Haloacid dehalogenase-like hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

haloacid dehalogenase-like hydrolase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HGI6_LEIBR

TriTrypDb:

LbrM.28.1490 , LBRM2903_280020800

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGI6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.487
CLV_PCSK_SKI1_1	197	201	PF00082	0.317
CLV_PCSK_SKI1_1	251	255	PF00082	0.345
CLV_PCSK_SKI1_1	326	330	PF00082	0.465
DEG_APCC_DBOX_1	27	35	PF00400	0.507
DOC_ANK_TNKS_1	184	191	PF00023	0.482
DOC_CDC14_PxL_1	38	46	PF14671	0.428
DOC_MAPK_gen_1	251	258	PF00069	0.465
DOC_MAPK_gen_1	323	333	PF00069	0.598
DOC_PP1_RVXF_1	140	146	PF00149	0.550
DOC_PP1_RVXF_1	195	201	PF00149	0.517
DOC_PP4_FxxP_1	329	332	PF00568	0.482
DOC_PP4_MxPP_1	1	4	PF00568	0.386
DOC_USP7_MATH_1	165	169	PF00917	0.574
DOC_USP7_MATH_1	51	55	PF00917	0.428
DOC_USP7_MATH_1	78	82	PF00917	0.556
DOC_WW_Pin1_4	15	20	PF00397	0.508
DOC_WW_Pin1_4	76	81	PF00397	0.529
LIG_14-3-3_CanoR_1	6	16	PF00244	0.416
LIG_APCC_ABBA_1	149	154	PF00400	0.511
LIG_BRCT_BRCA1_1	195	199	PF00533	0.550
LIG_BRCT_BRCA1_1	227	231	PF00533	0.550
LIG_BRCT_BRCA1_1	273	277	PF00533	0.465
LIG_CtBP_PxDLS_1	226	230	PF00389	0.529
LIG_deltaCOP1_diTrp_1	137	145	PF00928	0.497
LIG_FHA_1	210	216	PF00498	0.428
LIG_FHA_1	44	50	PF00498	0.494
LIG_FHA_1	99	105	PF00498	0.504
LIG_FHA_2	106	112	PF00498	0.550
LIG_FHA_2	243	249	PF00498	0.547
LIG_FHA_2	8	14	PF00498	0.532
LIG_GBD_Chelix_1	114	122	PF00786	0.321
LIG_LIR_Apic_2	327	332	PF02991	0.484
LIG_LIR_Nem_3	154	160	PF02991	0.560
LIG_PDZ_Class_2	328	333	PF00595	0.497
LIG_SH2_CRK	192	196	PF00017	0.550
LIG_SH2_CRK	38	42	PF00017	0.428
LIG_SH2_GRB2like	134	137	PF00017	0.514
LIG_SH2_NCK_1	171	175	PF00017	0.476
LIG_SH2_NCK_1	50	54	PF00017	0.487
LIG_SH2_SRC	50	53	PF00017	0.557
LIG_SH2_STAT5	192	195	PF00017	0.529
LIG_SH2_STAT5	26	29	PF00017	0.439
LIG_SH2_STAT5	63	66	PF00017	0.529
LIG_SH2_STAT5	7	10	PF00017	0.408
LIG_SH2_STAT5	87	90	PF00017	0.496
LIG_SH3_2	77	82	PF14604	0.550
LIG_SH3_3	159	165	PF00018	0.556
LIG_SH3_3	309	315	PF00018	0.515
LIG_SH3_3	74	80	PF00018	0.553
LIG_SUMO_SIM_anti_2	234	242	PF11976	0.428
LIG_SUMO_SIM_anti_2	262	269	PF11976	0.529
LIG_SUMO_SIM_anti_2	309	314	PF11976	0.576
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.443
LIG_SUMO_SIM_par_1	225	230	PF11976	0.529
LIG_UBA3_1	148	153	PF00899	0.467
LIG_UBA3_1	253	261	PF00899	0.428
MOD_CDC14_SPxK_1	79	82	PF00782	0.550
MOD_CDK_SPxK_1	76	82	PF00069	0.550
MOD_CK1_1	124	130	PF00069	0.429
MOD_CK1_1	169	175	PF00069	0.448
MOD_CK1_1	180	186	PF00069	0.505
MOD_CK1_1	24	30	PF00069	0.496
MOD_CK1_1	242	248	PF00069	0.431
MOD_CK2_1	242	248	PF00069	0.556
MOD_GlcNHglycan	154	157	PF01048	0.317
MOD_GlcNHglycan	172	175	PF01048	0.317
MOD_GlcNHglycan	179	182	PF01048	0.424
MOD_GlcNHglycan	241	244	PF01048	0.288
MOD_GSK3_1	124	131	PF00069	0.504
MOD_GSK3_1	165	172	PF00069	0.552
MOD_GSK3_1	176	183	PF00069	0.595
MOD_GSK3_1	225	232	PF00069	0.586
MOD_N-GLC_1	190	195	PF02516	0.267
MOD_NEK2_1	12	17	PF00069	0.490
MOD_NEK2_1	170	175	PF00069	0.526
MOD_NEK2_1	229	234	PF00069	0.513
MOD_NEK2_1	271	276	PF00069	0.518
MOD_NEK2_1	88	93	PF00069	0.550
MOD_PK_1	324	330	PF00069	0.568
MOD_PKA_2	27	33	PF00069	0.499
MOD_Plk_1	124	130	PF00069	0.428
MOD_Plk_1	51	57	PF00069	0.428
MOD_Plk_1	66	72	PF00069	0.404
MOD_Plk_4	12	18	PF00069	0.490
MOD_Plk_4	124	130	PF00069	0.535
MOD_Plk_4	147	153	PF00069	0.470
MOD_Plk_4	166	172	PF00069	0.453
MOD_Plk_4	30	36	PF00069	0.490
MOD_Plk_4	51	57	PF00069	0.476
MOD_ProDKin_1	15	21	PF00069	0.508
MOD_ProDKin_1	76	82	PF00069	0.529
TRG_ENDOCYTIC_2	192	195	PF00928	0.514
TRG_ENDOCYTIC_2	38	41	PF00928	0.487
TRG_ENDOCYTIC_2	50	53	PF00928	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I9	Leptomonas seymouri	37%	100%
A0A0N0P7W9	Leptomonas seymouri	32%	100%
A0A0N1I1D8	Leptomonas seymouri	65%	100%
A0A0N1I836	Leptomonas seymouri	27%	100%
A0A0N1I9R7	Leptomonas seymouri	29%	100%
A0A0N1ILU0	Leptomonas seymouri	31%	88%
A0A0N1IM34	Leptomonas seymouri	28%	100%
A0A0N1PEM6	Leptomonas seymouri	31%	85%
A0A1X0NRL0	Trypanosomatidae	34%	100%
A0A1X0NYN3	Trypanosomatidae	38%	100%
A0A1X0NYY3	Trypanosomatidae	31%	100%
A0A1X0P2Q4	Trypanosomatidae	31%	96%
A0A3Q8IAZ9	Leishmania donovani	29%	100%
A0A3Q8IDX0	Leishmania donovani	82%	100%
A0A3Q8IEU6	Leishmania donovani	30%	83%
A0A3Q8IGR3	Leishmania donovani	41%	99%
A0A3R7M7Z1	Trypanosoma rangeli	34%	100%
A0A3S7X1G8	Leishmania donovani	28%	100%
A0A422MX56	Trypanosoma rangeli	33%	100%
A0A422N4F0	Trypanosoma rangeli	27%	87%
A1A8B5	Escherichia coli O1:K1 / APEC	28%	100%
A1JNL2	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	30%	100%
A4HGI1	Leishmania braziliensis	40%	100%
A4HGI8	Leishmania braziliensis	29%	100%
A4HGI9	Leishmania braziliensis	27%	100%
A4HGJ0	Leishmania braziliensis	29%	88%
A4I3L4	Leishmania infantum	82%	100%
A4I3L5	Leishmania infantum	29%	100%
A4I3L6	Leishmania infantum	28%	100%
A4I3L7	Leishmania infantum	30%	83%
A4TPD3	Yersinia pestis (strain Pestoides F)	29%	100%
A4W7B7	Enterobacter sp. (strain 638)	29%	100%
A6T5I9	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	28%	100%
A7FLB5	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	29%	100%
A7MFJ6	Cronobacter sakazakii (strain ATCC BAA-894)	29%	100%
A7ZIK4	Escherichia coli O139:H28 (strain E24377A / ETEC)	28%	100%
A7ZXA4	Escherichia coli O9:H4 (strain HS)	28%	100%
A8AK07	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	27%	100%
A8GAR8	Serratia proteamaculans (strain 568)	30%	100%
A9MM14	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	27%	100%
A9MWC0	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	28%	100%
A9QZP3	Yersinia pestis bv. Antiqua (strain Angola)	29%	100%
B1IZE7	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	28%	100%
B1JHR2	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	29%	100%
B1LJK3	Escherichia coli (strain SMS-3-5 / SECEC)	28%	100%
B1XFN4	Escherichia coli (strain K12 / DH10B)	28%	100%
B2K6W6	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	28%	100%
B2U4Q1	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	28%	100%
B4SWV0	Salmonella newport (strain SL254)	28%	100%
