain Sb227)	29%	100%
Q3Z4V2	Shigella sonnei (strain Ss046)	29%	100%
Q45494	Bacillus subtilis (strain 168)	25%	100%
Q4Q8C9	Leishmania major	40%	98%
Q4Q8D0	Leishmania major	78%	100%
Q4Q8D1	Leishmania major	31%	100%
Q57SA6	Salmonella choleraesuis (strain SC-B67)	30%	100%
Q5PFM4	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	30%	100%
Q66DS5	Yersinia pseudotuberculosis serotype I (strain IP32953)	32%	100%
Q7CK25	Yersinia pestis	31%	100%
Q83M49	Shigella flexneri	28%	100%
Q89B25	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	28%	100%
Q8FKA2	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	29%	100%
Q8KA73	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	29%	100%
Q8X8L6	Escherichia coli O157:H7	32%	100%
Q8XE50	Escherichia coli O157:H7	29%	100%
Q8Z8U7	Salmonella typhi	30%	100%
Q8ZRB6	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	30%	100%
V5BGL5	Trypanosoma cruzi	28%	96%
V5D8D2	Trypanosoma cruzi	39%	97%