LeishMANIAdb
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Pyridoxal phosphate phosphatase PHOSPHO2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Pyridoxal phosphate phosphatase PHOSPHO2
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HGI5_LEIBR
TriTrypDb:
LbrM.28.1480 , LBRM2903_280020700
Length:
182

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGI5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGI5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 172 174 PF00675 0.321
CLV_PCSK_SKI1_1 176 180 PF00082 0.478
CLV_PCSK_SKI1_1 48 52 PF00082 0.321
CLV_PCSK_SKI1_1 89 93 PF00082 0.321
DEG_MDM2_SWIB_1 50 58 PF02201 0.481
DEG_Nend_Nbox_1 1 3 PF02207 0.461
DOC_MAPK_gen_1 120 127 PF00069 0.521
DOC_MAPK_gen_1 154 162 PF00069 0.411
DOC_MAPK_HePTP_8 66 78 PF00069 0.521
DOC_MAPK_MEF2A_6 154 162 PF00069 0.476
DOC_MAPK_MEF2A_6 69 78 PF00069 0.521
DOC_PP1_RVXF_1 46 52 PF00149 0.607
DOC_USP7_MATH_1 140 144 PF00917 0.411
DOC_USP7_MATH_2 108 114 PF00917 0.521
DOC_USP7_UBL2_3 44 48 PF12436 0.227
DOC_USP7_UBL2_3 89 93 PF12436 0.521
DOC_WW_Pin1_4 113 118 PF00397 0.521
DOC_WW_Pin1_4 32 37 PF00397 0.692
LIG_14-3-3_CanoR_1 112 116 PF00244 0.417
LIG_14-3-3_CanoR_1 120 126 PF00244 0.506
LIG_FHA_1 27 33 PF00498 0.570
LIG_FHA_2 163 169 PF00498 0.521
LIG_FHA_2 85 91 PF00498 0.411
LIG_LIR_Gen_1 98 108 PF02991 0.521
LIG_Pex14_2 50 54 PF04695 0.521
LIG_SH2_STAP1 101 105 PF00017 0.521
LIG_SH2_STAT3 10 13 PF00017 0.559
LIG_SH3_3 30 36 PF00018 0.465
LIG_SUMO_SIM_anti_2 55 60 PF11976 0.411
MOD_CDK_SPxxK_3 113 120 PF00069 0.521
MOD_CK1_1 113 119 PF00069 0.521
MOD_CK1_1 37 43 PF00069 0.515
MOD_CK1_1 72 78 PF00069 0.411
MOD_CK2_1 162 168 PF00069 0.521
MOD_CK2_1 54 60 PF00069 0.521
MOD_GlcNHglycan 138 141 PF01048 0.211
MOD_GlcNHglycan 23 27 PF01048 0.490
MOD_GlcNHglycan 36 39 PF01048 0.487
MOD_GlcNHglycan 7 10 PF01048 0.557
MOD_GlcNHglycan 78 81 PF01048 0.321
MOD_GSK3_1 132 139 PF00069 0.411
MOD_GSK3_1 18 25 PF00069 0.441
MOD_GSK3_1 28 35 PF00069 0.608
MOD_GSK3_1 50 57 PF00069 0.501
MOD_GSK3_1 72 79 PF00069 0.521
MOD_NEK2_1 121 126 PF00069 0.611
MOD_NEK2_1 136 141 PF00069 0.431
MOD_NEK2_1 62 67 PF00069 0.455
MOD_NEK2_1 74 79 PF00069 0.515
MOD_NEK2_1 84 89 PF00069 0.509
MOD_PKA_2 111 117 PF00069 0.411
MOD_Plk_1 132 138 PF00069 0.416
MOD_Plk_1 54 60 PF00069 0.485
MOD_Plk_1 62 68 PF00069 0.457
MOD_Plk_1 72 78 PF00069 0.422
MOD_Plk_4 132 138 PF00069 0.488
MOD_Plk_4 28 34 PF00069 0.467
MOD_Plk_4 54 60 PF00069 0.451
MOD_ProDKin_1 113 119 PF00069 0.521
MOD_ProDKin_1 32 38 PF00069 0.690
TRG_ENDOCYTIC_2 101 104 PF00928 0.607
TRG_ENDOCYTIC_2 12 15 PF00928 0.545
TRG_ER_diArg_1 153 156 PF00400 0.470
TRG_Pf-PMV_PEXEL_1 173 177 PF00026 0.321