B4T9F2	Salmonella heidelberg (strain SL476)	28%	100%
B4TMD5	Salmonella schwarzengrund (strain CVM19633)	28%	100%
B5BD74	Salmonella paratyphi A (strain AKU_12601)	28%	100%
B5EXJ7	Salmonella agona (strain SL483)	27%	100%
B5FKW1	Salmonella dublin (strain CT_02021853)	28%	100%
B5QU47	Salmonella enteritidis PT4 (strain P125109)	28%	100%
B5R6V8	Salmonella gallinarum (strain 287/91 / NCTC 13346)	28%	100%
B5Y0T3	Klebsiella pneumoniae (strain 342)	28%	100%
B5Z3V4	Escherichia coli O157:H7 (strain EC4115 / EHEC)	28%	100%
B6HZQ3	Escherichia coli (strain SE11)	28%	100%
B7L683	Escherichia coli (strain 55989 / EAEC)	28%	100%
B7LMD3	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	28%	100%
B7M3T9	Escherichia coli O8 (strain IAI1)	28%	100%
B7MDA5	Escherichia coli O45:K1 (strain S88 / ExPEC)	28%	100%
B7MQG2	Escherichia coli O81 (strain ED1a)	27%	100%
B7N900	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	28%	100%
B7NJ48	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	28%	100%
B7UJR9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	28%	100%
C4ZTK3	Escherichia coli (strain K12 / MC4100 / BW2952)	28%	100%
D0A7S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A841	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AZV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AZV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AZV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AZV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	83%
P27848	Escherichia coli (strain K12)	33%	100%
P44771	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	35%	100%
P46891	Escherichia coli (strain K12)	28%	100%
P57140	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	30%	100%
P75399	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	23%	100%
Q0T7D7	Shigella flexneri serotype 5b (strain 8401)	28%	100%
Q0TKJ5	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	28%	100%
Q1C4L7	Yersinia pestis bv. Antiqua (strain Antiqua)	29%	100%
Q1CL56	Yersinia pestis bv. Antiqua (strain Nepal516)	29%	100%
Q1RF89	Escherichia coli (strain UTI89 / UPEC)	28%	100%
Q325F5	Shigella boydii serotype 4 (strain Sb227)	28%	100%
Q3Z4V2	Shigella sonnei (strain Ss046)	28%	100%
Q4Q8C8	Leishmania major	29%	100%
Q4Q8C9	Leishmania major	28%	84%
Q4Q8D0	Leishmania major	28%	86%
Q4Q8D1	Leishmania major	82%	100%
Q57SA6	Salmonella choleraesuis (strain SC-B67)	28%	100%
Q5PFM4	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	28%	100%
Q66DS5	Yersinia pseudotuberculosis serotype I (strain IP32953)	28%	100%
Q7CK25	Yersinia pestis	29%	100%
Q83M49	Shigella flexneri	28%	100%
Q89B25	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	26%	100%
Q8FKA2	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	28%	100%
Q8KA73	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	26%	100%
Q8X8L6	Escherichia coli O157:H7	33%	100%
Q8XE50	Escherichia coli O157:H7	28%	100%
Q8Z8U7	Salmonella typhi	28%	100%
Q8ZRB6	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	28%	100%
V5BGL5	Trypanosoma cruzi	30%	100%
V5D8D2	Trypanosoma cruzi	33%	100%