Homologs

Protein Taxonomy Sequence identity Coverage
A0A422MX56 Trypanosoma rangeli 32% 66%
A1A8B5 Escherichia coli O1:K1 / APEC 29% 67%
A1JNL2 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) 30% 67%
A4HGI1 Leishmania braziliensis 100% 100%
A4I3L3 Leishmania infantum 76% 97%
A4TPD3 Yersinia pestis (strain Pestoides F) 29% 67%
A6T5I9 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) 33% 67%
A7FLB5 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) 28% 67%
A7MFJ6 Cronobacter sakazakii (strain ATCC BAA-894) 30% 67%
A7ZIK4 Escherichia coli O139:H28 (strain E24377A / ETEC) 29% 67%
A7ZXA4 Escherichia coli O9:H4 (strain HS) 29% 67%
A8GAR8 Serratia proteamaculans (strain 568) 29% 66%
A9QZP3 Yersinia pestis bv. Antiqua (strain Angola) 29% 67%
B1IZE7 Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) 28% 71%
B1JHR2 Yersinia pseudotuberculosis serotype O:3 (strain YPIII) 28% 67%
B1LJK3 Escherichia coli (strain SMS-3-5 / SECEC) 29% 67%
B1XFN4 Escherichia coli (strain K12 / DH10B) 29% 67%
B2K6W6 Yersinia pseudotuberculosis serotype IB (strain PB1/+) 28% 67%
B2U4Q1 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) 29% 67%
B5Y0T3 Klebsiella pneumoniae (strain 342) 33% 67%
B5Z3V4 Escherichia coli O157:H7 (strain EC4115 / EHEC) 29% 67%
B6HZQ3 Escherichia coli (strain SE11) 29% 67%
B7LMD3 Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) 29% 67%
B7M3T9 Escherichia coli O8 (strain IAI1) 28% 67%
B7MDA5 Escherichia coli O45:K1 (strain S88 / ExPEC) 29% 67%
B7MQG2 Escherichia coli O81 (strain ED1a) 28% 67%
B7N900 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) 28% 67%
B7NJ48 Escherichia coli O7:K1 (strain IAI39 / ExPEC) 29% 67%
B7UJR9 Escherichia coli O127:H6 (strain E2348/69 / EPEC) 29% 67%
C4ZTK3 Escherichia coli (strain K12 / MC4100 / BW2952) 29% 67%
E9AZV3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 97%
P27848 Escherichia coli (strain K12) 39% 68%
P44771 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 35% 67%
P46891 Escherichia coli (strain K12) 29% 67%
P57140 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 34% 67%
Q0T7D7 Shigella flexneri serotype 5b (strain 8401) 29% 67%
Q0TKJ5 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 29% 67%
Q1C4L7 Yersinia pestis bv. Antiqua (strain Antiqua) 29% 67%
Q1CL56 Yersinia pestis bv. Antiqua (strain Nepal516) 29% 67%
Q1RF89 Escherichia coli (strain UTI89 / UPEC) 29% 67%
Q325F5 Shigella boydii serotype 4 (strain Sb227) 29% 70%
Q32JB1 Shigella dysenteriae serotype 1 (strain Sd197) 32% 100%
Q3Z4V2 Shigella sonnei (strain Ss046) 29% 67%
Q4Q8D2 Leishmania major 74% 100%
Q66DS5 Yersinia pseudotuberculosis serotype I (strain IP32953) 28% 67%
Q7CK25 Yersinia pestis 29% 67%
Q83M49 Shigella flexneri 29% 67%
Q8FKA2 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 29% 67%
Q8KA73 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 31% 66%
Q8X8L6 Escherichia coli O157:H7 39% 68%
Q8XE50 Escherichia coli O157:H7 29% 67%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS